KEGG   ORTHOLOGY: K00512
Entry
K00512                      KO                                     
Symbol
CYP17A
Name
steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]
Pathway
map00140  Steroid hormone biosynthesis
map01100  Metabolic pathways
map04913  Ovarian steroidogenesis
map04917  Prolactin signaling pathway
map04927  Cortisol synthesis and secretion
map04934  Cushing syndrome
Module
M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Reaction
R02211  progesterone,NADPH-hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating)
R03783  pregnenolone,NADPH-hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating)
R04852  11beta-hydroxyprogesterone,NADPH-hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating)
R04853  20alpha-hydroxycholesterol,NADPH-hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating)
R08517  17alpha-hydroxypregnenolone,NADPH---hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating, acetate-releasing)
R08518  17alpha-hydroxyprogesterone,NADPH---hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating, acetate-releasing)
R13212  5alpha-pregnane-3,20-dione,NADPH---hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating)
R13213  allopregnanolone,NADPH---hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating)
R13218  5alpha-pregnane-3alpha,17alpha-diol-20-one,NADPH---hemoprotein reductase:oxygen oxidoreductase (17alpha-hydroxylating, acetate-releasing)
Disease
H00216  Congenital adrenal hyperplasia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
   04917 Prolactin signaling pathway
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
   04927 Cortisol synthesis and secretion
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.19  steroid 17alpha-monooxygenase
     K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
    1.14.14.32  17alpha-hydroxyprogesterone deacetylase
     K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP17 family
   K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
Other DBs
GO: 0004508 0047442
Genes
HSA: 1586(CYP17A1)
PTR: 450141(CYP17A1)
PPS: 100989182(CYP17A1)
GGO: 101152080
PON: 100439753
NLE: 100596228
HMH: 116484149
MCC: 678693(CYP17A1)
MCF: 102133235(CYP17A1)
MTHB: 126962752
MNI: 105478336
CSAB: 103216445(CYP17A1)
CATY: 105581896
PANU: 101026704
TGE: 112630974
MLEU: 105537798
RRO: 104656530
RBB: 108515083
TFN: 117067514
PTEH: 111538851
CANG: 105522771
CJC: 100400572(CYP17A1)
SBQ: 101048584
CIMI: 108306253(CYP17A1)
CSYR: 103251416
MMUR: 105874387
LCAT: 123650072
PCOQ: 105824322
OGA: 100959209
MMU: 13074(Cyp17a1)
MCAL: 110285327
MPAH: 110334801
RNO: 25146(Cyp17a1)
MCOC: 116101357
ANU: 117722327
MUN: 110556807
CGE: 100758683
MAUA: 101831170(Cyp17a1)
PROB: 127233418
PLEU: 114696710
MORG: 121453907
MFOT: 126504210
AAMP: 119802303
NGI: 103744072
HGL: 101726496
CPOC: 100729670
CCAN: 109691327
DORD: 105986673
DSP: 122115926
PLOP: 125346105
NCAR: 124985398
MMMA: 107149847
OCU: 100346394
OPI: 101532918
TUP: 102472543
GVR: 103596172
CFA: 477807(CYP17A1)
CLUD: 112672259
VVP: 112917782
VLG: 121485837
NPO: 129493641
AML: 100476785
UMR: 103681600
UAH: 113251880
UAR: 123795915
ELK: 111145221
LLV: 125084794
MPUF: 101671806
MNP: 132015377
MLK: 131828491
NVS: 122901070
ORO: 101384623
EJU: 114205173
ZCA: 113923407
MLX: 118025661
NSU: 110589350
LWW: 102745940
FCA: 493967(CYP17A1)
PYU: 121037171
PCOO: 112854651
PBG: 122493194
PVIV: 125147397
LRUF: 124507106
PTG: 102966057
PPAD: 109272832
PUC: 125932918
AJU: 106966901
HHV: 120239617
BTA: 112444495 132342070 281739(CYP17A1)
BBIS: 105002787
CHX: 102182376 102182663(CYP17A1A)
OAS: 105601846(CYP17) 493968(CYP17A1)
ODA: 120873501
SSC: 403330(CYP17A1)
CFR: 102519078
CBAI: 105081696
CDK: 105095024
VPC: 102528385
BACU: 103007900
BMUS: 118882672
LVE: 103081477
