KEGG   PATHWAY: tdw03083
Entry
tdw03083                    Pathway                                
Name
Polycomb repressive complex - Triplophysa dalaica
Class
Genetic Information Processing; Chromosome
Pathway map
tdw03083  Polycomb repressive complex
tdw03083

Organism
Triplophysa dalaica [GN:tdw]
Gene
130426412  ezh1; histone-lysine N-methyltransferase EZH1 [KO:K17451] [EC:2.1.1.356]
130413153  ezh2; histone-lysine N-methyltransferase EZH2 [KO:K11430] [EC:2.1.1.356]
130414054  eed; polycomb protein eed [KO:K11462]
130425825  suz12a; polycomb protein suz12-A isoform X1 [KO:K11463]
130410723  rbb4l; histone-binding protein RBBP7 [KO:K10752]
130432861  phf1; PHD finger protein 1 [KO:K11467]
130418295  mtf2; metal-response element-binding transcription factor 2 isoform X1 [KO:K11485]
130440159  phf19; PHD finger protein 19 [KO:K11486]
130429598  lcor; LOW QUALITY PROTEIN: ligand-dependent corepressor [KO:K26260]
130421289  aebp2; zinc finger protein AEBP2 isoform X1 [KO:K17452]
130432538  jarid2a; protein Jumonji isoform X1 [KO:K11478]
130415475  jarid2b; protein Jumonji [KO:K11478]
130430099  bap1; ubiquitin carboxyl-terminal hydrolase BAP1 [KO:K08588] [EC:3.4.19.12]
130436732  asxl2; putative Polycomb group protein ASXL2 [KO:K11471]
130409341  asxl1; putative Polycomb group protein ASXL1 isoform X1 [KO:K11471]
130437732  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [KO:K09667] [EC:2.4.1.255]
130440013  hcfc1b; host cell factor 1b isoform X1 [KO:K14966]
130409930  hcfc1a; host cell factor 1a [KO:K14966]
130436542  yy1a; transcriptional repressor protein YY1a [KO:K09201]
130434038  yy1b; transcriptional repressor protein YY1b [KO:K09201]
130424320  methyl-CpG-binding domain protein 5-like isoform X1 [KO:K23219]
130424816  mbd6; methyl-CpG-binding domain protein 6 [KO:K26585]
130439244  foxk2a; forkhead box protein K2 [KO:K09404]
130426324  foxk1; forkhead box protein K1 [KO:K09404]
130426547  foxk2b; forkhead box protein K2 [KO:K09404]
130415545  rnf2; E3 ubiquitin-protein ligase RING2 [KO:K10695] [EC:2.3.2.27]
130413553  bmi1a; polycomb complex protein BMI-1-A [KO:K11459]
130415064  bmi1b; polycomb complex protein BMI-1-B [KO:K11459]
130426068  cbx2; chromobox protein homolog 2 [KO:K11451]
130426548  cbx4; E3 SUMO-protein ligase CBX4 [KO:K11452] [EC:2.3.2.-]
130438582  cbx7b; chromobox protein homolog 7 [KO:K11454]
130426878  cbx7a; chromobox homolog 7a isoform X1 [KO:K11454]
130426549  cbx8a; chromobox protein homolog 8a [KO:K11455]
130432614  phc1; polyhomeotic-like protein 1 [KO:K11456]
130425239  phc2b; polyhomeotic-like protein 2b isoform X1 [KO:K11457]
130409670  phc2a; polyhomeotic-like protein 2 isoform X1 [KO:K11457]
130417607  phc3; polyhomeotic-like protein 3 isoform X1 [KO:K11458]
130409081  sex comb on midleg-like protein 2 isoform X1 [KO:K11465]
130410705  scml2; sex comb on midleg-like protein 2 [KO:K11465]
130433218  polycomb protein SCMH1-like [KO:K11461]
130420527  sfmbt2; scm-like with four MBT domains protein 2 isoform X1 [KO:K26269]
130409927  sfmbt1; scm-like with four MBT domains protein 1 [KO:K26269]
130418861  aurkb; aurora kinase B isoform X1 [KO:K11479] [EC:2.7.11.1]
130437308  ube2d1a; ubiquitin-conjugating enzyme E2 D1a [KO:K06689] [EC:2.3.2.23]
130437610  ube2d2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
130431438  ube2d3; ubiquitin-conjugating enzyme E2 D3 isoform X1 [KO:K06689] [EC:2.3.2.23]
130438513  ube2d2l; ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast), like [KO:K06689] [EC:2.3.2.23]
130438935  ube2d1b; ubiquitin-conjugating enzyme E2 D1b [KO:K06689] [EC:2.3.2.23]
130440379  ube2d4; ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
130428579  usp16; ubiquitin carboxyl-terminal hydrolase 16 [KO:K11844] [EC:3.4.19.12]
130432881  usp45; ubiquitin carboxyl-terminal hydrolase 45 [KO:K11844] [EC:3.4.19.12]
130424392  rybpb; RING1 and YY1-binding protein B [KO:K11469]
130409806  rybpa; RING1 and YY1-binding protein A [KO:K11469]
130421047  yaf2; YY1-associated factor 2 isoform X1 [KO:K11468]
