KEGG   PATHWAY: ssc04612
Entry
ssc04612                    Pathway                                
Name
Antigen processing and presentation - Sus scrofa (pig)
Class
Organismal Systems; Immune system
Pathway map
ssc04612  Antigen processing and presentation
ssc04612

Other DBs
GO: 0019885 0019886 0042591
Organism
Sus scrofa (pig) [GN:ssc]
Gene
396991  IFNG; interferon gamma precursor [KO:K04687]
397086  TNF; tumor necrosis factor [KO:K03156]
397572  PSME1; proteasome activator complex subunit 1 [KO:K06696]
397522  PSME2; proteasome activator complex subunit 2 [KO:K06697]
397625  PSME3; proteasome activator complex subunit 3 [KO:K06698]
396648  HSP70.2; heat shock 70 kDa protein 1B [KO:K03283]
100144518  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
396906  HSPA6; heat shock 70 kDa protein [KO:K03283]
100511890  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
100621324  HSPA2; LOW QUALITY PROTEIN: heat shock-related 70 kDa protein 2 [KO:K26598]
100524853  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
397028  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
396742  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
396650  SLA-7; MHC class I antigen 7 precursor [KO:K06751]
100135031  SLA-2; MHC class I antigen 2 precursor [KO:K06751]
100037288  SLA-3; MHC class I antigen 3 precursor [KO:K06751]
100037293  SLA-1; MHC class I antigen 1 isoform X2 [KO:K06751]
100135029  SLA-5; MHC class I antigen 5 precursor [KO:K06751]
100135036  SLA-8; MHC class I antigen 8 precursor [KO:K06751]
100135037  SLA-6; MHC class I antigen 6 precursor [KO:K06751]
407060  HSPA5; 78 kDa glucose-regulated protein isoform X2 [KO:K09490] [EC:3.6.4.10]
100519184  CANX; calnexin precursor [KO:K08054]
397033  B2M; beta-2-microglobulin precursor [KO:K08055]
110255236  B2M; beta-2-microglobulin [KO:K08055]
100156204  PDIA3; protein disulfide-isomerase A3 precursor [KO:K08056] [EC:5.3.4.1]
100381266  CALR; calreticulin precursor [KO:K08057]
100155428  TAPBP; tapasin [KO:K08058]
733649  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
733650  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
396627  CD8A; T-cell surface glycoprotein CD8 alpha chain precursor [KO:K06458]
396636  CD8B; T-cell surface glycoprotein CD8 beta chain precursor [KO:K06459]
110261595  uncharacterized protein LOC110261595 [KO:K10784]
100620407  uncharacterized protein LOC100620407 [KO:K10784]
100626606  uncharacterized protein LOC100626606 [KO:K10784]
110255290  LOW QUALITY PROTEIN: uncharacterized protein LOC110255290 [KO:K10784]
100621559  T-cell receptor beta-1 chain C region [KO:K10785]
110257615  uncharacterized protein LOC110257615 [KO:K10785]
100523789  NKG2-A/NKG2-B type II integral membrane protein isoform X1 [KO:K06541]
100622915  KLRD1; LOW QUALITY PROTEIN: natural killer cells antigen CD94 [KO:K06516]
100174943  IFI30; gamma-interferon-inducible-lysosomal thiol reductase precursor [KO:K08059]
100154477  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
100037961  CTSB; cathepsin B precursor [KO:K01363] [EC:3.4.22.1]
445528  SLA-DMA; SLA-DM alpha chain precursor [KO:K06752]
100135040  SLA-DRA; MHC class II DR-alpha precursor [KO:K06752]
100135049  SLA-DOB; MHC class II, DO beta precursor [KO:K06752]
100135050  SLA-DMB; MHC class II, DM beta precursor [KO:K06752]
100037921  SLA-DQB1; SLA class II histocompatibility antigen, DQ haplotype C beta chain precursor [KO:K06752]
100153387  SLA-DQA1; SLA class II histocompatibility antigen, DQ haplotype D alpha chain precursor [KO:K06752]
100153386  SLA-DRB1; MHC class II histocompatibility antigen SLA-DRB1 precursor [KO:K06752]
100157996  SLA-DOA; SLA class II histocompatibility antigen, DO alpha chain precursor [KO:K06752]
106504372  DLA class II histocompatibility antigen, DR-1 beta chain-like precursor [KO:K06752]
396660  CD74; CD74 antigen [KO:K06505]
396926  CTSV; cathepsin L1 precursor [KO:K01365] [EC:3.4.22.15]
100515919  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
100153090  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
404704  CD4; T-cell surface glycoprotein CD4 precursor [KO:K06454]
100517711  RFX5; DNA-binding protein RFX5 isoform X1 [KO:K08061]
100628226  RFXANK; DNA-binding protein RFXANK [KO:K08062]
100155648  RFXAP; LOW QUALITY PROTEIN: regulatory factor X-associated protein [KO:K08063]
100736562  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100151920  NFYA; nuclear transcription factor Y subunit alpha [KO:K08064]
100157587  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
100525647  NFYC; nuclear transcription factor Y subunit gamma isoform X2 [KO:K08066]
Reference
PMID:15771591
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
PMID:15814328
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
PMID:11905820
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
PMID:15304636
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:12776207
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
PMID:12974477
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
PMID:15224093
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
PMID:16181333
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
PMID:15653312
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
PMID:11244040
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
PMID:15745856
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
PMID:15224094
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
PMID:15653315
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
PMID:20010787
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
ssc03050  Proteasome
ssc04650  Natural killer cell mediated cytotoxicity
ssc04660  T cell receptor signaling pathway
KO pathway
ko04612   
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