Entry
Name
glutaryl-CoA dehydrogenase (ETF);
glutaryl coenzyme A dehydrogenase;
glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating);
glutaryl-CoA dehydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
BRITE hierarchy
Sysname
glutaryl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase (decarboxylating)
Reaction(IUBMB)
glutaryl-CoA + electron-transfer flavoprotein = crotonyl-CoA + CO2 + reduced electron-transfer flavoprotein (overall reaction) [RN:
R02488 ];
(1a) glutaryl-CoA + electron-transfer flavoprotein = (E)-glutaconyl-CoA + reduced electron-transfer flavoprotein [RN:
R10074 ];
(1b) (E)-glutaconyl-CoA = crotonyl-CoA + CO2 [RN:
R03028 ]
Reaction(KEGG)
Substrate
glutaryl-CoA [CPD:
C00527 ];
electron-transfer flavoprotein [CPD:
C04253 ];
(E)-glutaconyl-CoA [CPD:
C02411 ]
Product
crotonyl-CoA [CPD:
C00877 ];
CO2 [CPD:
C00011 ];
reduced electron-transfer flavoprotein [CPD:
C04570 ];
(E)-glutaconyl-CoA [CPD:
C02411 ]
Comment
Contains FAD. The enzyme catalyses the oxidation of glutaryl-CoA to glutaconyl-CoA (which remains bound to the enzyme), and the decarboxylation of the latter to crotonyl-CoA (cf. EC
7.2.4.5 , glutaconyl-CoA decarboxylase). FAD is the electron acceptor in the oxidation of the substrate, and its reoxidation by electron-transfer flavoprotein completes the catalytic cycle. The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (this entry), and a non-decarboxylating enzyme that only catalyses the oxidation to glutaconyl-CoA [EC
1.3.99.32 , glutaryl-CoA dehydrogenase (acceptor)].
History
EC 1.3.8.6 created 1972 as EC 1.3.99.7, transferred 2012 to EC 1.3.8.6, modified 2013, modified 2019
Pathway
ec01110 Biosynthesis of secondary metabolites
ec01120 Microbial metabolism in diverse environments
Orthology
K00252 glutaryl-CoA dehydrogenase
Genes
PLEU : 114687085(Gcdh) 114688976
AJM : 119048183 119049660(GCDH)
PRUF : 121362359 121362363
DRE : 393860(gcdha) 450003(gcdhb)
SRX : 107706691 107713099 107718595 107731476
SANH : 107653471 107659974
SGH : 107550261 107551881 107563244 107581332
CCAR : 109047444 109091992
CAUA : 113050796 113050893 113091921
NCC : 104942041(gcdh) 104967895
CGOB : 115012461 115015597(gcdh)
PLEP : 121942115(gcdha) 121957217
SLUC : 116039556 116046743
ECRA : 117957089(gcdha) 117958113
PFLV : 114546011 114569684
GAT : 120824791(gcdha) 120828186(gcdhb)
PPUG : 119217729(gcdha) 119219881(gcdhb)
MSAM : 119883101(gcdhb) 119899636(gcdha)
OAU : 116326886(gcdhb) 116330517
CVG : 107087655(gcdh) 107096619
CTUL : 119786868 119797987
AOCE : 111570605 111582739
