KEGG   PATHWAY: rbb04120
Entry
rbb04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Rhinopithecus bieti (black snub-nosed monkey)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
rbb04120  Ubiquitin mediated proteolysis
rbb04120

Other DBs
GO: 0016567
Organism
Rhinopithecus bieti (black snub-nosed monkey) [GN:rbb]
Gene
108512109  PIAS4; E3 SUMO-protein ligase PIAS4 [KO:K16065] [EC:2.3.2.27]
108512296  VHL; von Hippel-Lindau disease tumor suppressor isoform X1 [KO:K03871]
108512586  UBA2; LOW QUALITY PROTEIN: SUMO-activating enzyme subunit 2 [KO:K10685] [EC:6.2.1.45]
108512658  FZR1; fizzy-related protein homolog isoform X1 [KO:K03364]
108512865  HERC3; probable E3 ubiquitin-protein ligase HERC3 [KO:K10614] [EC:2.3.2.26]
108513343  FANCL; E3 ubiquitin-protein ligase FANCL isoform X1 [KO:K10606] [EC:2.3.2.27]
108513614  FBXW11; LOW QUALITY PROTEIN: F-box/WD repeat-containing protein 11 [KO:K03362]
108514076  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
108514077  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
108514199  CUL3; LOW QUALITY PROTEIN: cullin-3 [KO:K03869]
108514338  UBE2M; NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
108514535  WWP2; NEDD4-like E3 ubiquitin-protein ligase WWP2 [KO:K05630] [EC:2.3.2.26]
108514691  PIAS1; E3 SUMO-protein ligase PIAS1 [KO:K04706] [EC:2.3.2.-]
108514859  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 [KO:K04553] [EC:2.3.2.23]
108515041  UBE2W; ubiquitin-conjugating enzyme E2 W isoform X1 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
108515043  TCEB1; transcription elongation factor B polypeptide 1 isoform X1 [KO:K03872]
108515136  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
108515485  ERCC8; DNA excision repair protein ERCC-8 isoform X1 [KO:K10570]
108515508  VHLL; LOW QUALITY PROTEIN: von Hippel-Lindau-like protein [KO:K03871]
108515670  CBLC; E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
108516481  UBE2Z; ubiquitin-conjugating enzyme E2 Z [KO:K10585] [EC:2.3.2.23]
108516528  [KO:K10595] [EC:2.3.2.26]
108516664  UBE2K; LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 K [KO:K04649] [EC:2.3.2.23]
108516882  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
108517203  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
108517322  UBA6; ubiquitin-like modifier-activating enzyme 6 [KO:K10699] [EC:6.2.1.45]
108517356  [KO:K04506] [EC:2.3.2.27]
108517384  CUL5; cullin-5 [KO:K10612]
108517521  RHOBTB1; rho-related BTB domain-containing protein 1 isoform X1 [KO:K07868]
108517807  [KO:K10456]
108518069  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
108518107  TRIM32; E3 ubiquitin-protein ligase TRIM32 [KO:K10607] [EC:2.3.2.27]
108518985  [KO:K10447]
108519030  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
108519184  UBE2Q2; ubiquitin-conjugating enzyme E2 Q2 isoform X1 [KO:K10582] [EC:2.3.2.23]
108519345  MID1; E3 ubiquitin-protein ligase Midline-1 isoform X1 [KO:K08285] [EC:2.3.2.27]
108519428  STUB1; E3 ubiquitin-protein ligase CHIP isoform X1 [KO:K09561] [EC:2.3.2.27]
108519448  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
108519777  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
108520119  UBA3; NEDD8-activating enzyme E1 catalytic subunit isoform X1 [KO:K10686] [EC:6.2.1.64]
108520178  UBR5; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase UBR5 [KO:K10593] [EC:2.3.2.26]
108520651  [KO:K10580] [EC:2.3.2.23]
108520713  UBE2G1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
108521009  UBE3C; ubiquitin-protein ligase E3C [KO:K10589] [EC:2.3.2.26]
108521624  TRIM37; E3 ubiquitin-protein ligase TRIM37 [KO:K10608] [EC:2.3.2.27]
108521807  CUL4A; cullin-4A [KO:K10609]
108521962  DDB2; DNA damage-binding protein 2 [KO:K10140]
108522304  CUL1; cullin-1 [KO:K03347]
