KEGG   PATHWAY: rbb04024
Entry
rbb04024                    Pathway                                
Name
cAMP signaling pathway - Rhinopithecus bieti (black snub-nosed monkey)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
rbb04024  cAMP signaling pathway
rbb04024

Other DBs
GO: 0019933
Organism
Rhinopithecus bieti (black snub-nosed monkey) [GN:rbb]
Gene
108543339  VIP; VIP peptides [KO:K05264]
108528802  CRH; corticoliberin [KO:K05256]
108538506  CGA; glycoprotein hormones alpha chain [KO:K08522]
108523623  LHB; lutropin subunit beta [KO:K08521]
108524866  choriogonadotropin subunit beta-like [KO:K08521]
108543039  GPHA2; glycoprotein hormone alpha-2 [KO:K25483]
108544293  GPHB5; glycoprotein hormone beta-5 [KO:K25484]
108528124  TSHB; thyrotropin subunit beta [KO:K05251]
108532667  POMC; pro-opiomelanocortin [KO:K05228]
108541419  GCG; glucagon [KO:K05259]
108516414  GIP; gastric inhibitory polypeptide [KO:K05258]
108515635  FSHB; follitropin subunit beta [KO:K05250]
108539363  NPPA; LOW QUALITY PROTEIN: natriuretic peptides A [KO:K12334]
108530575  ADCYAP1; LOW QUALITY PROTEIN: pituitary adenylate cyclase-activating polypeptide [KO:K05262]
108542470  ADRB1; LOW QUALITY PROTEIN: beta-1 adrenergic receptor [KO:K04141]
108532068  ADRB2; beta-2 adrenergic receptor [KO:K04142]
108523468  LOW QUALITY PROTEIN: D(1A) dopamine receptor-like [KO:K04144]
108523462  D(1A) dopamine receptor [KO:K04144]
108529476  DRD5; D(1B) dopamine receptor [KO:K05840]
108540662  ADORA2A; adenosine receptor A2a [KO:K04266]
108532069  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
108515276  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
108513697  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
108532376  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
108521707  VIPR2; vasoactive intestinal polypeptide receptor 2 isoform X1 [KO:K04590]
108529368  CRHR1; corticotropin-releasing factor receptor 1 isoform X1 [KO:K04578]
108532984  CRHR2; corticotropin-releasing factor receptor 2 isoform X1 [KO:K04579]
108527512  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
108530805  TSHR; thyrotropin receptor isoform X1 [KO:K04249]
108533098  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
108528361  GLP1R; glucagon-like peptide 1 receptor [KO:K04581]
108531059  GIPR; gastric inhibitory polypeptide receptor [KO:K04580]
108518871  GPR119; glucose-dependent insulinotropic receptor [KO:K08424]
108537919  FSHR; follicle-stimulating hormone receptor isoform X1 [KO:K04247]
108518838  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
108541624  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
108541626  neuroendocrine secretory protein 55 [KO:K04632]
108541613  EDN1; endothelin-1 [KO:K16366]
108530326  EDN2; endothelin-2 [KO:K16367]
108525089  endothelin-3 [KO:K05227]
108541617  EDN3; endothelin-3 [KO:K05227]
108530466  SST; somatostatin [KO:K05237]
108523352  NPY; pro-neuropeptide Y [KO:K05232]
108512294  GHRL; appetite-regulating hormone [KO:K05254]
108529970  OXT; oxytocin-neurophysin 1 [KO:K05243]
108531259  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
108538396  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
108516728  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
108515322  HTR1F; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 1F [KO:K04153]
108521244  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
108536133  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
108532444  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
108536354  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
108539121  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
108528421  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
108514998  ADORA1; adenosine receptor A1 isoform X1 [KO:K04265]
108514049  EDNRA; endothelin-1 receptor isoform X1 [KO:K04197]
108530882  NPY1R; neuropeptide Y receptor type 1 isoform X1 [KO:K04204]
108544348  SSTR1; LOW QUALITY PROTEIN: somatostatin receptor type 1 [KO:K04217]
108537341  SSTR2; somatostatin receptor type 2 [KO:K04218]
108519397  SSTR5; somatostatin receptor type 5 [KO:K04221]
108540087  HCAR1; hydroxycarboxylic acid receptor 1 [KO:K08401]
108540964  hydroxycarboxylic acid receptor 2 [KO:K08402]
108512309  FFAR2; free fatty acid receptor 2 [KO:K04328]
108513155  SUCNR1; LOW QUALITY PROTEIN: succinate receptor 1 [KO:K10042]
108534626  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
108530949  OXTR; oxytocin receptor [KO:K04229]
108540408  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
108519632  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
108534866  GNAI1; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
108526962  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
108534793  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
108536960  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
108543021  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
108540946  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
108517430  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
108543933  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
108522948  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
108514094  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
108538326  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
108526738  ADCY10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
108521065  CNGA1; LOW QUALITY PROTEIN: cGMP-gated cation channel alpha-1 [KO:K04948]
108536976  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
108529485  CNGA3; cyclic nucleotide-gated cation channel alpha-3 isoform X1 [KO:K04950]
108543248  CNGA4; cyclic nucleotide-gated cation channel alpha-4 isoform X1 [KO:K04951]
108533890  CNGB1; cyclic nucleotide-gated cation channel beta-1 [KO:K04952]
108531635  CNGB3; cyclic nucleotide-gated cation channel beta-3 isoform X1 [KO:K04953]
108536001  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