130438121  pcgf1; polycomb group RING finger protein 1 isoform X1 [KO:K11487]
130412050  lysine-specific demethylase 2B isoform X1 [KO:K10276] [EC:1.14.11.27]
130437647  kdm2ab; lysine-specific demethylase 2A isoform X1 [KO:K10276] [EC:1.14.11.27]
130407068  kdm2ba; lysine (K)-specific demethylase 2Ba isoform X1 [KO:K10276] [EC:1.14.11.27]
130439808  kdm2aa; lysine (K)-specific demethylase 2Aa isoform X1 [KO:K10276] [EC:1.14.11.27]
130429608  bcor; BCL-6 corepressor isoform X1 [KO:K23215]
130438070  bcorl1; LOW QUALITY PROTEIN: BCL-6 corepressor-like protein 1 [KO:K26199]
130408428  skp1; S-phase kinase-associated protein 1 [KO:K03094]
130426108  usp7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
130438100  polycomb group RING finger protein 3 isoform X1 [KO:K11488]
130437178  pcgf5a; polycomb group RING finger protein 5-A isoform X1 [KO:K11489]
130439484  pcgf5b; polycomb group RING finger protein 5-B [KO:K11489]
130411735  auts2a; autism susceptibility gene 2 protein isoform X1 [KO:K23214]
130428899  auts2b; autism susceptibility gene 2 protein homolog isoform X1 [KO:K23214]
130438735  fbrs; autism susceptibility gene 2 protein [KO:K26253]
130419030  fbrsl1; autism susceptibility gene 2 protein isoform X1 [KO:K26254]
130426532  dcaf7; DDB1- and CUL4-associated factor 7 isoform X1 [KO:K11805]
130432639  tex10; testis-expressed protein 10 homolog [KO:K14827]
130430586  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
130438581  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
130425789  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
130425803  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
130426874  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
130432220  pcgf6; polycomb group RING finger protein 6 isoform X1 [KO:K11470]
130434045  e2f6; transcription factor E2F4 [KO:K09390]
130413739  tfdp1b; transcription factor Dp-1b [KO:K04683]
130427925  tfdp1a; transcription factor Dp-1a [KO:K04683]
130434733  max; protein max isoform X1 [KO:K04453]
130437293  mgaa; MAX dimerization protein MGA a isoform X1 [KO:K23399]
130413401  lethal(3)malignant brain tumor-like protein 4 isoform X1 [KO:K24387]
130439154  l3mbtl2; lethal(3)malignant brain tumor-like protein 2 isoform X1 [KO:K24387]
130433363  l3mbtl1b; lethal(3)malignant brain tumor-like protein 4 [KO:K24387]
130434703  l3mbtl3; lethal(3)malignant brain tumor-like protein 3 isoform X1 [KO:K24387]
130409664  l3mbtl1; lethal(3)malignant brain tumor-like protein 1 isoform X1 [KO:K24387]
130433357  cbx3b; chromobox protein homolog 3b [KO:K11586]
130408514  wdr5; WD repeat-containing protein 5 [KO:K14963]
130415467  hdac1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
Reference
PMID:21881606
  Authors
Richly H, Aloia L, Di Croce L
  Title
Roles of the Polycomb group proteins in stem cells and cancer.
  Journal
Cell Death Dis 2:e204 (2011)
DOI:10.1038/cddis.2011.84
Reference
PMID:28202673
  Authors
Chittock EC, Latwiel S, Miller TC, Muller CW
  Title
Molecular architecture of polycomb repressive complexes.
  Journal
Biochem Soc Trans 45:193-205 (2017)
DOI:10.1042/BST20160173
Reference
PMID:33202645
  Authors
Geng Z, Gao Z
  Title
Mammalian PRC1 Complexes: Compositional Complexity and Diverse Molecular Mechanisms.
  Journal
Int J Mol Sci 21:ijms21228594 (2020)
DOI:10.3390/ijms21228594
Reference
PMID:35681061
  Authors
Kim JJ, Kingston RE
  Title
Context-specific Polycomb mechanisms in development.
  Journal
Nat Rev Genet 23:680-695 (2022)
DOI:10.1038/s41576-022-00499-0
Reference
PMID:36076977
  Authors
Dong GJ, Xu JL, Qi YR, Yuan ZQ, Zhao W
  Title
Critical Roles of Polycomb Repressive Complexes in Transcription and Cancer.
  Journal
Int J Mol Sci 23:ijms23179574 (2022)
DOI:10.3390/ijms23179574
Reference
PMID:37086328
  Authors
Ryan CW, Peirent ER, Regan SL, Guxholli A, Bielas SL
  Title
H2A monoubiquitination: insights from human genetics and animal models.
  Journal
Hum Genet 10.1007/s00439-023-02557-x (2023)
DOI:10.1007/s00439-023-02557-x
KO pathway
ko03083   
LinkDB

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