KEGG   PATHWAY: rbb04530
Entry
rbb04530                    Pathway                                
Name
Tight junction - Rhinopithecus bieti (black snub-nosed monkey)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
rbb04530  Tight junction
rbb04530

Other DBs
GO: 0005923
Organism
Rhinopithecus bieti (black snub-nosed monkey) [GN:rbb]
Gene
108512114  TJP3; tight junction protein ZO-3 isoform X1 [KO:K06097]
108512247  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
108512472  [KO:K12075]
108512577  RAPGEF6; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 6 [KO:K08020]
108512721  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
108512890  MSN; moesin [KO:K05763]
108513035  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
108513135  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
108513143  CLDN11; claudin-11 [KO:K06087]
108514290  MYH10; myosin-10 [KO:K10352]
108514303  CLDN7; claudin-7 [KO:K06087]
108514586  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
108514761  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
108515198  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
108515376  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
108515504  ARHGEF2; rho guanine nucleotide exchange factor 2 [KO:K12791]
108515802  [KO:K12751]
108515883  [KO:K04392]
108516009  MYL6B; myosin light chain 6B isoform X1 [KO:K12751]
108516010  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
108516076  [KO:K04354]
108516461  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
108516553  CLDN2; claudin-2 [KO:K06087]
108516617  LLGL1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
108516742  CLDN24; putative claudin-24 [KO:K06087]
108516749  [KO:K06087]
108516960  [KO:K18584]
108517082  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
108517371  CLDN3; LOW QUALITY PROTEIN: claudin-3 [KO:K06087]
108517463  WAS; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein [KO:K05747]
108517508  [KO:K04440] [EC:2.7.11.24]
108517542  NF2; LOW QUALITY PROTEIN: merlin [KO:K16684]
108517988  CLDN17; claudin-17 [KO:K06087]
108518005  CLDN8; claudin-8 [KO:K06087]
108518303  JAM2; LOW QUALITY PROTEIN: junctional adhesion molecule B [KO:K06735]
108518375  CLDN5; claudin-5 [KO:K06087]
108518420  [KO:K07374]
108518432  MYH9; myosin-9 isoform X1 [KO:K10352]
108518487  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
108518653  PPP2CB; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
108518761  AMOT; angiomotin isoform X1 [KO:K16819]
108518847  RAB13; ras-related protein Rab-13 isoform X1 [KO:K06109]
108518934  CLDN15; claudin-15 [KO:K06087]
108519844  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
108519926  CLDN10; claudin-10 isoform X1 [KO:K06087]
108520366  [KO:K08018]
108520763  ACTR3B; actin-related protein 3B [KO:K18584]
108521141  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108521178  F11R; junctional adhesion molecule A [KO:K06089]
108522504  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
108522934  [KO:K12751]
108522955  [KO:K06087]
108522956  [KO:K06087]
108522968  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
108522983  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
108523051  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
108523111  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 [KO:K07200]
108523261  EPB41L4B; LOW QUALITY PROTEIN: band 4.1-like protein 4B [KO:K21111]
108523322  CLDN9; LOW QUALITY PROTEIN: claudin-9 [KO:K06087]
108523323  CLDN6; LOW QUALITY PROTEIN: claudin-6 [KO:K06087]
108523346  AMOTL2; angiomotin-like protein 2 isoform X1 [KO:K06104]
108523680  [KO:K05757]
108523953  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
108523982  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
108524397  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
108525461  [KO:K07374]
108525726  [KO:K07374]
108525739  [KO:K04353]
108526422  MPDZ; multiple PDZ domain protein [KO:K06095]
108526524  CLDN4; claudin-4 isoform X1 [KO:K06087]
108526537  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
108526799  TJP1; LOW QUALITY PROTEIN: tight junction protein ZO-1 [KO:K05701]
108526989  RHOA; transforming protein RhoA [KO:K04513]
108527463  MARVELD3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
108527577  CD1A; LOW QUALITY PROTEIN: T-cell surface glycoprotein CD1a [KO:K06448]
108527582  CD1E; T-cell surface glycoprotein CD1e, membrane-associated isoform X1 [KO:K06448]
108527584  CD1B; T-cell surface glycoprotein CD1b [KO:K06448]
108527585  CD1C; T-cell surface glycoprotein CD1c isoform X1 [KO:K06448]
108527586  CD1D; antigen-presenting glycoprotein CD1d isoform X1 [KO:K06448]
108527653  RAB8B; ras-related protein Rab-8B [KO:K07902]
108527683  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108527784  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
108527894  [KO:K06094]
108528085  RAP1A; ras-related protein Rap-1A [KO:K04353]
108529253  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
108529400  ITGB1; integrin beta-1 [KO:K05719]
108529414  MYH11; myosin-11 isoform X1 [KO:K10352]
108529557  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
108529570  HSPA4; LOW QUALITY PROTEIN: heat shock 70 kDa protein 4 [KO:K09489]
108529694  JAM3; junctional adhesion molecule C [KO:K06785]
108529771  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
