KEGG   PATHWAY: cabi04020
Entry
cabi04020                   Pathway                                
Name
Calcium signaling pathway - Chelonoidis abingdonii (Abingdon island giant tortoise)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
cabi04020  Calcium signaling pathway
cabi04020

Other DBs
GO: 0019722
Organism
Chelonoidis abingdonii (Abingdon island giant tortoise) [GN:cabi]
Gene
116814680  TRHR; thyrotropin-releasing hormone receptor isoform X1 [KO:K04282]
116814810  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
116814921  PTGFR; prostaglandin F2-alpha receptor isoform X1 [KO:K04262]
116814990  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
116815032  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116815054  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
116815071  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
116815119  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
116815149  [KO:K01116] [EC:3.1.4.11]
116815240  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
116815509  ORAI3; protein orai-3 [KO:K16058]
116815701  [KO:K04282]
116815708  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
116815736  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
116816012  TGFA; protransforming growth factor alpha [KO:K08774]
116816028  [KO:K04963]
116816175  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
116816233  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
116816553  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
116816696  [KO:K04632]
116816699  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
116816737  [KO:K04137]
116816818  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
116816893  CALM1; calmodulin-1 [KO:K02183]
116817183  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
116817222  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
116817263  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
116817304  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
116817342  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
116817379  [KO:K04282]
116817612  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
116817734  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
116817796  [KO:K10784]
116817847  TFEB; transcription factor EB isoform X1 [KO:K15590]
116817867  P2RX2; LOW QUALITY PROTEIN: P2X purinoceptor 2 [KO:K05216]
116817874  TPCN1; two pore calcium channel protein 1 [KO:K16896]
116817900  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
116817901  [KO:K04345] [EC:2.7.11.11]
116817973  [KO:K23450]
116818020  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
116818071  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116818083  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
116818102  FGF18; fibroblast growth factor 18 [KO:K04358]
116818114  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
116818183  CALM2; calmodulin-2 [KO:K02183]
116818243  ASPH; aspartyl/asparaginyl beta-hydroxylase [KO:K00476] [EC:1.14.11.16]
116818245  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116818340  FGF1; fibroblast growth factor 1 [KO:K18496]
116818402  [KO:K04266]
116818483  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
116818534  BDKRB2; B2 bradykinin receptor [KO:K03916]
116818819  [KO:K04222]
116818831  FGF20; fibroblast growth factor 20 [KO:K04358]
116818933  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
116819036  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
116819067  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
116819290  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
116819340  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116819401  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
116819442  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
116819796  [KO:K05096] [EC:2.7.10.1]
116819953  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
116819978  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
116820037  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
116820420  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
116820562  HRH1; histamine H1 receptor [KO:K04149]
116820944  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
116821059  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
116821211  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
116821225  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
116821295  F2R; proteinase-activated receptor 1 [KO:K03914]
116821327  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
116821412  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
116821536  NFATC4; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
116821746  ADRB1; beta-1 adrenergic receptor [KO:K04141]
116821847  GRPR; gastrin-releasing peptide receptor [KO:K04169]
116822049  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
116822120  FGF6; fibroblast growth factor 6 [KO:K04358]
116822121  FGF23; fibroblast growth factor 23 [KO:K22428]
116822139  DRD5; D(1B) dopamine receptor [KO:K05840]
116822352  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
116822411  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
116822526  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
116822553  FGF3; fibroblast growth factor 3 [KO:K04358]
116822675  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
116822994  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
116823168  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
116823465  ORAI2; protein orai-2 isoform X1 [KO:K16057]
116823503  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
116823552  [KO:K04222]
116823615  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
116823756  FGF9; fibroblast growth factor 9 [KO:K04358]
116823939  [KO:K04853]
116823980  [KO:K00476] [EC:1.14.11.16]
116824088  PDGFC; platelet-derived growth factor C [KO:K05450]
116824205  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
116824334  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
116824466  GNA15; guanine nucleotide-binding protein subunit alpha-15 isoform X1 [KO:K04637]
116824527  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
116824631  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
116824639  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
116824763  [KO:K04809]
116824876  [KO:K05849]
116824906  PLN; cardiac phospholamban [KO:K05852]
116824917  [KO:K04226]
116825183  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
116825297  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
116825358  [KO:K04515] [EC:2.7.11.17]
116825412  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
116825420  [KO:K04345] [EC:2.7.11.11]
116825535  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
116825876  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
116826031  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
116826036  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
116826053  GNAS; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
116826163  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
116826290  [KO:K05094] [EC:2.7.10.1]
116826457  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
116826638  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
116826662  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
116826700  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
116826800  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
116826851  TRDN; triadin [KO:K23449]
116826923  [KO:K04150]
116826976  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
116827029  OXTR; oxytocin receptor [KO:K04229]
116827036  ADORA2B; adenosine receptor A2b [KO:K04267]
