KEGG   PATHWAY: bta00830
Entry
bta00830                    Pathway                                
Name
Retinol metabolism - Bos taurus (cow)
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
bta00830  Retinol metabolism
bta00830

Other DBs
GO: 0006776
Organism
Bos taurus (cow) [GN:bta]
Gene
100138004  [KO:K00699] [EC:2.4.1.17]
100138638  [KO:K11154] [EC:1.1.1.-]
100138908  [KO:K00699] [EC:2.4.1.17]
100139075  [KO:K11154] [EC:1.1.1.-]
100140261  [KO:K00699] [EC:2.4.1.17]
100296421  [KO:K00699] [EC:2.4.1.17]
281285  LRAT; lecithin retinol acyltransferase [KO:K00678] [EC:2.3.1.135]
281360  DHRS4; dehydrogenase/reductase SDR family member 4 [KO:K11147] [EC:1.1.-.-]
281448  RDH5; retinol dehydrogenase 5 precursor [KO:K00061] [EC:1.1.1.315]
281449  RDH8; retinol dehydrogenase 8 [KO:K11150] [EC:1.1.1.-]
281482  DHRS3; short-chain dehydrogenase/reductase 3 [KO:K11146] [EC:1.1.1.300]
281615  ALDH1A1; aldehyde dehydrogenase 1A1 [KO:K07249] [EC:1.2.1.36]
282043  RPE65; retinoid isomerohydrolase [KO:K11158] [EC:3.1.1.64 5.3.3.22]
282214  CYP3A28; cytochrome P450 3A28 [KO:K07424] [EC:1.14.14.1]
282609  DGAT1; diacylglycerol O-acyltransferase 1 [KO:K11155] [EC:2.3.1.20 2.3.1.75 2.3.1.76]
282851  DHRS9; dehydrogenase/reductase SDR family member 9 precursor [KO:K11149] [EC:1.1.-.-]
282852  RDH10; retinol dehydrogenase 10 [KO:K11151] [EC:1.1.1.-]
282870  CYP1A1; cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
286792  UGT1A6; UDP-glucuronosyltransferase 1-6 precursor [KO:K00699] [EC:2.4.1.17]
338074  AOX1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
369021  RDH12; retinol dehydrogenase 12 precursor [KO:K11153] [EC:1.1.1.300]
503552  CYP1A2; cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
504769  CYP2B6; cytochrome P450 family 2 subfamily B member 6 precursor [KO:K07412] [EC:1.14.14.1]
505468  CYP2C88; cytochrome P450 2C19 [KO:K07413] [EC:1.14.14.1]
505515  ADH5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
505995  RDH11; retinol dehydrogenase 11 isoform X1 [KO:K11152] [EC:1.1.1.300]
507093  ALDH1A3; retinaldehyde dehydrogenase 3 [KO:K07249] [EC:1.2.1.36]
507988  CYP3A74; cytochrome P450 family 3 subfamily A member 74 [KO:K07424] [EC:1.14.14.1]
508082  RDH13; retinol dehydrogenase 13 [KO:K11161] [EC:1.1.1.300]
509744  ADH1C; alcohol dehydrogenase 1C [KO:K13951] [EC:1.1.1.1]
510380  CYP2C89; cytochrome P450 family 2 subfamily C member 89 [KO:K07413] [EC:1.14.14.1]
510551  ADH6; alcohol dehydrogenase 6 [KO:K13952] [EC:1.1.1.1]
511498  CYP2C23; cytochrome P450 family 2 subfamily C member 23 [KO:K07413] [EC:1.14.14.1]
511743  UGT2A1; UDP-glucuronosyltransferase 2A1 precursor [KO:K00699] [EC:2.4.1.17]
511890  CYP4A11; cytochrome P450, family 4, subfamily A, polypeptide 11 [KO:K07425] [EC:1.14.14.80]
514971  CYP2S1; cytochrome P450 family 2 subfamily S member 1 precursor [KO:K07420] [EC:1.14.14.1]
515638  MGC152010; UDP glucuronosyltransferase 2 family precursor [KO:K00699] [EC:2.4.1.17]
516085  CYP4A22; cytochrome P450, family 4, subfamily A, polypeptide 22 [KO:K07425] [EC:1.14.14.80]
517246  CYP3A24; cytochrome P450 3A24 isoform X1 [KO:K07424] [EC:1.14.14.1]
518393  AOX4; aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
519940  RDH16; retinol dehydrogenase 16 [KO:K11154] [EC:1.1.1.-]
520508  ADH4; all-trans-retinol dehydrogenase [NAD(+)] ADH4 [KO:K13980] [EC:1.1.1.1]
521298  AWAT2; acyl-CoA wax alcohol acyltransferase 2 [KO:K11156] [EC:2.3.1.75 2.3.1.76]
526682  CYP3A76; cytochrome P450 family 3 subfamily A member 76 [KO:K07424] [EC:1.14.14.1]
526726  SDR16C5; epidermal retinol dehydrogenase 2 [KO:K15734] [EC:1.1.1.105]
526979  [KO:K00699] [EC:2.4.1.17]
530553  [KO:K00699] [EC:2.4.1.17]
530571  CYP2B39; cytochrome P450 2B4-like [KO:K07412] [EC:1.14.14.1]
531699  AOX2; aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
