Entry Name Renin secretion - Rhinopithecus bieti (black snub-nosed monkey)
Description The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. Renin is synthesized, stored in, and released into circulation by the juxtaglomerular (JG) cells of the kidney. Secretion of renin from JG cells at the organ level is controlled by the four main mechanisms: the sympathetic nervous system, the local JG apparatus baroreflex, the macula densa mechanism, and several hormones acting locally within the JG apparatus. Renin secretion at the level of renal JG cells appears to be controlled mainly by classic second messengers, namely cAMP, cGMP, and free cytosolic calcium concentration. While cAMP generally stimulates renin release and the intracellular calcium concentration suppresses the exocytosis of renin, the effects of cGMP in the regulation of the renin system are more complex as it both may stimulate or inhibit renin release.
Class Organismal Systems; Endocrine systemBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Rhinopithecus bieti (black snub-nosed monkey) [GN:
rbb ]
Gene 108542470 ADRB1; LOW QUALITY PROTEIN: beta-1 adrenergic receptor [KO:K04141 ]
108513564 ADRB3; LOW QUALITY PROTEIN: beta-3 adrenergic receptor [KO:K04143 ]
108530575 ADCYAP1; LOW QUALITY PROTEIN: pituitary adenylate cyclase-activating polypeptide [KO:K05262 ]
108532376 ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587 ]
108541624 GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632 ]
108540349 CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
108529255 KCNMA1; calcium-activated potassium channel subunit alpha-1 isoform X1 [KO:K04936 ]
108514647 PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755 ] [EC:3.1.4.17 ]
108532373 PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755 ] [EC:3.1.4.17 ]
108526644 PDE1A; LOW QUALITY PROTEIN: calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755 ] [EC:3.1.4.17 ]
108519632 GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630 ]
108534866 GNAI1; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
108526962 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630 ]
108529632 ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056 ]
108514698 CLCA1; LOW QUALITY PROTEIN: calcium-activated chloride channel regulator 1 [KO:K05027 ]
108514705 CLCA2; calcium-activated chloride channel regulator 2 [KO:K05028 ]
108514673 CLCA4; calcium-activated chloride channel regulator 4 [KO:K05030 ]
108522695 CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850 ]
108515198 CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851 ]
108521361 voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853 ]
108545075 CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857 ]
108542641 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634 ]
108526885 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
108527564 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
108528737 ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
108523739 ITPR2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959 ]
108514692 CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183 ]
108516875 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
108540785 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference Authors Kurtz A
Title Renin release: sites, mechanisms, and control.
Journal Reference Authors Schweda F, Friis U, Wagner C, Skott O, Kurtz A
Title Renin release.
Journal Reference Authors Castrop H, Hocherl K, Kurtz A, Schweda F, Todorov V, Wagner C
Title Physiology of kidney renin.
Journal Reference Authors Friis UG, Madsen K, Stubbe J, Hansen PB, Svenningsen P, Bie P, Skott O, Jensen BL
Title Regulation of renin secretion by renal juxtaglomerular cells.
Journal Reference Authors Kim SM, Briggs JP, Schnermann J
Title Convergence of major physiological stimuli for renin release on the Gs-alpha/cyclic adenosine monophosphate signaling pathway.
Journal Reference Authors Kurtz A
Title Control of renin synthesis and secretion.
Journal Reference Authors Kurtz A, Wagner C
Title Cellular control of renin secretion.
Journal J Exp Biol 202:219-25 (1999)
Reference Authors Persson PB
Title Renin: origin, secretion and synthesis.
Journal Reference Authors Schweda F, Kurtz A
Title Cellular mechanism of renin release.
Journal Reference Authors Sparks MA, Crowley SD, Gurley SB, Mirotsou M, Coffman TM
Title Classical Renin-Angiotensin system in kidney physiology.
Journal Reference Authors Harrison-Bernard LM
Title The renal renin-angiotensin system.
Journal Reference Authors Schnermann J, Briggs JP
Title Synthesis and secretion of renin in mice with induced genetic mutations.
Journal Reference Authors Ryan MJ, Black TA, Millard SL, Gross KW, Hajduczok G
Title Endothelin-1 increases calcium and attenuates renin gene expression in As4.1 cells.
Journal Reference Authors Hautmann M, Friis UG, Desch M, Todorov V, Castrop H, Segerer F, Otto C, Schutz G, Schweda F
Title Pituitary adenylate cyclase-activating polypeptide stimulates renin secretion via activation of PAC1 receptors.
Journal Related KO pathway LinkDB All DBs
