KEGG ORTHOLOGY: K13285

ORTHOLOGY: K13285

Entry

K13285                      KO

Symbol

sipB, ipaB, bipB

Name

invasin B

Pathway

map05100

Bacterial invasion of epithelial cells

map05131

Shigellosis

map05132

Salmonella infection

Network

nt06181  Salmonella
nt06182  Shigella
nt06521  NLR signaling

Element

N00949

Shigella IpaB to NLRC4 Inflammasome signaling pathway

N01081

Shigella IpaB/C/D to ITGA/B-TALIN/VINCULIN signaling pathway

N01126

Salmonella SipB to Inflammasome signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K13285  sipB, ipaB, bipB; invasin B
   05131 Shigellosis
    K13285  sipB, ipaB, bipB; invasin B
   05100 Bacterial invasion of epithelial cells
    K13285  sipB, ipaB, bipB; invasin B
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K13285  sipB, ipaB, bipB; invasin B
Transporters [BR:ko02000]
Other transporters
  Pores ion channels
   K13285  sipB, ipaB, bipB; invasin B

Other DBs

TC:

1.C.36.3

Genes

ECM:	EcSMS35_4020

EUM:	ECUMN_4182

ECT:	ECIAI39_4254

EOC:	CE10_4294(sipB)

ELO:	EC042_4008

EAL:	EAKF1_ch2273c

EMA:	C1192_24310

ESF:	ACK8NJ_00255

STY:	STY3008(sipB)

STT:	t2787(sipB)

SEX:	STBHUCCB_29310

SENT:

TY21A_14080

STM:	STM2885(sipB)

SEO:	STM14_3484(sipB)

SEV:	STMMW_28471

SEY:	SL1344_2864(sipB)

SEM:	STMDT12_C29340

SEJ:	STMUK_2874(sipB)

SEB:	STM474_3024(sipB)

SEF:	UMN798_3133(sipB)

SETU:

STU288_14580

SETC:

CFSAN001921_02650

SENR:

STMDT2_27841(sipB)

SEND:

DT104_28821(sipB)

SENI:

CY43_15065

SEEN:

SE451236_20520

SPT:	SPA2743(sipB)

SEK:

SSPA2557

SPQ:	SPAB_03588

SEI:	SPC_2927(sipB)

SEC:	SCH_2817(sipB)

SEH:	SeHA_C3075

SHB:

SU5_03366

SENH:

CFSAN002069_17845

SEEH:

SEEH1578_23235

SEE:	SNSL254_A3090

SENN:

SN31241_39770

SEW:	SeSA_A3038

SEA:	SeAg_B3007

SENS:

Q786_13885

SED:

SeD_A3195

SEG:	SG2787(sipB)

SEL:	SPUL_2882(sipB)

SEGA:

SPUCDC_2868(sipB)

SET:	SEN2726(sipB)

SENA:

SENO:

SENV:

SENQ:

SENL:

SENJ:

SEEC:

SEEB:

SEEP:

SENB:

SENE:

SENC:

SES:	SARI_00088

SBG:	SBG_2505(sipB)

SBZ:

A464_2909

SBV:	N643_12260

SALZ:

EOS98_05075

SFL:	CP0128(ipaB)

SFE:	SFxv_4971(ipaB)

SSN:	SSON_P090(ipaB)

SBC:	SbBS512_A0160

SDY:	SDY_P166(ipaB)

SDZ:	Asd1617_06362

SHIG:

LXH19_00255

EPT:	HWQ17_00205(sctE)

CNT:	JT31_22620

KLU:	K7B04_18810(sctE)

KGN:	GY169_10290(sctE)

SYM:	K6K13_16235(sctE) K6K13_18815(sctE)

YRE:	HEC60_07295(sctE) HEC60_24990(sctE)

YEN:	YE3537(yspB)

YEW:

CH47_80

YAL:

AT01_1832

YRU:

BD65_2679

YMA:	DA391_20790

YHI:	D5F51_13195 D5F51_18630

YEL:	LC20_01543

YCA:	F0T03_18030

YEG:	PL78_14605 PL78_18175

SFW:	WN53_18300

FSM:	CCS41_07260

RBAD:

