KEGG   PATHWAY: phas04530
Entry
phas04530                   Pathway                                
Name
Tight junction - Phyllostomus hastatus (greater spear-nosed bat)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
phas04530  Tight junction
phas04530

Other DBs
GO: 0005923
Organism
Phyllostomus hastatus (greater spear-nosed bat) [GN:phas]
Gene
123804352  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
123804388  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
123804418  CGN; cingulin [KO:K06102]
123804436  RAB13; ras-related protein Rab-13 [KO:K06109]
123804635  RAP1A; ras-related protein Rap-1A [KO:K04353]
123805116  CLDN2; claudin-2 [KO:K06087]
123805200  AMOT; angiomotin isoform X1 [KO:K16819]
123805367  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
123805392  AMOTL1; angiomotin-like protein 1 isoform X1 [KO:K06104]
123805953  PARD6A; partitioning defective 6 homolog alpha [KO:K06093]
123806176  MARVELD3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
123806258  MYH11; myosin-11 isoform X1 [KO:K10352]
123806370  CLDN3; claudin-3 [KO:K06087]
123806418  CLDN15; claudin-15 [KO:K06087]
123806468  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
123806472  CLDN4; claudin-4 [KO:K06087]
123806560  [KO:K07374]
123806591  CLDN5; claudin-5 [KO:K06087]
123806690  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
123806803  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
123806895  SYNPO; synaptopodin [KO:K21112]
123806902  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123807193  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123807197  CLDN6; claudin-6 [KO:K06087]
123807198  CLDN9; claudin-9 [KO:K06087]
123807437  ACTB; actin, cytoplasmic 1 [KO:K05692]
123807483  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
123807506  CLDN23; claudin-23 [KO:K06087]
123807700  [KO:K06087]
123807711  [KO:K06087]
123808033  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
123808060  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
123808176  PALS1; protein PALS1 isoform X1 [KO:K06091]
123808250  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
123808323  CGNL1; cingulin-like protein 1 isoform X1 [KO:K21110]
123808347  RAB8B; ras-related protein Rab-8B [KO:K07902]
123808493  [KO:K05756]
123809230  MYH10; myosin-10 isoform X1 [KO:K10352]
123809254  CLDN7; claudin-7 [KO:K06087]
123809281  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
123809360  MICALL2; MICAL-like protein 2 isoform X1 [KO:K21068]
123809588  [KO:K05701]
123809600  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
123809960  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
123810363  ACTR3; actin-related protein 3 [KO:K18584]
123810462  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123810934  NF2; merlin isoform X1 [KO:K16684]
123811487  PRKCE; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
123811729  ACTR2; actin-related protein 2 [KO:K17260]
123812042  CLDN12; claudin-12 [KO:K06087]
123812817  MYL6B; myosin light chain 6B [KO:K12751]
123812818  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
123812820  YBX3; Y-box-binding protein 3 isoform X1 [KO:K06099]
123812863  [KO:K07374]
123812864  TUBA1C; tubulin alpha-1C chain [KO:K07374]
123812897  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
123813125  ARHGEF18; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
123813127  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
123813225  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
123813684  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
123813693  TJP3; tight junction protein ZO-3 isoform X1 [KO:K06097]
123813698  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
123813791  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
123813870  CRB3; protein crumbs homolog 3 [KO:K06090]
123814292  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
123814354  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
123814577  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
123814829  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
123814902  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
123815319  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
123815383  PCNA; proliferating cell nuclear antigen [KO:K04802]
123815904  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
123816090  MYH9; myosin-9 isoform X1 [KO:K10352]
123816373  PATJ; inaD-like protein isoform X1 [KO:K06092]
123816440  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123816905  ACTG1; actin, cytoplasmic 2 [KO:K05692]
123816974  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
123817138  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
123817582  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
123817947  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
123817999  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
123818031  RDX; radixin isoform X1 [KO:K05762]
123818143  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
123818169  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
123818226  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
123818464  F11R; junctional adhesion molecule A [KO:K06089]
123818504  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
123818736  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
123818828  CLDN10; claudin-10 isoform X1 [KO:K06087]
123819048  [KO:K06099]
123819178  [KO:K06448]
123819501  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
123819725  MPDZ; multiple PDZ domain protein isoform X1 [KO:K06095]
123819753  EPB41L4B; band 4.1-like protein 4B isoform X1 [KO:K21111]
123819768  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
123819834  CLDN25; putative claudin-25 [KO:K06087]
123820643  CD1E; T-cell surface glycoprotein CD1e, membrane-associated [KO:K06448]
123820644  [KO:K06448]
123820791  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
123820887  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
123821540  CLDN20; claudin-20 [KO:K06087]
123821582  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
123821633  TJAP1; tight junction-associated protein 1 isoform X1 [KO:K06105]
123821913  AFDN; afadin isoform X1 [KO:K05702]
123821976  [KO:K06109]
123822139  EZR; ezrin isoform X1 [KO:K08007]
123822157  BVES; blood vessel epicardial substance [KO:K21108]
123822396  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
123822762  TUBA3C; LOW QUALITY PROTEIN: tubulin alpha-3C chain [KO:K07374]
123822936  SYMPK; symplekin isoform X1 [KO:K06100]
123822970  [KO:K06274]
123823406  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
123823427  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
123823555  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
123823676  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
123824185  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
123824261  [KO:K06099]
123824292  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
123824296  MSN; moesin [KO:K05763]
123824430  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
123824464  [KO:K06448]
123824468  [KO:K06448]
123824471  [KO:K06448]
123824520  [KO:K04513]
123824594  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
123824754  OCLN; occludin [KO:K06088]
123824765  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
123824782  MARVELD2; MARVEL domain-containing protein 2 isoform X1 [KO:K17291]
123825242  [KO:K06448]
123825248  [KO:K06448]
123825685  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
123826024  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
123826130  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
123826253  [KO:K12757]
123826263  [KO:K12757]
123826438  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
123826609  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
123826784  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
123827048  CLDN1; claudin-1 [KO:K06087]
123827050  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
123827105  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
123827145  CLDN11; claudin-11 [KO:K06087]
123827204  CLDN16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
123827469  JAM2; junctional adhesion molecule B isoform X1 [KO:K06735]
123827782  RAP2C; ras-related protein Rap-2c [KO:K07839]
123827960  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
123827989  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
123828008  IGSF5; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
123828016  CLDN8; claudin-8 [KO:K06087]
123828076  CLDN17; claudin-17 [KO:K06087]
123828089  CLDN14; claudin-14 [KO:K06087]
123828105  [KO:K07374]
123828245  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
123828358  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
123828429  RAB8A; ras-related protein Rab-8A [KO:K07901]
123828736  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
123828790  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
123829354  [KO:K06448]
123829421  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
123829510  CTTN; src substrate cortactin isoform X1 [KO:K06106]
123829562  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
123829974  CLDN34; claudin-34 [KO:K06087]
123830199  MYH14; myosin-14 isoform X1 [KO:K10352]
123830380  RHOA; transforming protein RhoA [KO:K04513]
123830387  CLDN18; claudin-18 [KO:K06087]
123830412  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
123830627  AMOTL2; angiomotin-like protein 2 isoform X1 [KO:K06104]
123831161  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
123831409  JUN; transcription factor AP-1 [KO:K04448]
123831601  CLDN19; claudin-19 isoform X1 [KO:K06087]
123831835  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
123831995  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
123832611  JAM3; junctional adhesion molecule C [KO:K06785]
123832781  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
123832920  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
123833042  [KO:K04802]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
phas04520  Adherens junction
phas04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

DBGET integrated database retrieval system