KEGG   PATHWAY: rbb04810
Entry
rbb04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Rhinopithecus bieti (black snub-nosed monkey)
Class
Cellular Processes; Cell motility
Pathway map
rbb04810  Regulation of actin cytoskeleton
rbb04810

Other DBs
GO: 0030036
Organism
Rhinopithecus bieti (black snub-nosed monkey) [GN:rbb]
Gene
108512087  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
108512122  [KO:K00889] [EC:2.7.1.68]
108512247  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
108512265  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
108512297  BRK1; protein BRICK1 [KO:K05752]
108512401  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
108512498  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108512667  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
108512721  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
108512764  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
108512890  MSN; moesin [KO:K05763]
108513073  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
108513076  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
108513251  VAV2; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV2 [KO:K05730]
108513599  FGF18; fibroblast growth factor 18 [KO:K04358]
108513636  SOS2; son of sevenless homolog 2 [KO:K03099]
108513891  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
108513979  [KO:K04289]
108514133  RGCC; regulator of cell cycle RGCC [KO:K26108]
108514260  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
108514290  MYH10; myosin-10 [KO:K10352]
108514609  NCKAP1L; nck-associated protein 1-like [KO:K05750]
108514611  ITGA5; integrin alpha-5 [KO:K06484]
108514672  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108514729  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
108515073  FGF8; fibroblast growth factor 8 [KO:K04358]
108515338  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
108515537  INSRR; insulin receptor-related protein isoform X1 [KO:K05086] [EC:2.7.10.1]
108515569  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
108515579  FGF2; fibroblast growth factor 2 [KO:K18497]
108515641  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
108515883  [KO:K04392]
108515968  C9; complement component C9 [KO:K04000]
108516025  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
108516304  FGD3; LOW QUALITY PROTEIN: FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
108516444  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
108516461  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
108516776  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
108516871  VCL; LOW QUALITY PROTEIN: vinculin [KO:K05700]
108516960  [KO:K18584]
108517209  IQGAP1; LOW QUALITY PROTEIN: ras GTPase-activating-like protein IQGAP1 [KO:K16848]
108517282  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
108517295  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
108517319  FGF7; fibroblast growth factor 7 [KO:K04358]
108517416  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
108517420  ITGB5; integrin beta-5 [KO:K06588]
108517753  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
108517986  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108518185  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
108518204  SLC9A1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
108518278  PFN2; profilin-2 [KO:K05759]
108518432  MYH9; myosin-9 isoform X1 [KO:K10352]
108518604  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
108518612  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
108518638  CFL1; cofilin-1 isoform X1 [KO:K05765]
108518797  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
108518899  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
108519129  BDKRB2; LOW QUALITY PROTEIN: B2 bradykinin receptor [KO:K03916]
108519130  BDKRB1; B1 bradykinin receptor [KO:K03915]
108519241  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
108519578  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
108519705  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
108519844  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
108520474  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
108520530  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
108520703  TMSB4X; thymosin beta-4 [KO:K05764]
108520763  ACTR3B; actin-related protein 3B [KO:K18584]
108520869  SOS1; son of sevenless homolog 1 [KO:K03099]
108521318  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
108521588  ITGB7; integrin beta-7 [KO:K06590]
108521689  MOS; LOW QUALITY PROTEIN: proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
108521880  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108521952  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
108522039  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
108522273  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
108522647  [KO:K05730]
108522676  [KO:K05733] [EC:2.7.11.1]
108522901  ITGA1; integrin alpha-1 [KO:K06480]
108522903  ITGA2; integrin alpha-2 [KO:K06481]
108523051  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
108523085  ITGAE; integrin alpha-E [KO:K06524]
108523244  WASL; LOW QUALITY PROTEIN: neural Wiskott-Aldrich syndrome protein [KO:K23612]
108523453  [KO:K05759]
108523680  [KO:K05757]
108523695  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
108523748  KRAS; GTPase KRas isoform X1 [KO:K07827]
108523982  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
108524142  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
108524318  CRK; adapter molecule crk isoform X1 [KO:K04438]
108524384  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
108524661  ITGA9; LOW QUALITY PROTEIN: integrin alpha-9 [KO:K06585]
108524810  PFN1; profilin-1 [KO:K05759]
108526452  FGF20; fibroblast growth factor 20 [KO:K04358]
108526525  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
108526595  SCIN; adseverin [KO:K05768]
108526617  [KO:K06483]
108526629  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
108526642  NCKAP1; nck-associated protein 1 [KO:K05750]
108526909  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
108526989  RHOA; transforming protein RhoA [KO:K04513]
108527072  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
108527422  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
108527563  PAK5; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
108527615  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
108527690  ITGAD; LOW QUALITY PROTEIN: integrin alpha-D [KO:K06594]
108527702  ITGB6; LOW QUALITY PROTEIN: integrin beta-6 [KO:K06589]
108527840  ITGAX; integrin alpha-X isoform X1 [KO:K06462]
108528119  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
108528122  NRAS; GTPase NRas [KO:K07828]
108528527  PPP1R12A; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12A [KO:K06270]
108528604  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
108528639  FAM49B; protein FAM49B isoform X1 [KO:K27976]
108529019  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
108529242  FAM49A; protein FAM49A [KO:K27976]
108529317  ITGB8; LOW QUALITY PROTEIN: integrin beta-8 [KO:K06591]
108529400  ITGB1; integrin beta-1 [KO:K05719]
108529414  MYH11; myosin-11 isoform X1 [KO:K10352]
