KEGG   PATHWAY: umr00670
Entry
umr00670                    Pathway                                
Name
One carbon pool by folate - Ursus maritimus (polar bear)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
umr00670  One carbon pool by folate
umr00670

Module
umr_M00035  Methionine degradation [PATH:umr00670]
umr_M00141  C1-unit interconversion, eukaryotes [PATH:umr00670]
umr_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:umr00670]
umr_M00555  Betaine biosynthesis, choline => betaine [PATH:umr00670]
umr_M00621  Glycine cleavage system [PATH:umr00670]
umr_M00974  Betaine metabolism, animals, betaine => glycine [PATH:umr00670]
Other DBs
GO: 0035999
Organism
Ursus maritimus (polar bear) [GN:umr]
Gene
103656463  SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
103658499  SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
103660242  MTHFS; 5-formyltetrahydrofolate cyclo-ligase isoform X1 [KO:K01934] [EC:6.3.3.2]
103662006  MTR; methionine synthase isoform X1 [KO:K00548] [EC:2.1.1.13]
103662083  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
103662214  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
103662898  ATIC; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
103663014  [KO:K00287] [EC:1.5.1.3]
103663016  CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
103664079  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
103664511  MAT2B; methionine adenosyltransferase 2 subunit beta isoform X2 [KO:K00789] [EC:2.5.1.6]
103664709  TYMS; thymidylate synthase [KO:K00560] [EC:2.1.1.45]
103665392  MTHFD2L; probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 isoform X1 [KO:K13403] [EC:1.5.1.15 3.5.4.9]
103666650  MTHFR; methylenetetrahydrofolate reductase isoform X1 [KO:K25004]
103666965  MTHFD1L; monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X1 [KO:K13402] [EC:6.3.4.3]
103667864  MAT1A; S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
103669466  ALDH1L1; cytosolic 10-formyltetrahydrofolate dehydrogenase [KO:K00289] [EC:1.5.1.6]
103669822  AHCY; adenosylhomocysteinase isoform X1 [KO:K01251] [EC:3.13.2.1]
103670577  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
103671402  MTHFD2; bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [KO:K13403] [EC:1.5.1.15 3.5.4.9]
103671452  MAT2A; S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
103672303  MTHFD1; C-1-tetrahydrofolate synthase, cytoplasmic [KO:K00288] [EC:1.5.1.5 3.5.4.9 6.3.4.3]
103673116  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
103674705  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
103674737  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
103674822  AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
103675010  AHCYL1; S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
103676565  ALDH1L2; mitochondrial 10-formyltetrahydrofolate dehydrogenase [KO:K00289] [EC:1.5.1.6]
103676699  AHCYL2; adenosylhomocysteinase 3 isoform X1 [KO:K01251] [EC:3.13.2.1]
103679941  SARDH; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
103680733  FTCD; formimidoyltransferase-cyclodeaminase isoform X1 [KO:K13990] [EC:2.1.2.5 4.3.1.4]
103680763  CBS; cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]
103681460  BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
103681471  DHFR; dihydrofolate reductase [KO:K00287] [EC:1.5.1.3]
103681493  DMGDH; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
103681494  BHMT2; LOW QUALITY PROTEIN: S-methylmethionine--homocysteine S-methyltransferase BHMT2 [KO:K00547] [EC:2.1.1.10]
Compound
C00002  ATP
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00037  Glycine
C00065  L-Serine
C00073  L-Methionine
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00155  L-Homocysteine
C00212  Adenosine
C00213  Sarcosine
C00234  10-Formyltetrahydrofolate
C00364  dTMP
C00365  dUMP
C00415  Dihydrofolate
C00440  5-Methyltetrahydrofolate
C00445  5,10-Methenyltetrahydrofolate
C00504  Folate
C00576  Betaine aldehyde
C00664  5-Formiminotetrahydrofolate
C00719  Betaine
C01026  N,N-Dimethylglycine
C02291  L-Cystathionine
C03479  Folinic acid
Related
pathway
umr00260  Glycine, serine and threonine metabolism
umr00270  Cysteine and methionine metabolism
umr00790  Folate biosynthesis
KO pathway
ko00670   

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