Entry Name Renin secretion - Peromyscus leucopus (white-footed mouse)
Description The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. Renin is synthesized, stored in, and released into circulation by the juxtaglomerular (JG) cells of the kidney. Secretion of renin from JG cells at the organ level is controlled by the four main mechanisms: the sympathetic nervous system, the local JG apparatus baroreflex, the macula densa mechanism, and several hormones acting locally within the JG apparatus. Renin secretion at the level of renal JG cells appears to be controlled mainly by classic second messengers, namely cAMP, cGMP, and free cytosolic calcium concentration. While cAMP generally stimulates renin release and the intracellular calcium concentration suppresses the exocytosis of renin, the effects of cGMP in the regulation of the renin system are more complex as it both may stimulate or inhibit renin release.
Class Organismal Systems; Endocrine systemBRITE hierarchy
Pathway map Other DBs Organism Peromyscus leucopus (white-footed mouse) [GN:
pleu ]
Gene 114680674 Plcb3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858 ] [EC:3.1.4.11 ]
114683255 Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
114683299 Cacna1s; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857 ]
114686204 Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851 ]
114689696 Pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755 ] [EC:3.1.4.17 ]
114689701 Adcyap1r1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587 ]
114691978 Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
114696421 Adcyap1; pituitary adenylate cyclase-activating polypeptide isoform X1 [KO:K05262 ]
114696597 Pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755 ] [EC:3.1.4.17 ]
114698249 Clca1; calcium-activated chloride channel regulator 1 [KO:K05027 ]
114698288 Clca4; calcium-activated chloride channel regulator 4 [KO:K05030 ]
114698768 Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348 ] [EC:3.1.3.16 ]
114699988 Gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630 ]
114700183 Kcnma1; calcium-activated potassium channel subunit alpha-1 isoform X1 [KO:K04936 ]
114700198 Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
114700762 Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X8 [KO:K04850 ]
114701281 Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853 ]
114703666 Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858 ] [EC:3.1.4.11 ]
114703672 Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
114703726 Pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755 ] [EC:3.1.4.17 ]
114704549 Orai1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056 ]
114705057 Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
114708228 Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
114708260 Calml6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183 ]
114708393 Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959 ]
114710969 Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference Authors Kurtz A
Title Renin release: sites, mechanisms, and control.
Journal Reference Authors Schweda F, Friis U, Wagner C, Skott O, Kurtz A
Title Renin release.
Journal Reference Authors Castrop H, Hocherl K, Kurtz A, Schweda F, Todorov V, Wagner C
Title Physiology of kidney renin.
Journal Reference Authors Friis UG, Madsen K, Stubbe J, Hansen PB, Svenningsen P, Bie P, Skott O, Jensen BL
Title Regulation of renin secretion by renal juxtaglomerular cells.
Journal Reference Authors Kim SM, Briggs JP, Schnermann J
Title Convergence of major physiological stimuli for renin release on the Gs-alpha/cyclic adenosine monophosphate signaling pathway.
Journal Reference Authors Kurtz A
Title Control of renin synthesis and secretion.
Journal Reference Authors Kurtz A, Wagner C
Title Cellular control of renin secretion.
Journal J Exp Biol 202:219-25 (1999)
Reference Authors Persson PB
Title Renin: origin, secretion and synthesis.
Journal Reference Authors Schweda F, Kurtz A
Title Cellular mechanism of renin release.
Journal Reference Authors Sparks MA, Crowley SD, Gurley SB, Mirotsou M, Coffman TM
Title Classical Renin-Angiotensin system in kidney physiology.
Journal Reference Authors Harrison-Bernard LM
Title The renal renin-angiotensin system.
Journal Reference Authors Schnermann J, Briggs JP
Title Synthesis and secretion of renin in mice with induced genetic mutations.
Journal Reference Authors Ryan MJ, Black TA, Millard SL, Gross KW, Hajduczok G
Title Endothelin-1 increases calcium and attenuates renin gene expression in As4.1 cells.
Journal Reference Authors Hautmann M, Friis UG, Desch M, Todorov V, Castrop H, Segerer F, Otto C, Schutz G, Schweda F
Title Pituitary adenylate cyclase-activating polypeptide stimulates renin secretion via activation of PAC1 receptors.
Journal Related KO pathway