108529768  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
108529808  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
108530204  DIAPH1; LOW QUALITY PROTEIN: protein diaphanous homolog 1 [KO:K05740]
108530219  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
108530233  APC2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
108530266  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
108530360  [KO:K05756]
108530457  KNG1; kininogen-1 isoform X1 [KO:K03898]
108530562  ROCK1; LOW QUALITY PROTEIN: rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
108530908  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
108530933  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
108531061  [KO:K05732]
108531367  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
108531442  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
108532047  PDGFRB; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
108532191  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
108532286  FGFR3; LOW QUALITY PROTEIN: fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
108532444  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
108532456  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
108532746  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
108532869  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
108532932  C8B; complement component C8 beta chain [KO:K03998]
108532933  C8A; complement component C8 alpha chain [KO:K03997]
108532943  [KO:K05765]
108532960  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108533237  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
108533552  [KO:K12757]
108533553  MYL12B; myosin regulatory light chain 12B [KO:K12757]
108533731  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
108533750  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
108533956  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
108533999  PXN; paxillin isoform X1 [KO:K05760]
108534092  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
108534125  ACTG1; actin, cytoplasmic 2 [KO:K05692]
108534134  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
108534276  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108534391  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
108534413  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
108534558  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
108534757  PDGFD; platelet-derived growth factor D [KO:K05450]
108534775  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
108534812  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
108535339  FGF10; fibroblast growth factor 10 [KO:K04358]
108535399  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
108535405  ITGAL; LOW QUALITY PROTEIN: integrin alpha-L [KO:K05718]
108535417  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
108535524  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
108535636  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
108535803  MYH14; myosin-14 isoform X1 [KO:K10352]
108535827  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
108536070  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108536084  CRKL; crk-like protein [KO:K04438]
108536133  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
108536294  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
108536468  RDX; radixin isoform X1 [KO:K05762]
108536494  FGF6; fibroblast growth factor 6 [KO:K04358]
108536498  FGF23; fibroblast growth factor 23 [KO:K22428]
108536834  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
108537087  GSN; gelsolin isoform X1 [KO:K05768]
108537092  C5; complement C5 [KO:K03994]
108537210  ABI2; LOW QUALITY PROTEIN: abl interactor 2 [KO:K05751]
108537357  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
108537873  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
108538219  FGF19; fibroblast growth factor 19 [KO:K22603]
108538230  FGF4; fibroblast growth factor 4 [KO:K04358]
108538232  [KO:K05692]
108538237  ACTB; actin, cytoplasmic 1 [KO:K05692]
108538240  FGF3; fibroblast growth factor 3 [KO:K04358]
108538283  FGF9; fibroblast growth factor 9 [KO:K04358]
108538451  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
108538680  CFL2; cofilin-2 isoform X1 [KO:K05765]
108538743  ENAH; protein enabled homolog isoform X1 [KO:K05746]
108538888  ARHGEF4; rho guanine nucleotide exchange factor 4 [KO:K05769]
108539029  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
108539069  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108539083  PAK4; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
108539226  INS; insulin isoform X1 [KO:K04526]
108539355  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108539652  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
108539787  ITGB2; LOW QUALITY PROTEIN: integrin beta-2 [KO:K06464]
108540305  APC; LOW QUALITY PROTEIN: adenomatous polyposis coli protein [KO:K02085]
108540354  PIKFYVE; LOW QUALITY PROTEIN: 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
108540539  EZR; ezrin isoform X1 [KO:K08007]
108540547  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
108540803  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
108541026  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
108541175  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
108541537  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
108541844  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
108541957  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
108542054  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
108542265  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
108542315  PDGFA; LOW QUALITY PROTEIN: platelet-derived growth factor subunit A [KO:K04359]
108542482  DIAPH3; LOW QUALITY PROTEIN: protein diaphanous homolog 3 [KO:K05745]
108542522  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
108542580  FGD1; LOW QUALITY PROTEIN: FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
108542672  ARHGEF6; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 6 [KO:K05729]
108542878  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
108543178  FN1; fibronectin isoform X1 [KO:K05717]
108543210  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
108543525  HRAS; GTPase HRas isoform X1 [KO:K02833]
108543875  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
108544023  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
108544148  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
108544577  FGF16; fibroblast growth factor 16 [KO:K04358]
108544591  PIK3CB; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
108544611  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
108544682  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
108544739  C6; complement component C6 [KO:K03995]
108544742  C7; complement component C7 isoform X1 [KO:K03996]
108544759  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
108544776  PFN3; profilin-3 [KO:K05759]
108545061  PPP1R12B; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12B [KO:K12329]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
rbb04010  MAPK signaling pathway
rbb04510  Focal adhesion
rbb04520  Adherens junction
KO pathway
ko04810   

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