KEGG   PATHWAY: ppam04530
Entry
ppam04530                   Pathway                                
Name
Tight junction - Pteronotus mesoamericanus (Parnell's mustached bat)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
ppam04530  Tight junction
ppam04530

Other DBs
GO: 0005923
Organism
Pteronotus mesoamericanus (Parnell's mustached bat) [GN:ppam]
Gene
129061238  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
129061371  CRB3; protein crumbs homolog 3 [KO:K06090]
129061554  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
129062023  CGN; cingulin isoform X1 [KO:K06102]
129062370  RAB13; ras-related protein Rab-13 isoform X1 [KO:K06109]
129062452  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
129062461  [KO:K06448]
129062467  [KO:K06448]
129063035  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
129063449  CLDN12; claudin-12 [KO:K06087]
129063844  RAP1A; ras-related protein Rap-1A [KO:K04353]
129064194  RAB8B; ras-related protein Rab-8B [KO:K07902]
129064216  CGNL1; cingulin-like protein 1 isoform X1 [KO:K21110]
129064222  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
129064690  CLDN23; claudin-23 [KO:K06087]
129064706  [KO:K06087]
129064707  CLDN22; claudin-22 [KO:K06087]
129064836  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
129064991  ARHGEF18; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 18 [KO:K21066]
129065007  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
129065127  WAS; actin nucleation-promoting factor WAS [KO:K05747]
129065641  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
129065757  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
129065805  MICALL2; MICAL-like protein 2 [KO:K21068]
129065941  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
129065951  PALS1; protein PALS1 isoform X1 [KO:K06091]
129066545  SYNPO; synaptopodin [KO:K21112]
129066572  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
129066683  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
129066690  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
129066701  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
129067476  TJAP1; tight junction-associated protein 1 isoform X1 [KO:K06105]
129067577  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
129067668  BVES; blood vessel epicardial substance [KO:K21108]
129067800  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
129067867  CLDN20; claudin-20 [KO:K06087]
129067883  EZR; ezrin [KO:K08007]
129068140  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
129068519  CTTN; src substrate cortactin [KO:K06106]
129068523  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
129068758  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
129068771  [KO:K12757]
129069086  CLDN19; claudin-19 [KO:K06087]
129069129  ACTB; actin, cytoplasmic 1 [KO:K05692]
129069153  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
129069687  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
129070464  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
129070617  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
129070681  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
129070719  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
129070771  JUN; transcription factor Jun [KO:K04448]
129070834  PATJ; inaD-like protein isoform X1 [KO:K06092]
129070838  PCNA; proliferating cell nuclear antigen [KO:K04802]
129071097  [KO:K06099]
129071118  MSN; moesin [KO:K05763]
129071129  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
129071335  MYH9; myosin-9 isoform X1 [KO:K10352]
129071481  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
129071721  ACTR3; actin-related protein 3 [KO:K18584]
129071786  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
129071845  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
129071974  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
129072270  MYH10; myosin-10 isoform X1 [KO:K10352]
129072323  CLDN7; claudin-7 [KO:K06087]
129072395  CLDN17; claudin-17 [KO:K06087]
129072410  CLDN8; claudin-8 [KO:K06087]
129072450  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
129072585  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
129072591  CLDN14; claudin-14 [KO:K06087]
129072638  IGSF5; immunoglobulin superfamily member 5 [KO:K06786]
129072798  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
129073196  [KO:K07374]
129073238  CLDN2; claudin-2 [KO:K06087]
129073330  CLDN11; claudin-11 [KO:K06087]
129073372  RAP2C; ras-related protein Rap-2c [KO:K07839]
129073753  [KO:K07298] [EC:2.7.11.1]
129073757  [KO:K07298] [EC:2.7.11.1]
129074137  TIAM1; rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
129074248  [KO:K12757]
129074297  TJP3; tight junction protein ZO-3 [KO:K06097]
129074356  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
129074464  [KO:K04513]
129074599  MARVELD2; MARVEL domain-containing protein 2 isoform X1 [KO:K17291]
129074601  OCLN; occludin [KO:K06088]
129074944  RAB8A; ras-related protein Rab-8A [KO:K07901]
129075024  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
129075131  PARD6A; partitioning defective 6 homolog alpha [KO:K06093]
