KEGG   PATHWAY: acoz00230
Entry
acoz00230                   Pathway                                
Name
Purine metabolism - Anopheles coluzzii
Class
Metabolism; Nucleotide metabolism
Pathway map
acoz00230  Purine metabolism
acoz00230

Module
acoz_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:acoz00230]
acoz_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:acoz00230]
acoz_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:acoz00230]
acoz_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:acoz00230]
acoz_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:acoz00230]
acoz_M00546  Purine degradation, xanthine => urea [PATH:acoz00230]
acoz_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:acoz00230]
acoz_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:acoz00230]
Other DBs
GO: 0006163 0042278
Organism
Anopheles coluzzii [GN:acoz]
Gene
120949837  ADP-ribose pyrophosphatase, mitochondrial [KO:K13988] [EC:3.6.1.13]
120949960  phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
120961151  ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
120947708  amidophosphoribosyltransferase-like isoform X1 [KO:K00764] [EC:2.4.2.14]
120956491  trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
120950358  phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
120947737  multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
120952797  adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
120951290  bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
120950938  adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
120961404  cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
120951051  snake venom 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
120953694  protein 5NUC [KO:K19970] [EC:3.1.3.5]
120949002  purine nucleoside phosphorylase isoform X1 [KO:K03783] [EC:2.4.2.1]
120949003  purine nucleoside phosphorylase-like [KO:K03783] [EC:2.4.2.1]
120957045  inosine-5'-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
120951225  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
120951583  LOW QUALITY PROTEIN: nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
120950856  nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
120952836  soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
120955698  ectonucleoside triphosphate diphosphohydrolase 5 isoform X1 [KO:K01511] [EC:3.6.1.6]
120960068  inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
120951441  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120951442  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120952638  indole-3-acetaldehyde oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120953808  xanthine dehydrogenase 1-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120953811  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120953812  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120953813  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120953814  aldehyde oxidase 3-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120956350  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120956351  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120955684  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
120955121  GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
120951212  guanine deaminase [KO:K01487] [EC:3.5.4.3]
120956803  guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
120958486  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
120960721  LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
120950558  ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
120955123  5'-deoxynucleotidase HDDC2 [KO:K07023] [EC:3.1.3.89]
120953957  deoxynucleoside kinase isoform X1 [KO:K05961] [EC:2.7.1.145]
120954022  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
120949147  exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
120952762  adenylate cyclase type 2 [KO:K01768] [EC:4.6.1.1]
120959989  Ca(2+)/calmodulin-responsive adenylate cyclase isoform X1 [KO:K08041] [EC:4.6.1.1]
120955519  adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
120955699  adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
120949475  adenylyl cyclase 78C [KO:K08048] [EC:4.6.1.1]
120960963  adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
120956774  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
120959411  head-specific guanylate cyclase [KO:K12318] [EC:4.6.1.2]
120954549  guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
120949895  uncharacterized protein LOC120949895 [KO:K12322] [EC:4.6.1.2]
120961064  atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
120958106  atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
120959163  guanylate cyclase 32E [KO:K01769] [EC:4.6.1.2]
120961144  transmembrane protease serine 9-like [KO:K01769] [EC:4.6.1.2]
120950772  soluble guanylate cyclase 88E isoform X1 [KO:K01769] [EC:4.6.1.2]
120958204  receptor-type guanylate cyclase Gyc76C-like isoform X1 [KO:K01769] [EC:4.6.1.2]
120956599  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1-like isoform X1 [KO:K13755] [EC:3.1.4.17]
120955168  cGMP-dependent 3',5'-cyclic phosphodiesterase-like [KO:K18283] [EC:3.1.4.17]
120958870  probable cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
120948436  cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13763] [EC:3.1.4.35]
120950959  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
120959301  dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11-like isoform X1 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
120948325  adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
120959892  AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
120958329  adenosine kinase [KO:K00856] [EC:2.7.1.20]
120957230  adenosine kinase [KO:K00856] [EC:2.7.1.20]
120951791  adenosine deaminase 2-A-like [KO:K19572] [EC:3.5.4.4]
120953538  adenosine deaminase 2-like [KO:K19572] [EC:3.5.4.4]
120950636  adenosine deaminase 2-like [KO:K19572] [EC:3.5.4.4]
120953356  adenylate kinase [KO:K00939] [EC:2.7.4.3]
120955700  adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
120953613  adenylate kinase isoenzyme 6 homolog [KO:K18532] [EC:2.7.4.3]
120958966  GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
120949950  nucleoside-triphosphatase THEP1 [KO:K06928] [EC:3.6.1.15]
120959054  cAMP-specific 3',5'-cyclic phosphodiesterase-like isoform X1 [KO:K13293] [EC:3.1.4.53]
120952983  uncharacterized protein LOC120952983 isoform X1 [KO:K13293] [EC:3.1.4.53]
120949498  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 isoform X1 [KO:K18437] [EC:3.1.4.53]
120951632  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
120958706  uricase [KO:K00365] [EC:1.7.3.3]
120954727  5-hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
120956369  2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase-like isoform X1 [KO:K13485] [EC:4.1.1.97]
120959569  allantoinase [KO:K01466] [EC:3.5.2.5]
120951678  allantoicase-like [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
acoz00030  Pentose phosphate pathway
acoz00220  Arginine biosynthesis
acoz00250  Alanine, aspartate and glutamate metabolism
acoz00260  Glycine, serine and threonine metabolism
acoz00340  Histidine metabolism
acoz00630  Glyoxylate and dicarboxylate metabolism
acoz00730  Thiamine metabolism
acoz00740  Riboflavin metabolism
acoz00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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