KEGG   PATHWAY: rno00564
Entry
rno00564                    Pathway                                
Name
Glycerophospholipid metabolism - Rattus norvegicus (rat)
Class
Metabolism; Lipid metabolism
Pathway map
rno00564  Glycerophospholipid metabolism
rno00564

Module
rno_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:rno00564]
rno_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:rno00564]
rno_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:rno00564]
Other DBs
GO: 0006650
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100359680  Lpcat2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
100361138  Dgkq; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
114101  Cds2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
140544  Pcyt1a; choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
140866  Dgka; diacylglycerol kinase alpha [KO:K00901] [EC:2.7.1.107]
170919  Agpat4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
192259  Plb1; phospholipase B1, membrane-associated precursor [KO:K14621] [EC:3.1.1.4 3.1.1.5]
192260  Cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
192270  Plpp3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
24530  Lcat; phosphatidylcholine-sterol acyltransferase precursor [KO:K00650] [EC:2.3.1.43]
246115  Plpp2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
246246  Pnpla7; patatin-like phospholipase domain-containing protein 7 [KO:K14676] [EC:3.1.1.5]
24653  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
24913  Plaat3; phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
25062  Gpd2; glycerol-3-phosphate dehydrogenase, mitochondrial precursor [KO:K00111] [EC:1.1.5.3]
25096  Pld1; phospholipase D1 isoform 2 [KO:K01115] [EC:3.1.4.4]
25097  Pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
25511  Pemt; phosphatidylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.17 2.1.1.71]
25514  Lypla1; acyl-protein thioesterase 1 [KO:K06128] [EC:3.1.1.5]
25666  Dgkg; diacylglycerol kinase gamma [KO:K00901] [EC:2.7.1.107]
286936  Pcyt1b; choline-phosphate cytidylyltransferase B [KO:K00968] [EC:2.7.7.15]
287406  Adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
287644  Phospho1; phosphoethanolamine/phosphocholine phosphatase [KO:K06124] [EC:3.1.3.75]
289439  Lpcat2b; lysophosphatidylcholine acyltransferase 2B [KO:K13510] [EC:2.3.1.23 2.3.1.67]
289733  Pla2g3; group 3 secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
290567  Chat; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
290843  Gpat4; glycerol-3-phosphate acyltransferase 6 [KO:K13506] [EC:2.3.1.15]
29194  Chka; choline kinase alpha isoform 2 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
29354  Pla2g5; phospholipase A2 group V precursor [KO:K01047] [EC:3.1.1.4]
29359  Pla2g10; group 10 secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
293620  Ptdss2; phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
29367  Chkb; choline/ethanolamine kinase [KO:K14156] [EC:2.7.1.32 2.7.1.82]
29387  Pla2g2c; group IIC secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
294324  Agpat3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
29526  Pla2g1b; phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
296048  Lpcat4; lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
296091  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
296130  Gpat2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
29653  Gpam; glycerol-3-phosphate acyltransferase 1, mitochondrial [KO:K00629] [EC:2.3.1.15]
29692  Pla2g2a; phospholipase A2, membrane associated precursor [KO:K01047] [EC:3.1.1.4]
298579  Pla2g2d; group IID secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
298581  Pla2g2e; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
303698  Pgs1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial isoform X1 [KO:K00995] [EC:2.7.8.5]
305166  Gpat3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
305684  Samd8; sphingomyelin synthase-related protein 1 isoform 1 [KO:K22697] [EC:2.7.8.48 3.1.4.62]
306582  Agpat5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform 1 [KO:K19007] [EC:2.3.1.51]
308309  Mboat7; lysophospholipid acyltransferase 7 [KO:K13516] [EC:2.3.1.-]
309014  Plpp4; phospholipid phosphatase 4 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
310773  Cept1; choline/ethanolaminephosphotransferase 1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
