KEGG   PATHWAY: phas04020
Entry
phas04020                   Pathway                                
Name
Calcium signaling pathway - Phyllostomus hastatus (greater spear-nosed bat)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
phas04020  Calcium signaling pathway
phas04020

Other DBs
GO: 0019722
Organism
Phyllostomus hastatus (greater spear-nosed bat) [GN:phas]
Gene
123804347  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
123804625  NGF; beta-nerve growth factor [KO:K02582]
123804735  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
123804784  CASQ2; calsequestrin-2 [KO:K23445]
123805109  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
123805153  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
123805396  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
123805619  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
123805628  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
123805699  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
123805718  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
123805860  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
123805975  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
123806040  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
123806334  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
123806344  ORAI2; protein orai-2 isoform X1 [KO:K16057]
123806400  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
123806642  P2RX6; LOW QUALITY PROTEIN: P2X purinoceptor 6 [KO:K05221]
123806670  ADORA2A; adenosine receptor A2a [KO:K04266]
123806682  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
123806765  DRD1; D(1A) dopamine receptor [KO:K04144]
123806766  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123806839  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
123806865  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
123806893  TACR3; neuromedin-K receptor [KO:K04224]
123807056  ADRB2; beta-2 adrenergic receptor isoform X1 [KO:K04142]
123807136  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
123807471  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
123807508  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
123807517  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
123807535  ADRB3; beta-3 adrenergic receptor isoform X1 [KO:K04143]
123807646  FGF20; fibroblast growth factor 20 [KO:K04358]
123807653  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
123807679  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
123808002  CALM1; calmodulin-1 [KO:K02183]
123808021  RYR3; ryanodine receptor 3 [KO:K04963]
123808036  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
123808069  FGF7; fibroblast growth factor 7 [KO:K04358]
123808500  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
123808622  BDKRB1; B1 bradykinin receptor [KO:K03915]
123808665  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
123808688  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
123808746  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
123808839  BDKRB2; B2 bradykinin receptor [KO:K03916]
123808974  ITPKA; inositol-trisphosphate 3-kinase A isoform X1 [KO:K00911] [EC:2.7.1.127]
123809296  ADORA2B; adenosine receptor A2b [KO:K04267]
123809409  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
123809456  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
123809457  P2RX1; P2X purinoceptor 1 [KO:K05215]
123809715  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
123809782  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
123810370  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
123810431  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
123810721  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
123810790  FGF1; fibroblast growth factor 1 [KO:K18496]
123810976  FGF18; fibroblast growth factor 18 [KO:K04358]
123811124  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
123811159  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
123811378  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
123811379  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
123811380  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
123811430  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
123811468  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
123811490  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
123811605  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
123811737  CALM2; calmodulin-2 [KO:K02183]
123811744  TACR1; substance-P receptor [KO:K04222]
123811770  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
123811817  [KO:K05863]
123811930  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
123811931  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
123812345  HRH2; LOW QUALITY PROTEIN: histamine H2 receptor [KO:K04150]
123812354  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
123812915  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
123812987  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
123813058  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
123813109  AVPR1A; vasopressin V1a receptor [KO:K04226]
123813112  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
123813423  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
123813509  FGF23; fibroblast growth factor 23 [KO:K22428]
123813510  FGF6; fibroblast growth factor 6 [KO:K04358]
123813552  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
123813667  FGF2; fibroblast growth factor 2 [KO:K18497]
123813713  TBXA2R; thromboxane A2 receptor isoform X1 [KO:K04264]
123813723  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
123813822  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
123813831  GNA15; guanine nucleotide-binding protein subunit alpha-15 isoform X1 [KO:K04637]
123813918  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
123813920  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
123814030  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
123814055  EDNRA; endothelin-1 receptor [KO:K04197]
123814072  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
123814141  PDGFC; platelet-derived growth factor C [KO:K05450]
123814376  HRH1; histamine H1 receptor [KO:K04149]
123814381  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
123814398  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
123814493  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
123814527  OXTR; oxytocin receptor [KO:K04229]
123814577  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
123814755  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
123814793  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
123814917  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
123814975  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
123814977  TNNC2; troponin C, skeletal muscle [KO:K12042]
123815116  [KO:K04632]
123815210  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
123815292  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
123815364  NTSR1; neurotensin receptor type 1 [KO:K04211]
123815386  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
123815475  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
123815579  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
123815667  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
123815768  CCKAR; cholecystokinin receptor type A [KO:K04194]
123815784  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
123815821  STIM2; stromal interaction molecule 2 [KO:K18196]
123815823  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
123815893  DRD5; D(1B) dopamine receptor [KO:K05840]
123815944  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
123816152  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
123816209  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
123816381  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
123816440  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123816462  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
123816483  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
123816576  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
123816681  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
123816799  SMIM6; small integral membrane protein 6 [KO:K26468]