116827043  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
116827141  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
116827248  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
116827504  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
116827529  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
116827662  CYSLTR2; cysteinyl leukotriene receptor 2 isoform X1 [KO:K04323]
116827810  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
116827815  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
116827918  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
116827987  P2RX3; P2X purinoceptor 3 isoform X1 [KO:K05217]
116828106  GRIN3B; glutamate receptor ionotropic, NMDA 3B isoform X1 [KO:K05214]
116828184  RYR2; ryanodine receptor 2 [KO:K04962]
116828262  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
116828272  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
116828360  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
116828574  [KO:K04143]
116828613  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
116828614  P2RX1; P2X purinoceptor 1 isoform X1 [KO:K05215]
116828657  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
116828860  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
116828863  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
116829087  FGF16; fibroblast growth factor 16 [KO:K04358]
116829285  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
116829505  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
116829677  [KO:K05863]
116830109  HRH2; histamine H2 receptor [KO:K04150]
116830148  [KO:K05869] [EC:2.7.11.17]
116830171  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
116830190  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
116830490  ADRB2; beta-2 adrenergic receptor [KO:K04142]
116830643  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
116830742  [KO:K05099] [EC:2.7.10.1]
116830754  [KO:K05850] [EC:7.2.2.10]
116830805  [KO:K04634]
116830809  [KO:K04636]
116830876  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
116830885  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
116830989  SLN; sarcolipin [KO:K22642]
116831198  TNNC2; troponin C, skeletal muscle isoform X1 [KO:K12042]
116831381  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
116831529  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
116831884  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
116831942  MST1; LOW QUALITY PROTEIN: hepatocyte growth factor-like protein [KO:K23441]
116832025  [KO:K00907] [EC:2.7.11.18]
116832045  AVPR1B; vasopressin V1b receptor [KO:K04227]
116832231  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
116832362  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
116832379  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
116832380  [KO:K19663] [EC:2.7.11.13]
116832403  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
116832476  EDNRA; endothelin-1 receptor [KO:K04197]
116832542  TBXA2R; thromboxane A2 receptor [KO:K04264]
116832636  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
116832819  ITPKA; inositol-trisphosphate 3-kinase A isoform X1 [KO:K00911] [EC:2.7.1.127]
116832888  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
116832904  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
116832913  [KO:K04161]
116832981  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
116833072  TACR3; neuromedin-K receptor [KO:K04224]
116833113  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
116833117  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
116833187  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
116833219  [KO:K04198]
116833239  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
116833533  [KO:K05850] [EC:7.2.2.10]
116833592  TACR2; LOW QUALITY PROTEIN: substance-K receptor [KO:K04223]
116833741  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
116833966  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
116834011  [KO:K05858] [EC:3.1.4.11]
116834151  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
116834210  [KO:K13242] [EC:1.14.13.39]
116834229  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
116834314  CASQ1; LOW QUALITY PROTEIN: calsequestrin-1 [KO:K23468]
116834346  [KO:K04850]
116834610  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
116834624  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
116834662  [KO:K00907] [EC:2.7.11.18]
116834664  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
116834714  CYSLTR1; cysteinyl leukotriene receptor 1 isoform X1 [KO:K04322]
116834732  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
116834738  [KO:K05869] [EC:2.7.11.17]
116834788  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
116834972  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
116835238  CALM3; calmodulin-3 [KO:K02183]
116835397  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
116835455  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
116835748  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116835750  MCOLN2; mucolipin-2 [KO:K04993]
116835754  MCOLN3; mucolipin-3 [KO:K04994]
116836199  HGF; hepatocyte growth factor [KO:K05460]
116836353  CASQ2; calsequestrin-2 [KO:K23445]
116836436  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
116836472  EDNRB; endothelin receptor type B [KO:K04198]
116836497  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
116836651  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
116836721  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
116836785  [KO:K05220]
116836787  [KO:K05218]
116836801  ORAI1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
116836884  [KO:K05840]
116836897  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116836905  FGF17; fibroblast growth factor 17 [KO:K04358]
116837131  ADORA2A; adenosine receptor A2a [KO:K04266]
116837142  FGF4; fibroblast growth factor 4 [KO:K04358]
116837143  FGF19; fibroblast growth factor 19 [KO:K22603]
116837250  DRD1; D(1A) dopamine receptor [KO:K04144]
116837308  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
116837706  NTSR1; neurotensin receptor type 1 [KO:K04211]
116837811  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
116837850  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
116838081  [KO:K04163]
116838637  FGF22; fibroblast growth factor 22 [KO:K04358]
116838655  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
116838746  [KO:K04851]
116838786  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
116838811  VEGFB; vascular endothelial growth factor B [KO:K05448]
116838816  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
116838819  [KO:K05849]
116838844  [KO:K02183]
116838917  [KO:K05849]
116839023  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
116839037  LTB4R2; leukotriene B4 receptor 2 isoform X1 [KO:K04297]
116839405  FGF10; fibroblast growth factor 10 [KO:K04358]
116839704  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
116839779  PTAFR; platelet-activating factor receptor [KO:K04279]
116839818  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
116839939  AGTR1; type-1 angiotensin II receptor [KO:K04166]
116840043  FGF21; fibroblast growth factor 21 [KO:K22429]
116840111  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
116840138  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
116840175  STIM2; stromal interaction molecule 2 [KO:K18196]
116840177  CCKAR; cholecystokinin receptor type A [KO:K04194]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
cabi04010  MAPK signaling pathway
cabi04070  Phosphatidylinositol signaling system
cabi04210  Apoptosis
KO pathway
ko04020   

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