KEGG   PATHWAY: cgib00600
Entry
cgib00600                   Pathway                                
Name
Sphingolipid metabolism - Carassius gibelio (silver crucian carp)
Class
Metabolism; Lipid metabolism
Pathway map
cgib00600  Sphingolipid metabolism
cgib00600

Module
cgib_M00066  Lactosylceramide biosynthesis [PATH:cgib00600]
cgib_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:cgib00600]
cgib_M00094  Ceramide biosynthesis [PATH:cgib00600]
cgib_M00099  Sphingosine biosynthesis [PATH:cgib00600]
cgib_M00100  Sphingosine degradation [PATH:cgib00600]
Other DBs
GO: 0006665
Organism
Carassius gibelio (silver crucian carp) [GN:cgib]
Gene
127983799  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
127966831  serine palmitoyltransferase 1 [KO:K00654] [EC:2.3.1.50]
127976305  serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
127938355  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
127969625  serine palmitoyltransferase 3 [KO:K00654] [EC:2.3.1.50]
128021442  serine palmitoyltransferase 1-like isoform X1 [KO:K00654] [EC:2.3.1.50]
128031713  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
128026057  serine palmitoyltransferase 3-like [KO:K00654] [EC:2.3.1.50]
127951064  3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
128025200  3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
127942835  ceramide synthase 1-like isoform X1 [KO:K04710] [EC:2.3.1.299]
127987482  ceramide synthase 1-like [KO:K04710] [EC:2.3.1.299]
127942805  ceramide synthase 4a [KO:K24621] [EC:2.3.1.297]
127975447  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
127935326  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
127938313  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
127950578  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
127978550  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
128030916  ceramide synthase 2 isoform X1 [KO:K24621] [EC:2.3.1.297]
127987291  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
127962031  ceramide synthase 2-like [KO:K24622] [EC:2.3.1.297 2.3.1.298]
127933777  ceramide synthase 2-like isoform X1 [KO:K24622] [EC:2.3.1.297 2.3.1.298]
127976940  ceramide synthase 2 isoform X1 [KO:K24622] [EC:2.3.1.297 2.3.1.298]
128017385  ceramide synthase 2-like isoform X1 [KO:K24622] [EC:2.3.1.297 2.3.1.298]
127942858  ceramide synthase 5-like [KO:K23727] [EC:2.3.1.291]
127965543  ceramide synthase 6-like [KO:K23727] [EC:2.3.1.291]
127988163  ceramide synthase 5 [KO:K23727] [EC:2.3.1.291]
128020071  ceramide synthase 6 [KO:K23727] [EC:2.3.1.291]
127971973  N-acylsphingosine amidohydrolase (acid ceramidase) 1a [KO:K12348] [EC:3.5.1.23]
127948605  acid ceramidase [KO:K12348] [EC:3.5.1.23]
127968705  acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
128026988  acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
128024995  neutral ceramidase isoform X1 [KO:K12349] [EC:3.5.1.23]
127961810  alkaline ceramidase 2 [KO:K01441] [EC:3.5.1.23]
127963909  alkaline ceramidase 1 [KO:K01441] [EC:3.5.1.23]
128016443  alkaline ceramidase 2-like [KO:K01441] [EC:3.5.1.23]
127966815  alkaline ceramidase 3-like [KO:K04711] [EC:3.5.1.-]
128020976  alkaline ceramidase 3-like [KO:K04711] [EC:3.5.1.-]
127970523  sphingolipid delta(4)-desaturase DES1-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
127976755  sphingolipid delta(4)-desaturase/C4-monooxygenase DES2-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
128031775  sphingolipid delta(4)-desaturase/C4-monooxygenase DES2-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