CSEM : 103384209 103393651(gcdh)
POV : 109627202(gcdh) 109643747
SSEN : 122770503(gcdha) 122785914(gcdhb)
HHIP : 117752078(gcdha) 117765842
LCF : 108875708 108898695(gcdh)
SDU : 111223692(gcdh) 111229293
SLAL : 111662499(gcdh) 111666738
XGL : 120788395 120800964(gcdha)
HCQ : 109527380 109530010(gcdh)
BPEC : 110171346 110175720
SASA : 106564571 106589338 106601351(GCDH) 106607075
OTW : 112226289 112247205 112258824 121840489(gcdha)
OMY : 110485680 110485681 110486498 110538293
OGO : 124000114 124004010(gcdha)
SALP : 111981875 112069391
SNH : 120032895(gcdha) 120038403 120046331
AANG : 118217290(gcdhb) 118221519(gcdha)
ARUT : 117409787 117965561
DSI : Dsimw501_GD22569(Dsim_GD22569)
AALB : 109405866 109407205
CEL : CELE_F54D5.7(F54D5.7)
NTE : NEUTE1DRAFT86191(NEUTE1DRAFT_86191)
FGR : FGSG_10804 FGSG_11484
FOX : FOXG_10219 FOXG_12736
ANG : ANI_1_1364094(An11g10470)
TASA : A1Q1_06352 A1Q1_07372
PPL : POSPLDRAFT_89240 POSPLDRAFT_96011
FME : FOMMEDRAFT_112379 FOMMEDRAFT_136459
GTR : GLOTRDRAFT_100021 GLOTRDRAFT_134369
LBC : LACBIDRAFT_296371(GCD)
ABP : AGABI1DRAFT56516(AGABI1DRAFT_56516)
ABV : AGABI2DRAFT192796(AGABI2DRAFT_192796)
MLR : MELLADRAFT_111712 MELLADRAFT_54358
PTM : GSPATT00021665001 GSPATT00023352001
SMIN : v1.2.010129.t1(symbB.v1.2.010129.t1)
FCY : FRACYDRAFT_264525(ACD4)
TPS : THAPSDRAFT_23830(GCD1)
XPH : XppCFBP6546_03975(XppCFBP6546P_03975)
XHD : LMG31886_28360(bcd_2)
SINC : DAIF1_01740(acdA_1)
LARE : HIV01_004850 HIV01_006200
LCIC : INQ41_08355 INQ41_12675
PAEB : NCGM1900_0456(gcdH)
PAEU : BN889_00520(gcdH_2)
PCQ : PcP3B5_58220(mmgC_13)
PVD : CFBP1590__5326(gcdh)
PPRC : PFLCHA0_c01180(mmgC1)
PFW : PF1751_v1c01140(gcdH)
PPUU : PputUW4_00108(mmgC)
PCZ : PCL1606_29630 PCL1606_59590
PSEM : TO66_00585 TO66_15645
PSIL : PMA3_00275 PMA3_18640
PTAE : NCTC10697_04411(mmgC1)
MBS : MRBBS_0327 MRBBS_3172
MPQ : ABA45_01505 ABA45_15055
MARI : ACP86_10425 ACP86_11300
MLQ : ASQ50_07525 ASQ50_08525
PSYC : DABAL43B_0983(gcdH)
ABB : ABBFA_02871(mmgC_13)
ALC : OTEC02_08670 OTEC02_15435
ASJ : AsACE_CH01453(gcdH-1) AsACE_CH02009(gcdH-2)
AVB : RYU24_09120(gcdH_1) RYU24_15810(gcdH_2)
COZ : A3Q34_12165 A3Q34_17630 A3Q34_19115
COLW : A3Q33_00890 A3Q33_11690 A3Q33_19435
COLA : DBO93_03190 DBO93_07190
CBER : B5D82_11660 B5D82_16475
SALH : HMF8227_01068(gcdH)
MICC : AUP74_02692(acdA_2)
ALG : AQULUS_20190(acdA_1)
ASIP : AQUSIP_22640(acdA_1)
LCJ : NCTC11976_01392(gcdH)
LANT : TUM19329_06570(gcdH)
GAI : IMCC3135_19655(mmgC_2)
CUH : BJN34_15175 BJN34_35995
BMV : BMASAVP1_A0845(gcdH)
BML : BMA10229_A2678(gcdH)
