KEGG   PATHWAY: aml05417
Entry
aml05417                    Pathway                                
Name
Lipid and atherosclerosis - Ailuropoda melanoleuca (giant panda)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
aml05417  Lipid and atherosclerosis
aml05417

Organism
Ailuropoda melanoleuca (giant panda) [GN:aml]
Gene
100473745  APOB; apolipoprotein B-100 [KO:K14462]
100480084  APOA4; apolipoprotein A-IV [KO:K08760]
100477643  APOA1; apolipoprotein A-I isoform X1 [KO:K08757]
100473450  LDLR; low-density lipoprotein receptor isoform X2 [KO:K12473]
100471706  OLR1; oxidized low-density lipoprotein receptor 1 isoform X3 [KO:K08763]
100477081  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
100478167  MMP1; LOW QUALITY PROTEIN: interstitial collagenase [KO:K01388] [EC:3.4.24.7]
100481181  LOW QUALITY PROTEIN: interstitial collagenase [KO:K01388] [EC:3.4.24.7]
100476723  RHOA; transforming protein RhoA [KO:K04513]
100466003  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100483990  NOS3; nitric oxide synthase, endothelial isoform X2 [KO:K13242] [EC:1.14.13.39]
100463775  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100479294  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100479580  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100475291  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100483828  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100467916  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100468763  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100480414  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100465793  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100471095  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100473937  BAD; bcl2-associated agonist of cell death [KO:K02158]
100469922  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
100484344  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
100477951  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100482196  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100477600  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
100479008  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
100477326  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100466388  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
100483288  POU2F1; POU domain, class 2, transcription factor 1 isoform X5 [KO:K09364]
100472278  POU2F2; POU domain, class 2, transcription factor 2 isoform X14 [KO:K09364]
100476345  CD40; tumor necrosis factor receptor superfamily member 5 isoform X2 [KO:K03160]
100467917  CD40LG; CD40 ligand [KO:K03161]
100473028  LOW QUALITY PROTEIN: cytochrome P450 1A1-like [KO:K07408] [EC:1.14.14.1]
100482335  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100477105  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
100470141  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
100468223  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
109490984  LOW QUALITY PROTEIN: dual oxidase 1 [KO:K21421] [EC:1.-.-.-]
100472606  NCF1; neutrophil cytosol factor 1 [KO:K08011]
100482979  cytochrome b-245 light chain isoform X3 [KO:K08009]
100476832  NCF2; neutrophil cytosol factor 2 [KO:K08010]
100468228  NCF4; neutrophil cytosol factor 4 [KO:K08012]
100465648  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100474271  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100481360  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100469938  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
100465076  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100475919  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
100475975  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
100474867  FOS; proto-oncogene c-Fos [KO:K04379]
100483834  JUN; transcription factor AP-1 [KO:K04448]
100474348  C-C motif chemokine 2 [KO:K14624]
100476475  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
100472054  CXCL8; interleukin-8 [KO:K10030]
100476678  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
100469111  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
100465223  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100465476  MAPK14; mitogen-activated protein kinase 14 isoform X3 [KO:K04441] [EC:2.7.11.24]
100480235  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100480483  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100473836  HRAS; GTPase HRas isoform X1 [KO:K02833]
100483919  KRAS; GTPase KRas isoform X1 [KO:K07827]
100464196  NRAS; GTPase NRas [KO:K07828]
100470035  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100472388  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100480158  RELA; transcription factor p65 isoform X1 [KO:K04735]
100467906  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100470595  SELE; E-selectin [KO:K06494]
100467827  SELP; P-selectin isoform X3 [KO:K06496]
100480380  VCAM1; vascular cell adhesion protein 1 isoform X1 [KO:K06527]
100478420  LOW QUALITY PROTEIN: stromelysin-1 [KO:K01394] [EC:3.4.24.17]
100477912  stromelysin-1 [KO:K01394] [EC:3.4.24.17]
100475429  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
100473767  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