533086  HSD17B6; 17-beta-hydroxysteroid dehydrogenase type 6 precursor [KO:K13369] [EC:1.1.1.62 1.1.1.105 1.1.1.239]
533587  UGT2B10; UDP glucuronosyltransferase 2 family, polypeptide B10 precursor [KO:K00699] [EC:2.4.1.17]
534696  BCO1; beta,beta-carotene 15,15'-dioxygenase [KO:K00515] [EC:1.13.11.63]
534808  ADH7; LOW QUALITY PROTEIN: all-trans-retinol dehydrogenase [NAD(+)] ADH7 [KO:K13951] [EC:1.1.1.1]
535075  ALDH1A2; retinal dehydrogenase 2 [KO:K07249] [EC:1.2.1.36]
535243  CYP2C90; cytochrome P450 family 2 subfamily C member 90 precursor [KO:K07413] [EC:1.14.14.1]
539047  CYP26A1; cytochrome P450, family 26, subfamily A, polypeptide 1 isoform 1 [KO:K07437] [EC:1.14.14.-]
539048  CYP26C1; cytochrome P450 26C1 [KO:K12665] [EC:1.14.14.-]
540544  [KO:K00699] [EC:2.4.1.17]
540615  [KO:K00699] [EC:2.4.1.17]
540707  CYP2A13; cytochrome P450 2A13 [KO:K07411] [EC:1.14.14.1]
540868  CYP26B1; cytochrome P450 26B1 [KO:K12664] [EC:1.14.14.-]
614455  RETSAT; all-trans-retinol 13,14-reductase precursor [KO:K09516] [EC:1.3.99.23]
615303  [KO:K00699] [EC:2.4.1.17]
616593  CYP2C87; cytochrome P450 family 2 subfamily C member 87 precursor [KO:K07413] [EC:1.14.14.1]
617338  CYP27C1; cytochrome P450 27C1 [KO:K17951] [EC:1.14.19.53]
618939  CYP2W1; cytochrome P450 2W1 [KO:K07423] [EC:1.14.14.-]
751790  UGT1A1; UDP-glucuronosyltransferase 1-1 precursor [KO:K00699] [EC:2.4.1.17]
781988  [KO:K00699] [EC:2.4.1.17]
782370  [KO:K00699] [EC:2.4.1.17]
784417  CYP4A59; cytochrome P450 4A25 isoform X1 [KO:K07425] [EC:1.14.14.80]
785540  CYP2C281; cytochrome P450 2C31 [KO:K07413] [EC:1.14.14.1]
785567  PNPLA4; patatin-like phospholipase domain-containing protein 4 [KO:K11157] [EC:3.1.1.-]
Compound
C00376  Retinal
C00473  Retinol
C00777  Retinoate
C00778  Rhodopsin
C00899  11-cis-Retinol
C02075  Retinyl ester
C02094  beta-Carotene
C02110  11-cis-Retinal
C02588  Retinyl palmitate
C03455  11-cis-Retinyl palmitate
C05914  Bathorhodopsin
C05915  Lumirhodopsin
C05916  Metarhodopsin
C05917  Iodopsin
C11061  all-trans-Retinoyl-beta-glucuronide
C15492  all-trans-13,14-Dihydroretinol
C15493  9-cis-Retinoic acid
C16677  all-trans-4-Hydroxyretinoic acid
C16678  all-trans-4-Oxoretinoic acid
C16679  all-trans-18-Hydroxyretinoic acid
C16680  all-trans-5,6-Epoxyretinoic acid
C16681  9-cis-Retinal
C16682  9-cis-Retinol
C16683  4-Oxoretinol
C21797  all-trans-3,4-Didehydroretinol
Reference
PMID:16968212
  Authors
Travis GH, Golczak M, Moise AR, Palczewski K.
  Title
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.
  Journal
Annu Rev Pharmacol Toxicol 47:469-512 (2007)
DOI:10.1146/annurev.pharmtox.47.120505.105225
Reference
PMID:17618621
  Authors
Muniz A, Villazana-Espinoza ET, Hatch AL, Trevino SG, Allen DM, Tsin AT.
  Title
A novel cone visual cycle in the cone-dominated retina.
  Journal
Exp Eye Res 85:175-84 (2007)
DOI:10.1016/j.exer.2007.05.003
Reference
PMID:11093772
  Authors
Marill J, Cresteil T, Lanotte M, Chabot GG.
  Title
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
  Journal
Mol Pharmacol 58:1341-8 (2000)
DOI:10.1124/mol.58.6.1341
Reference
PMID:17893666
  Authors
Nezzar H, Chiambaretta F, Marceau G, Blanchon L, Faye B, Dechelotte P, Rigal D, Sapin V.
  Title
Molecular and metabolic retinoid pathways in the human ocular surface.
  Journal
Mol Vis 13:1641-50 (2007)
Reference
PMID:16688755
  Authors
Blomhoff R, Blomhoff HK.
  Title
Overview of retinoid metabolism and function.
  Journal
J Neurobiol 66:606-30 (2006)
DOI:10.1002/neu.20242
Reference
PMID:16428379
  Authors
Liden M, Eriksson U.
  Title
Understanding retinol metabolism: structure and function of retinol dehydrogenases.
  Journal
J Biol Chem 281:13001-4 (2006)
DOI:10.1074/jbc.R500027200
KO pathway
ko00830   

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