108512653  CALM2; calmodulin [KO:K02183]
108514692  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
108529886  CALML3; calmodulin-like protein 3 [KO:K02183]
108529898  CALML5; calmodulin-like protein 5 [KO:K02183]
108531068  CALM3; calmodulin isoform X1 [KO:K02183]
108533995  calmodulin [KO:K02183]
108535906  CALM1; calmodulin [KO:K02183]
108532044  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
108544005  LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515] [EC:2.7.11.17]
108529387  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
108516884  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
108512486  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
108540302  CAMK4; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
108533685  BVES; blood vessel epicardial substance [KO:K21108]
108541838  POPDC2; popeye domain-containing protein 2 isoform X1 [KO:K26206]
108533686  POPDC3; popeye domain-containing protein 3 [KO:K26207]
108528238  KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
108537872  HCN2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
108527340  HCN4; LOW QUALITY PROTEIN: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
108519929  ABCC4; multidrug resistance-associated protein 4 isoform X1 [KO:K05673]
108515949  RAPGEF3; rap guanine nucleotide exchange factor 3 [KO:K08014]
108518542  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
108535827  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
108535524  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
108524801  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
108540404  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
108521233  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
108537794  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
108521141  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108517508  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
108528085  RAP1A; ras-related protein Rap-1A [KO:K04353]
108525739  ras-related protein Rap-1A [KO:K04353]
108532250  RAP1B; ras-related protein Rap-1b [KO:K07836]
108536834  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
108513251  VAV2; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV2 [KO:K05730]
108534558  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
108522647  LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV3-like [KO:K05730]
108523982  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
108515883  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
108512764  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
108534092  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
108543210  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
108530209  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
108526989  RHOA; transforming protein RhoA [KO:K04513]
108544169  AFDN; afadin isoform X1 [KO:K05702]
108544591  PIK3CB; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
108532960  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108539355  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108535636  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
108534276  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108541175  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
108512498  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108539069  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108521880  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108541537  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
108517986  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108514672  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108512087  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
108523695  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
108536070  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108514761  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
108540003  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
108527683  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108530264  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
108527779  PPP1R1B; protein phosphatase 1 regulatory subunit 1B [KO:K15494]
108518604  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
108532746  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
108512265  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
108540349  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
108519245  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
108518996  CREB3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3 [KO:K09048]
108542557  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
108512141  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
108518846  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
108535460  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
108538320  CREBBP; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
108528445  EP300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
108519651  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
108534930  FOS; proto-oncogene c-Fos [KO:K04379]
108532921  JUN; transcription factor AP-1 [KO:K04448]
108526558  GLI3; LOW QUALITY PROTEIN: transcriptional activator GLI3 [KO:K06230]
108519687  GLI1; zinc finger protein GLI1 [KO:K16797]
108529288  PTCH1; LOW QUALITY PROTEIN: protein patched homolog 1 [KO:K06225]
108521862  HHIP; hedgehog-interacting protein isoform X1 [KO:K06231]
108519636  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
108532817  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
108543519  RELA; transcription factor p65 [KO:K04735]
108525405  transcription factor SOX-9 [KO:K18435]
108537316  SOX9; LOW QUALITY PROTEIN: transcription factor SOX-9 [KO:K18435]
108531438  AMH; LOW QUALITY PROTEIN: muellerian-inhibiting factor [KO:K04665]
108514544  PPARA; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
108543226  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
