KEGG   PATHWAY: pcw00830
Entry
pcw00830                    Pathway                                
Name
Retinol metabolism - Phascolarctos cinereus (koala)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
pcw00830  Retinol metabolism
pcw00830

Other DBs
GO: 0006776
Organism
Phascolarctos cinereus (koala) [GN:pcw]
Gene
110212705  BCO1; beta,beta-carotene 15,15'-dioxygenase isoform X1 [KO:K00515] [EC:1.13.11.63]
110209668  alcohol dehydrogenase class 4 mu/sigma chain-like [KO:K13951] [EC:1.1.1.1]
110204324  alcohol dehydrogenase E chain-like [KO:K13951] [EC:1.1.1.1]
110209846  alcohol dehydrogenase class 4 mu/sigma chain-like [KO:K13951] [EC:1.1.1.1]
110204264  alcohol dehydrogenase E chain-like [KO:K13951] [EC:1.1.1.1]
110203899  alcohol dehydrogenase E chain-like [KO:K13951] [EC:1.1.1.1]
110223057  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
110198918  DHRS3; short-chain dehydrogenase/reductase 3 isoform X1 [KO:K11146] [EC:1.1.1.300]
110194438  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
110211540  DHRS9; dehydrogenase/reductase SDR family member 9 [KO:K11149] [EC:1.1.-.-]
110197440  retinol dehydrogenase 8-like [KO:K11150] [EC:1.1.1.-]
110214089  RDH8; retinol dehydrogenase 8 isoform X1 [KO:K11150] [EC:1.1.1.-]
110215940  retinol dehydrogenase 8-like [KO:K11150] [EC:1.1.1.-]
110197262  RDH10; retinol dehydrogenase 10 [KO:K11151] [EC:1.1.1.-]
110220629  RDH11; retinol dehydrogenase 11 [KO:K11152] [EC:1.1.1.300]
110220578  RDH12; retinol dehydrogenase 12 isoform X1 [KO:K11153] [EC:1.1.1.300]
110220123  RDH13; retinol dehydrogenase 13 isoform X1 [KO:K11161] [EC:1.1.1.300]
110210954  RDH16; LOW QUALITY PROTEIN: retinol dehydrogenase 16 [KO:K11154] [EC:1.1.1.-]
110221381  SDR16C5; epidermal retinol dehydrogenase 2 isoform X1 [KO:K15734] [EC:1.1.1.105]
110211084  LOW QUALITY PROTEIN: 17-beta-hydroxysteroid dehydrogenase type 6-like [KO:K13369] [EC:1.1.1.62 1.1.1.105 1.1.1.239]
110213622  LRAT; lecithin retinol acyltransferase isoform X1 [KO:K00678] [EC:2.3.1.135]
110214325  DGAT1; diacylglycerol O-acyltransferase 1 [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
110201013  AWAT2; acyl-CoA wax alcohol acyltransferase 2 [KO:K11156] [EC:2.3.1.75 2.3.1.76]
110221518  PNPLA4; patatin-like phospholipase domain-containing protein 4 isoform X1 [KO:K11157] [EC:3.1.1.-]
110212969  RPE65; retinoid isomerohydrolase isoform X1 [KO:K11158] [EC:3.1.1.64 5.3.3.22]
110210897  RDH5; 11-cis retinol dehydrogenase [KO:K00061] [EC:1.1.1.315]
110207269  aldehyde oxidase 3-like isoform X1 [KO:K00157] [EC:1.2.3.1]
110207271  AOX1; aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
110197327  aldehyde oxidase 2-like isoform X1 [KO:K00157] [EC:1.2.3.1]
110205281  ALDH1A2; retinal dehydrogenase 2 [KO:K07249] [EC:1.2.1.36]
110223863  retinal dehydrogenase 1-like isoform X1 [KO:K07249] [EC:1.2.1.36]
110223801  retinal dehydrogenase 1-like [KO:K07249] [EC:1.2.1.36]
110223822  retinal dehydrogenase 1 [KO:K07249] [EC:1.2.1.36]
110192524  ALDH1A3; aldehyde dehydrogenase family 1 member A3 [KO:K07249] [EC:1.2.1.36]
110192764  cytochrome P450 26A1 isoform X1 [KO:K07437] [EC:1.14.14.-]
110218442  cytochrome P450 26B1 [KO:K12664] [EC:1.14.14.-]
110192755  LOW QUALITY PROTEIN: cytochrome P450 26C1 [KO:K12665] [EC:1.14.14.-]
110213927  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
110213926  LOW QUALITY PROTEIN: cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
110203005  cytochrome P450 2A13-like [KO:K07411] [EC:1.14.14.1]
110198215  cytochrome P450 2B4-like [KO:K07412] [EC:1.14.14.1]
110198316  LOW QUALITY PROTEIN: cytochrome P450 2B11-like [KO:K07412] [EC:1.14.14.1]
110203819  cytochrome P450 2B4-like [KO:K07412] [EC:1.14.14.1]
110204171  cytochrome P450 2B4-like [KO:K07412] [EC:1.14.14.1]
110200601  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
110215468  cytochrome P450 2C19-like isoform X1 [KO:K07413] [EC:1.14.14.1]
110200600  cytochrome P450 2C23-like isoform X1 [KO:K07413] [EC:1.14.14.1]
110213986  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
110192769  cytochrome P450 2C19-like isoform X1 [KO:K07413] [EC:1.14.14.1]
110202396  cytochrome P450 2S1 [KO:K07420] [EC:1.14.14.1]
110201906  cytochrome P450 3A24-like isoform X1 [KO:K07424] [EC:1.14.14.1]
110201914  cytochrome P450 3A4-like isoform X1 [KO:K07424] [EC:1.14.14.1]
110201917  cytochrome P450 3A9-like [KO:K07424] [EC:1.14.14.1]
110201912  cytochrome P450 3A24-like [KO:K07424] [EC:1.14.14.1]
110202488  cytochrome P450 2W1-like [KO:K07423] [EC:1.14.14.-]
110209309  cytochrome P450 4A11-like [KO:K07425] [EC:1.14.14.80]
110209310  LOW QUALITY PROTEIN: cytochrome P450 4A6-like [KO:K07425] [EC:1.14.14.80]
110201908  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2A2-like [KO:K00699] [EC:2.4.1.17]
110217405  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
110198831  UDP-glucuronosyltransferase 1-6-like isoform X1 [KO:K00699] [EC:2.4.1.17]
110204147  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B14-like [KO:K00699] [EC:2.4.1.17]
110204150  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
110204146  UDP-glucuronosyltransferase 2B14-like [KO:K00699] [EC:2.4.1.17]
110204389  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1-7-like [KO:K00699] [EC:2.4.1.17]
110196321  all-trans-retinol 13,14-reductase-like isoform X1 [KO:K09516] [EC:1.3.99.23]
110196356  RETSAT; all-trans-retinol 13,14-reductase isoform X1 [KO:K09516] [EC:1.3.99.23]
110194704  cytochrome P450 27C1 isoform X1 [KO:K17951] [EC:1.14.19.53]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   
LinkDB

DBGET integrated database retrieval system