Entry |
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Name |
Progesterone-mediated oocyte maturation - Loxodonta africana (African savanna elephant)
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Description |
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
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Class |
Organismal Systems; Endocrine system
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Pathway map |
lav04914 | Progesterone-mediated oocyte maturation |

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Other DBs |
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Organism |
Loxodonta africana (African savanna elephant) [GN: lav]
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Gene |
100653731 | PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649] |
100665045 | PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649] |
100675496 | PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649] |
100657948 | PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153] |
100658340 | PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153] |
100666266 | PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153] |
100666344 | GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630] |
100670234 | GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630] |
100667957 | GNAI3; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630] |
100667643 | CPEB4; cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602] |
100667978 | CPEB1; cytoplasmic polyadenylation element-binding protein 1 isoform X1 [KO:K02602] |
100655725 | CPEB3; cytoplasmic polyadenylation element-binding protein 3 isoform X1 [KO:K02602] |
100659712 | CPEB2; LOW QUALITY PROTEIN: cytoplasmic polyadenylation element-binding protein 2 [KO:K02602] |
100676217 | HSP90AA1; LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha [KO:K04079] |
100657179 | PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1 [KO:K06633] [EC:2.7.11.1] |
100675028 | MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X3 [KO:K06679] |
100667589 | mitotic spindle assembly checkpoint protein MAD2A-like [KO:K02537] |
100668722 | mitotic spindle assembly checkpoint protein MAD2A isoform X1 [KO:K02537] |
100661726 | MAD2L2; mitotic spindle assembly checkpoint protein MAD2B isoform X1 [KO:K13728] |
100676448 | ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348] |
100656382 | ANAPC2; anaphase-promoting complex subunit 2 isoform X1 [KO:K03349] |
100660117 | CDC27; LOW QUALITY PROTEIN: cell division cycle protein 27 homolog [KO:K03350] |
100654071 | ANAPC7; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 7 [KO:K03354] |
100668375 | ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357] |
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Compound |
C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
C11554 | 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate |
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Reference |
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Authors |
Schmitt A, Nebreda AR. |
Title |
Signalling pathways in oocyte meiotic maturation. |
Journal |
J Cell Sci 115:2457-9 (2002) |
Reference |
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Authors |
Cato AC, Nestl A, Mink S. |
Title |
Rapid actions of steroid receptors in cellular signaling pathways. |
Journal |
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Reference |
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Authors |
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ. |
Title |
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes. |
Journal |
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Reference |
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Authors |
Nebreda AR, Ferby I. |
Title |
Regulation of the meiotic cell cycle in oocytes. |
Journal |
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Reference |
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Authors |
Ferrell JE Jr. |
Title |
Xenopus oocyte maturation: new lessons from a good egg. |
Journal |
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Reference |
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Authors |
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA. |
Title |
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes. |
Journal |
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Reference |
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Authors |
Duckworth BC, Weaver JS, Ruderman JV. |
Title |
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A. |
Journal |
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Reference |
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Authors |
Abrieu A, Doree M, Fisher D. |
Title |
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes. |
Journal |
J Cell Sci 114:257-67 (2001) |
Related pathway |
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KO pathway |
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LinkDB |
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