KEGG   PATHWAY: biu04510
Entry
biu04510                    Pathway                                
Name
Focal adhesion - Bos indicus (zebu cattle)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
biu04510  Focal adhesion
biu04510

Other DBs
GO: 0005925
Organism
Bos indicus (zebu cattle) [GN:biu]
Gene
109552991  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
109553009  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
109553526  VEGFC; vascular endothelial growth factor C [KO:K05449]
109553704  VCL; vinculin isoform X1 [KO:K05700]
109553708  THBS3; thrombospondin-3 [KO:K04659]
109553773  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109553931  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
109554117  VEGFB; vascular endothelial growth factor B [KO:K16858]
109554386  BAD; bcl2-associated agonist of cell death [KO:K02158]
109554414  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
109554439  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
109554525  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
109555031  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
109555118  FLNA; filamin-A [KO:K04437]
109555129  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
109555197  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
109555345  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
109555415  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
109555471  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
109555827  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
109555878  [KO:K16060]
109555931  RAP1A; ras-related protein Rap-1A [KO:K04353]
109555956  ITGB5; integrin beta-5 [KO:K06588]
109556235  JUN; transcription factor AP-1 [KO:K04448]
109556345  [KO:K02649]
109556449  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
109556565  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
109556793  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
109557291  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
109557393  LAMB1; laminin subunit beta-1 [KO:K05636]
109557411  MET; LOW QUALITY PROTEIN: hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
109557414  CAV1; caveolin-1 isoform X1 [KO:K06278]
109557415  CAV2; caveolin-2 [KO:K12958]
109557698  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
109557750  ZYX; zyxin [KO:K06273]
109557823  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
109557878  HGF; hepatocyte growth factor [KO:K05460]
109557883  [KO:K06249] [EC:3.4.21.-]
109557884  [KO:K06249] [EC:3.4.21.-]
109557919  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
109558214  COL1A2; collagen alpha-2(I) chain [KO:K06236]
109558343  ITGA5; integrin alpha-5 [KO:K06484]
109558606  VWF; von Willebrand factor [KO:K03900]
109558630  [KO:K17386]
109558641  [KO:K06275]
109558642  [KO:K06275]
109558936  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
109559043  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
109559169  COL2A1; collagen alpha-1(II) chain [KO:K19719]
109559248  RAP1B; ras-related protein Rap-1b [KO:K07836]
109559400  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
109559448  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
109559531  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
109559636  EMP1; epithelial membrane protein 1 [KO:K26255]
109559745  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
109559805  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109559825  [KO:K17386]
109559893  PARVB; beta-parvin [KO:K06275]
109559983  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
109560131  IBSP; bone sialoprotein 2 [KO:K06253]
109560352  SPP1; osteopontin [KO:K06250]
109560475  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
109560478  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
109560650  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
109560940  [KO:K02833]
109560955  VAV1; proto-oncogene vav [KO:K05730]
109561056  SHC2; SHC-transforming protein 2 [KO:K17447]
109561193  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
109561279  COL6A2; LOW QUALITY PROTEIN: collagen alpha-2(VI) chain [KO:K06238]
109561327  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
109561331  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
109561393  COMP; cartilage oligomeric matrix protein [KO:K04659]
109561418  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
109561676  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
109561764  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
109562140  DIAPH1; LOW QUALITY PROTEIN: protein diaphanous homolog 1 [KO:K05740]
109562197  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
109562486  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
109562580  SHC3; SHC-transforming protein 3 [KO:K17448]
109563014  TLN1; talin-1 isoform X1 [KO:K06271]
109563393  TNC; tenascin isoform X1 [KO:K06252]
109563451  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
109563454  [KO:K06238]
109563465  [KO:K06238]
109563534  LAMA2; LOW QUALITY PROTEIN: laminin subunit alpha-2 [KO:K05637]
109563807  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
109563811  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
109564125  THBS2; thrombospondin-2 [KO:K04659]
109564346  SOS2; son of sevenless homolog 2 [KO:K03099]
109564670  THBS4; thrombospondin-4 [KO:K04659]
109564697  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109564717  ITGA11; integrin alpha-11 [KO:K06587]
109564916  THBS1; thrombospondin-1 [KO:K16857]
109564925  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
109565067  TLN2; talin-2 isoform X1 [KO:K06271]
109565147  SHC4; SHC-transforming protein 4 [KO:K17449]
109565282  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
109565356  PGF; placenta growth factor isoform X1 [KO:K16859]
109565687  VAV2; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV2 [KO:K05730]
109565743  ITGAV; integrin alpha-V [KO:K06487]
109565881  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