H2866_16690(sctE)

RCB:	O1V66_09055(sctE)

ROU:	AB3G37_14680(sctE)

PPAV:

LOZ86_18880(sctE)

SGL:

SG0574

SOD:	Sant_3183(yspB)

SLIG:

GTU79_25415(sctE)

EAM:	EAMY_0790(sipB1) EAMY_1591(sipB3)

EAY:	EAM_1570 EAM_2654

ETA:	ETA_18960(sipB1) ETA_26820(sipB2)

EPY:	EpC_19830(sipB)

EPR:	EPYR_02141(sipB)

ERJ:	EJP617_27360(sipB)

ETP:	LU633_00965(sctE)

ERWE:

GKQ23_06045

ETO:	RIN69_00925(sctE)

PSTW:

DSJ_24165

PMR:

PMI2683

PMIB:

BB2000_2683

PVG:	CRN77_06230

PHAU:

PH4a_04955

PROT:

BTA34_14680

PCOL:

F1325_16890

PPEE:

I6G31_11715(sctE)

PAPP:

QQS39_16530(sctE)

PSI:

S70_09760

PSX:

DR96_1233

PSTA:

BGK56_12745

PTHA:

OI982_13380(sctE)

PRG:	RB151_002100(sipB)

PALA:

CO695_03870

PHEI:

NCTC12003_00209(sipB)

PRQ:	CYG50_15220

PRJ:	NCTC6933_00199(sipB)

PVC:	G3341_00760

PHAG:

PZ638_00735(sctE)

PZJ:	QS795_000825

PZN:	ACE2AM_01005(sctE)

PXH:	ACE2AL_00805(sctE)

PLAZ:

ACIH2S_00915(sctE)

PROV:

ABE954_01110(sctE)

MMK:

MU9_22

ANS:	ArsFIN_03170(ipaB) ArsFIN_08880(sipB)

AET:	LDL57_02880(sctE)

AAPC:

QG404_02700(sctE) QG404_11505(sctE)

ARSE:

QE177_01530(sctE) QE177_03460(sctE)

XAL:	XALC_1504(xipB)

XPH:	XppCFBP6546_12470(sctE)

XAN:	AC801_21745

SOU:	PDM29_01425(sctE)

SARC:

PDM28_13630(sctE)

SCYC:

AB1723_09325(sctE)

PFUV:

NLK61_05465(sctE)

PFE:	PSF113_1790(sipB)

PZA:	HU749_010155(sctE)

PPUU:

PputUW4_03623(sipB)

PUM:	HGP31_22705(sctE)

PBZ:	GN234_09170

PVW:	HU752_024780(sctE)

PAZE:

KSS91_08890(sctE)

PTK:	EXN22_19215

PHOM:

KJF94_05890(sctE)

PAGB:

AWM79_23070

CVI:	CV_2619(sipB)

CVC:	BKX93_23055

CHRO:

CXB49_11135

CHRI:

DK842_20070

CHRB:

DK843_03045

CRZ:	D1345_20400

CHAE:

CH06BL_42050(cipB)

CSUT:

U6115_13110

CHRU:

DXT74_05420

IOD:	EJO50_05040

IFL:	C1H71_02495

BMA:	BMAA1531(bipB)

BML:	BMA10229_2071(bipB)

BMN:	BMA10247_A0753(bipB)

BMAZ:

BM44_4992(bipB)

BMAL:

DM55_4863(bipB)

BMAE:

DM78_4109(bipB)

BMAQ:

DM76_3816(bipB)

BMAI:

DM57_08295

BMAF:

DM51_3237(bipB)

BMAB:

BM45_3893(bipB)

BPS:	BPSS1532(bipB)

BPM:	BURPS1710b_A0571(bipB)

BPL:	BURPS1106A_A2074(bipB)

BPD:	BURPS668_A2162

BPR:	GBP346_B1492

BPSE:

BDL_4841(bipB)

BPSM:

BBQ_4618(bipB)

BPSU:

BBN_4976(bipB)

BPSD:

BBX_4003(bipB)

BPZ:	BP1026B_II1628(bipB)

