KEGG   PATHWAY: chx04530
Entry
chx04530                    Pathway                                
Name
Tight junction - Capra hircus (goat)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
chx04530  Tight junction
chx04530

Other DBs
GO: 0005923
Organism
Capra hircus (goat) [GN:chx]
Gene
102189115  CRB3; protein crumbs homolog 3 [KO:K06090]
108634307  CLDN34; claudin-34 [KO:K06087]
102182828  CLDN8; claudin-8 [KO:K06087]
108634709  CLDN5; claudin-5 [KO:K06087]
102172421  CLDN2; claudin-2 [KO:K06087]
102189710  CLDN1; claudin-1 [KO:K06087]
102189431  CLDN16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
102188714  CLDN18; claudin-18 isoform X2 [KO:K06087]
102179140  CLDN14; claudin-14 [KO:K06087]
102183102  CLDN17; claudin-17 [KO:K06087]
102177753  CLDN11; claudin-11 [KO:K06087]
102177119  CLDN19; claudin-19 [KO:K06087]
102176608  CLDN20; claudin-20 [KO:K06087]
102174403  CLDN10; claudin-10 isoform X1 [KO:K06087]
102179399  CLDN25; putative claudin-25 [KO:K06087]
102188896  CLDN7; claudin-7 [KO:K06087]
102178787  CLDN3; claudin-3 [KO:K06087]
102170379  CLDN4; claudin-4 [KO:K06087]
102187730  CLDN6; claudin-6 [KO:K06087]
102188006  CLDN9; claudin-9 [KO:K06087]
102186369  claudin-22 [KO:K06087]
102186657  putative claudin-24 [KO:K06087]
102173066  CLDN23; claudin-23 [KO:K06087]
102178033  CLDN15; claudin-15 isoform X1 [KO:K06087]
102175266  CLDN12; claudin-12 [KO:K06087]
102185782  OCLN; occludin isoform X1 [KO:K06088]
102175451  F11R; junctional adhesion molecule A [KO:K06089]
102189619  JAM2; junctional adhesion molecule B isoform X1 [KO:K06735]
102170518  BVES; blood vessel epicardial substance [KO:K21108]
102188638  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102174045  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
102187092  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
102185594  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
102168546  MPP5; MAGUK p55 subfamily member 5 isoform X3 [KO:K06091]
102172672  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
102174294  TJP3; tight junction protein ZO-3 isoform X1 [KO:K06097]
102188460  PATJ; inaD-like protein isoform X1 [KO:K06092]
102168826  MPDZ; multiple PDZ domain protein isoform X1 [KO:K06095]
102186420  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
102179047  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
102188568  AMOT; angiomotin [KO:K16819]
102186136  AMOTL1; angiomotin-like protein 1 isoform X1 [KO:K06104]
102169708  AMOTL2; angiomotin-like protein 2 isoform X1 [KO:K06104]
102184969  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
102173438  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102186619  NF2; merlin isoform X1 [KO:K16684]
102173503  LLGL2; lethal(2) giant larvae protein homolog 2 isoform X1 [KO:K06094]
102181627  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
102178485  DLG1; disks large homolog 1 isoform X3 [KO:K12076]
102182705  SCRIB; LOW QUALITY PROTEIN: protein scribble homolog [KO:K16175]
102175016  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
108637886  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
102182013  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
102170070  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
102182533  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
102181952  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
102170971  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2 [KO:K04354]
102188298  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
102185098  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
102170463  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
102178667  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
102179429  TJAP1; tight junction-associated protein 1 [KO:K06105]
102169162  DLG2; disks large homolog 2 isoform X12 [KO:K12075]
102173541  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
102185187  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
102170194  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
102178031  CGN; cingulin [KO:K06102]
102182596  CGNL1; cingulin-like protein 1 isoform X1 [KO:K21110]
102181739  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
102181169  RHOA; transforming protein RhoA [KO:K04513]
102186866  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
102185948  MARVELD3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
102187530  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X2 [KO:K04416] [EC:2.7.11.25]
102182774  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102170408  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100861087  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102185423  JUN; transcription factor AP-1 [KO:K04448]
102175634  T-cell surface glycoprotein CD1a isoform X2 [KO:K06448]
102176927  CD1E; T-cell surface glycoprotein CD1e, membrane-associated [KO:K06448]
102178587  T-cell surface glycoprotein CD1b-1 [KO:K06448]
102179433  T-cell surface glycoprotein CD1b-2 [KO:K06448]
102179999  T-cell surface glycoprotein CD1a-like [KO:K06448]
102180271  antigen-presenting glycoprotein CD1d isoform X1 [KO:K06448]
102189921  LOW QUALITY PROTEIN: T-cell surface glycoprotein CD1c [KO:K06448]
102182494  T-cell surface glycoprotein CD1b-3 [KO:K06448]
102183142  T-cell surface glycoprotein CD1b-2 isoform X2 [KO:K06448]
102191288  T-cell surface glycoprotein CD1b-2-like [KO:K06448]
102168221  T-cell surface glycoprotein CD1b-2-like [KO:K06448]
108635602  T-cell surface glycoprotein CD1b-2 [KO:K06448]
102179446  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
