KEGG   PATHWAY: phas04972
Entry
phas04972                   Pathway                                
Name
Pancreatic secretion - Phyllostomus hastatus (greater spear-nosed bat)
Description
The pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesize and secrete digestive enzymes. Stimulation of the cell by secretagogues such as acetylcholine (ACh) and cholecystokinin (CCK) causes the generation of an intracellular Ca2+ signal. This signal, in turn, triggers the fusion of the zymogen granules with the apical plasma membrane, leading to the polarised secretion of the enzymes. The major task of pancreatic duct cells is the secretion of fluid and bicarbonate ions (HCO3-), which neutralize the acidity of gastric contents that enter the duodenum. An increase in intracellular cAMP by secretin is one of the major signals of pancreatic HCO3- secretion. Activation of the CFTR Cl- channel and the CFTR-dependent Cl-/HCO3- exchange activities is responsible for cAMP-induced HCO3- secretion.
Class
Organismal Systems; Digestive system
Pathway map
phas04972  Pancreatic secretion
phas04972

Other DBs
GO: 0030157
Organism
Phyllostomus hastatus (greater spear-nosed bat) [GN:phas]
Gene
123804299  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 isoform X1 [KO:K01539] [EC:7.2.2.13]
123804347  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
123804635  RAP1A; ras-related protein Rap-1A [KO:K04353]
123804759  [KO:K01176] [EC:3.2.1.1]
123805699  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
123805948  CTRL; chymotrypsin-like protease CTRL-1 isoform X1 [KO:K09632] [EC:3.4.21.-]
123806074  [KO:K01310] [EC:3.4.21.1]
123806075  CTRB2; chymotrypsinogen B2 [KO:K01310] [EC:3.4.21.1]
123806278  [KO:K01047] [EC:3.1.1.4]
123806862  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
123807136  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
123807353  SCT; secretin [KO:K05263]
123807356  KCNQ1; potassium voltage-gated channel subfamily KQT member 1 isoform X1 [KO:K04926]
123808635  RAB11A; ras-related protein Rab-11A [KO:K07904]
123808665  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
123809424  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 isoform X1 [KO:K01540]
123809456  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
123810351  SCTR; secretin receptor isoform X1 [KO:K04588]
123810462  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123810931  PLA2G3; group 3 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
123811468  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
123812135  SLC26A3; chloride anion exchanger isoform X1 [KO:K14078]
123812354  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
123812719  RAP1B; ras-related protein Rap-1b [KO:K07836]
123812947  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
123813552  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
123814381  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
123814582  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
123814755  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
123814917  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
123815116  [KO:K04632]
123815292  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
123815768  CCKAR; cholecystokinin receptor type A [KO:K04194]
123815823  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
123815824  BST1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 [KO:K18152] [EC:3.2.2.6 2.4.99.20]
123815944  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
123816397  CLCA2; LOW QUALITY PROTEIN: calcium-activated chloride channel regulator 2 [KO:K05028]
123816461  CLCA1; calcium-activated chloride channel regulator 1 [KO:K05027]
123816509  [KO:K05030]
123816510  [KO:K05030]
123817558  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
123817937  SLC4A2; anion exchange protein 2 isoform X1 [KO:K13855]
123818082  SLC12A2; solute carrier family 12 member 2 isoform X1 [KO:K10951]
123818256  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
123818387  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
123818757  CPB2; carboxypeptidase B2 [KO:K01300] [EC:3.4.17.20]
123819693  [KO:K04634]
123820487  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
123820550  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
123820560  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
123820599  [KO:K01539] [EC:7.2.2.13]
123820868  KCNMA1; calcium-activated potassium channel subunit alpha-1 isoform X1 [KO:K04936]
123821116  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
123822352  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
123822448  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
123822544  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
123823122  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
123823511  [KO:K12298] [EC:3.1.1.3 3.1.1.13]
123823512  [KO:K12298] [EC:3.1.1.3 3.1.1.13]
123824140  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
123824520  [KO:K04513]
123824765  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
123824963  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
123825463  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
123825494  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
123825823  CA2; carbonic anhydrase 2 isoform X1 [KO:K18245] [EC:4.2.1.1]
123826121  RAB27B; ras-related protein Rab-27B [KO:K07886]
123826843  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
123827032  TRPC1; short transient receptor potential channel 1 [KO:K04964]
123827086  CPB1; carboxypeptidase B [KO:K01291] [EC:3.4.17.2]
123827155  CPA3; mast cell carboxypeptidase A [KO:K08780] [EC:3.4.17.1]
123827776  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
123828384  RAB3D; ras-related protein Rab-3D [KO:K07884]
123828429  RAB8A; ras-related protein Rab-8A [KO:K07901]
123828911  PNLIPRP1; inactive pancreatic lipase-related protein 1 [KO:K14074] [EC:3.1.1.3]
123828980  [KO:K14075] [EC:3.1.1.3]
123828983  [KO:K14073] [EC:3.1.1.3]
123829335  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
123829542  TPCN2; two pore channel protein 2 isoform X1 [KO:K14077]
123829789  CPA2; carboxypeptidase A2 [KO:K01298] [EC:3.4.17.15]
123829822  CPA1; carboxypeptidase A1 [KO:K08779] [EC:3.4.17.1]
123829841  [KO:K01312] [EC:3.4.21.4]
123830380  RHOA; transforming protein RhoA [KO:K04513]
123830469  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
123830757  CCK; cholecystokinin isoform X1 [KO:K05226]
123830965  [KO:K01312] [EC:3.4.21.4]
123831297  SLC4A4; electrogenic sodium bicarbonate cotransporter 1 isoform X1 [KO:K13575]
123831548  [KO:K01047] [EC:3.1.1.4]
123831818  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
123831872  [KO:K01345] [EC:3.4.21.70]
123832005  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
123832016  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
123832120  [KO:K01047] [EC:3.1.1.4]
123832149  [KO:K01047] [EC:3.1.1.4]
123832151  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
123832250  PLA2G2F; group IIF secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
123832251  PLA2G2C; putative inactive group IIC secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
123832341  [KO:K01346] [EC:3.4.21.71]
123832904  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
123833093  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
Compound
C00001  H2O
C00011  CO2
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00238  Potassium cation
C00288  HCO3-
C00575  3',5'-Cyclic AMP
C00698  Cl-
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01353  Carbonic acid
C01996  Acetylcholine
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:17850212
  Authors
Petersen OH, Tepikin AV
  Title
Polarized calcium signaling in exocrine gland cells.