108522431  RNF7; RING-box protein 2 isoform X1 [KO:K10611]
108522824  [KO:K10609]
108522890  UBE2QL1; ubiquitin-conjugating enzyme E2Q-like protein 1 isoform X1 [KO:K10582] [EC:2.3.2.23]
108523037  UBA1; ubiquitin-like modifier-activating enzyme 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
108523147  HERC1; LOW QUALITY PROTEIN: probable E3 ubiquitin-protein ligase HERC1 [KO:K10594] [EC:2.3.2.26]
108523192  [KO:K10573] [EC:2.3.2.23]
108523321  TCEB2; transcription elongation factor B polypeptide 2 [KO:K03873]
108523335  [KO:K06688] [EC:2.3.2.23]
108523545  UBE2N; ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
108523576  SMURF1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
108523708  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
108524152  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
108524569  [KO:K02927]
108525735  [KO:K10580] [EC:2.3.2.23]
108525766  [KO:K06688] [EC:2.3.2.23]
108525947  ANAPC4; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 4 [KO:K03351]
108526191  [KO:K10580] [EC:2.3.2.23]
108526490  FBXO4; LOW QUALITY PROTEIN: F-box only protein 4 [KO:K10291]
108526636  UBE2Q1; ubiquitin-conjugating enzyme E2 Q1 [KO:K10582] [EC:2.3.2.23]
108526765  BRCA1; breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
108526976  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
108527408  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
108527984  PARK2; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
108528465  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
108528599  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
108528684  BIRC6; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 6 [KO:K10586] [EC:2.3.2.23]
108528779  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
108529052  FBXW7; F-box/WD repeat-containing protein 7 isoform X1 [KO:K10260]
108529558  SKP1; LOW QUALITY PROTEIN: S-phase kinase-associated protein 1 [KO:K03094]
108529559  UBE2B; ubiquitin-conjugating enzyme E2 B [KO:K10574] [EC:2.3.2.23]
108529634  [KO:K02927]
108529637  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
108530000  UBOX5; RING finger protein 37 isoform X1 [KO:K10600]
108530851  UBE2D2; ubiquitin-conjugating enzyme E2 D2 isoform X1 [KO:K06689] [EC:2.3.2.23]
108530959  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
108531015  NHLRC1; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase NHLRC1 [KO:K10602] [EC:2.3.2.27]
108531474  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
108531557  UBE2H; ubiquitin-conjugating enzyme E2 H [KO:K10576] [EC:2.3.2.23]
108531561  [KO:K03873]
108531641  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
108531642  [KO:K10582] [EC:2.3.2.23]
108531768  CDC34; LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 R1 [KO:K02207] [EC:2.3.2.23]
108531914  UBE2F; NEDD8-conjugating enzyme UBE2F isoform X1 [KO:K10687] [EC:2.3.2.34]
108532163  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
108532254  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
108532499  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
108532632  UBE2J1; LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
108532810  UBE2D3; ubiquitin-conjugating enzyme E2 D3 [KO:K06689] [EC:2.3.2.23]
108532892  UBE2U; ubiquitin-conjugating enzyme E2 U isoform X1 [KO:K10584] [EC:2.3.2.23]
108533341  UBE2C; ubiquitin-conjugating enzyme E2 C isoform X1 [KO:K06688] [EC:2.3.2.23]
108533477  CUL7; LOW QUALITY PROTEIN: cullin-7 [KO:K10613]
108533616  DDB1; DNA damage-binding protein 1 [KO:K10610]
108533724  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
108534107  [KO:K03358]
108534205  UBA52; ubiquitin-60S ribosomal protein L40 isoform X1 [KO:K02927]
108534360  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