108529896  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
108530261  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
108530264  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
108530271  TJP2; LOW QUALITY PROTEIN: tight junction protein ZO-2 [KO:K06098]
108530360  [KO:K05756]
108530370  CLDN19; claudin-19 isoform X1 [KO:K06087]
108530477  CLDN1; claudin-1 [KO:K06087]
108530478  CLDN16; claudin-16 [KO:K06087]
108530521  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
108530562  ROCK1; LOW QUALITY PROTEIN: rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
108530959  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
108531085  SYMPK; LOW QUALITY PROTEIN: symplekin [KO:K06100]
108531097  VASP; LOW QUALITY PROTEIN: vasodilator-stimulated phosphoprotein [KO:K06274]
108531367  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
108531541  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
108532039  [KO:K21112]
108532908  PATJ; inaD-like protein isoform X1 [KO:K06092]
108532921  JUN; transcription factor AP-1 [KO:K04448]
108532936  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
108533227  CGN; cingulin [KO:K06102]
108533343  PCNA; proliferating cell nuclear antigen [KO:K04802]
108533460  TJAP1; tight junction-associated protein 1 isoform X1 [KO:K06105]
108533552  [KO:K12757]
108533553  MYL12B; myosin regulatory light chain 12B [KO:K12757]
108533685  BVES; blood vessel epicardial substance [KO:K21108]
108533710  MPP5; LOW QUALITY PROTEIN: MAGUK p55 subfamily member 5 [KO:K06091]
108533731  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
108534006  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
108534125  ACTG1; actin, cytoplasmic 2 [KO:K05692]
108534524  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
108534550  ARHGEF18; rho guanine nucleotide exchange factor 18 [KO:K21066]
108534563  CRB3; protein crumbs homolog 3 [KO:K06090]
108534812  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
108535312  NEDD4; E3 ubiquitin-protein ligase NEDD4 [KO:K10591] [EC:2.3.2.26]
108535744  AMOTL1; LOW QUALITY PROTEIN: angiomotin-like protein 1 [KO:K06104]
108535803  MYH14; myosin-14 isoform X1 [KO:K10352]
108536030  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
108536369  CLDN25; putative claudin-25 [KO:K06087]
108536465  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
108536468  RDX; radixin isoform X1 [KO:K05762]
108536574  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
108536704  GATA4; LOW QUALITY PROTEIN: transcription factor GATA-4 [KO:K09183]
108536809  [KO:K07839]
108536834  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
108536870  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
108537039  [KO:K12751]
108537346  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
108537351  LLGL2; lethal(2) giant larvae protein homolog 2 isoform X1 [KO:K06094]
108537733  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
108537794  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
108538232  [KO:K05692]
108538237  ACTB; actin, cytoplasmic 1 [KO:K05692]
108538451  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
108538745  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
108538800  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
108538832  ARHGAP17; LOW QUALITY PROTEIN: rho GTPase-activating protein 17 [KO:K20638]
108538843  CTTN; src substrate cortactin isoform X1 [KO:K06106]
108539029  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
108539314  DLG3; LOW QUALITY PROTEIN: disks large homolog 3 [KO:K21098]
108539474  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
108540003  [KO:K04345] [EC:2.7.11.11]
108540539  EZR; ezrin isoform X1 [KO:K08007]
108540572  CLDN12; claudin-12 [KO:K06087]
108540605  CLDN34; claudin-34 [KO:K06087]
108540803  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
108541057  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
108541190  OCLN; occludin [KO:K06088]
108541191  MARVELD2; MARVEL domain-containing protein 2 isoform X1 [KO:K17291]
108541597  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
108541714  TUBA8; tubulin alpha-8 chain [KO:K07374]
108541780  [KO:K12751]
108541844  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
108542139  YBX3; Y-box-binding protein 3 isoform X1 [KO:K06099]
108542156  CLDN20; claudin-20 [KO:K06087]
108542572  [KO:K12751]
108543281  RAB8A; ras-related protein Rab-8A [KO:K07901]
108543389  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
108543686  MICALL2; MICAL-like protein 2 isoform X1 [KO:K21068]
108543832  CLDN14; claudin-14 [KO:K06087]
108543866  CLDN23; LOW QUALITY PROTEIN: claudin-23 [KO:K06087]
108543920  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
108543976  WHAMM; LOW QUALITY PROTEIN: WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
108544169  AFDN; afadin isoform X1 [KO:K05702]
108544615  CLDN18; claudin-18 isoform X1 [KO:K06087]
108544682  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
108544746  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
108545053  CGNL1; cingulin-like protein 1 isoform X1 [KO:K21110]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
rbb04520  Adherens junction
rbb04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

DBGET integrated database retrieval system