KEGG   PATHWAY: pcad00330
Entry
pcad00330                   Pathway                                
Name
Arginine and proline metabolism - Physeter macrocephalus (sperm whale)
Class
Metabolism; Amino acid metabolism
Pathway map
pcad00330  Arginine and proline metabolism
pcad00330

Module
pcad_M00015  Proline biosynthesis, glutamate => proline [PATH:pcad00330]
pcad_M00047  Creatine pathway [PATH:pcad00330]
pcad_M00134  Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:pcad00330]
pcad_M00135  GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:pcad00330]
pcad_M00970  Proline degradation, proline => glutamate [PATH:pcad00330]
pcad_M00972  Proline metabolism [PATH:pcad00330]
Other DBs
GO: 0006525 0006560
Organism
Physeter macrocephalus (sperm whale) [GN:pcad]
Gene
102974582  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
102975860  [KO:K00933] [EC:2.7.3.2]
102976726  ALDH2; aldehyde dehydrogenase, mitochondrial isoform X1 [KO:K00128] [EC:1.2.1.3]
102976849  SMOX; spermine oxidase isoform X2 [KO:K12259] [EC:1.5.3.16 1.5.3.-]
102977469  SAT1; diamine acetyltransferase 1 [KO:K00657] [EC:2.3.1.57]
102978315  CKB; creatine kinase B-type [KO:K00933] [EC:2.7.3.2]
102978628  CKM; creatine kinase M-type [KO:K27382]
102978670  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase isoform X1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
102979032  HOGA1; 4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X9 [KO:K18123] [EC:4.1.3.16]
102979684  P4HA3; prolyl 4-hydroxylase subunit alpha-3 isoform X1 [KO:K00472] [EC:1.14.11.2]
102980202  GATM; glycine amidinotransferase, mitochondrial isoform X1 [KO:K00613] [EC:2.1.4.1]
102981468  [KO:K14755] [EC:6.3.2.11]
102981552  PYCR1; pyrroline-5-carboxylate reductase 1, mitochondrial isoform X1 [KO:K00286] [EC:1.5.1.2]
102981661  P4HA2; prolyl 4-hydroxylase subunit alpha-2 isoform X1 [KO:K00472] [EC:1.14.11.2]
102982447  L3HYPDH; trans-3-hydroxy-L-proline dehydratase isoform X1 [KO:K18384] [EC:4.2.1.77]
102982667  ALDH4A1; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial isoform X2 [KO:K00294] [EC:1.2.1.88]
102982978  AMD1; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
102983982  AZIN2; antizyme inhibitor 2 [KO:K01583] [EC:4.1.1.19]
102985231  AOC1; amiloride-sensitive amine oxidase [copper-containing] [KO:K11182] [EC:1.4.3.22]
102985527  PYCR2; pyrroline-5-carboxylate reductase 2 [KO:K00286] [EC:1.5.1.2]
102985806  NOS3; nitric oxide synthase, endothelial isoform X2 [KO:K13242] [EC:1.14.13.39]
102985848  ARG1; arginase-1 [KO:K01476] [EC:3.5.3.1]
102986210  SAT2; thialysine N-epsilon-acetyltransferase isoform X1 [KO:K00657] [EC:2.3.1.57]
102986412  CKMT2; creatine kinase S-type, mitochondrial [KO:K00933] [EC:2.7.3.2]
102986882  [KO:K00819] [EC:2.6.1.13]
102987207  ALDH18A1; delta-1-pyrroline-5-carboxylate synthase isoform X1 [KO:K12657] [EC:2.7.2.11 1.2.1.41]
102987295  SMS; spermine synthase [KO:K00802] [EC:2.5.1.22]
102988318  ALDH3A2; aldehyde dehydrogenase family 3 member A2 [KO:K00128] [EC:1.2.1.3]
102988845  PRODH2; hydroxyproline dehydrogenase isoform X1 [KO:K11394] [EC:1.5.5.3]
102989668  GOT1; aspartate aminotransferase, cytoplasmic isoform X1 [KO:K14454] [EC:2.6.1.1]
102989672  ALDH1B1; aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
102990400  DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
102990839  CNDP2; cytosolic non-specific dipeptidase [KO:K08660] [EC:3.4.13.18]
102990841  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
102990905  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
102991016  GAMT; guanidinoacetate N-methyltransferase isoform X1 [KO:K00542] [EC:2.1.1.2]
102991113  GOT2; aspartate aminotransferase, mitochondrial isoform X3 [KO:K14455] [EC:2.6.1.1]
102991690  CNDP1; beta-Ala-His dipeptidase [KO:K05604] [EC:3.4.13.20]
102991958  [KO:K01611] [EC:4.1.1.50]
