KEGG   PATHWAY: biu04512
Entry
biu04512                    Pathway                                
Name
ECM-receptor interaction - Bos indicus (zebu cattle)
Description
The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
biu04512  ECM-receptor interaction
biu04512

Other DBs
GO: 0005201
Organism
Bos indicus (zebu cattle) [GN:biu]
Gene
109553708  THBS3; thrombospondin-3 [KO:K04659]
109555197  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
109555345  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
109555677  SV2A; synaptic vesicle glycoprotein 2A [KO:K06258]
109555827  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
109555956  ITGB5; integrin beta-5 [KO:K06588]
109556449  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
109556472  GP5; platelet glycoprotein V [KO:K06260]
109556565  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
109557291  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
109557335  [KO:K06259]
109557393  LAMB1; laminin subunit beta-1 [KO:K05636]
109557879  [KO:K06259]
109557883  [KO:K06249] [EC:3.4.21.-]
109557884  [KO:K06249] [EC:3.4.21.-]
109558214  COL1A2; collagen alpha-2(I) chain [KO:K06236]
109558343  ITGA5; integrin alpha-5 [KO:K06484]
109558606  VWF; von Willebrand factor [KO:K03900]
109559043  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
109559169  COL2A1; collagen alpha-1(II) chain [KO:K19719]
109559400  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
109560068  FRAS1; extracellular matrix protein FRAS1 [KO:K23379]
109560131  IBSP; bone sialoprotein 2 [KO:K06253]
109560132  MEPE; matrix extracellular phosphoglycoprotein isoform X1 [KO:K26442]
109560186  DMP1; dentin matrix acidic phosphoprotein 1 isoform X1 [KO:K23328]
109560275  NPNT; nephronectin isoform X1 [KO:K06824]
109560352  SPP1; osteopontin [KO:K06250]
109561193  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
109561279  COL6A2; LOW QUALITY PROTEIN: collagen alpha-2(VI) chain [KO:K06238]
109561393  COMP; cartilage oligomeric matrix protein [KO:K04659]
109561676  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
109562276  [KO:K06267]
109562876  FREM1; FRAS1-related extracellular matrix protein 1 [KO:K23380]
109563393  TNC; tenascin isoform X1 [KO:K06252]
109563451  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
109563454  [KO:K06238]
109563465  [KO:K06238]
109563534  LAMA2; LOW QUALITY PROTEIN: laminin subunit alpha-2 [KO:K05637]
109563807  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
109564125  THBS2; thrombospondin-2 [KO:K04659]
109564448  SV2C; synaptic vesicle glycoprotein 2C isoform X1 [KO:K06258]
109564670  THBS4; thrombospondin-4 [KO:K04659]
109564717  ITGA11; integrin alpha-11 [KO:K06587]
109564916  THBS1; thrombospondin-1 [KO:K16857]
109565743  ITGAV; integrin alpha-V [KO:K06487]
109565881  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
109566354  SDC1; syndecan-1 [KO:K06257]
109566462  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
109566555  LAMC3; laminin subunit gamma-3 [KO:K06247]
109566959  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
109566999  [KO:K23380]
109567101  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
109567207  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
109567262  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
109567481  SDC4; syndecan-4 [KO:K16338]
109567659  LAMA5; laminin subunit alpha-5 [KO:K06240]
109567924  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
109567974  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
109569730  CD44; CD44 antigen isoform X1 [KO:K06256]
109570361  LAMC1; laminin subunit gamma-1 [KO:K05635]
109570417  AGRN; agrin isoform X1 [KO:K06254]
109570495  LAMC2; laminin subunit gamma-2 [KO:K06246]
109570638  LAMB3; laminin subunit beta-3 [KO:K06244]
