KEGG   PATHWAY: rbb04110
Entry
rbb04110                    Pathway                                
Name
Cell cycle - Rhinopithecus bieti (black snub-nosed monkey)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
rbb04110  Cell cycle
rbb04110

Other DBs
GO: 0000278
Organism
Rhinopithecus bieti (black snub-nosed monkey) [GN:rbb]
Gene
108512070  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
108512332  MTBP; mdm2-binding protein isoform X1 [KO:K26116]
108512384  ORC4; LOW QUALITY PROTEIN: origin recognition complex subunit 4 [KO:K02606]
108512612  TTK; LOW QUALITY PROTEIN: dual specificity protein kinase TTK [KO:K08866] [EC:2.7.12.1]
108512658  FZR1; fizzy-related protein homolog isoform X1 [KO:K03364]
108513709  TRIP13; pachytene checkpoint protein 2 homolog [KO:K22399]
108513754  MCM3; DNA replication licensing factor MCM3 isoform X1 [KO:K02541] [EC:5.6.2.3]
108513913  E2F5; transcription factor E2F5 isoform X1 [KO:K04682]
108513941  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
108514363  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
108514433  AURKB; aurora kinase B isoform X1 [KO:K11479] [EC:2.7.11.1]
108514552  SMC1B; LOW QUALITY PROTEIN: structural maintenance of chromosomes protein 1B [KO:K06636]
108514714  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
108515044  DBF4; LOW QUALITY PROTEIN: protein DBF4 homolog A [KO:K06629]
108515398  ORC5; LOW QUALITY PROTEIN: origin recognition complex subunit 5 [KO:K02607]
108515423  E2F4; transcription factor E2F4 [KO:K04682]
108515587  CCNA2; cyclin-A2 [KO:K06627]
108515633  MAU2; MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
108515863  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
108516053  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
108516257  YWHAQ; 14-3-3 protein theta [KO:K16197]
108516606  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
108516676  PDS5A; sister chromatid cohesion protein PDS5 homolog A [KO:K11267]
108516698  NDC80; kinetochore protein NDC80 homolog [KO:K11547]
108516882  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
108517380  ATM; LOW QUALITY PROTEIN: serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
108517523  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
108517530  PDS5B; LOW QUALITY PROTEIN: sister chromatid cohesion protein PDS5 homolog B [KO:K11267]
108517558  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
108517663  CDC25A; LOW QUALITY PROTEIN: M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
108517680  [KO:K06631] [EC:2.7.11.21]
108517708  CDC7; cell division cycle 7-related protein kinase [KO:K02214] [EC:2.7.11.1]
108518069  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
108518169  SFN; 14-3-3 protein sigma [KO:K06644]
108518376  CDC45; cell division control protein 45 homolog [KO:K06628]
108518653  PPP2CB; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
108518925  YWHAG; 14-3-3 protein gamma [KO:K16198]
108519216  [KO:K10779]
108519583  BUB3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
108519603  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
108519858  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
108519991  CDT1; DNA replication factor Cdt1 [KO:K10727]
108520042  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
108520193  YWHAZ; LOW QUALITY PROTEIN: 14-3-3 protein zeta/delta [KO:K16197]
108520298  SMC1A; structural maintenance of chromosomes protein 1A [KO:K06636]
108521255  SGO1; LOW QUALITY PROTEIN: shugoshin 1 [KO:K11580]
108521415  TICRR; LOW QUALITY PROTEIN: treslin [KO:K26117]
108521614  ESPL1; separin [KO:K02365] [EC:3.4.22.49]
108521835  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
108522131  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
108522304  CUL1; cullin-1 [KO:K03347]
108522364  [KO:K02605]
108522389  TFDP2; transcription factor Dp-2 isoform X1 [KO:K09392]
108523343  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
108523405  KNL1; LOW QUALITY PROTEIN: protein CASC5 [KO:K11542]
108523708  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
108523953  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
108524017  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
108524181  CDC14A; LOW QUALITY PROTEIN: dual specificity protein phosphatase CDC14A [KO:K06639] [EC:3.1.3.16 3.1.3.48]
108524248  YWHAE; 14-3-3 protein epsilon [KO:K06630]
108524262  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
108524397  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
108525947  ANAPC4; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 4 [KO:K03351]
108526889  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X1 [KO:K06637] [EC:2.7.11.1]
108527145  [KO:K06067] [EC:3.5.1.98]
108527358  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
108527572  NIPBL; LOW QUALITY PROTEIN: nipped-B-like protein [KO:K06672]
108527600  YWHAH; 14-3-3 protein eta isoform X1 [KO:K16198]
108528282  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
108528336  CDKN1A; LOW QUALITY PROTEIN: cyclin-dependent kinase inhibitor 1 [KO:K06625]
108528445  EP300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
108528465  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
108528490  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
108528761  MYC; myc proto-oncogene protein [KO:K04377]
108529282  CDC14B; dual specificity protein phosphatase CDC14B isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
108529398  FBXO5; F-box only protein 5 isoform X1 [KO:K10292]
108529557  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
108529558  SKP1; LOW QUALITY PROTEIN: S-phase kinase-associated protein 1 [KO:K03094]
108529637  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
108529804  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
108530341  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
108530560  ESCO1; N-acetyltransferase ESCO1 isoform X1 [KO:K11268] [EC:2.3.1.-]