102991967  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
102992255  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
102992526  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
102992756  AGMAT; agmatinase, mitochondrial isoform X2 [KO:K27001]
102993268  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
102994278  P4HA1; prolyl 4-hydroxylase subunit alpha-1 isoform X1 [KO:K00472] [EC:1.14.11.2]
102994850  LAP3; cytosol aminopeptidase [KO:K11142] [EC:3.4.11.1 3.4.11.5]
102996126  PRODH; proline dehydrogenase 1, mitochondrial isoform X2 [KO:K00318] [EC:1.5.5.2]
102996947  SRM; spermidine synthase isoform X1 [KO:K00797] [EC:2.5.1.16]
112064077  [KO:K01611] [EC:4.1.1.50]
112067041  [KO:K00318] [EC:1.5.5.2]
114484457  [KO:K01611] [EC:4.1.1.50]
Compound
C00012  Peptide
C00019  S-Adenosyl-L-methionine
C00022  Pyruvate
C00025  L-Glutamate
C00048  Glyoxylate
C00062  L-Arginine
C00077  L-Ornithine
C00086  Urea
C00134  Putrescine
C00148  L-Proline
C00179  Agmatine
C00213  Sarcosine
C00223  p-Coumaroyl-CoA
C00300  Creatine
C00315  Spermidine
C00334  4-Aminobutanoate
C00406  Feruloyl-CoA
C00431  5-Aminopentanoate
C00436  N-Carbamoylputrescine
C00441  L-Aspartate 4-semialdehyde
C00533  Nitric oxide
C00555  4-Aminobutyraldehyde
C00581  Guanidinoacetate
C00750  Spermine
C00763  D-Proline
C00791  Creatinine
C00884  Homocarnosine
C00986  1,3-Diaminopropane
C01035  4-Guanidinobutanoate
C01043  N-Carbamoylsarcosine
C01110  5-Amino-2-oxopentanoic acid
C01137  S-Adenosylmethioninamine
C01157  Hydroxyproline
C01165  L-Glutamate 5-semialdehyde
C01250  N-Acetyl-L-glutamate 5-semialdehyde
C01682  Nopaline
C02305  Phosphocreatine
C02565  N-Methylhydantoin
C02647  4-Guanidinobutanal
C02714  N-Acetylputrescine
C02946  4-Acetamidobutanoate
C03078  4-Guanidinobutanamide
C03166  Phosphoguanidinoacetate
C03287  L-Glutamyl 5-phosphate
C03296  N2-Succinyl-L-arginine
C03375  Norspermidine
C03415  N2-Succinyl-L-ornithine
C03564  1-Pyrroline-2-carboxylate
C03771  5-Guanidino-2-oxopentanoate
C03912  (S)-1-Pyrroline-5-carboxylate
C04137  Octopine
C04281  L-1-Pyrroline-3-hydroxy-5-carboxylate
C05147  trans-3-Hydroxy-L-proline
C05931  N-Succinyl-L-glutamate
C05932  N-Succinyl-L-glutamate 5-semialdehyde
C05933  N(omega)-Hydroxyarginine
C05936  N4-Acetylaminobutanal
C05938  L-4-Hydroxyglutamate semialdehyde
C05945  L-Arginine phosphate
C05946  (4R)-4-Hydroxy-2-oxoglutarate
C05947  L-erythro-4-Hydroxyglutamate
C10497  Feruloylputrescine
C15699  gamma-L-Glutamylputrescine
C15700  gamma-Glutamyl-gamma-aminobutyraldehyde
C15767  4-(L-gamma-Glutamylamino)butanoate
C18172  Carboxyspermidine
C18174  Carboxynorspermidine
C18326  p-Coumaroylputrescine
C19706  cis-3-Hydroxy-L-proline
C20560  N1-(3-Aminopropyl)agmatine
C22886  N1-[(S)-3-amino-3-carboxypropyl]agmatine
Reference
PMID:5288244
  Authors
Haake P, Allen GW.
  Title
Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase).
  Journal
Proc Natl Acad Sci U S A 68:2691-3 (1971)
DOI:10.1073/pnas.68.11.2691
Reference
PMID:16499623
  Authors
Kurihara S, Oda S, Kumagai H, Suzuki H.
  Title
Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
  Journal
FEMS Microbiol Lett 256:318-23 (2006)
DOI:10.1111/j.1574-6968.2006.00137.x
Reference
PMID:15590624
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
DOI:10.1074/jbc.M411114200
Related
pathway
pcad00020  Citrate cycle (TCA cycle)
pcad00220  Arginine biosynthesis
pcad00250  Alanine, aspartate and glutamate metabolism
pcad00260  Glycine, serine and threonine metabolism
pcad00270  Cysteine and methionine metabolism
pcad00310  Lysine degradation
pcad00410  beta-Alanine metabolism
pcad00470  D-Amino acid metabolism
pcad00480  Glutathione metabolism
pcad00630  Glyoxylate and dicarboxylate metabolism
pcad00650  Butanoate metabolism
pcad00770  Pantothenate and CoA biosynthesis
KO pathway
ko00330   

DBGET integrated database retrieval system