KEGG   PATHWAY: lav04914
lav04914                    Pathway                                

Progesterone-mediated oocyte maturation - Loxodonta africana (African savanna elephant)
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Organismal Systems; Endocrine system
Pathway map
lav04914  Progesterone-mediated oocyte maturation

Other DBs
GO: 0001556
Loxodonta africana (African savanna elephant) [GN:lav]
100658131  PGR; LOW QUALITY PROTEIN: progesterone receptor [KO:K08556]
100653731  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100665045  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100675496  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100657948  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:]
100658340  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:]
100666266  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:]
100654943  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:]
100674229  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:]
100673395  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:]
100673331  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:]
100656926  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:]
100661039  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:]
100666344  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100670234  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100667957  GNAI3; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
100671072  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:]
100673570  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:]
100674724  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:]
100675525  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:]
100670244  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:]
100653532  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:]
100653771  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:]
100661616  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:]
100663448  ADCY9; LOW QUALITY PROTEIN: adenylate cyclase type 9 [KO:K08049] [EC:]
100656966  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:]
100674245  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:]
100665161  AURKA; aurora kinase A [KO:K11481] [EC:]
100667643  CPEB4; cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602]
100667978  CPEB1; cytoplasmic polyadenylation element-binding protein 1 isoform X1 [KO:K02602]
100655725  CPEB3; cytoplasmic polyadenylation element-binding protein 3 isoform X1 [KO:K02602]
100659712  CPEB2; LOW QUALITY PROTEIN: cytoplasmic polyadenylation element-binding protein 2 [KO:K02602]
100660485  SPDYA; speedy protein A [KO:K08694]
100662224  LOW QUALITY PROTEIN: speedy protein E4-like [KO:K08694]
100667931  speedy protein E4A-like [KO:K08694]
100658431  SPDYC; speedy protein C [KO:K08694]
100668134  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:]
100668529  CDK1; cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:]
100667107  CCNA1; cyclin-A1 [KO:K06627]
100654979  CCNA2; cyclin-A2 [KO:K06627]
100653879  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:]
100656361  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
100676217  HSP90AA1; LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha [KO:K04079]
100667623  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:]
100658240  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:]
100665157  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:]
100654322  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:]
100658801  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:]
100659843  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:]
100676062  RPS6KA1; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:]
100657179  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1 [KO:K06633] [EC:]
100654684  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
100659655  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
100673511  CCNB3; G2/mitotic-specific cyclin-B3 [KO:K21771]
100664614  STK10; serine/threonine-protein kinase 10 [KO:K08837] [EC:]
100675411  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:]
100659991  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:]
100664658  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:]
100670954  CDC25C; M-phase inducer phosphatase 3 [KO:K05867] [EC:]
100661112  INS; insulin [KO:K04526]
100664710  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
100655087  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:]
100663184  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:]
100657536  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:]
100660187  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:]
100660871  PDE3B; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:]
100661512  KRAS; GTPase KRas isoform X2 [KO:K07827]
100671404  ARAF; serine/threonine-protein kinase A-Raf isoform X3 [KO:K08845] [EC:]
100664119  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:]
100655727  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:]
100660153  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1 [KO:K02178] [EC:]
100675028  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X3 [KO:K06679]
100667589  mitotic spindle assembly checkpoint protein MAD2A-like [KO:K02537]
100668722  mitotic spindle assembly checkpoint protein MAD2A isoform X1 [KO:K02537]
100661726  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B isoform X1 [KO:K13728]
100677598  FZR1; fizzy-related protein homolog [KO:K03364]
100676448  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
100656382  ANAPC2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
100660117  CDC27; LOW QUALITY PROTEIN: cell division cycle protein 27 homolog [KO:K03350]
100677309  ANAPC5; anaphase-promoting complex subunit 5 [KO:K03352]
100663426  CDC16; cell division cycle protein 16 homolog [KO:K03353]
100654071  ANAPC7; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 7 [KO:K03354]
100670672  CDC23; cell division cycle protein 23 homolog [KO:K03355]
100668375  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
100674745  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
100659806  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
100669891  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
100655677  KIF22; kinesin-like protein KIF22 isoform X4 [KO:K10403]
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Schmitt A, Nebreda AR.
Signalling pathways in oocyte meiotic maturation.
J Cell Sci 115:2457-9 (2002)
Cato AC, Nestl A, Mink S.
Rapid actions of steroid receptors in cellular signaling pathways.
Sci STKE 2002:RE9 (2002)
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
Biol Cell 93:27-33 (2001)
Nebreda AR, Ferby I.
Regulation of the meiotic cell cycle in oocytes.
Curr Opin Cell Biol 12:666-75 (2000)
Ferrell JE Jr.
Xenopus oocyte maturation: new lessons from a good egg.
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
Biochem J 369:227-38 (2003)
Duckworth BC, Weaver JS, Ruderman JV.
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
Proc Natl Acad Sci U S A 99:16794-9 (2002)
Abrieu A, Doree M, Fisher D.
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
J Cell Sci 114:257-67 (2001)
lav04010  MAPK signaling pathway
lav04110  Cell cycle
KO pathway

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