108537328  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 [KO:K00232] [EC:1.3.3.6]
108525049  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
108513076  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
108542734  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
108513895  LIPE; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
108530562  ROCK1; LOW QUALITY PROTEIN: rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
108516461  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
108528527  PPP1R12A; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12A [KO:K06270]
108523051  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
108542529  TNNI3; troponin I, cardiac muscle isoform X1 [KO:K12044]
108544714  PLN; cardiac phospholamban [KO:K05852]
108523688  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
108520719  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
108534362  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
108522194  RYR2; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
108542864  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
108541249  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
108530279  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
108537403  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
108523108  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
108537157  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
108537879  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
108532018  GRIA1; LOW QUALITY PROTEIN: glutamate receptor 1 [KO:K05197]
108529017  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
108528828  LOW QUALITY PROTEIN: glutamate receptor 3-like [KO:K05199]
108513175  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
108526537  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
108528132  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
108524039  ATP1A4; sodium/potassium-transporting ATPase subunit alpha-4 isoform X1 [KO:K01539] [EC:7.2.2.13]
108524041  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
108535342  ATP1B4; protein ATP1B4 [KO:K01540]
108522426  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 isoform X1 [KO:K01540]
108514361  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
108527281  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
108536391  FXYD2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538]
108512341  FXYD1; phospholemman [KO:K13360]
108518204  SLC9A1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
108529632  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
108515001  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
108512290  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
108527219  ATP2B1; LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 1 [KO:K05850] [EC:7.2.2.10]
108535088  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
108522695  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
108515198  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
108521361  voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
108545075  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
108539719  PDE3A; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
108535503  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
108534220  cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
108531003  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
108517809  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
108532877  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
108527976  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
PMID:24281338
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
  Journal
Pharmaceuticals (Basel) 5:1291-331 (2012)
DOI:10.3390/ph5121291
Reference
PMID:24613710
  Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
  Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
  Journal
Cell Calcium 55:385-393 (2014)
DOI:10.1016/j.ceca.2014.01.006
Reference
PMID:22082266
  Authors
Shirshev SV
  Title
Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
  Journal
Biochemistry (Mosc) 76:981-98 (2011)
DOI:10.1134/S000629791109001X
Reference
PMID:18176800
  Authors
Roscioni SS, Elzinga CR, Schmidt M
  Title
Epac: effectors and biological functions.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 377:345-57 (2008)
DOI:10.1007/s00210-007-0246-7
Reference
PMID:24450633
  Authors
Roberts OL, Dart C
  Title
cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).
  Journal
Biochem Soc Trans 42:89-97 (2014)
DOI:10.1042/BST20130253
Reference
PMID:16765984
  Authors
Schaub MC, Hefti MA, Zaugg M
  Title
Integration of calcium with the signaling network in cardiac myocytes.
  Journal
J Mol Cell Cardiol 41:183-214 (2006)
DOI:10.1016/j.yjmcc.2006.04.005
Reference
PMID:19874988
  Authors
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
  Title
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
  Journal
J Am Coll Cardiol 54:1747-62 (2009)
DOI:10.1016/j.jacc.2009.05.015
Reference
PMID:15142747
  Authors
Saucerman JJ, McCulloch AD
  Title
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
  Journal
Prog Biophys Mol Biol 85:261-78 (2004)
DOI:10.1016/j.pbiomolbio.2004.01.005
Reference
PMID:21212391
  Authors
Yang JH, Saucerman JJ
  Title
Computational models reduce complexity and accelerate insight into cardiac signaling networks.
  Journal
Circ Res 108:85-97 (2011)
DOI:10.1161/CIRCRESAHA.110.223602
Reference
PMID:22022314
  Authors
Taggart P, Boyett MR, Logantha S, Lambiase PD
  Title
Anger, emotion, and arrhythmias: from brain to heart.
  Journal
Front Physiol 2:67 (2011)
DOI:10.3389/fphys.2011.00067
Reference
PMID:21852968
  Authors
Bozzi Y, Dunleavy M, Henshall DC
  Title
Cell signaling underlying epileptic behavior.
  Journal
Front Behav Neurosci 5:45 (2011)
DOI:10.3389/fnbeh.2011.00045
Reference
PMID:10880354
  Authors
Lizcano JM, Morrice N, Cohen P
  Title
Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.