109570783  TNR; tenascin-R isoform X1 [KO:K06252]
109570804  TNN; tenascin-N [KO:K06252]
109571025  CD47; leukocyte surface antigen CD47 isoform X1 [KO:K06266]
109571374  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
109573568  ITGA2B; integrin alpha-IIb [KO:K06476]
109573749  COL1A1; collagen alpha-1(I) chain [KO:K06236]
109574049  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
109574140  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
109574171  CHAD; chondroadherin [KO:K06248]
109574196  GP1BA; platelet glycoprotein Ib alpha chain [KO:K06261]
109574210  ITGA3; integrin alpha-3 [KO:K06482]
109574379  VTN; vitronectin [KO:K06251]
109574799  ITGA1; integrin alpha-1 [KO:K06480]
109574862  ITGA2; integrin alpha-2 [KO:K06481]
109575690  SV2B; synaptic vesicle glycoprotein 2B [KO:K06258]
109575885  [KO:K06243]
109575895  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
109575927  [KO:K06243]
109576023  DAG1; dystroglycan isoform X1 [KO:K06265]
109576217  ITGA9; integrin alpha-9 [KO:K06585]
109576426  GP9; platelet glycoprotein IX [KO:K06263]
109576847  TNXB; tenascin-X [KO:K06252]
109577653  [KO:K06240]
109577655  [KO:K06240]
109577666  LAMA1; laminin subunit alpha-1 [KO:K05637]
Compound
G10505  Hyaluronic acid
Reference
  Authors
van der Flier A, Sonnenberg A.
  Title
Function and interactions of integrins.
  Journal
Cell Tissue Res 305:285-98 (2001)
DOI:10.1007/s004410100417
Reference
  Authors
Reddy KV, Mangale SS.
  Title
Integrin receptors: the dynamic modulators of endometrial function.
  Journal
Tissue Cell 35:260-73 (2003)
DOI:10.1016/S0040-8166(03)00039-9
Reference
  Authors
Milner R, Campbell IL.
  Title
The integrin family of cell adhesion molecules has multiple functions within the CNS.
  Journal
J Neurosci Res 69:286-91 (2002)
DOI:10.1002/jnr.10321
Reference
  Authors
Cichy J, Pure E.
  Title
The liberation of CD44.
  Journal
J Cell Biol 161:839-43 (2003)
DOI:10.1083/jcb.200302098
Reference
PMID:7698997
  Authors
Elenius K, Jalkanen M.
  Title
Function of the syndecans--a family of cell surface proteoglycans.
  Journal
J Cell Sci 107 ( Pt 11):2975-82 (1994)
Reference
  Authors
Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS.
  Title
The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
  Journal
J Biol Chem 275:451-60 (2000)
DOI:10.1074/jbc.275.1.451
Reference
  Authors
Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L.
  Title
Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
  Journal
Crit Rev Oncol Hematol 49:245-58 (2004)
DOI:10.1016/j.critrevonc.2003.09.009
Reference
  Authors
Canobbio I, Balduini C, Torti M.
  Title
Signalling through the platelet glycoprotein Ib-V-IX complex.
  Journal
Cell Signal 16:1329-44 (2004)
DOI:10.1016/j.cellsig.2004.05.008
Reference
  Authors
Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R.
  Title
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
  Journal
EMBO J 20:2120-30 (2001)
DOI:10.1093/emboj/20.9.2120
Reference
  Authors
Martin PT.
  Title
Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
  Journal
Glycobiology 13:55R-66R (2003)
DOI:10.1093/glycob/cwg076
Reference
  Authors
Toole BP.
  Title
Hyaluronan: from extracellular glue to pericellular cue.
  Journal
Nat Rev Cancer 4:528-39 (2004)
DOI:10.1038/nrc1391
Reference
  Authors
Bosman FT, Stamenkovic I.
  Title
Functional structure and composition of the extracellular matrix.
  Journal
J Pathol 200:423-8 (2003)
DOI:10.1002/path.1437
Reference
  Authors
van der Ven AT, Vivante A, Hildebrandt F
  Title
Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.
  Journal
J Am Soc Nephrol 29:36-50 (2018)
DOI:10.1681/ASN.2017050561
Related
pathway
biu04510  Focal adhesion
KO pathway
ko04512   

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