100480874  IL1B; interleukin-1 beta [KO:K04519]
100477151  IL6; interleukin-6 precursor [KO:K05405]
117803984  interleukin-6-like [KO:K05405]
100471563  TNF; tumor necrosis factor [KO:K03156]
100477321  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
100468647  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
100483310  heat shock 70 kDa protein 1-like [KO:K03283]
100483558  heat shock 70 kDa protein 1 [KO:K03283]
100469467  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
117800506  heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
100470494  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
100484576  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
100471414  HSP90AB1; LOW QUALITY PROTEIN: heat shock protein HSP 90-beta [KO:K04079]
100467363  HSP90AA1; LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha [KO:K04079]
117803466  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
100474020  HSP90B1; endoplasmin [KO:K09487]
100465129  TLR2; toll-like receptor 2 [KO:K10159]
100472839  lipopolysaccharide-binding protein [KO:K05399]
100476795  lipopolysaccharide-binding protein isoform X1 [KO:K05399]
100467208  CD14; monocyte differentiation antigen CD14 [KO:K04391]
100468714  LY96; lymphocyte antigen 96 isoform X1 [KO:K05400]
100472815  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
100470794  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X2 [KO:K05403]
100479307  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
100469127  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
100484977  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
100483216  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100484077  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X3 [KO:K04403]
100468085  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
100466506  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
100464675  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100471679  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100470223  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100466997  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100463778  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
100466406  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100482907  MIB1; E3 ubiquitin-protein ligase MIB1 [KO:K10645] [EC:2.3.2.27]
100472529  MIB2; E3 ubiquitin-protein ligase MIB2 [KO:K10645] [EC:2.3.2.27]
100484543  TANK; TRAF family member-associated NF-kappa-B activator isoform X2 [KO:K12650]
100465112  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
100484104  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
100474086  IRF7; LOW QUALITY PROTEIN: interferon regulatory factor 7 [KO:K09447]
100471184  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
100476812  interferon alpha-2 [KO:K05414]
100477312  interferon alpha-1/2 [KO:K05414]
100477562  LOW QUALITY PROTEIN: interferon alpha-1/2 [KO:K05414]
100478321  interferon alpha-1/2 [KO:K05414]
100478068  interferon alpha-like [KO:K05414]
100476556  IFNB1; interferon beta [KO:K05415]
100463982  CD36; platelet glycoprotein 4 [KO:K06259]
100482938  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
100479839  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
100475696  RXRB; retinoic acid receptor RXR-beta isoform X2 [KO:K08525]
100475450  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
100479606  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
100464496  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
100480126  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
100480092  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
100476091  VAV1; proto-oncogene vav isoform X3 [KO:K05730]
100472456  TLR6; toll-like receptor 6 isoform X2 [KO:K10169]
100471801  RAP1A; ras-related protein Rap-1A [KO:K04353]
100480240  RAP1B; ras-related protein Rap-1b [KO:K07836]
100463753  CCL5; C-C motif chemokine 5 [KO:K12499]
100469047  C-C motif chemokine 3 [KO:K05408]
100469295  C-C motif chemokine 3 isoform X1 [KO:K05408]
100464006  regakine-1-like [KO:K05408]
100463732  growth-regulated alpha protein [KO:K05505]
100466241  growth-regulated protein homolog gamma-like isoform X1 [KO:K05505]
100471490  growth-regulated alpha protein [KO:K05505]
100470471  IL12A; interleukin-12 subunit alpha isoform X2 [KO:K05406]
100477772  IL12B; interleukin-12 subunit beta [KO:K05425]
100468792  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
100484109  IL18; interleukin-18 [KO:K05482]
100480574  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
100481422  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
100479063  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
100475184  ERO1A; ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
100467161  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X8 [KO:K04958]
100475467  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2 [KO:K04515] [EC:2.7.11.17]
100466256  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X5 [KO:K04515] [EC:2.7.11.17]
100474459  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X3 [KO:K04515] [EC:2.7.11.17]
100478243  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