310849  Sgms2; phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
311341  Pla2g4b; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
311821  Agpat2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta precursor [KO:K13509] [EC:2.3.1.51]
312828  Etnk1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
313977  Lpin1; phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
313997  Mboat2; lysophospholipid acyltransferase 2 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
314553  Ptdss1; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
316737  Lpin2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
353229  Sgms1; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
360426  Pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform 1 [KO:K16343] [EC:3.1.1.4]
360753  Pnpla6; neuropathy target esterase isoform 1 [KO:K14676] [EC:3.1.1.5]
360843  Etnk2; ethanolamine kinase 2 [KO:K00894] [EC:2.7.1.82]
361076  Dgkh; diacylglycerol kinase eta isoform X4 [KO:K00901] [EC:2.7.1.107]
361401  Pla2g15; phospholipase A2 group XV precursor [KO:K06129] [EC:3.1.1.5]
361467  Lpcat1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
361527  Pld3; 5'-3' exonuclease PLD3 [KO:K16860] [EC:3.1.4.4]
362039  Pla2g12a; group XIIA secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
362219  Gpcpd1; glycerophosphocholine phosphodiesterase GPCPD1 [KO:K18695] [EC:3.1.4.2]
362261  Lpin3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
362434  Lpcat3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
362702  Lclat1; lysocardiolipin acyltransferase 1 isoform X1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
362713  Selenoi; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
362792  Pld4; 5'-3' exonuclease PLD4 [KO:K16860] [EC:3.1.4.4]
362866  Chpt1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
363159  Gpd1l1; glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
363521  [KO:K13511] [EC:2.3.1.-]
366196  Crls1; cardiolipin synthase (CMP-forming) [KO:K08744] [EC:2.7.8.41]
367415  Pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X2 [KO:K01047] [EC:3.1.1.4]
367745  Dgkk; diacylglycerol kinase kappa isoform X1 [KO:K00901] [EC:2.7.1.107]
368088  Dgkd; diacylglycerol kinase delta isoform X2 [KO:K00901] [EC:2.7.1.107]
406165  Agpat1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [KO:K13509] [EC:2.3.1.51]
497978  Dgke; diacylglycerol kinase epsilon isoform 1 [KO:K00901] [EC:2.7.1.107]
498741  Mboat1; lysophospholipid acyltransferase 1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
502711  Gpd1l3; similar to Gpd1l protein isoform 1 [KO:K00006] [EC:1.1.1.8]
54248  Dgkb; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
60666  Gpd1; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
64369  Plpp1; phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
679692  Lpgat1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 [KO:K13514] [EC:2.3.1.-]
680466  Plpp5; phospholipid phosphatase 5 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
681361  Pisd; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform 1 [KO:K01613] [EC:4.1.1.65]
687071  Etnppl; ethanolamine-phosphate phospho-lyase isoform X1 [KO:K14286] [EC:4.2.3.2]
688705  Dgki; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
690388  Pla2g2f; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
691810  Pla2g4c; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
691905  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
691907  Pla2g4f; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
81821  Dgkz; diacylglycerol kinase zeta isoform 2 [KO:K00901] [EC:2.7.1.107]
81925  Cds1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
83510  Lypla2; acyl-protein thioesterase 2 [KO:K06130] [EC:3.1.1.5]
83817  Ache; acetylcholinesterase precursor [KO:K01049] [EC:3.1.1.7]
84470  Gnpat; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
85311  Pla1a; phospholipase A1 member A precursor [KO:K13618] [EC:3.1.1.111]
89841  Pcyt2; ethanolamine-phosphate cytidylyltransferase [KO:K00967] [EC:2.7.7.14]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
rno00010  Glycolysis / Gluconeogenesis
rno00260  Glycine, serine and threonine metabolism
rno00561  Glycerolipid metabolism
rno00562  Inositol phosphate metabolism
rno00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
rno00565  Ether lipid metabolism
rno00620  Pyruvate metabolism
KO pathway
ko00564   

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