Entry
Name
Ubiquitin mediated proteolysis - Rhinopithecus bieti (black snub-nosed monkey)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
Other DBs
Organism
Rhinopithecus bieti (black snub-nosed monkey) [GN:
rbb ]
Gene
108512296 VHL; von Hippel-Lindau disease tumor suppressor isoform X1 [KO:K03871 ]
108513614 FBXW11; LOW QUALITY PROTEIN: F-box/WD repeat-containing protein 11 [KO:K03362 ]
108514076 BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060 ]
108515043 TCEB1; transcription elongation factor B polypeptide 1 isoform X1 [KO:K03872 ]
108515136 BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362 ]
108515508 VHLL; LOW QUALITY PROTEIN: von Hippel-Lindau-like protein [KO:K03871 ]
108517521 RHOBTB1; rho-related BTB domain-containing protein 1 isoform X1 [KO:K07868 ]
108518069 ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348 ]
108519030 PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063 ] [EC:2.3.2.-]
108523321 TCEB2; transcription elongation factor B polypeptide 2 [KO:K03873 ]
108523708 CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353 ]
108525947 ANAPC4; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 4 [KO:K03351 ]
108529052 FBXW7; F-box/WD repeat-containing protein 7 isoform X1 [KO:K10260 ]
108529558 SKP1; LOW QUALITY PROTEIN: S-phase kinase-associated protein 1 [KO:K03094 ]
108529637 ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352 ]
108531474 PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064 ] [EC:2.3.2.-]
108534205 UBA52; ubiquitin-60S ribosomal protein L40 isoform X1 [KO:K02927 ]
108534360 ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354 ]
108535289 BIRC7; baculoviral IAP repeat-containing protein 7 isoform X1 [KO:K16061 ]
108536302 CDC27; LOW QUALITY PROTEIN: cell division cycle protein 27 homolog [KO:K03350 ]
108539293 FBXW8; LOW QUALITY PROTEIN: F-box/WD repeat-containing protein 8 [KO:K10264 ]
108542865 ANAPC2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349 ]
108543744 ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228 ]
Reference
Authors
Kamura T.
Title
[Cullin-based E3 family]
Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
Authors
Matsuda N.
Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
Authors
Tokunaga F.
Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
Authors
Nalepa G, Rolfe M, Harper JW.
Title
Drug discovery in the ubiquitin-proteasome system.
Journal
Reference
Authors
Hsu YJ, Goodman SR.
Title
Spectrin and ubiquitination: a review.
Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
Authors
Hatakeyama S, Nakayama KI.
Title
Ubiquitylation as a quality control system for intracellular proteins.
Journal
Reference
Authors
Lee J, Zhou P.
Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
Journal
Related pathway
KO pathway