128026536  sphingolipid delta(4)-desaturase DES1-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
127933305  phosphatidylcholine:ceramide cholinephosphotransferase 1-like [KO:K04714] [EC:2.7.8.27]
127945883  phosphatidylcholine:ceramide cholinephosphotransferase 2-like [KO:K04714] [EC:2.7.8.27]
127976272  phosphatidylcholine:ceramide cholinephosphotransferase 1-like [KO:K04714] [EC:2.7.8.27]
127948989  phosphatidylcholine:ceramide cholinephosphotransferase 2-like [KO:K04714] [EC:2.7.8.27]
127968995  phosphatidylcholine:ceramide cholinephosphotransferase 1-like [KO:K04714] [EC:2.7.8.27]
128025003  phosphatidylcholine:ceramide cholinephosphotransferase 1-like [KO:K04714] [EC:2.7.8.27]
127966622  sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
128021204  sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]
127945164  sphingomyelin phosphodiesterase 2-like [KO:K12351] [EC:3.1.4.12]
127960146  sphingomyelin phosphodiesterase 2 [KO:K12351] [EC:3.1.4.12]
128011970  sphingomyelin phosphodiesterase 2-like [KO:K12351] [EC:3.1.4.12]
127974944  sphingomyelin phosphodiesterase 5 [KO:K12352] [EC:3.1.4.12]
127947462  sphingomyelin phosphodiesterase 3-like [KO:K12352] [EC:3.1.4.12]
128014702  sphingomyelin phosphodiesterase 3-like [KO:K12352] [EC:3.1.4.12]
128030294  sphingomyelin phosphodiesterase 5-like [KO:K12352] [EC:3.1.4.12]
127941896  sphingomyelin phosphodiesterase 4-like isoform X1 [KO:K12353] [EC:3.1.4.12]
127942064  sphingomyelin phosphodiesterase 4-like isoform X1 [KO:K12353] [EC:3.1.4.12]
127986170  sphingomyelin phosphodiesterase 4 isoform X1 [KO:K12353] [EC:3.1.4.12]
127968877  ectonucleotide pyrophosphatase/phosphodiesterase family member 7 [KO:K12354] [EC:3.1.4.12]
127938295  zgc:153896; ectonucleotide pyrophosphatase/phosphodiesterase family member 7 [KO:K12354] [EC:3.1.4.12]
128025615  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
127944187  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
127972266  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
127956943  ceramide kinase [KO:K04715] [EC:2.7.1.138]
128011089  ceramide kinase-like isoform X1 [KO:K04715] [EC:2.7.1.138]
127942550  phospholipid phosphatase 2-like isoform X1 [KO:K01080] [EC:3.1.3.4]
127963387  phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
127983909  phospholipid phosphatase 3-like isoform X1 [KO:K01080] [EC:3.1.3.4]
127953224  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
127953425  phosphatidic acid phosphatase type 2D isoform X1 [KO:K01080] [EC:3.1.3.4]
127966667  phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
127937531  phospholipid phosphatase 2-like isoform X1 [KO:K01080] [EC:3.1.3.4]
127938725  phospholipid phosphatase 3-like isoform X1 [KO:K01080] [EC:3.1.3.4]
127950700  phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
128021388  phospholipid phosphatase 1-like isoform X1 [KO:K01080] [EC:3.1.3.4]
127988447  phospholipid phosphatase 2b [KO:K01080] [EC:3.1.3.4]
128019077  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
127938542  sphingosine-1-phosphate phosphatase 1-like [KO:K04716] [EC:3.1.3.-]
127970182  sphingosine-1-phosphate phosphatase 1 [KO:K04716] [EC:3.1.3.-]
127984425  sphingosine-1-phosphate phosphatase 1-like [KO:K04716] [EC:3.1.3.-]
128025999  sphingosine-1-phosphate phosphatase 1-like [KO:K04716] [EC:3.1.3.-]
128029044  sphingosine-1-phosphate phosphatase 2 [KO:K04717] [EC:3.1.3.-]
127941919  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
127952549  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
