KEGG   PATHWAY: rbb04350
Entry
rbb04350                    Pathway                                
Name
TGF-beta signaling pathway - Rhinopithecus bieti (black snub-nosed monkey)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
rbb04350  TGF-beta signaling pathway
rbb04350

Other DBs
GO: 0007179
Organism
Rhinopithecus bieti (black snub-nosed monkey) [GN:rbb]
Gene
108512070  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
108512317  HAMP; hepcidin [KO:K23106]
108512386  ACVR2A; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
108512438  IGSF1; immunoglobulin superfamily member 1 isoform X1 [KO:K26168]
108512466  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
108513142  SKIL; ski-like protein isoform X1 [KO:K18499]
108513398  HFE; hereditary hemochromatosis protein isoform X1 [KO:K26535]
108513693  [KO:K04662]
108513788  ACVR2B; activin receptor type-2B isoform X1 [KO:K13596] [EC:2.7.11.30]
108513913  E2F5; transcription factor E2F5 isoform X1 [KO:K04682]
108514667  SMAD6; mothers against decapentaplegic homolog 6 [KO:K04677]
108514714  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
108515008  FMOD; fibromodulin [KO:K08121]
108515275  [KO:K19558]
108515335  BMP7; bone morphogenetic protein 7 [KO:K16621]
108515423  E2F4; transcription factor E2F4 [KO:K04682]
108516070  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
108516558  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
108516589  SMAD9; mothers against decapentaplegic homolog 9 isoform X1 [KO:K16791]
108516595  GREM1; gremlin-1 [KO:K23318]
108516611  SMAD5; mothers against decapentaplegic homolog 5 [KO:K16790]
108516998  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
108517059  [KO:K16622]
108517065  [KO:K16622]
108518314  FST; follistatin [KO:K04661]
108518621  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
108518653  PPP2CB; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
108519603  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
108519713  INHBC; inhibin beta C chain [KO:K22688]
108519714  INHBE; inhibin beta E chain [KO:K22689]
108519858  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
108520255  TNF; tumor necrosis factor isoform X1 [KO:K03156]
108521535  SP1; transcription factor Sp1 [KO:K04684]
108521602  AMHR2; anti-Muellerian hormone type-2 receptor isoform X1 [KO:K04672] [EC:2.7.11.30]
108521608  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
108521743  BAMBI; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
108521835  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
108522130  ID4; LOW QUALITY PROTEIN: DNA-binding protein inhibitor ID-4 [KO:K17695]
108522162  NCOR1; LOW QUALITY PROTEIN: nuclear receptor corepressor 1 [KO:K04650]
108522225  SMAD7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
108522304  CUL1; cullin-1 [KO:K03347]
108523050  TGIF2; homeobox protein TGIF2 [KO:K19553]
108523115  EMP3; epithelial membrane protein 3 [KO:K26257]
108523393  TFRC; transferrin receptor protein 1 isoform X1 [KO:K06503]
108523576  SMURF1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
108523695  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
108523953  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
108524017  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
108524136  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
108525104  [KO:K21283]
108525277  CHRD; chordin isoform X1 [KO:K04657]
108525582  NOG; noggin [KO:K04658]
108526586  INHBA; inhibin beta A chain isoform X1 [KO:K04667]
108526966  THBS1; thrombospondin-1 [KO:K16857]
108526989  RHOA; transforming protein RhoA [KO:K04513]
108527145  [KO:K06067] [EC:3.5.1.98]
108527222  DCN; decorin [KO:K04660]
108527338  NEO1; neogenin [KO:K06766]
108527400  LRRC32; leucine-rich repeat-containing protein 32 isoform X1 [KO:K26316]
108528282  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
108528445  EP300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
108528465  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
108528681  LTBP1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
108528761  MYC; myc proto-oncogene protein [KO:K04377]
108528889  ZFYVE16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
108529557  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
108529558  SKP1; LOW QUALITY PROTEIN: S-phase kinase-associated protein 1 [KO:K03094]
108529865  TF; serotransferrin [KO:K14736]
108529873  [KO:K14736]
108530109  FBN1; fibrillin-1 [KO:K06825]
108530339  NODAL; nodal homolog isoform X1 [KO:K04666]
108530562  ROCK1; LOW QUALITY PROTEIN: rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
108531192  ZFYVE9; zinc finger FYVE domain-containing protein 9 [KO:K04679]
108531364  HFE2; hemojuvelin isoform X1 [KO:K23100]
108531438  AMH; LOW QUALITY PROTEIN: muellerian-inhibiting factor [KO:K04665]
108531666  RGMA; repulsive guidance molecule A isoform X1 [KO:K23096]
108531719  GDF6; growth/differentiation factor 6 [KO:K20012]
108531867  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
108532274  IFNG; LOW QUALITY PROTEIN: interferon gamma [KO:K04687]
108532763  GDF7; LOW QUALITY PROTEIN: growth/differentiation factor 7 [KO:K20013]
108533001  BMP2; LOW QUALITY PROTEIN: bone morphogenetic protein 2 [KO:K21283]
108533071  RPS6KB1; LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
108533135  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
108533551  TGIF1; homeobox protein TGIF1 isoform X1 [KO:K19383]
108534321  BMP6; bone morphogenetic protein 6 [KO:K16620]
108534409  GREM2; gremlin-2 [KO:K23318]
108534939  TGFB3; transforming growth factor beta-3 [KO:K13377]
108535489  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
108536029  SKI; ski oncogene [KO:K26503]
108536070  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108536158  TGFB1; transforming growth factor beta-1 isoform X1 [KO:K13375]
108536248  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
108536465  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
108537064  CDKN2B; LOW QUALITY PROTEIN: cyclin-dependent kinase 4 inhibitor B [KO:K04685]
108537211  BMPR2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
108538214  TFR2; transferrin receptor protein 2 [KO:K23910]
108538320  CREBBP; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
108538449  ID3; DNA-binding protein inhibitor ID-3 [KO:K17694]
108538480  GDF5; growth/differentiation factor 5 [KO:K04664]
108538722  [KO:K04668]
108538746  LEFTY1; left-right determination factor 1 [KO:K04668]
108540597  [KO:K03094]
108541027  PITX2; pituitary homeobox 2 isoform X1 [KO:K04686]
108541273  RGMB; RGM domain family member B [KO:K06847]
108542121  INHBB; inhibin beta B chain [KO:K22687]
108542264  NRROS; negative regulator of reactive oxygen species [KO:K26317]
108542959  BMP5; bone morphogenetic protein 5 [KO:K04663]
108542977  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
108544116  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
108544121  ACVR1C; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
108544295  [KO:K03094]
108544586  THSD4; thrombospondin type-1 domain-containing protein 4 isoform X1 [KO:K23377]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Related
pathway
rbb04010  MAPK signaling pathway
rbb04110  Cell cycle
rbb04120  Ubiquitin mediated proteolysis
rbb04210  Apoptosis
KO pathway
ko04350   

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