129075216  MARVELD3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
129075383  JAM3; junctional adhesion molecule C isoform X1 [KO:K06785]
129075493  JAM2; junctional adhesion molecule B [KO:K06735]
129075541  [KO:K06099]
129075769  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
129075823  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
129076018  MYL6B; myosin light chain 6B [KO:K12751]
129076173  AMOT; angiomotin [KO:K16819]
129076246  [KO:K12757]
129076293  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
129076727  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
129076959  CLDN34; claudin-34 [KO:K06087]
129077675  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
129077762  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
129077765  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
129078275  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
129078323  MPDZ; multiple PDZ domain protein isoform X1 [KO:K06095]
129078413  [KO:K04392]
129078555  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
129078611  [KO:K12757]
129078613  [KO:K12757]
129078629  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
129078745  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
129078927  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
129079006  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
129079095  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
129079273  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
129079362  EPB41L4B; band 4.1-like protein 4B isoform X1 [KO:K21111]
129079396  [KO:K06099]
129079415  [KO:K06099]
129079776  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
129079879  CLDN1; claudin-1 [KO:K06087]
129079981  CLDN16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
129080199  [KO:K06099]
129080325  [KO:K07374]
129080327  [KO:K07374]
129080341  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
129080356  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
129080417  [KO:K06448]
129080706  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
129080851  [KO:K07374]
129080936  CLDN10; claudin-10 isoform X1 [KO:K06087]
129080992  TUBA8; tubulin alpha-8 chain [KO:K07374]
129081338  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
129081552  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
129081983  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
129082072  [KO:K04802]
129082098  F11R; junctional adhesion molecule A [KO:K06089]
129082864  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
129082871  SYMPK; symplekin [KO:K06100]
129082952  MYH14; myosin-14 [KO:K10352]
129083237  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
129083298  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
129083376  CLDN9; claudin-9 [KO:K06087]
129083377  CLDN6; claudin-6 [KO:K06087]
129083419  CLDN3; claudin-3 [KO:K06087]
129083444  CLDN15; claudin-15 [KO:K06087]
129083566  [KO:K12755]
129083711  MYH11; myosin-11 isoform X1 [KO:K10352]
129083773  CLDN4; claudin-4 [KO:K06087]
129083853  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
129083854  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
129084372  SCRIB; LOW QUALITY PROTEIN: protein scribble homolog [KO:K16175]
129084868  TUBA1C; tubulin alpha-1C chain [KO:K07374]
129084870  [KO:K07374]
129084873  [KO:K07374]
129084876  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
129084896  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
129085020  YBX3; Y-box-binding protein 3 isoform X1 [KO:K06099]
129085376  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
129085855  AMOTL1; angiomotin-like protein 1 isoform X1 [KO:K06104]
129085899  RDX; radixin [KO:K05762]
129085967  [KO:K04513]
129086002  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
129086139  CLDN25; LOW QUALITY PROTEIN: putative claudin-25 [KO:K06087]
129086225  CLDN5; claudin-5 [KO:K06087]
129086316  [KO:K07374]
129086325  [KO:K07374]
129086478  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
129086502  NHERF1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
129086550  ACTG1; actin, cytoplasmic 2 [KO:K05692]
129086754  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
129087036  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
129087184  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
129087246  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
129087293  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
129087297  [KO:K05756]
129087348  NF2; merlin isoform X1 [KO:K16684]
129087688  RHOA; transforming protein RhoA [KO:K04513]
129087838  CLDN18; claudin-18 isoform X1 [KO:K06087]
129087909  [KO:K05758]
129088138  AFDN; afadin isoform X1 [KO:K05702]
129088157  [KO:K06448]
129088203  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
129088299  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
129088366  AMOTL2; angiomotin-like protein 2 isoform X1 [KO:K06104]
129088444  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
ppam04520  Adherens junction
ppam04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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