127974964  sphingosine kinase 2-like isoform X1 [KO:K04718] [EC:2.7.1.91]
128030567  sphingosine kinase 2-like isoform X1 [KO:K04718] [EC:2.7.1.91]
127970262  sphingosine-1-phosphate lyase 1 [KO:K01634] [EC:4.1.2.27]
128026194  sphingosine-1-phosphate lyase 1-like [KO:K01634] [EC:4.1.2.27]
127966256  ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
128021528  ceramide glucosyltransferase-like [KO:K00720] [EC:2.4.1.80]
127975518  lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
127961136  non-lysosomal glucosylceramidase [KO:K17108] [EC:3.2.1.45]
128017117  non-lysosomal glucosylceramidase-like isoform X1 [KO:K17108] [EC:3.2.1.45]
127983997  beta-1,4-galactosyltransferase 6-like [KO:K07553] [EC:2.4.1.274]
127938496  beta-1,4-galactosyltransferase 6 isoform X1 [KO:K07553] [EC:2.4.1.274]
127944703  beta-1,4-galactosyltransferase 5-like [KO:K09905] [EC:2.4.1.274 2.4.1.-]
128011176  beta-1,4-galactosyltransferase 5 [KO:K09905] [EC:2.4.1.274 2.4.1.-]
128020540  beta-galactosidase [KO:K12309] [EC:3.2.1.23]
127949701  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K04628] [EC:2.4.1.47]
127960912  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K04628] [EC:2.4.1.47]
127983797  galactocerebrosidase [KO:K01202] [EC:3.2.1.46]
127976364  galactocerebrosidase [KO:K01202] [EC:3.2.1.46]
127941929  galactose-3-O-sulfotransferase 2 [KO:K01019] [EC:2.8.2.11]
127952098  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
127956997  galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
127966911  galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
127988040  galactosylceramide sulfotransferase-like isoform X1 [KO:K01019] [EC:2.8.2.11]
127934008  arylsulfatase A-like [KO:K01134] [EC:3.1.6.8]
127977802  arylsulfatase A-like [KO:K01134] [EC:3.1.6.8]
127978996  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
127978997  sialidase-1-like isoform X1 [KO:K01186] [EC:3.2.1.18]
127935517  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
127935518  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
127935839  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
127941604  sialidase-4-like isoform X1 [KO:K12357] [EC:3.2.1.18]
127941605  sialidase-3-like [KO:K12357] [EC:3.2.1.18]
127941607  sialidase-4-like [KO:K12357] [EC:3.2.1.18]
127985936  sialidase-3-like isoform X1 [KO:K12357] [EC:3.2.1.18]
127985939  sialidase-3-like isoform X1 [KO:K12357] [EC:3.2.1.18]
128028663  sialidase-4 [KO:K12357] [EC:3.2.1.18]
127971961  alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
128027729  alpha-galactosidase A-like [KO:K01189] [EC:3.2.1.22]
127960243  beta-1,4 N-acetylgalactosaminyltransferase 1-like [KO:K00725] [EC:2.4.1.92]
128015731  beta-1,4 N-acetylgalactosaminyltransferase 1-like [KO:K00725] [EC:2.4.1.92]
127957931  beta-hexosaminidase subunit beta-like isoform X1 [KO:K12373] [EC:3.2.1.52]
127947500  beta-hexosaminidase subunit alpha-like [KO:K12373] [EC:3.2.1.52]
128013728  beta-hexosaminidase subunit alpha-like isoform X1 [KO:K12373] [EC:3.2.1.52]
128005939  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
127971684  ganglioside GM2 activator [KO:K12383]
127970370  prosaposin [KO:K12382]
128026518  prosaposin-like [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
cgib00260  Glycine, serine and threonine metabolism
cgib00601  Glycosphingolipid biosynthesis - lacto and neolacto series
cgib00603  Glycosphingolipid biosynthesis - globo and isoglobo series
cgib00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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