BPQ:	BPC006_II2056

BPK:

BBK_4141

BPSH:

DR55_3744(bipB)

BPSA:

BBU_4503(bipB)

BPSO:

X996_3530(bipB)

BUT:	X994_5585(bipB)

BTE:	BTH_II0841

BTQ:	BTQ_4128(bipB)

BTJ:	BTJ_5160(bipB)

BTZ:	BTL_3631(bipB)

BTD:	BTI_4011(bipB)

BTV:	BTHA_4257(bipB)

BTHE:

BTN_5614(bipB)

BTHM:

BTRA_3622(bipB)

BTHA:

DR62_3380

BTHL:

BG87_3584(bipB)

BOK:	DM82_5839(bipB)

BOC:	BG90_4792(bipB)

BHG:	I6G56_20410(bipB)

BUD:	AQ610_23185

BUL:	BW21_6005(bipB)

BDL:

AK34_4706

BCON:

NL30_37135

PPK:	U875_22770

PPNO:

DA70_15445

PPNM:

LV28_15235

PRB:	X636_11405

PPUL:

RO07_13580 RO07_21085

PSPU:

NA29_05190

PVE:	UC34_25105

POX:	MB84_05400

PFG:	AB870_12310

PFIB:

PI93_019420

RAND:

ACQUFY_09530(sctE)

JAB:	VN23_02555

HEE:	hmeg3_15775

GLC:	JQN73_18885(sctE)

PCU:	PC_RS06660

PNL:

PNK_0349

» show all

Reference

PMID:14662750

Authors

Hernandez LD, Pypaert M, Flavell RA, Galan JE

Title

A Salmonella protein causes macrophage cell death by inducing autophagy.

Journal

J Cell Biol 163:1123-31 (2003)
DOI:10.1083/jcb.200309161

Reference

PMID:11207575

Authors

Tran Van Nhieu G, Bourdet-Sicard R, Dumenil G, Blocker A, Sansonetti PJ

Title

Bacterial signals and cell responses during Shigella entry into epithelial cells.

Journal

Cell Microbiol 2:187-93 (2000)
DOI:10.1046/j.1462-5822.2000.00046.x

Reference

PMID:10545510

Authors

Blocker A, Gounon P, Larquet E, Niebuhr K, Cabiaux V, Parsot C, Sansonetti P

Title

The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranes.

Journal

J Cell Biol 147:683-93 (1999)
DOI:10.1083/jcb.147.3.683

Sequence

[sfl:CP0128]

LinkDB

ORTHOLOGY: K13286

Entry

K13286                      KO

Symbol

sipC, ipaC, bipC

Name

invasin C

Pathway

map05100

Bacterial invasion of epithelial cells

map05131

Shigellosis

map05132

Salmonella infection

Network

nt06182 Shigella

Element

N01079

Shigella IpaC to Actin signaling pathway

N01081

Shigella IpaB/C/D to ITGA/B-TALIN/VINCULIN signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K13286  sipC, ipaC, bipC; invasin C
   05131 Shigellosis
    K13286  sipC, ipaC, bipC; invasin C
   05100 Bacterial invasion of epithelial cells
    K13286  sipC, ipaC, bipC; invasin C
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K13286  sipC, ipaC, bipC; invasin C
Cytoskeleton proteins [BR:ko04812]
Prokaryotic cytoskeleton proteins
  Actin homologs
   Actin-binding proteins
    K13286  sipC, ipaC, bipC; invasin C

Genes

EMA:	C1192_24315

STY:	STY3007(sipC)

STT:	t2786(sipC)

SEX:	STBHUCCB_29300

SENT:

TY21A_14075

STM:	STM2884(sipC)

SEO:	STM14_3483(sipC)

SEV:	STMMW_28461

SEY:	SL1344_2863(sipC)

SEM:	STMDT12_C29330

SEJ:	STMUK_2873(sipC)

SEB:	STM474_3023(sipC)

SEF:	UMN798_3132(sipC)

SETU:

STU288_14575

SETC:

CFSAN001921_02655

SENR:

STMDT2_27831(sipC)

SEND:

