KEGG   ORTHOLOGY: K00512
Entry
K00512                      KO                                     

Name
CYP17A
Definition
steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]
Pathway
map00140  Steroid hormone biosynthesis
map01100  Metabolic pathways
map04913  Ovarian steroidogenesis
map04917  Prolactin signaling pathway
map04927  Cortisol synthesis and secretion
map04934  Cushing syndrome
Module
M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
Disease
H00216  Congenital adrenal hyperplasia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
   04917 Prolactin signaling pathway
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
   04927 Cortisol synthesis and secretion
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.19  steroid 17alpha-monooxygenase
     K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
    1.14.14.32  17alpha-hydroxyprogesterone deacetylase
     K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP17 family
   K00512  CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase
Other DBs
RN: R02211 R03783 R04852 R04853 R08517 R08518
GO: 0004508 0047442
Genes
HSA: 1586(CYP17A1)
PTR: 450141(CYP17A1)
PPS: 100989182
GGO: 101152080
PON: 100439753
NLE: 100596228
MCC: 678693(CYP17A1)
MCF: 102133235(CYP17)
CSAB: 103216445(CYP17A1)
CATY: 105581896
PANU: 101026704
RRO: 104656530
RBB: 108515083
TFN: 117067514
PTEH: 111538851
CJC: 100400572(CYP17A1)
SBQ: 101048584
MMUR: 105874387
MMU: 13074(Cyp17a1)
MCAL: 110285327
MPAH: 110334801
RNO: 25146(Cyp17a1)
MCOC: 116101357
MUN: 110556807
CGE: 100758683
PLEU: 114696710
NGI: 103744072
HGL: 101726496
CCAN: 109691327
OCU: 100346394
TUP: 102472543
CFA: 477807(CYP17A1)
VVP: 112917782
VLG: 121485837
AML: 100476785
UMR: 103681600
UAH: 113251880
ORO: 101384623
ELK: 111145221
MPUF: 101671806
EJU: 114205173
MLX: 118025661
FCA: 493967(CYP17A1)
PTG: 102966057
PPAD: 109272832
AJU: 106966901
HHV: 120239617
BTA: 112441470 112444495 281739(CYP17A1)
BOM: 102270241 102270532
BIU: 109553214 109579081
BBUB: 102412624 112581551
CHX: 102182376 102182663(CYP17)
OAS: 105601846(CYP17) 493968(CYP17A1)
ODA: 120873501
SSC: 403330(CYP17A1)
CFR: 102519078
CDK: 105095024
BACU: 103007900
LVE: 103081477
OOR: 101283719
DLE: 111172355
PCAD: 102989171
ECB: 100034232(CYP17A1)
EPZ: 103558137
EAI: 106838161
MYB: 102259343
MYD: 102761363
MMYO: 118670308
MNA: 107542528
HAI: 109379659
DRO: 112300189
SHON: 118999460
AJM: 119059642
MMF: 118631983
PALE: 102884618
RAY: 107515566
MJV: 108410298
TOD: 119234280 119234908 119253889
LAV: 100660963
TMU: 101354636
MDO: 100028896
SHR: 100915970
PCW: 110194957
OAA: 100080906
GGA: 425056(CYP17A1)
PCOC: 116231659
MGP: 100540331
CJO: 107316091
NMEL: 110399428
APLA: 101792920
ACYG: 106031836
TGU: 100218933
LSR: 110473583
SCAN: 103813852
PMOA: 120502140
GFR: 102038147
FAB: 101821194
PHI: 102104333
PMAJ: 107206790
CCAE: 111931270
CCW: 104695563
ETL: 114071768
FPG: 101910363
FCH: 102054501
CLV: 102093575
EGZ: 104125602
NNI: 104022305
ACUN: 113481735
PADL: 103916301
