KEGG   PATHWAY: lav04010
Entry
lav04010                    Pathway                                
Name
MAPK signaling pathway - Loxodonta africana (African savanna elephant)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
lav04010  MAPK signaling pathway
lav04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Loxodonta africana (African savanna elephant) [GN:lav]
Gene
100653528  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
100653533  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
100653562  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
100653605  [KO:K04391]
100653832  TGFB3; transforming growth factor beta-3 isoform X1 [KO:K13377]
100653890  [KO:K04391]
100653943  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
100653996  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X4 [KO:K04864]
100654322  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
100654499  NGF; beta-nerve growth factor [KO:K02582]
100654730  RELA; transcription factor p65 isoform X2 [KO:K04735]
100654736  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
100654759  KITLG; kit ligand isoform X1 [KO:K05461]
100654848  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
100654943  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100655007  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
100655063  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
100655087  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100655149  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
100655176  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
100655474  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100655585  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
100655620  [KO:K04460] [EC:3.1.3.16]
100655623  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X3 [KO:K04446]
100655692  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta isoform X2 [KO:K04402]
100655727  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100655752  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
100655943  KIT; mast/stem cell growth factor receptor Kit isoform X2 [KO:K05091] [EC:2.7.10.1]
100655944  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
100655977  DUSP6; LOW QUALITY PROTEIN: dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
100656031  EFNA3; ephrin-A3 [KO:K05462]
100656098  RRAS; ras-related protein R-Ras isoform X3 [KO:K07829]
100656129  FGF5; fibroblast growth factor 5 [KO:K04358]
100656200  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100656215  ANGPT2; angiopoietin-2 [KO:K05466]
100656232  KDR; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100656285  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
100656286  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
100656322  EFNA1; ephrin-A1 isoform X2 [KO:K05462]
100656420  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
100656437  TAOK2; LOW QUALITY PROTEIN: serine/threonine-protein kinase TAO2 [KO:K04429] [EC:2.7.11.1]
100656450  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X2 [KO:K04404]
100656534  TGFB2; transforming growth factor beta-2 isoform X2 [KO:K13376]
100656577  MAX; protein max isoform X2 [KO:K04453]
100656674  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
100656712  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
100656755  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
100656767  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
100656791  FGF20; fibroblast growth factor 20 [KO:K04358]
100656834  FGF18; LOW QUALITY PROTEIN: fibroblast growth factor 18 [KO:K04358]
100656926  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100656938  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
100656966  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100657363  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3 [KO:K07209] [EC:2.7.11.10]
100657379  SOS1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
100657533  FGF2; fibroblast growth factor 2 [KO:K18497]
100657536  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100657587  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100657597  EFNA5; ephrin-A5 [KO:K05462]
100657622  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
100657715  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
100657728  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
100657751  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X4 [KO:K03171]
100657834  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
100657845  VEGFC; vascular endothelial growth factor C [KO:K05449]
100657917  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X2 [KO:K04469]
100657946  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
100657989  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100658037  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 [KO:K17333]
100658205  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
100658240  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100658253  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100658490  PLA2G4A; cytosolic phospholipase A2 isoform X2 [KO:K16342] [EC:3.1.1.4]
100658495  FGF16; LOW QUALITY PROTEIN: fibroblast growth factor 16 [KO:K04358]
100658801  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
100658813  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
100658997  DUSP10; LOW QUALITY PROTEIN: dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
100659051  NRAS; GTPase NRas [KO:K07828]
100659125  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100659138  CACNA2D3; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
100659146  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
100659201  PSPN; persephin [KO:K25416]
100659273  CRK; adapter molecule crk isoform X1 [KO:K04438]
100659447  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
100659843  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
100659949  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
100659992  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
100660187  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100660311  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
100660332  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
100660444  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
100660454  MAP3K20; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
100660460  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
100660813  DAXX; LOW QUALITY PROTEIN: death domain-associated protein 6 [KO:K02308]