DT104_28811(sipC)

SENI:

CY43_15060

SEEN:

SE451236_20515

SPT:	SPA2742(sipC)

SEK:

SSPA2556

SPQ:	SPAB_03587

SEI:	SPC_2926(sipC)

SEC:	SCH_2816(sipC)

SHB:

SENH:

SEEH:

SENN:

SENS:

SEG:	SG2786(sipC)

SEL:	SPUL_2881(sipC)

SEGA:

SPUCDC_2867(sipC)

SET:	SEN2725(sipC)

SENA:

SENO:

SENV:

SENQ:

SENL:

SENJ:

SEEC:

SEEB:

SEEP:

SENB:

BN855_29240(sipC)

SENE:

IA1_13795

SENC:

SEET0819_21240

SES:	SARI_00089

SBG:	SBG_2504(sipC)

SBZ:

A464_2908

SBV:	N643_12255

SALZ:

EOS98_05080

SFL:	CP0127(ipaC)

SFE:	SFxv_4970(ipaC)

SSN:	SSON_P089(ipaC)

SBC:	SbBS512_A0159(ipaC)

SDY:	SDY_P165(ipaC)

SDZ:	Asd1617_06361

YRE:	HEC60_24985

YMA:	DA391_20785

FSM:	CCS41_07265

PHEI:

NCTC12003_00210

PRQ:	CYG50_15215

XAL:	XALC_1505(xipC)

XPH:	XppCFBP6546_12475(XppCFBP6546P_12475)

XAN:	AC801_21740

PFE:	PSF113_1791(ipaC)

PZA:	HU749_010160

PUM:	HGP31_22700

PHOM:

KJF94_05895

CVI:	CV_2618(sipC)

CVC:	BKX93_23060

CHRO:

CXB49_11130

CHRI:

DK842_20065

CHRB:

DK843_03040

CRZ:	D1345_20395

CHAE:

CH06BL_42040(cipC)

CSUT:

U6115_13105

CHRU:

DXT74_05425

IOD:	EJO50_05045

IFL:	C1H71_02490

BMA:	BMAA1530(bipC)

BML:	BMA10229_2072(bipC)

BMN:	BMA10247_A0754(bipC)

BMAZ:

BMAL:

BMAE:

BMAQ:

BMAI:

BMAF:

BMAB:

BPS:	BPSS1531(bipC)

BPM:	BURPS1710b_A0570(bipC)

BPL:	BURPS1106A_A2073

BPD:	BURPS668_A2161

BPR:	GBP346_B1491

BPSE:

BPSM:

BPSU:

BPSD:

BPZ:	BP1026B_II1627(bipC)

BPQ:	BPC006_II2055

BPK:

BPSH:

BPSA:

BPSO:

BUT:

BTE:	BTH_II0842

BTQ:

BTJ:

BTZ:

BTD:

BTV:

BTHE:

BTHM:

BTHA:

BTHL:

BOK:

BOC:

BHG:	I6G56_20415

BUD:	AQ610_23190

BUL:

BW21_6004

PPK:	U875_22765

PPNO:

DA70_15440

PPNM:

LV28_15240

PRB:	X636_11410

PPUL:

RO07_25420

PSPU:

NA29_05195

POX:	MB84_05405

PFG:	AB870_12315

» show all

Reference

PMID:15488740

Authors

Lilic M, Stebbins CE

Title

Re-structuring the host cell: up close with Salmonella's molecular machinery.

Journal

Microbes Infect 6:1205-11 (2004)
DOI:10.1016/j.micinf.2004.08.001

Reference

PMID:10545510

Authors

Blocker A, Gounon P, Larquet E, Niebuhr K, Cabiaux V, Parsot C, Sansonetti P

Title

The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranes.