  Journal
Annu Rev Physiol 70:273-99 (2008)
DOI:10.1146/annurev.physiol.70.113006.100618
Reference
PMID:20625287
  Authors
Williams JA
  Title
Regulation of acinar cell function in the pancreas.
  Journal
Curr Opin Gastroenterol 26:478-83 (2010)
DOI:10.1097/MOG.0b013e32833d11c6
Reference
PMID:16891880
  Authors
Williams JA
  Title
Regulation of pancreatic acinar cell function.
  Journal
Curr Opin Gastroenterol 22:498-504 (2006)
DOI:10.1097/01.mog.0000239863.96833.c0
Reference
PMID:15689674
  Authors
Bi Y, Williams JA
  Title
Receptor biology and signal transduction in pancreatic acinar cells.
  Journal
Curr Opin Gastroenterol 20:427-34 (2004)
DOI:10.1097/00001574-200409000-00002
Reference
PMID:14660554
  Authors
Yamasaki M, Masgrau R, Morgan AJ, Churchill GC, Patel S, Ashcroft SJ, Galione A
  Title
Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells.
  Journal
J Biol Chem 279:7234-40 (2004)
DOI:10.1074/jbc.M311088200
Reference
PMID:9548666
  Authors
Kanno T
  Title
Ca2+ signaling in the pancreatic acinus.
  Journal
Pancreas 16:273-6 (1998)
Reference
PMID:18626068
  Authors
Heitzmann D, Warth R
  Title
Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
  Journal
Physiol Rev 88:1119-82 (2008)
DOI:10.1152/physrev.00020.2007
Reference
PMID:14637169
  Authors
Konturek SJ, Zabielski R, Konturek JW, Czarnecki J
  Title
Neuroendocrinology of the pancreas; role of brain-gut axis in pancreatic secretion.
  Journal
Eur J Pharmacol 481:1-14 (2003)
DOI:10.1016/j.ejphar.2003.08.042
Reference
PMID:16888148
  Authors
Chu JY, Yung WH, Chow BK
  Title
Secretin: a pleiotrophic hormone.
  Journal
Ann N Y Acad Sci 1070:27-50 (2006)
DOI:10.1196/annals.1317.013
Reference
PMID:16930743
  Authors
Siu FK, Lam IP, Chu JY, Chow BK
  Title
Signaling mechanisms of secretin receptor.
  Journal
Regul Pept 137:95-104 (2006)
DOI:10.1016/j.regpep.2006.02.011
Reference
PMID:15709963
  Authors
Steward MC, Ishiguro H, Case RM
  Title
Mechanisms of bicarbonate secretion in the pancreatic duct.
  Journal
Annu Rev Physiol 67:377-409 (2005)
DOI:10.1146/annurev.physiol.67.031103.153247
Reference
PMID:20224219
  Authors
Kim D, Steward MC
  Title
The role of CFTR in bicarbonate secretion by pancreatic duct and airway epithelia.
  Journal
J Med Invest 56 Suppl:336-42 (2009)
DOI:10.2152/jmi.56.336
Reference
PMID:17205399
  Authors
Whitcomb DC, Lowe ME
  Title
Human pancreatic digestive enzymes.
  Journal
Dig Dis Sci 52:1-17 (2007)
DOI:10.1007/s10620-006-9589-z
Reference
PMID:10835353
  Authors
Cancela JM, Gerasimenko OV, Gerasimenko JV, Tepikin AV, Petersen OH
  Title
Two different but converging messenger pathways to intracellular Ca(2+) release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate.
  Journal
EMBO J 19:2549-57 (2000)
DOI:10.1093/emboj/19.11.2549
Reference
PMID:10078532
  Authors
Cancela JM, Churchill GC, Galione A
  Title
Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells.
  Journal
Nature 398:74-6 (1999)
DOI:10.1038/18032
Reference
PMID:11087843
  Authors
Parekh AB
  Title
Calcium signaling and acute pancreatitis: specific response to a promiscuous messenger.
  Journal
Proc Natl Acad Sci U S A 97:12933-4 (2000)
DOI:10.1073/pnas.97.24.12933
Reference
PMID:19088252
  Authors
Williams JA, Chen X, Sabbatini ME
  Title
Small G proteins as key regulators of pancreatic digestive enzyme secretion.
  Journal
Am J Physiol Endocrinol Metab 296:E405-14 (2009)
DOI:10.1152/ajpendo.90874.2008
Related
pathway
phas04020  Calcium signaling pathway
phas04530  Tight junction
phas04973  Carbohydrate digestion and absorption
phas04974  Protein digestion and absorption
phas04975  Fat digestion and absorption
phas04977  Vitamin digestion and absorption
KO pathway
ko04972   

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