OOR: 101283719
DLE: 111172355
PCAD: 102989171
PSIU: 116741612
NASI: 112393002
ECB: 100034232(CYP17A1)
EPZ: 103558137
EAI: 106838161
MYB: 102259343
MYD: 102761363
MMYO: 118670308
MLF: 102417518
PKL: 118718912
EFUS: 103288524
MNA: 107542528
DRO: 112300189
SHON: 118999460
AJM: 119059642
PDIC: 114497592
PHAS: 123828947
MMF: 118631983
PPAM: 129077302
HAI: 109379659
RFQ: 117036161
PALE: 102884618
PGIG: 120609141
PVP: 105309652
RAY: 107515566
MJV: 108410298
SARA: 101555669
LAV: 100660963
TMU: 101354636
ETF: 101641397
DNM: 101441314
MDO: 100028896
GAS: 123234242
SHR: 100915970
AFZ: 127551531
PCW: 110194957
OAA: 100080906
GGA: 425056(CYP17A1)
PCOC: 116231659
MGP: 100540331
CJO: 107316091
TPAI: 128077760
LMUT: 125694083
NMEL: 110399428
APLA: 101792920
ACYG: 106031836
CATA: 118248702
AFUL: 116491607
TGU: 100218933
LSR: 110473583
SCAN: 103813852
PMOA: 120502140
OTC: 121341799
PRUF: 121350302
GFR: 102038147
FAB: 101821194
OMA: 130254684
PHI: 102104333
PMAJ: 107206790
CCAE: 111931270
CCW: 104695563
CBRC: 103624562
ETL: 114071768
ZAB: 102070509
ZLE: 135449587
ACHL: 103809385
SVG: 106857584
MMEA: 130581524
HRT: 120755804
FPG: 101910363
FCH: 102054501
CLV: 102093575
EGZ: 104125602
NNI: 104022305
PLET: 104618241
EHS: 104508633
ACUN: 113481735
TALA: 104366646
PADL: 103916301
AFOR: 103897707
ACHC: 115348606
HALD: 104314833
HLE: 104830098
AGEN: 126042899
GCL: 127017763
CCRI: 104161242
CSTI: 104553046
CMAC: 104485256
MUI: 104536211
BREG: 104634307
FGA: 104083220
GSTE: 104261700
LDI: 104355067
MNB: 103779364
OHA: 104336177
NNT: 104400042
SHAB: 115608953
DPUB: 104307099
PGUU: 104461069
ACAR: 104518499
CPEA: 104390883
AVIT: 104273742
CVF: 104283370
RTD: 128911280
CUCA: 104059767
TEO: 104377577
BRHI: 104495232
AAM: 106494668
AROW: 112967993
NPD: 112957074
TGT: 104565299
DNE: 112989287
SCAM: 104138131
ASN: 102372221
AMJ: 102567971(CYP17A1)
CPOO: 109323822
GGN: 109287570
PSS: 102457785
CMY: 102945773
CCAY: 125640071
DCC: 119858827
CPIC: 101933089
TST: 117880996
CABI: 116817103
MRV: 120408966
ASAO: 132769882
PVT: 110077624
SUND: 121925460
PBI: 103063631
PMUR: 107290855
CTIG: 120316288
TSR: 106541312
PGUT: 117678655
APRI: 131200733
PTEX: 113439073
NSS: 113410986
VKO: 123024050
PMUA: 114597528
PRAF: 128414286
HCG: 128349368
GJA: 107117909
STOW: 125437989
EMC: 129332683
XLA: 100036774(cyp17a1.L)
XTR: 100145650(cyp17a1)
RTEM: 120946990
BGAR: 122942304
MUO: 115469991
GSH: 117358874
DRE: 399692(cyp17a1) 796487(cyp17a2)
IPU: 100313515(cyp17) 108275468
TRU: 100125766(cyp17a2) 100125798(cyp17a1) 115249663
NCC: 104957534
CGOB: 115019922
PGEO: 117459816
ESP: 116686493
GAT: 100192329(cyp17a2) 100192330(cyp17a1)
ONL: 100702216(cyp17a2) 100703469(cyp17)
OLA: 100125816(cyp17) 101170547(cyp17a2)
OMY: 100137017(cyp17a1) 110509408
ONE: 115136350
SNH: 120017914
PSEX: 120514450
CMK: 103177103
RTP: 109937010
CPLA: 122561334
HOC: 132826540
LERI: 129704116
LPIC: 129281073
DSV: 119442568
RSAN: 119377837
RMP: 119159398
BGT: 106073674
CRG: 105337314
PMAX: 117327584
RPHI: 132715500
OSN: 115223139
AG: AAF65823(CYP17A1) AAG02227(CYP17A1)
 » show all
Reference
PMID:3025870 (CYP17A1)
  Authors
Chung BC, Picado-Leonard J, Haniu M, Bienkowski M, Hall PF, Shively JE, Miller WL
  Title
Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues.
  Journal
Proc Natl Acad Sci U S A 84:407-11 (1987)
DOI:10.1073/pnas.84.2.407
  Sequence
[hsa:1586]
Reference
PMID:17569754 (CYP17A2)
  Authors
Zhou LY, Wang DS, Kobayashi T, Yano A, Paul-Prasanth B, Suzuki A, Sakai F, Nagahama Y
  Title
A novel type of P450c17 lacking the lyase activity is responsible for C21-steroid biosynthesis in the fish ovary and head kidney.
  Journal
Endocrinology 148:4282-91 (2007)
DOI:10.1210/en.2007-0487
  Sequence
[ola:101170547]
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