100660911  TAB1; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
100660941  DDIT3; DNA damage-inducible transcript 3 protein isoform X2 [KO:K04452]
100661039  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
100661112  INS; insulin [KO:K04526]
100661156  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
100661291  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
100661392  VEGFA; vascular endothelial growth factor A [KO:K05448]
100661430  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
100661451  PDGFD; platelet-derived growth factor D [KO:K05450]
100661492  IKBKG; LOW QUALITY PROTEIN: NF-kappa-B essential modulator [KO:K07210]
100661512  KRAS; GTPase KRas isoform X2 [KO:K07827]
100661626  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
100661766  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
100661838  AREG; amphiregulin [KO:K09782]
100661893  FGF21; LOW QUALITY PROTEIN: fibroblast growth factor 21 [KO:K22429]
100661927  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
100661934  PPM1B; protein phosphatase 1B isoform X2 [KO:K04461] [EC:3.1.3.16]
100662046  CRKL; crk-like protein [KO:K04438]
100662121  EREG; proepiregulin [KO:K09784]
100662122  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
100662194  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100662289  FGFR1; fibroblast growth factor receptor 1 isoform X3 [KO:K04362] [EC:2.7.10.1]
100662383  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X2 [KO:K04415] [EC:2.7.11.25]
100662511  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
100662521  ATF4; cyclic AMP-dependent transcription factor ATF-4 isoform X2 [KO:K04374]
100662583  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X2 [KO:K05083] [EC:2.7.10.1]
100662586  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100662664  DUSP7; LOW QUALITY PROTEIN: dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100662772  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349]
100662939  FGF8; fibroblast growth factor 8 [KO:K04358]
100662989  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100662994  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100663120  FGF10; fibroblast growth factor 10 [KO:K04358]
100663184  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100663257  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
100663544  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
100663604  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
100663606  CACNA1E; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
100663624  MAPT; microtubule-associated protein tau [KO:K04380]
100663661  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
100663725  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
100663763  FGF1; fibroblast growth factor 1 [KO:K18496]
100664075  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
100664100  NF1; LOW QUALITY PROTEIN: neurofibromin [KO:K08052]
100664103  CDC42; cell division control protein 42 homolog [KO:K04393]
100664119  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
100664128  [KO:K05093] [EC:2.7.10.1]
100664201  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
100664202  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X7 [KO:K04462] [EC:2.1.1.367]
100664204  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100664361  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100664379  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100664462  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
100664658  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
100664710  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
100664775  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
100664832  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100664871  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
100664990  IGF2; insulin-like growth factor II [KO:K13769]
100665081  SRF; serum response factor isoform X2 [KO:K04378]
100665124  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
100665139  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
100665157  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100665171  [KO:K25416]
100665180  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
100665185  RAP1B; ras-related protein Rap-1b [KO:K07836]
100665212  MAP3K9; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
100665332  TGFA; protransforming growth factor alpha [KO:K08774]
100665493  HGF; hepatocyte growth factor [KO:K05460]
100665537  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100665736  ARRB1; beta-arrestin-1 isoform X6 [KO:K04439]
100665819  VEGFD; vascular endothelial growth factor D [KO:K05449]
100665821  CACNG5; voltage-dependent calcium channel gamma-5 subunit isoform X2 [KO:K04870]
100665874  MYC; myc proto-oncogene protein [KO:K04377]
100666073  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
100666105  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
100666554  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
100666654  IL1RAP; interleukin-1 receptor accessory protein isoform X2 [KO:K04723]
100666839  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X4 [KO:K04407] [EC:2.7.11.1]
100666856  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X13 [KO:K04436]
100667057  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
100667110  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
100667149  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
100667155  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
100667170  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
100667623  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100667634  TGFB1; transforming growth factor beta-1 [KO:K13375]
100667885  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
100668003  [KO:K04409] [EC:2.7.11.1]
100668077  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
100668116  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
100668196  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
100668366  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
100668635  FGF23; fibroblast growth factor 23 [KO:K22428]
100668650  NTRK1; LOW QUALITY PROTEIN: high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
100668746  ARTN; artemin [KO:K25415]
100668807  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100668860  FGF4; fibroblast growth factor 4 [KO:K04358]
100668915  FGF6; fibroblast growth factor 6 [KO:K04358]