AAM: 106494668
ASN: 102372221
AMJ: 102567971(CYP17A1)
CPOO: 109323822
GGN: 109287570
PSS: 102457785
CMY: 102945773
CPIC: 101933089
TST: 117880996
CABI: 116817103
ACS: 100553634 100553834
PVT: 110077624
PBI: 103063631
PMUR: 107290855
TSR: 106541312
PGUT: 117678655
PMUA: 114597528
GJA: 107117909
XLA: 100036774(cyp17a1.L)
XTR: 100145650(cyp17a1)
NPR: 108784547 108784564
DRE: 399692(cyp17a1) 796487(cyp17a2)
SRX: 107707716 107750198
SANH: 107673162 107695149
SGH: 107574436 107588661
CCAR: 109076732 109111078
CAUA: 113041336 113056832 113074379 113085111
IPU: 100313515(cyp17) 108275468
PHYP: 113530739 113542020
AMEX: 103036160 111194069
EEE: 113570353 113585465
TRU: 100125766(cyp17a2) 100125798(cyp17a1) 115249663
LCO: 104935158 104936651
NCC: 104957534
ELY: 117248465 117272651
PLEP: 121954365 121962489
SLUC: 116034661 116053620
ECRA: 117935140 117960349
PFLV: 114546162 114571983
GAT: 100192329(cyp17a2) 100192330(cyp17a1)
MSAM: 119912282 119917252
CUD: 121504405 121510915
MZE: 101475441 101477086
ONL: 100702216(cyp17a2) 100703469(cyp17)
OAU: 116332169 116335890
OLA: 100125816(cyp17) 101170547(cyp17a2)
OML: 112156384 112161529
XMA: 102221767 102238057
XCO: 114138338 114157614
XHE: 116712776 116732588 116732589
PRET: 103476526 103480951
CVG: 107083007 107099069
CTUL: 119773762 119787729
NFU: 107375507 107396730
KMR: 108239115 108251556
ALIM: 106511002 106515325
AOCE: 111563640 111579695
CSEM: 103387725 103389439
POV: 109634757 109639880
LCF: 108892361 108895342
SDU: 111233121 111239202
SLAL: 111661066 111669513
XGL: 120796819 120797261
HCQ: 109516617 109523214
BPEC: 110156961 110160276
MALB: 109972947 109973668
SASA: 106576693 106592366
OTW: 112252939
OMY: 100137017(cyp17a1) 110509408
SALP: 111951662 112078788
ELS: 105006241 105008018
SFM: 108926160 108933747
PKI: 111836781 111859263
LOC: 102683310 102696373
PSPA: 121321480 121326245
ARUT: 117409034 117415544
LCM: 102350866 102365866
CMK: 103172382 103177103
RTP: 109937010
DSV: 119442568
RSAN: 119377837 119385974 119385976 119386340 119388354
RMP: 119159398
BGT: 106073674
GAE: 121367969 121367970 121388399
PMAX: 117327584
ATEN: 116286226 116287483 116289234 116290675 116292213 116292286 116300224 116300467 116304432 116305619 116307262 116308086 116309069
AG: AAF65823(CYP17A1) AAG02227(CYP17A1)
 » show all
Reference
PMID:3025870 (CYP17A1)
  Authors
Chung BC, Picado-Leonard J, Haniu M, Bienkowski M, Hall PF, Shively JE, Miller WL
  Title
Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues.
  Journal
Proc Natl Acad Sci U S A 84:407-11 (1987)
DOI:10.1073/pnas.84.2.407
  Sequence
[hsa:1586]
Reference
PMID:17569754 (CYP17A2)
  Authors
Zhou LY, Wang DS, Kobayashi T, Yano A, Paul-Prasanth B, Suzuki A, Sakai F, Nagahama Y
  Title
A novel type of P450c17 lacking the lyase activity is responsible for C21-steroid biosynthesis in the fish ovary and head kidney.
  Journal
Endocrinology 148:4282-91 (2007)
DOI:10.1210/en.2007-0487
  Sequence
[ola:101170547]
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