108534379  UBE3B; ubiquitin-protein ligase E3B isoform X1 [KO:K10588] [EC:2.3.2.26]
108534614  [KO:K03872]
108534998  CUL4B; LOW QUALITY PROTEIN: cullin-4B [KO:K10609]
108535053  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
108535289  BIRC7; baculoviral IAP repeat-containing protein 7 isoform X1 [KO:K16061]
108535312  NEDD4; E3 ubiquitin-protein ligase NEDD4 [KO:K10591] [EC:2.3.2.26]
108535496  ANAPC10; anaphase-promoting complex subunit 10 [KO:K03357]
108535559  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
108535700  CDC20; cell division cycle protein 20 homolog [KO:K03363]
108535786  DET1; DET1 homolog isoform X1 [KO:K10571]
108535938  [KO:K06643] [EC:2.3.2.27]
108535955  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
108536071  PPIL2; peptidyl-prolyl cis-trans isomerase-like 2 isoform X1 [KO:K10598] [EC:5.2.1.8]
108536078  UBE2L3; ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
108536248  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
108536302  CDC27; LOW QUALITY PROTEIN: cell division cycle protein 27 homolog [KO:K03350]
108536380  UBE4A; LOW QUALITY PROTEIN: ubiquitin conjugation factor E4 A [KO:K10596] [EC:2.3.2.27]
108536957  UBE2E3; ubiquitin-conjugating enzyme E2 E3 [KO:K20217] [EC:2.3.2.23]
108537098  KLHL9; kelch-like protein 9 [KO:K10447]
108537423  UBE2O; (E3-independent) E2 ubiquitin-conjugating enzyme isoform X1 [KO:K10581] [EC:2.3.2.24]
108537571  UBE2A; ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:2.3.2.23]
108538264  MGRN1; E3 ubiquitin-protein ligase MGRN1 isoform X1 [KO:K10604] [EC:2.3.2.27]
108539293  FBXW8; LOW QUALITY PROTEIN: F-box/WD repeat-containing protein 8 [KO:K10264]
108539373  UBE4B; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
108539375  FBXO2; F-box only protein 2 [KO:K10099]
108539645  [KO:K04551]
108539769  AIRE; autoimmune regulator [KO:K10603]
108539825  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
108539981  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
108540037  [KO:K10580] [EC:2.3.2.23]
108540359  SAE1; SUMO-activating enzyme subunit 1 isoform X1 [KO:K10684] [EC:6.2.1.45]
108540530  [KO:K02927]
108540597  [KO:K03094]
108540738  UBE2D1; ubiquitin-conjugating enzyme E2 D1 isoform X1 [KO:K06689] [EC:2.3.2.23]
108540790  RHOBTB2; rho-related BTB domain-containing protein 2 [KO:K07868]
108541057  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
108541230  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
108541690  CDC23; cell division cycle protein 23 homolog [KO:K03355]
108541777  [KO:K06688] [EC:2.3.2.23]
108541919  RFWD2; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RFWD2 [KO:K10143] [EC:2.3.2.27]
108542184  UBE2R2; ubiquitin-conjugating enzyme E2 R2 [KO:K02207] [EC:2.3.2.23]
108542511  UBE2S; ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
108542604  CUL2; cullin-2 [KO:K03870]
108542865  ANAPC2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
108543059  [KO:K20217] [EC:2.3.2.23]
108543063  UBE2E1; ubiquitin-conjugating enzyme E2 E1 isoform X1 [KO:K20217] [EC:2.3.2.23]
108543228  SYVN1; E3 ubiquitin-protein ligase synoviolin isoform X1 [KO:K10601] [EC:2.3.2.27]
108543663  [KO:K10687] [EC:2.3.2.34]
108543716  HUWE1; E3 ubiquitin-protein ligase HUWE1 [KO:K10592] [EC:2.3.2.26]
108543744  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
108544010  UBE2D4; ubiquitin-conjugating enzyme E2 D4 isoform X1 [KO:K06689] [EC:2.3.2.23]
108544203  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
108544270  TRIP12; E3 ubiquitin-protein ligase TRIP12 [KO:K10590] [EC:2.3.2.26]
108544295  [KO:K03094]
108544485  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
Reference
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
rbb03050  Proteasome
KO pathway
ko04120   

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