100668928  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
100668949  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
100668973  ERBB3; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100669040  MAP2K5; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
100669054  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
100669156  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
100669335  HSPA1A; heat shock 70 kDa protein 1A [KO:K03283]
100669548  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X3 [KO:K05454]
100669618  [KO:K03283]
100670080  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100670137  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
100670174  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X6 [KO:K08018]
100670400  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
100670432  JUN; transcription factor AP-1 [KO:K04448]
100670509  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
100670704  CSF1; macrophage colony-stimulating factor 1 isoform X3 [KO:K05453]
100670735  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
100670835  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
100670884  RASA1; ras GTPase-activating protein 1 [KO:K04352]
100670956  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
100670995  NTF3; neurotrophin-3 [KO:K04356]
100671064  RELB; transcription factor RelB [KO:K09253]
100671102  NGFR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 16 [KO:K02583]
100671240  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
100671392  TGFBR2; TGF-beta receptor type-2 isoform X2 [KO:K04388] [EC:2.7.11.30]
100671404  ARAF; serine/threonine-protein kinase A-Raf isoform X3 [KO:K08845] [EC:2.7.11.1]
100671471  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100671479  FGF9; fibroblast growth factor 9 [KO:K04358]
100671723  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
100671733  PRKCG; LOW QUALITY PROTEIN: protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100671889  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
100672020  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
100672078  PRKCB; LOW QUALITY PROTEIN: protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
100672143  TNFRSF1A; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100672176  RET; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
100672193  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
100672256  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
100672366  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
100672411  NTF4; neurotrophin-4 [KO:K12457]
100672515  PPM1A; protein phosphatase 1A isoform X2 [KO:K04457] [EC:3.1.3.16]
100672580  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
100672735  STMN1; stathmin isoform X2 [KO:K04381]
100672750  PDGFC; platelet-derived growth factor C [KO:K05450]
100672847  FGF7; fibroblast growth factor 7 [KO:K04358]
100673038  MAPKAPK5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
100673084  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100673089  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100673091  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
100673238  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
100673331  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100673395  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100673552  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100673821  MAP3K10; mitogen-activated protein kinase kinase kinase 10 isoform X2 [KO:K04418] [EC:2.7.11.25]
100673872  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
100674054  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100674229  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100674245  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100674649  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
100674746  IL1B; interleukin-1 beta [KO:K04519]
100674763  FLNA; LOW QUALITY PROTEIN: filamin-A [KO:K04437]
100674799  FOS; LOW QUALITY PROTEIN: proto-oncogene c-Fos [KO:K04379]
100674895  PGF; placenta growth factor isoform X2 [KO:K16859]
100674925  MAP3K6; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
100675032  IL1A; interleukin-1 alpha [KO:K04383]
100675095  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X2 [KO:K18019] [EC:3.1.3.48]
100675131  PLA2G4D; LOW QUALITY PROTEIN: cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
100675192  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
100675304  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
100675363  NTRK2; LOW QUALITY PROTEIN: BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
100675410  PLA2G4F; LOW QUALITY PROTEIN: cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
100675598  CACNA1H; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
100675607  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
100675766  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100676022  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
100676062  RPS6KA1; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
100676181  IRAK1; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
100676220  RAP1A; ras-related protein Rap-1A [KO:K04353]
100676444  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
100676745  [KO:K25414]
100677038  FLT4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
100677125  TNF; tumor necrosis factor isoform X2 [KO:K03156]
100677352  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100677364  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100677466  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X2 [KO:K04422] [EC:2.7.11.25]
100677678  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
100677738  ANGPT4; angiopoietin-4 [KO:K05467]
104846285  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
104846809  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
104847136  [KO:K03283]
111749631  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
111750996  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
111751488  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
111751572  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
111753010  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
lav04070  Phosphatidylinositol signaling system
lav04110  Cell cycle
lav04115  p53 signaling pathway
lav04210  Apoptosis
lav04310  Wnt signaling pathway
lav04668  TNF signaling pathway
KO pathway
ko04010   

DBGET integrated database retrieval system