108530611  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
108530701  RB1; retinoblastoma-associated protein [KO:K06618]
108531239  ORC1; origin recognition complex subunit 1 [KO:K02603]
108531271  RBL2; LOW QUALITY PROTEIN: retinoblastoma-like protein 2 [KO:K16332]
108531421  STAG1; cohesin subunit SA-1 isoform X1 [KO:K06671]
108531451  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
108531808  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
108532163  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
108532183  ORC2; origin recognition complex subunit 2 [KO:K02604]
108532197  DBF4B; protein DBF4 homolog B isoform X1 [KO:K06629]
108532254  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
108532870  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
108533038  E2F1; LOW QUALITY PROTEIN: transcription factor E2F1 [KO:K17454]
108533135  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
108533343  PCNA; proliferating cell nuclear antigen [KO:K04802]
108533372  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
108533456  MAD2L1BP; MAD2L1-binding protein [KO:K26093]
108533479  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
108533501  CCND3; LOW QUALITY PROTEIN: G1/S-specific cyclin-D3 [KO:K10152]
108533547  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
108534107  [KO:K03358]
108534360  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
108534719  CDC6; cell division control protein 6 homolog [KO:K02213]
108534772  ORC6; origin recognition complex subunit 6 isoform X1 [KO:K02608]
108534939  TGFB3; transforming growth factor beta-3 [KO:K13377]
108535053  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
108535349  MCM4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
108535350  PRKDC; DNA-dependent protein kinase catalytic subunit isoform X1 [KO:K06642] [EC:2.7.11.1]
108535496  ANAPC10; anaphase-promoting complex subunit 10 [KO:K03357]
108535700  CDC20; cell division cycle protein 20 homolog [KO:K03363]
108535876  ATR; LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
108535938  [KO:K06643] [EC:2.3.2.27]
108536116  RAD21; LOW QUALITY PROTEIN: double-strand-break repair protein rad21 homolog [KO:K06670]
108536158  TGFB1; transforming growth factor beta-1 isoform X1 [KO:K13375]
108536302  CDC27; LOW QUALITY PROTEIN: cell division cycle protein 27 homolog [KO:K03350]
108536465  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
108536486  [KO:K11580]
108536489  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
108536746  PTTG2; LOW QUALITY PROTEIN: securin-2 [KO:K06635]
108537054  CDKN2A; cyclin-dependent kinase inhibitor 2A [KO:K06621]
108537064  CDKN2B; LOW QUALITY PROTEIN: cyclin-dependent kinase 4 inhibitor B [KO:K04685]
108537522  ESCO2; N-acetyltransferase ESCO2 isoform X1 [KO:K11268] [EC:2.3.1.-]
108537525  MCM2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
108537931  PTTG1; securin [KO:K06635]
108538096  CCNB3; G2/mitotic-specific cyclin-B3 [KO:K21771]
108538127  MCM7; DNA replication licensing factor MCM7 isoform X1 [KO:K02210] [EC:5.6.2.3]
108538137  CDKN1C; cyclin-dependent kinase inhibitor 1C [KO:K09993]
108538320  CREBBP; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
108538448  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
108538612  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
108538745  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
108538812  PLK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
108538864  SMC3; LOW QUALITY PROTEIN: structural maintenance of chromosomes protein 3 [KO:K06669]
108539380  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
108539644  MCM6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
108539896  CCNE2; LOW QUALITY PROTEIN: G1/S-specific cyclin-E2 [KO:K06626]
108539976  CDKN2D; cyclin-dependent kinase 4 inhibitor D isoform X1 [KO:K06623]
108540597  [KO:K03094]
108540866  MCM5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
108541124  CCNH; cyclin-H isoform X1 [KO:K06634]
108541164  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
108541177  CDK7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
108541546  WEE2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
108541690  CDC23; cell division cycle protein 23 homolog [KO:K03355]
108541696  CDC25C; LOW QUALITY PROTEIN: M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
108541757  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
108541788  WEE1; LOW QUALITY PROTEIN: wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
108542326  PPP2R5C; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform [KO:K11584]
108542336  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
108542865  ANAPC2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
108542976  WAPL; wings apart-like protein homolog isoform X1 [KO:K25163]
108543026  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
108543220  CDCA5; LOW QUALITY PROTEIN: sororin [KO:K17390]
108543678  DDX11; probable ATP-dependent DNA helicase DDX11 isoform X1 [KO:K11273] [EC:3.6.4.13]
108543744  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
108543747  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
108544295  [KO:K03094]
108544296  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
108544549  [KO:K16197]
108544822  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
  Journal
Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
  Journal
Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
  Authors
Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
  Journal
EMBO J 18:396-410 (1999)
DOI:10.1093/emboj/18.2.396
Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
  Journal
EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
rbb03030  DNA replication
rbb04010  MAPK signaling pathway
rbb04120  Ubiquitin mediated proteolysis
rbb04210  Apoptosis
KO pathway
ko04110   

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