109566002  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
109566263  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
109566382  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
109566462  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
109566555  LAMC3; laminin subunit gamma-3 [KO:K06247]
109566561  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
109566823  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
109566959  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
109567101  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
109567207  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
109567262  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
109567347  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
109567416  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
109567428  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
109567659  LAMA5; laminin subunit alpha-5 [KO:K06240]
109567924  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
109567943  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
109567974  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
109568429  PTK2; LOW QUALITY PROTEIN: focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
109568764  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
109569648  [KO:K06275]
109569649  [KO:K06275]
109569757  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
109569805  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
109569840  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
109570286  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109570361  LAMC1; laminin subunit gamma-1 [KO:K05635]
109570370  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
109570415  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
109570495  LAMC2; laminin subunit gamma-2 [KO:K06246]
109570638  LAMB3; laminin subunit beta-3 [KO:K06244]
109570783  TNR; tenascin-R isoform X1 [KO:K06252]
109570804  TNN; tenascin-N [KO:K06252]
109570973  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109570977  CRKL; crk-like protein [KO:K04438]
109571069  PXN; paxillin isoform X1 [KO:K05760]
109571193  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
109571374  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
109571395  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
109571417  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
109571760  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
109571856  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
109572253  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
109572496  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109572506  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
109572528  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
109572727  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
109572998  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
109573366  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
109573568  ITGA2B; integrin alpha-IIb [KO:K06476]
109573749  COL1A1; collagen alpha-1(I) chain [KO:K06236]
109573847  CRK; adapter molecule crk isoform X1 [KO:K04438]
109573916  ACTG1; actin, cytoplasmic 2 [KO:K05692]
109573971  ERBB2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
109574040  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
109574049  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
109574100  CDC42; cell division control protein 42 homolog [KO:K04393]
109574140  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
109574171  CHAD; chondroadherin [KO:K06248]
109574210  ITGA3; integrin alpha-3 [KO:K06482]
109574290  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
109574379  VTN; vitronectin [KO:K06251]
109574799  ITGA1; integrin alpha-1 [KO:K06480]
109574805  PIK3R1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
109574862  ITGA2; integrin alpha-2 [KO:K06481]
109575129  [KO:K05087] [EC:2.7.10.1]
109575210  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
109575777  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
109575885  [KO:K06243]
109575895  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
109575927  [KO:K06243]
109576011  FLNB; filamin-B isoform X1 [KO:K27392]
109576048  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
109576053  RAF1; LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
109576112  CTNNB1; catenin beta-1 [KO:K02105]
109576171  RHOA; transforming protein RhoA [KO:K04513]
109576217  ITGA9; integrin alpha-9 [KO:K06585]
109576337  CAV3; caveolin-3 [KO:K12959]
109576576  VEGFA; LOW QUALITY PROTEIN: vascular endothelial growth factor A [KO:K05448]
109576847  TNXB; tenascin-X [KO:K06252]
109577151  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
109577322  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
109577653  [KO:K06240]
109577655  [KO:K06240]
109577666  LAMA1; laminin subunit alpha-1 [KO:K05637]
109577777  [KO:K12757]
109577779  [KO:K12757]
109577782  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
109577829  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
109578066  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
109578171  MYL10; myosin regulatory light chain 10 [KO:K12756]
109578192  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109578361  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
109578517  EMP2; epithelial membrane protein 2 [KO:K26256]
109578544  ACTB; actin, cytoplasmic 1 [KO:K05692]
109578560  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
109578611  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
109578667  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
biu04010  MAPK signaling pathway
biu04060  Cytokine-cytokine receptor interaction
biu04070  Phosphatidylinositol signaling system
biu04110  Cell cycle
biu04151  PI3K-Akt signaling pathway
biu04310  Wnt signaling pathway
biu04512  ECM-receptor interaction
biu04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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