KEGG   PATHWAY: cabi04540
Entry
cabi04540                   Pathway                                
Name
Gap junction - Chelonoidis abingdonii (Abingdon island giant tortoise)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
cabi04540  Gap junction
cabi04540

Other DBs
GO: 0005921
Organism
Chelonoidis abingdonii (Abingdon island giant tortoise) [GN:cabi]
Gene
116814598  GJA1; gap junction alpha-1 protein [KO:K07372]
116814990  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
116815626  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
116815630  [KO:K07374]
116815722  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
116816034  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
116816166  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
116816657  [KO:K12319] [EC:4.6.1.2]
116816669  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
116816696  [KO:K04632]
116816930  NRAS; GTPase NRas [KO:K07828]
116817304  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
116817358  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
116817901  [KO:K04345] [EC:2.7.11.11]
116818020  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
116818083  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
116818245  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116819019  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116819340  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116819401  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
116819573  TUBB3; tubulin beta-3 chain [KO:K07375]
116819978  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
116820235  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116820748  HRAS; GTPase HRas [KO:K02833]
116820850  DRD2; D(2) dopamine receptor [KO:K04145]
116821225  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
116821649  GJD2; gap junction delta-2 protein [KO:K07373]
116821746  ADRB1; beta-1 adrenergic receptor [KO:K04141]
116822117  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
116822411  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
116822526  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
116822806  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116822994  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
116823168  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
116823406  [KO:K12319] [EC:4.6.1.2]
116824085  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X1 [KO:K12318] [EC:4.6.1.2]
116824086  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
116824088  PDGFC; platelet-derived growth factor C [KO:K05450]
116824200  [KO:K04289]
116824426  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
116824631  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
116824669  [KO:K07375]
116825420  [KO:K04345] [EC:2.7.11.11]
116825535  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
116826053  GNAS; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
116826099  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
116826976  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
116827043  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
116827248  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
116827431  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
116827755  [KO:K07374]
116827756  [KO:K07374]
116827794  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
116828360  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
116828386  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
116830202  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
116830341  KRAS; GTPase KRas isoform X1 [KO:K07827]
116830643  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
116830675  [KO:K07374]
116830764  [KO:K07375]
116830805  [KO:K04634]
116830876  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
116830980  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
116831075  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
116831562  [KO:K07374]
116831620  CSNK1D; casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
116832265  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
116832380  [KO:K19663] [EC:2.7.11.13]
116832636  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
116833187  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
116833851  [KO:K07373]
116834011  [KO:K05858] [EC:3.1.4.11]
116834610  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
116834742  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
116835050  [KO:K07374]
116835051  [KO:K07374]
116835056  [KO:K07374]
116835510  [KO:K07375]
116835511  [KO:K07375]
116835748  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116835979  TUBB; tubulin beta chain [KO:K07375]
116836010  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
116836173  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
116836497  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
116837250  DRD1; D(1A) dopamine receptor [KO:K04144]
116837565  [KO:K04630]
116837811  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
116838816  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
116839023  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
116839928  [KO:K07374]
116840087  [KO:K07827]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
PMID:14506308
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
PMID:15033580
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
PMID:10751659
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
PMID:10873290
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
PMID:12566218
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
PMID:15094344
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
PMID:15955302
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
PMID:15033579
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
PMID:15033578
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
cabi04010  MAPK signaling pathway
cabi04020  Calcium signaling pathway
cabi04060  Cytokine-cytokine receptor interaction
cabi04070  Phosphatidylinositol signaling system
cabi04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   

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