KEGG   PATHWAY: cabi04145
Entry
cabi04145                   Pathway                                
Name
Phagosome - Chelonoidis abingdonii (Abingdon island giant tortoise)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
cabi04145  Phagosome
cabi04145

Other DBs
GO: 0045335
Organism
Chelonoidis abingdonii (Abingdon island giant tortoise) [GN:cabi]
Gene
116814672  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
116815115  [KO:K06461]
116815626  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
116815630  [KO:K07374]
116815693  [KO:K08009]
116816073  THBS4; thrombospondin-4 [KO:K04659]
116816078  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
116816112  EEA1; early endosome antigen 1 isoform X1 [KO:K12478]
116816403  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
116816727  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
116817195  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
116817239  THBS3; LOW QUALITY PROTEIN: thrombospondin-3 [KO:K04659]
116817560  ACTB; actin, cytoplasmic 1 [KO:K05692]
116817621  [KO:K01368] [EC:3.4.22.27]
116817622  [KO:K01368] [EC:3.4.22.27]
116817623  [KO:K01368] [EC:3.4.22.27]
116817624  [KO:K01368] [EC:3.4.22.27]
116818142  [KO:K03662]
116818731  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
116818741  [KO:K10789] [EC:1.11.2.2]
116818742  [KO:K10789] [EC:1.11.2.2]
116818832  MSR1; macrophage scavenger receptor types I and II [KO:K06558]
116819286  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
116819351  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
116819521  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
116819573  TUBB3; tubulin beta-3 chain [KO:K07375]
116819599  [KO:K05692]
116819754  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
116819868  [KO:K21421] [EC:1.-.-.-]
116820060  CANX; calnexin isoform X1 [KO:K08054]
116820369  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
116820418  [KO:K06560]
116820470  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
116820837  [KO:K05692]
116820873  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
116821038  C1R; complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
116821463  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
116821480  ATP6V1D; V-type proton ATPase subunit D isoform X1 [KO:K02149]
116821634  [KO:K01365] [EC:3.4.22.15]
116821653  [KO:K05654] [EC:7.4.2.14]
116821654  [KO:K05654] [EC:7.4.2.14]
116821655  [KO:K06751]
116821656  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
116821657  [KO:K06752]
116821659  [KO:K06752]
116821665  [KO:K06751]
116821668  [KO:K06752]
116821850  [KO:K10169]
116822103  [KO:K06752]
116822136  STX18; syntaxin-18 isoform X1 [KO:K08492]
116822168  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
116823011  TFRC; transferrin receptor protein 1 [KO:K06503]
116823070  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
116823155  CALR3; calreticulin-3 [KO:K08057]
116823347  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
116823629  SEC22B; vesicle-trafficking protein SEC22b isoform X1 [KO:K08517]
116823848  M6PR; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
116824075  [KO:K10159]
116824076  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
116824127  NCF4; neutrophil cytosol factor 4 [KO:K08012]
116824669  [KO:K07375]
116825195  THBS2; thrombospondin-2 [KO:K04659]
116825333  [KO:K02145] [EC:7.1.2.2]
116825397  [KO:K06563]
116825565  [KO:K05653] [EC:7.4.2.14]
116825567  [KO:K06751]
116825720  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
116825753  [KO:K08763]
116825787  [KO:K06563]
116825795  PLA2R1; secretory phospholipase A2 receptor [KO:K06560]
116826049  [KO:K03990]
116826099  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
116826211  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
116826249  [KO:K06560]
116826252  [KO:K06560]
116826473  [KO:K03990]
116826481  [KO:K03990]
116826549  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
116826585  [KO:K03990]
116827016  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
116827300  [KO:K13882]
116827755  [KO:K07374]
116827756  [KO:K07374]
116827766  RAB5B; ras-related protein Rab-5B [KO:K07888]
116828240  [KO:K10067]
116828241  [KO:K10067]
116828242  [KO:K10068]
116828253  [KO:K10067]
116828254  [KO:K10068]
116828255  [KO:K10068]
116828257  [KO:K03991]
116828258  [KO:K10068]
116828274  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
116828451  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
116828596  NCF1; neutrophil cytosol factor 1 [KO:K08011]
116828727  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
116828956  STX7; syntaxin-7 [KO:K08488]
116828998  ACTL8; actin-like protein 8 [KO:K05692]
116829076  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
116829465  RILP; rab-interacting lysosomal protein [KO:K13883]
116829589  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X1 [KO:K02146]
116829838  [KO:K06560]
116829886  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
116829922  RAB5C; ras-related protein Rab-5C [KO:K07889]
116830088  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
116830202  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
116830675  [KO:K07374]
116830764  [KO:K07375]
116830818  CALR; calreticulin [KO:K08057]
116830888  [KO:K03990]
116830957  [KO:K06752]
116830961  [KO:K06751]
116831239  COLEC11; collectin-11 isoform X1 [KO:K10066]
116831306  SCARB1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
116831350  ITGAV; integrin alpha-V [KO:K06487]
116831562  [KO:K07374]
116831845  [KO:K10159]
116831987  COLEC12; collectin-12 [KO:K10062]
116832074  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
116832413  [KO:K06752]
116832637  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
116832757  [KO:K06752]
116832909  MARCO; macrophage receptor MARCO [KO:K13884]
116833203  ITGB5; integrin beta-5 [KO:K06588]
116833446  [KO:K06751]
116833535  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
116834747  [KO:K05692]
116834818  ACTG1; actin, cytoplasmic 2 [KO:K05692]
116835049  [KO:K06752]
116835050  [KO:K07374]
116835051  [KO:K07374]
116835056  [KO:K07374]
116835058  [KO:K06752]
116835059  [KO:K06752]
116835169  TLR4; toll-like receptor 4 [KO:K10160]
116835187  ATP6V1G1; LOW QUALITY PROTEIN: V-type proton ATPase subunit G 1 [KO:K02152]
116835459  SEC61A2; protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956]
116835510  [KO:K07375]
116835511  [KO:K07375]
116835793  ITGA2; LOW QUALITY PROTEIN: integrin alpha-2 [KO:K06481]
116835873  ITGB1; integrin beta-1 [KO:K05719]
116835894  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
116835979  TUBB; tubulin beta chain [KO:K07375]
116836030  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit isoform X1 [KO:K02155]
116836202  [KO:K06752]
116836203  [KO:K06752]
116836264  [KO:K05692]
116836306  [KO:K05692]
116836436  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
116836712  ATP6V0A2; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
116837147  RAB7A; ras-related protein Rab-7a [KO:K07897]
116837246  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
116837569  CD36; platelet glycoprotein 4 [KO:K06259]
116837603  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116837621  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
116837659  DYNC2H1; LOW QUALITY PROTEIN: cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
116837806  THBS1; thrombospondin-1 [KO:K16857]
116837900  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
116837933  [KO:K01365] [EC:3.4.22.15]
116838496  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
116838520  [KO:K06751]
116838521  [KO:K06751]
116839424  [KO:K05692]
116839499  MRC2; C-type mannose receptor 2 isoform X1 [KO:K06560]
116839510  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
116839782  STX12; syntaxin-12 [KO:K13813]
116839814  [KO:K06751]
116839815  [KO:K06752]
116839829  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
116839928  [KO:K07374]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
cabi04142  Lysosome
cabi04144  Endocytosis
cabi04620  Toll-like receptor signaling pathway
KO pathway
ko04145   

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