100479743  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
100470706  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
100476284  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100474476  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
100474087  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100475304  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
100471419  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
100483394  ABCA1; phospholipid-transporting ATPase ABCA1 [KO:K05641]
100470191  ATP-binding cassette sub-family G member 1 isoform X1 [KO:K05679]
117795036  ABCG1; ATP-binding cassette sub-family G member 1 isoform X1 [KO:K05679]
100468118  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
100475582  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
100471267  VLDLR; very low-density lipoprotein receptor isoform X1 [KO:K20053]
100473305  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
100479224  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
100470861  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
100464798  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X4 [KO:K17332]
100477832  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100481755  PLCB1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
100480603  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
100465232  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100474779  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
100480586  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
100478600  CALML6; calmodulin-like protein 6 [KO:K02183]
100470909  CALM2; calmodulin-2 [KO:K02183]
100484519  calmodulin [KO:K02183]
100484770  calmodulin-like protein 3 [KO:K02183]
100481177  CALM1; calmodulin-1 [KO:K02183]
100472122  CALM3; calmodulin-3 [KO:K02183]
100478732  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
117799706  calmodulin-alpha-like [KO:K02183]
100477289  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
100467653  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X5 [KO:K04348] [EC:3.1.3.16]
100474970  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X5 [KO:K04348] [EC:3.1.3.16]
100474742  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100467683  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
100463573  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
105235183  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
100479926  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100468235  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100472842  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100465439  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
100472074  cytochrome c [KO:K08738]
105241648  cytochrome c-like [KO:K08738]
100464163  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
100483760  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
100476854  caspase-6 isoform X2 [KO:K04396] [EC:3.4.22.59]
117795025  caspase-6 isoform X1 [KO:K04396] [EC:3.4.22.59]
100469056  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
100471992  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
100468516  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:E218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
DOI:10.1016/s0735-1097(02)01803-x
Reference
PMID:19286611
  Authors
Li D, Mehta JL
  Title
Intracellular signaling of LOX-1 in endothelial cell apoptosis.
  Journal
Circ Res 104:566-8 (2009)
DOI:10.1161/CIRCRESAHA.109.194209
Reference
PMID:24886290
  Authors
Lubrano V, Balzan S
  Title
LOX-1 and ROS, inseparable factors in the process of endothelial damage.
  Journal
Free Radic Res 48:841-8 (2014)
DOI:10.3109/10715762.2014.929122
Reference
PMID:23124189
  Authors
Xu S, Ogura S, Chen J, Little PJ, Moss J, Liu P
  Title
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers.
  Journal
Cell Mol Life Sci 70:2859-72 (2013)
DOI:10.1007/s00018-012-1194-z
Reference
PMID:21947818
  Authors
Mitra S, Goyal T, Mehta JL
  Title
Oxidized LDL, LOX-1 and atherosclerosis.
  Journal
Cardiovasc Drugs Ther 25:419-29 (2011)
DOI:10.1007/s10557-011-6341-5
Reference
PMID:21338316
  Authors
Lu J, Mitra S, Wang X, Khaidakov M, Mehta JL
  Title
Oxidative stress and lectin-like ox-LDL-receptor LOX-1 in atherogenesis and tumorigenesis.
  Journal
Antioxid Redox Signal 15:2301-33 (2011)
DOI:10.1089/ars.2010.3792
Reference
PMID:20203069
  Authors
Ou HC, Song TY, Yeh YC, Huang CY, Yang SF, Chiu TH, Tsai KL, Chen KL, Wu YJ, Tsai CS, Chang LY, Kuo WW, Lee SD
  Title
EGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting LOX-1-mediated signaling.
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Related
pathway
aml04020  Calcium signaling pathway
aml04115  p53 signaling pathway
aml04141  Protein processing in endoplasmic reticulum
aml04151  PI3K-Akt signaling pathway
aml04210  Apoptosis
aml04620  Toll-like receptor signaling pathway
aml04621  NOD-like receptor signaling pathway
aml04668  TNF signaling pathway
aml04670  Leukocyte transendothelial migration
aml04975  Fat digestion and absorption
aml04979  Cholesterol metabolism
aml05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   
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