Journal

J Cell Biol 147:683-93 (1999)
DOI:10.1083/jcb.147.3.683

Sequence

[sfl:CP0127]

LinkDB

ORTHOLOGY: K13287

Entry

K13287                      KO

Symbol

sipD, ipaD, bipD

Name

invasin D

Pathway

map05100

Bacterial invasion of epithelial cells

map05131

Shigellosis

Network

nt06182 Shigella

Element

N01081

Shigella IpaB/C/D to ITGA/B-TALIN/VINCULIN signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09160 Human Diseases
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K13287  sipD, ipaD, bipD; invasin D
   05100 Bacterial invasion of epithelial cells
    K13287  sipD, ipaD, bipD; invasin D
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K13287  sipD, ipaD, bipD; invasin D
Transporters [BR:ko02000]
Other transporters
  Pores ion channels
   K13287  sipD, ipaD, bipD; invasin D

Other DBs

TC:

1.C.36.3

Genes

ECM:	EcSMS35_4022

EUM:	ECUMN_4184

ECT:	ECIAI39_4256

EOC:	CE10_4296(sipD)

ELO:	EC042_4010

EAL:	EAKF1_ch2271c

EMA:	C1192_24320

STY:	STY3006(sipD)

STT:	t2785(sipD)

SEX:	STBHUCCB_29290

SENT:

TY21A_14070

STM:	STM2883(sipD)

SEO:	STM14_3482(sipD)

SEV:	STMMW_28451

SEY:	SL1344_2862(sipD)

SEM:	STMDT12_C29320

SEJ:	STMUK_2872(sipD)

SEB:	STM474_3022(sipD)

SEF:	UMN798_3131(sipD)

SETU:

STU288_14570

SETC:

CFSAN001921_02660

SENR:

STMDT2_27821(sipD)

SEND:

DT104_28801(sipD)

SENI:

CY43_15055

SEEN:

SE451236_20510

SPT:	SPA2741(sipD)

SEK:

SSPA2555

SPQ:	SPAB_03585

SEI:	SPC_2925(sipD)

SEC:	SCH_2815(sipD)

SHB:

SENH:

SEEH:

SENN:

SEW:	SeSA_A3036

SEA:	SeAg_B3005

SENS:

Q786_13875

SEG:	SG2785(sipD)

SEL:	SPUL_2880(sipD)

SEGA:

SPUCDC_2866(sipD)

SET:	SEN2724(sipD)

SENA:

SENO:

SENV:

SENQ:

SENL:

SENJ:

SEEC:

SEEB:

SEEP:

SENB:

SENE:

SENC:

SES:	SARI_00090

SBG:	SBG_2503(sipD)

SBZ:

A464_2907

SBV:	N643_12250

SALZ:

EOS98_05085

SFL:	CP0126(ipaD)

SFE:	SFxv_4969(ipaD)

SSN:	SSON_P088(ipaD)

SBC:	SbBS512_A0158(ipaD)

SDY:	SDY_P164(ipaD)

SDZ:	Asd1617_06360

SHIG:

LXH19_00245

EPT:	HWQ17_00215

CIF:	AL515_23035

CPAR:

CUC49_09640

CNT:	JT31_22630

KLU:	K7B04_18800

KGN:	GY169_10300

SYM:	K6K13_16225 K6K13_18805

YRE:	HEC60_07285 HEC60_24980(sctA)

YEN:	YE3535(yspD)

YEW:

CH47_82

YAL:

AT01_1830

YRU:

BD65_2681

YRB:	UGYR_13790

YHI:	D5F51_13185

YEL:	LC20_01545

YCA:	F0T03_18020

YEG:	PL78_14615 PL78_18185

SFW:	WN53_18195

FSM:	CCS41_07270

RBAD:

H2866_16700

RCB:	O1V66_09040

ROU:	AB3G37_14670

PPAV:

LOZ86_18870

SGL:

SG0006

SOD:	Sant_0085 Sant_0696 Sant_P0254

EAM:	EAMY_0792(sipD1) EAMY_1593(sipD3)

EAY:	EAM_1572 EAM_2652

ETA:	ETA_18940(sipD1) ETA_26800(sipD2)

EPY:	EpC_19810(sipD)

EPR:	EPYR_02139(sipD)

ERJ:	EJP617_27380(sipD)

ETP:	LU633_00975

ERWE:

PSTW:

PMR:

PMIB:

PVG:	CRN77_06245

PHAU:

PH4a_04925 PH4a_04940 PH4a_04945

PROT:

PCOL:

PCIB:

PPEE:

PAPP:

QQS39_16515 QQS39_16520

PSI:

PSX:

PSTA:

PTHA:

PRG:	RB151_002120

PHEI:

NCTC12003_00211

PRQ:	CYG50_15210

PRJ:	NCTC6933_00201

PVC:	G3341_00770

PHAG:

PZ638_00750

PZN:	ACE2AM_00995

PXH:	ACE2AL_00815

PLAZ:

ACIH2S_00925

PROV:

ABE954_01120

ANS:	ArsFIN_08900(ipaD)

AET:	LDL57_01560 LDL57_02865

XAL:	XALC_1477(xipD)

XPH:	XppCFBP6546_12505(XppCFBP6546P_12505)

XAN:	AC801_21710

XTH:	G4Q83_11490

PFUV:

NLK61_05455

PFE:	PSF113_1792(sipD)

PZA:	HU749_010165

PPUU:

PputUW4_03621(sipD)

PUM:	HGP31_22695

PBZ:	GN234_09160

PVW:	HU752_024770

PTK:	EXN22_19205

PHOM:

KJF94_05900

PAGB:

AWM79_23060

CVI:	CV_2617(sipD)

CVC:	BKX93_23065

CHRO:

CXB49_11125

CHRI:

DK842_20060

CHRB:

DK843_03035

CRZ:	D1345_20390

CHAE:

CH06BL_42030(cipD)

CSUT:

U6115_13100(sctA)

CHRU:

DXT74_05430

IOD:	EJO50_05050

IFL:	C1H71_02485

BMA:	BMAA1528(bprD)

BML:	BMA10229_2074(bipD)

BMN:	BMA10247_A0757(bipD)

BMAZ:

BMAL:

BMAE:

BMAQ:

BMAI:

BMAF:

BMAB:

BPS:	BPSS1529(bipD)

BPM:	BURPS1710b_A0568

BPL:	BURPS1106A_A2071

BPD:	BURPS668_A2159(bipD)

BPR:	GBP346_B1489

BPSE:

BPSM:

BPSU:

BPSD:

BPZ:	BP1026B_II1625(bipD)

BPQ:	BPC006_II2053

BPK:

BPSH:

BPSA:

BPSO:

BUT:

BTE:	BTH_II0844

BTQ:

BTJ:

BTZ:

BTD:

BTV:

BTHE:

BTHM:

BTHA:

BTHL:

BOK:

BOC:

BHG:	I6G56_20425(sctA)

BUD:	AQ610_23200

BUL:

BW21_6002

PPK:	U875_22760

PPNO:

DA70_15435

PPNM:

LV28_15245

PRB:	X636_24770

PPUL:

RO07_21070

PSPU:

NA29_05200

PVE:	UC34_01050

POX:	MB84_05410

PFG:	AB870_12320

JAB:	VN23_02565

HEE:	hmeg3_15765

GLC:	JQN73_18895

» show all

Reference

PMID:8522512

Authors

Kaniga K, Trollinger D, Galan JE

Title

Identification of two targets of the type III protein secretion system encoded by the inv and spa loci of Salmonella typhimurium that have homology to the Shigella IpaD and IpaA proteins.

Journal

J Bacteriol 177:7078-85 (1995)
DOI:10.1128/jb.177.24.7078-7085.1995

Sequence

[sey:SL1344_2862]

Reference

PMID:18389058

Authors

Cain RJ, Hayward RD, Koronakis V

Title

Deciphering interplay between Salmonella invasion effectors.

Journal

PLoS Pathog 4:e1000037 (2008)
DOI:10.1371/journal.ppat.1000037

Reference

PMID:15731041

Authors

Picking WL, Nishioka H, Hearn PD, Baxter MA, Harrington AT, Blocker A, Picking WD

Title

IpaD of Shigella flexneri is independently required for regulation of Ipa protein secretion and efficient insertion of IpaB and IpaC into host membranes.

Journal

Infect Immun 73:1432-40 (2005)
DOI:10.1128/IAI.73.3.1432-1440.2005

LinkDB

DBGET integrated database retrieval system