BUR : Bcep18194_A3906 Bcep18194_B1396
BANN : JFN94_03830 JFN94_18835
BURK : DM992_17540 DM992_25005
BUZ : AYM40_02675 AYM40_07415
PHS : C2L64_07820 C2L64_14570
PTER : C2L65_07560 C2L65_12600
PTS : CUJ90_02740 CUJ90_05785
PLG : NCTC10937_05144(mmgC1)
BPAR : BN117_0621(gcdH) BN117_3442(gcdH)
BPA : BPP0656(gcdH) BPP1209(gcdH)
BBH : BN112_2033(gcdH) BN112_2772(gcdH)
BBR : BB0663(gcdH) BB1426(gcdH)
BBM : BN115_0637(gcdH) BN115_1385(gcdH)
BBX : BBS798_0641(gcdH) BBS798_1388(gcdH)
BTRM : SAMEA390648702227(gcdH)
RHG : EXZ61_11735 EXZ61_19475
RTA : Rta_04870(gcdH) Rta_18180(gcdH)
LIH : L63ED372_00885(mmgC_3)
DIH : G7047_07695 G7047_15465
CARE : LT85_2005 LT85_3942
MASW : AM586_00680 AM586_25250
NOK : FAY22_01105 FAY22_12310 FAY22_12800
GLC : JQN73_16715 JQN73_21790
AON : DEH84_15650 DEH84_15710
URU : DSM104443_02150(acdA)
UPL : DSM104440_01979(mmgC_3)
FLE : KI610_13200 KI610_17055
AZO : azo1924(gcdH1) azo1930(gcdH2)
ACOM : CEW83_03385 CEW83_03865
AZR : CJ010_12585 CJ010_12620
AMIH : CO731_04098(acdA_2)
ORM : HTY61_03270 HTY61_16960 HTY61_17820
RBS : RHODOSMS8_00409(mmgC)
SFD : USDA257_c10480(mmgC3)
SAME : SAMCFNEI73_pC0946(mmgC)
EAH : FA04_22640 FA04_32450
REC : RHECIAT_CH0002307(gcdHch) RHECIAT_PA0000217(gcdHa)
REL : REMIM1_PD00287(gcdH)
REP : IE4803_CH02251(gcdH-1) IE4803_PA00217(gcdH-2)
REI : IE4771_CH02337(gcdH-1) IE4771_PC00219(gcdH-2)
RTR : RTCIAT899_CH14280 RTCIAT899_PB02060
RHL : LPU83_pLPU83d0051(Gcdh)
RGA : RGR602_PC01014(gcdH)
RPHA : AMC79_PB00222(gcdH)
RHK : Kim5_CH02332(gcdH-1) Kim5_PB00253(gcdH-2)
RII : FFM53_029850 FFM53_034540
NEN : NCHU2750_29990(gcdH)
BSEP : HAP48_0012600 HAP48_0028845
BQB : J4P68_0016400 J4P68_0030070
VGO : GJW-30_1_01669(mmgC_5)
MAQU : Maq22A_c08955(caiA)
MIND : mvi_19510(gcdH) mvi_63970
BBAR : RHAL1_00558 RHAL1_03924
HMC : HYPMC_0305(gcdH) HYPMC_3450(gcdH)
FIL : BN1229_v1_0804 BN1229_v1_3220(gcdH)
FIY : BN1229_v1_0808 BN1229_v1_2703(gcdH)
PLEO : OHA_1_00685(mmgC_1)
MMED : Mame_01541(acdA_2) Mame_01855(mmgC_4)
BNE : DA69_03015 DA69_12950
OAT : OAN307_c21520 OAN307_c23040 OAN307_c36170
OAR : OA238_c25970 OA238_c28100
OTM : OSB_05830(mmgC_2) OSB_20120(acdA)
LEJ : ETW24_09720 ETW24_16040
PABY : Ga0080574_TMP169 Ga0080574_TMP5044
SINL : DSM14862_00758(acdA_1)
SPSE : SULPSESMR1_02324(acdA)
RMM : ROSMUCSMR3_00145(mmgC)
PZH : CX676_20470 CX676_20620
PARO : CUV01_11205 CUV01_12995
PARU : CYR75_11595 CYR75_13475
PPAN : ESD82_02535 ESD82_07050
PMAU : CP157_01057(mmgC_1)
LVS : LOKVESSMR4R_01153(mmgC)
BOO : E2K80_00225 E2K80_07045
GCE : KYE46_05230 KYE46_09505
SPHP : LH20_14120 LH20_20795