KEGG ORTHOLOGY: K10170

ORTHOLOGY: K10170

Entry

K10170                      KO

Symbol

TLR8, CD288

Name

toll-like receptor 8

Pathway

map04142

Lysosome biogenesis

map04613

Neutrophil extracellular trap formation

map04620

Toll-like receptor signaling pathway

map05171

Coronavirus disease - COVID-19

Disease

H00096

Defects of toll-like receptor signaling

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome biogenesis
    K10170  TLR8, CD288; toll-like receptor 8
09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K10170  TLR8, CD288; toll-like receptor 8
   04620 Toll-like receptor signaling pathway
    K10170  TLR8, CD288; toll-like receptor 8
09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K10170  TLR8, CD288; toll-like receptor 8
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors
    K10170  TLR8, CD288; toll-like receptor 8
   04090 CD molecules
    K10170  TLR8, CD288; toll-like receptor 8
Pattern recognition receptors [BR:ko04054]
Membrane-bound pattern recognition receptors
  Toll-like receptors
   K10170  TLR8, CD288; toll-like receptor 8
CD molecules [BR:ko04090]
Proteins
  K10170  CD288, TLR8; toll-like receptor 8

Genes

HSA:	51311(TLR8)

PTR:	473522(TLR8)

PPS:	100986586(TLR8)

GGO:	101152298(TLR8)

PON:	100452322(TLR8)

PPYG:

129023863(TLR8)

NLE:	100586130(TLR8)

HMH:	116810998(TLR8)

SSYN:

129475152(TLR8)

MCC:	574292(TLR8)

MCF:	102139990(TLR8)

MTHB:

126946661

MNI:	105478127(TLR8)

CSAB:

103231602(TLR8)

CATY:

105574715(TLR8)

PANU:

101020701(TLR8)

TGE:	112615839(TLR8)

MLEU:

105550031(TLR8)

RRO:	104678073(TLR8)

RBB:	108520704(TLR8)

TFN:	117077288(TLR8)

PTEH:

111531645(TLR8)

CANG:

105518049(TLR8)

CJC:	100398832(TLR8)

SBQ:	101035511(TLR8)

CIMI:

108289376(TLR8)

ANAN:

105705304(TLR8)

CSYR:

103268521(TLR8)

MMUR:

105882439(TLR8)

LCAT:

123627996(TLR8)

ERUF:

138378312(TLR8)

PCOQ:

105820965(TLR8)

OGA:	100965735(TLR8)

MMU:	170744(Tlr8)

MCAL:

110287354(Tlr8)

MPAH:

110314075(Tlr8)

RNO:	684440(Tlr8)

MCOC:

116090566(Tlr8)

ANU:	117695526(Tlr8)

ASYL:

127674805(Tlr8)

CGE:	100767319(Tlr8)

MAUA:

101840550(Tlr8)

PROB:

127214482(Tlr8)

PLEU:

114702951(Tlr8)

PMAV:

102909546(Tlr8)

MORG:

121439517(Tlr8) 121444430

MFOT:

126487954

AAMP:

119805528(Tlr8)

NGI:	103749968(Tlr8)

HGL:	101726643(Tlr8)

CPOC:

100713058(Tlr8)

CCAN:

109695954(Tlr8)

DORD:

105997671(Tlr8)

DSP:	122108518(Tlr8)

DMER:

138840493(Tlr8)

PLOP:

125343891(Tlr8)

NCAR:

124972416

MMMA:

107144229(Tlr8)

ITI:	101956695(Tlr8)

OPI:	101522737(TLR8)

OCZ:	121164647(TLR8)

TUP:	102503004(TLR8)

GVR:	103589386(TLR8)

CFA:	100684828(TLR8)

CLUD:

112652913(TLR8)

VVP:	112932377(TLR8)

VLG:	121482416(TLR8)

NPO:	129518301(TLR8)

AML:	100467144(TLR8)

UMR:	103668102(TLR8)

UAH:	113240729(TLR8)

UAR:	123796366(TLR8)

ELK:

111157166

LLV:

125091677

MNP:	132007351(TLR8)

MLK:	131820746(TLR8)

NVS:	122896434(TLR8)

ORO:	101369550(TLR8)

EJU:	114218025(TLR8)

ZCA:	113931499(TLR8)

MLX:	118026718(TLR8)

MANO:

123844324(TLR8)

NSU:	110575087(TLR8)

LWW:	102744939(TLR8)