123816833  [KO:K10784]
123816955  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
123816974  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
123817124  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
123817314  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
123817411  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
123817558  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
123817951  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
123817981  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
123818083  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
123818320  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
123818419  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
123818874  EDNRB; endothelin receptor type B [KO:K04198]
123818951  HTR2A; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
123819032  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
123819323  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
123819347  SLN; sarcolipin [KO:K22642]
123819554  FGF10; fibroblast growth factor 10 [KO:K04358]
123819693  [KO:K04634]
123820197  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
123820198  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
123820238  GNA14; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
123820257  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
123820435  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
123820485  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
123820487  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
123820550  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
123820568  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
123820616  CASQ1; calsequestrin-1 [KO:K23468]
123820669  AVPR1B; vasopressin V1b receptor [KO:K04227]
123820715  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
123820880  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123820947  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
123820963  TACR2; substance-K receptor [KO:K04223]
123820989  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
123821009  [KO:K02183]
123821027  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
123821054  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
123821066  MRLN; myoregulin [KO:K22643]
123821068  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
123821079  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
123821240  TPCN1; two pore channel protein 1 isoform X1 [KO:K16896]
123821417  VEGFA; vascular endothelial growth factor A [KO:K05448]
123821438  PLN; cardiac phospholamban [KO:K05852]
123821574  TFEB; transcription factor EB [KO:K15590]
123821691  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
123821926  TRDN; triadin isoform X1 [KO:K23449]
123822014  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
123822368  P2RX4; P2X purinoceptor 4 [KO:K05218]
123822448  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
123822544  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
123822657  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
123822789  FGF9; fibroblast growth factor 9 [KO:K04358]
123823025  CALM3; calmodulin-3 [KO:K02183]
123823061  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
123823122  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
123823218  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
123823352  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
123823376  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
123823458  ORAI1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
123823716  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
123823738  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
123824140  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
123824352  FGF16; fibroblast growth factor 16 [KO:K04358]
123824375  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
123824381  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
123824736  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
123824873  F2R; proteinase-activated receptor 1 [KO:K03914]
123824963  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
123825463  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
123825494  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
123825515  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
123825658  [KO:K00871] [EC:2.7.11.19]
123825681  ORAI3; protein orai-3 isoform X1 [KO:K16058]
123826011  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
123826403  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
123826812  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
123827516  AGTR1; type-1 angiotensin II receptor [KO:K04166]
123828079  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
123828197  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123828203  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
123828205  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
123828245  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
123828262  PTGER1; prostaglandin E2 receptor EP1 subtype isoform X1 [KO:K04258]
123828462  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
123828714  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
123828777  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
123828974  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
123829013  ADRB1; beta-1 adrenergic receptor [KO:K04141]
123829150  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
123829212  FGF3; fibroblast growth factor 3 [KO:K04358]
123829213  FGF19; fibroblast growth factor 19 [KO:K22603]
123829335  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
123829410  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
123829436  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
123829542  TPCN2; two pore channel protein 2 isoform X1 [KO:K14077]
123829593  FGF4; fibroblast growth factor 4 [KO:K04358]
123829775  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
123829874  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
123829965  GRPR; gastrin-releasing peptide receptor [KO:K04169]
123829981  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
123830028  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
123830134  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
123830182  SPHK2; LOW QUALITY PROTEIN: sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
123830210  FGF21; fibroblast growth factor 21 isoform X1 [KO:K22429]
123830242  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
123830290  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
123830469  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
123830619  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
123830681  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
123830825  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
123831012  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
123831226  CALML3; calmodulin-like protein 3 [KO:K02183]
123831240  [KO:K02183]
123831289  FGF5; fibroblast growth factor 5 [KO:K04358]
123831483  P2RX3; P2X purinoceptor 3 [KO:K05217]
123831845  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
123832184  PTAFR; platelet-activating factor receptor [KO:K04279]
123832317  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
123832334  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
123832493  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
123832713  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
123832904  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
123833093  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
123833322  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
123833323  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
123833325  [KO:K00476] [EC:1.14.11.16]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
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Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
phas04010  MAPK signaling pathway
phas04070  Phosphatidylinositol signaling system
phas04210  Apoptosis
phas04720  Long-term potentiation
phas04730  Long-term depression
KO pathway
ko04020   

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