  Journal
Biochem J 349:547-57 (2000)
DOI:10.1042/bj3490547
Reference
PMID:21744067
  Authors
Gerlo S, Kooijman R, Beck IM, Kolmus K, Spooren A, Haegeman G
  Title
Cyclic AMP: a selective modulator of NF-kappaB action.
  Journal
Cell Mol Life Sci 68:3823-41 (2011)
DOI:10.1007/s00018-011-0757-8
Reference
PMID:7688165
  Authors
Lauder JM
  Title
Neurotransmitters as growth regulatory signals: role of receptors and second messengers.
  Journal
Trends Neurosci 16:233-40 (1993)
DOI:10.1016/0166-2236(93)90162-F
Reference
PMID:17077866
  Authors
Voglis G, Tavernarakis N
  Title
The role of synaptic ion channels in synaptic plasticity.
  Journal
EMBO Rep 7:1104-10 (2006)
DOI:10.1038/sj.embor.7400830
Reference
PMID:21346730
  Authors
Altarejos JY, Montminy M
  Title
CREB and the CRTC co-activators: sensors for hormonal and metabolic signals.
  Journal
Nat Rev Mol Cell Biol 12:141-51 (2011)
DOI:10.1038/nrm3072
Reference
PMID:24062645
  Authors
Bozzi Y, Borrelli E
  Title
The role of dopamine signaling in epileptogenesis.
  Journal
Front Cell Neurosci 7:157 (2013)
DOI:10.3389/fncel.2013.00157
Reference
PMID:14715909
  Authors
Ceulemans H, Bollen M
  Title
Functional diversity of protein phosphatase-1, a cellular economizer and reset button.
  Journal
Physiol Rev 84:1-39 (2004)
DOI:10.1152/physrev.00013.2003
Reference
PMID:16571352
  Authors
Lipinski RJ, Gipp JJ, Zhang J, Doles JD, Bushman W
  Title
Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.
  Journal
Exp Cell Res 312:1925-38 (2006)
DOI:10.1016/j.yexcr.2006.02.019
Reference
PMID:21693691
  Authors
Lasala C, Schteingart HF, Arouche N, Bedecarras P, Grinspon RP, Picard JY, Josso N, di Clemente N, Rey RA
  Title
SOX9 and SF1 are involved in cyclic AMP-mediated upregulation of anti-Mullerian gene expression in the testicular prepubertal Sertoli cell line SMAT1.
  Journal
Am J Physiol Endocrinol Metab 301:E539-47 (2011)
DOI:10.1152/ajpendo.00187.2011
Reference
PMID:19460777
  Authors
Rosenkranz AC, Rauch BH, Freidel K, Schror K
  Title
Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT.
  Journal
Cardiovasc Res 83:778-84 (2009)
DOI:10.1093/cvr/cvp163
Reference
PMID:11117527
  Authors
Lazennec G, Canaple L, Saugy D, Wahli W
  Title
Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators.
  Journal
Mol Endocrinol 14:1962-75 (2000)
DOI:10.1210/mend.14.12.0575
Reference
PMID:16460276
  Authors
Murthy KS
  Title
Signaling for contraction and relaxation in smooth muscle of the gut.
  Journal
Annu Rev Physiol 68:345-74 (2006)
DOI:10.1146/annurev.physiol.68.040504.094707
Reference
PMID:18064650
  Authors
Birukova AA, Zagranichnaya T, Alekseeva E, Bokoch GM, Birukov KG
  Title
Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection.
  Journal
J Cell Physiol 215:715-24 (2008)
DOI:10.1002/jcp.21354
Reference
PMID:9204709
  Authors
Houslay MD, Milligan G
  Title
Tailoring cAMP-signalling responses through isoform multiplicity.
  Journal
Trends Biochem Sci 22:217-24 (1997)
DOI:10.1016/S0968-0004(97)01050-5
Related
pathway
rbb00071  Fatty acid degradation
rbb04015  Rap1 signaling pathway
rbb04020  Calcium signaling pathway
rbb04151  PI3K-Akt signaling pathway
rbb04210  Apoptosis
rbb04260  Cardiac muscle contraction
rbb04340  Hedgehog signaling pathway
rbb04720  Long-term potentiation
rbb04740  Olfactory transduction
rbb04972  Pancreatic secretion
rbb04976  Bile secretion
KO pathway
ko04024   
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