FCA:	101091762(TLR8)

PYU:	121025162(TLR8)

PCOO:

112871637(TLR8)

PBG:	122477207(TLR8)

PVIV:

125157426(TLR8)

LRUF:

124509349

LGF:	123594153(TLR8)

AJU:

106971061

PPAD:

109248293(TLR8)

PUC:

125931479

HHV:	120233136(TLR8)

CCRU:

144229378(TLR8)

BTA:	532262(TLR8)

BOM:	102281878(TLR8)

BIU:	109555493(TLR8)

BJV:	133242001(TLR8)

BBUB:

102408845(TLR8)

BKE:	129638678(TLR8)

BBIS:

104981482(TLR8)

CHX:	100860909(TLR8)

OAS:	554259(TLR8)

OCAN:

138930143(TLR8)

BTAX:

128070286(TLR8)

CSUM:

138071209(TLR8)

ODA:	120882451(TLR8)

CCAD:

122435476(TLR8)

MREE:

136153405(TLR8)

OVR:	110147395(TLR8)

MBEZ:

129564615(TLR8)

SSC:	397384(TLR8)

CFR:	102518980(TLR8)

CBAI:

105077754(TLR8)

CDK:	105100628(TLR8)

VPC:	102541907(TLR8)

BACU:

103018208(TLR8)

BMUS:

118888583(TLR8)

LVE:	103082585(TLR8)

OOR:	101287601(TLR8)

LALB:

132513372(TLR8)

GMF:	115846461(TLR8)

DDP:	132418414(TLR8)

DLE:	111167212(TLR8)

PCAD:

102991441(TLR8)

PSIU:

116747689(TLR8)

PPHC:

136142449(TLR8)

NASI:

112409742(TLR8)

ECB:	100054367(TLR8)

EPZ:	103545204(TLR8)

EAI:	106848633(TLR8)

MYB:	102258490(TLR8)

MYD:	102771343(TLR8)

MMYO:

118654527(TLR8)

MLF:	102427949(TLR8)

MDT:	132223844(TLR8)

PKL:	118719933(TLR8)

EFUS:

103299727(TLR8)

MNA:	107529490(TLR8)

DRO:	112313399(TLR8)

SHON:

118987228(TLR8)

AJM:	119058330(TLR8)

PDIC:

114505753(TLR8)

PHAS:

123830143(TLR8)

MMF:	118636426(TLR8)

PPAM:

129076962(TLR8)

HAI:	109387358(TLR8)

RFQ:	117026860(TLR8)

PALE:

102894450(TLR8)

PGIG:

120611411(TLR8)

PVP:	105293981(TLR8)

RAY:	107497537(TLR8)

MJV:	108397207(TLR8)

TOD:	119246340(TLR8)

SARA:

101555560(TLR8)

SFUM:

130039370(TLR8)

SETR:

125999108(TLR8)

LAV:	100666560(TLR8)

TMU:

101348463

ETF:	101662469(TLR8)

DNM:	101429026(TLR8)

MDO:	100031968(TLR8)

GAS:	123239683(TLR8)

SHR:	100923069(TLR8)

AFZ:

127553640

PCW:	110222485(TLR8)

TVP:	118838218(TLR8)

PBRV:

138142060(TLR8)

MLAO:

141491465(TLR8)

OAA:	100084809(TLR8)

TACU:

119937870(TLR8)

ASN:	102375124(TLR8) 102375359

AMJ:	102557839(TLR8) 102558073

CPOO:

109306064(TLR8) 109306065

GGN:	109303374(TLR8) 109303457

PSS:	102445423(TLR8) 102456214 102456470

CIZ:	142006848 142006849 142006850

CMY:	102929320 102929541 102936357(TLR8)

CCAY:

125641231 125641237

LKP:	140907220 140907224(TLR8) 140915390

NDS:	141981675 141983117 141983125(TLR8)

DCC:	119846644(TLR8) 119861726 119863036

CPIC:

101942523(TLR8) 101942802

TST:	117869858(TLR8) 117869869 117869883

CABI:

116834084(TLR8)

MRV:	120388371 120401247(TLR8)

EMQ:	137165062(TLR8) 137165063

XLA:	108707525 108707526

XTR:	100495962 100496108(tlr8)

NPR:	108794926(TLR8)

RTEM:

120926526

ACAT:

141127947(TLR8)

PADS:

140333024(TLR8)

BBUF:

120995636 120995638

BGAR:

122930967 122930969

DTC:	141098402 141098403

PWL:	138250171(TLR8)

MUO:	115469694(TLR8)

GSH:	117361899(TLR8)

DRE:	403136(tlr8b) 403137(tlr8a)

DAES:

130235408 130236248(tlr8b)

SRX:	107707564 107716600 107758595

SANH:

107658565 107679936 107691259

SGH:	107564305 107589031

CCAR:

109045012 109045015 109097896(tlr8b)

CAUA:

113052899 113108207 113110277

CGIB:

127964770 127966052 128020231

PTET:

122333057 122333705(tlr8b)

LROH:

127171006 127172049(tlr8b)

GRF:	141298850(tlr8b) 141341011

OMC:	131546817 131548013(tlr8b)

PPRM:

120479182 120483249(tlr8b)

RKG:

130072545

MAMB:

125262379(tlr8b) 125270861

CIDE:

127518376 127521880

CERY:

137029435(tlr8b) 137035348

MASI:

127432564 127446973

TROS:

130546196(tlr8b) 130550969 130556131

TDW:	130411826(tlr8b) 130427275

MANU:

129446743(tlr8b) 129451954

PDAB:

135733628 135744340(tlr8b)

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

103023350(tlr8b) 103027915

CMAO:

118811359 118824628(tlr8b)

EEE:	113583207 113588854

CHAR:

105904388(tlr8b) 116218580

SPIL:

134078587 134100477(tlr8b)

ASAD:

121680130(tlr8b) 121702816

TRU:

TFS:

LCO:

NCC:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

CVE:

MSAM:

SCHU:

EARM:

CUD:

SPUL:

LMIX:

HTC:	141808667(tlr8a)

ALAT:

ASTR:

PKLU:

MZE:

ONL:	100696480 100710704

OAU:	116319286 116319328

OLA:

101169748

OML:

112154902

CSAI:

133445898(egfl6)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

KMR:

ALIM:

LTU:

AOCE:

EJA:

BFRE:

MCEP:

CSEM:

POV:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:	108890949 108901562(tmsb4x)

SDU:

SLAL:

XGL:

HCQ:

SBIA:

PEE:

PTAO:

BPEC:

ENY:

MALB:

BSPL:

SJO:

SSCO:

TTY:

GMH:	115533265 115533266 115533267 115533268 115533487

SASA:

100302030 106563113(TLR8b2) 106568387(TLR8b1) 106581917(TLR8a2)

STRU:

115155958(tlr8) 115159772 115161350 115202582

OTW:	112220235 112225286 112231491 112246496

OMY:	110501396 110509627 110520614 110523412

OGO:	124007281 124043608 124044252 124047924

ONE:	115101042 115108294 115113542 115119066

OKI:	109868596 109870795(tmsb4x) 109870891 109874182

OKE:	118373126 118385429 127914971

OMM:	135518124 135518955 135544592 135547272

OCLA:

139380505 139386141 139388265 139409887

SALP:

111959493(tlr8) 111964486 112068352 112071589

SNH:	120021740 120026365 120058003 120064357

SFON:

129816181 129819139 129820843 129863766

CCLU:

121536466 121542188 121553157 121583520

ELS:	105015276 105018722

OEP:	134017259 134038872(tlr8b)

PKI:

AANG:

AROT:

CCOG:

LOC:	102685072 102685268

PSPA:

121320651 121320652

ARUT:

117405786 117971111 117972786

PSEX:

LCM:

CMK:

SCAU:

HAKA:

CLEP:

143448468 143449502 143449884 143450393 143460324 143465303 143465939 143469704 143469727

AFIL:

PVUL:

LSAX:

BARL:

HRF:

HRJ:

HCRA:

OED:	125645661 125655119 125655135 125659473 125666374 130050948 130050950 130050952 130053210

PMAX:

117339175

AIRR:

138335235

DPOL:

127834435 127834522 127836405

MAEA:

128216476

» show all

Reference

PMID:11022119

Authors

Du X, Poltorak A, Wei Y, Beutler B

Title

Three novel mammalian toll-like receptors: gene structure, expression, and evolution.

Journal

Eur Cytokine Netw 11:362-71 (2000)

Sequence

[hsa:51311]

Reference

PMID:15229469

Authors

Akira S, Takeda K

Title

Toll-like receptor signalling.

Journal

Nat Rev Immunol 4:499-511 (2004)
DOI:10.1038/nri1391

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