KEGG ORTHOLOGY: K00512

ORTHOLOGY: K00512

Entry

K00512 KO

Name

CYP17A

Definition

steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]

Pathway

ko00140

Steroid hormone biosynthesis

ko01100

Metabolic pathways

ko04913

Ovarian steroidogenesis

ko04917

Prolactin signaling pathway

ko04927

Cortisol synthesis and secretion

ko04934

Cushing syndrome

Module

M00109

C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone

M00110

C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone

Disease

H00216

Congenital adrenal hyperplasia

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
   04917 Prolactin signaling pathway
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
   04927 Cortisol synthesis and secretion
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.19  steroid 17alpha-monooxygenase
     K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
    1.14.14.32  17alpha-hydroxyprogesterone deacetylase
     K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP17 family
   K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase

Other DBs

RN:	R02211 R03783 R04852 R04853 R08517 R08518

GO:	0004508 0047442

Genes

HSA:	1586(CYP17A1)

PTR:	450141(CYP17A1)

PPS:

GGO:

PON:

NLE:

MCC:	678693(CYP17A1)

MCF:	102133235(CYP17)

CSAB:

103216445(CYP17A1)

RRO:

104656530

RBB:

108515083

CJC:	100400572(CYP17A1)

SBQ:

101048584

MMU:	13074(Cyp17a1)

MCAL:

110285327

MPAH:

110334801

RNO:	25146(Cyp17a1)

MUN:

CGE:

NGI:

HGL:

CCAN:

OCU:

TUP:

CFA:	477807(CYP17A1)

VVP:

AML:

UMR:

UAH:

ORO:

ELK:

FCA:	493967(CYP17A1)

PTG:

102966057

PPAD:

109272832

AJU:

106966901

BTA:	112441470 112444495 281739(CYP17A1)

BOM:	102270241 102270532

BIU:	109553214 109579081

BBUB:

102412624 112581551

CHX:	102182376 102182663(CYP17)

OAS:	105601846(CYP17) 493968(CYP17A1)

SSC:	403330(CYP17A1)

CFR:

CDK:

BACU:

LVE:

OOR:

DLE:

PCAD:

ECB:	100034232(CYP17A1)

EPZ:

EAI:

MYB:

MYD:

MNA:

HAI:

DRO:

PALE:

RAY:

MJV:

LAV:

TMU:

MDO:

SHR:

PCW:

OAA:

GGA:	425056(CYP17A1)

MGP:

CJO:

NMEL:

APLA:

ACYG:

TGU:

LSR:

SCAN:

GFR:

FAB:

PHI:

PMAJ:

CCAE:

CCW:

ETL:

FPG:

FCH:

CLV:

EGZ:

NNI:

ACUN:

PADL:

AAM:

ASN:

AMJ:	102567971(CYP17A1)

PSS:

102457785

CMY:

102945773

CPIC:

101933089

ACS:	100553634 100553834

PVT:

PBI:

PMUR:

TSR:

PMUA:

GJA:

XLA:	100036774(cyp17a1.L)

XTR:	100145650(cyp17a1)

NPR:	108784547 108784564

DRE:	399692(cyp17a1) 796487(cyp17a2)

SRX:	107707716 107750198

SANH:

107673162 107695149

SGH:	107574436 107588661

CCAR:

109076732 109111078

IPU:	100313515(cyp17) 108275468

PHYP:

113530739 113542020

AMEX:

103036160 111194069

EEE:	113570353 113585465

TRU:	100125766(cyp17a2) 100125798(cyp17a1) 115249663

LCO:	104935158 104936651

NCC:

104957534

MZE:	101475441 101477086

ONL:	100702216(cyp17a2) 100703469(cyp17)

OLA:	100125816(cyp17) 101170547(cyp17a2)

XMA:	102221767 102238057

XCO:	114138338 114157614

PRET:

103476526 103480951

CVG:	107083007 107099069

NFU:	107375507 107396730

KMR:	108239115 108251556

ALIM:

106511002 106515325

AOCE:

111563640 111579695

CSEM:

103387725 103389439

POV:	109634757 109639880

LCF:	108892361 108895342

SDU:	111233121 111239202

SLAL:

111661066 111669513

HCQ:	109516617 109523214

BPEC:

MALB:

SASA:

OTW:

SALP:

ELS:	105006241 105008018

SFM:	108926160 108933747

PKI:	111836781 111859263

LCM:	102350866 102365866

CMK:	103172382 103177103

RTP:

109937010

AG:	AAF65823(CYP17A1) AAG02227(CYP17A1)

» show all

Reference

PMID:3025870 (CYP17A1)

Authors

Chung BC, Picado-Leonard J, Haniu M, Bienkowski M, Hall PF, Shively JE, Miller WL

Title

Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues.

Journal

Proc Natl Acad Sci U S A 84:407-11 (1987)
DOI:10.1073/pnas.84.2.407

Sequence

[hsa:1586]

Reference

PMID:17569754 (CYP17A2)

Authors

Zhou LY, Wang DS, Kobayashi T, Yano A, Paul-Prasanth B, Suzuki A, Sakai F, Nagahama Y

Title

A novel type of P450c17 lacking the lyase activity is responsible for C21-steroid biosynthesis in the fish ovary and head kidney.

Journal

Endocrinology 148:4282-91 (2007)
DOI:10.1210/en.2007-0487

Sequence

[ola:101170547]

LinkDB

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