102171306  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102183950  nuclease-sensitive element-binding protein 1-like [KO:K06099]
108634684  Y-box-binding protein 3-like [KO:K06099]
102172132  YBX3; Y-box-binding protein 3 isoform X1 [KO:K06099]
102173962  SYMPK; symplekin [KO:K06100]
102172276  PCNA; proliferating cell nuclear antigen [KO:K04802]
102169650  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102181989  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102178020  RUNX1; runt-related transcription factor 1 [KO:K08367]
102172434  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
106503247  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
102181781  EZR; ezrin [KO:K08007]
102168557  RDX; radixin isoform X1 [KO:K05762]
102176772  MSN; moesin [KO:K05763]
102169016  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
100860883  ACTG1; actin, cytoplasmic 2 [KO:K05692]
102179831  ACTB; actin, cytoplasmic 1 [KO:K05692]
102174706  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
102172156  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
102173178  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
102182890  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102181434  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
102168332  CTTN; src substrate cortactin isoform X1 [KO:K06106]
102174218  ACTR2; actin-related protein 2 [KO:K17260]
108634517  actin-related protein 3 [KO:K18584]
102176276  ACTR3; actin-related protein 3 [KO:K18584]
102182759  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
102172116  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
102170108  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
102190179  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
102175884  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
106503410  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
102186774  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
102172564  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
102177840  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
102183859  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
102189153  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
102173379  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102168790  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102182649  RAB13; ras-related protein Rab-13 isoform X1 [KO:K06109]
102170412  rho guanine nucleotide exchange factor 18 [KO:K21066]
102171022  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
102181692  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
102179873  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
102172718  EPB41L4B; band 4.1-like protein 4B isoform X1 [KO:K21111]
102188214  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
102171295  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
102181338  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
102169928  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
102181705  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
100861301  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
102179737  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
102180727  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
102177371  MYH10; myosin-10 isoform X1 [KO:K10352]
102187978  MYH14; myosin-14 isoform X1 [KO:K10352]
102178047  MYH9; myosin-9 [KO:K10352]
102177493  MYH11; myosin-11 isoform X1 [KO:K10352]
102170394  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
102171409  MYL6B; myosin light chain 6B [KO:K12751]
102168967  myosin light polypeptide 6-like [KO:K12751]
102178087  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
102174891  myosin regulatory light polypeptide 9 isoform X2 [KO:K12757]
102175348  myosin regulatory light chain 12B [KO:K12757]
102179049  IGSF5; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
102178670  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X9 [KO:K05631]
106502362  SYNPO; synaptopodin isoform X1 [KO:K21112]
102179802  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
102176966  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
106503986  MICALL2; MICAL-like protein 2 isoform X1 [KO:K21068]
102180027  RAB8A; ras-related protein Rab-8A [KO:K07901]
102172357  RAB8B; ras-related protein Rab-8B [KO:K07902]
102191417  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X2 [KO:K08020]
102176930  RAP1A; ras-related protein Rap-1A [KO:K04353]
102178060  ITGB1; integrin beta-1 precursor [KO:K05719]
106502495  AFDN; afadin isoform X1 [KO:K05702]
102180039  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
102187973  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
102185723  RAP2C; ras-related protein Rap-2c [KO:K07839]
108638534  ras-related protein Rap-2c-like [KO:K07839]
102186054  MARVELD2; MARVEL domain-containing protein 2 [KO:K17291]
102173837  tubulin alpha-3 chain isoform X1 [KO:K07374]
102187765  tubulin alpha-3 chain [KO:K07374]
102187059  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
102178119  tubulin alpha-1D chain [KO:K07374]
102177846  tubulin alpha-4A chain [KO:K07374]
102176404  TUBA8; tubulin alpha-8 chain [KO:K07374]
102178426  LOW QUALITY PROTEIN: tubulin alpha-1C chain [KO:K07374]
102177410  TUBA1A; tubulin alpha-1A chain [KO:K07374]
108636002  TUBA1C; tubulin alpha-1C chain [KO:K07374]
102178700  tubulin alpha-1B chain [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
chx04520  Adherens junction
chx04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
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