KEGG   PATHWAY: chx04810
Entry
chx04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Capra hircus (goat)
Class
Cellular Processes; Cell motility
Pathway map
chx04810  Regulation of actin cytoskeleton
chx04810

Other DBs
GO: 0030036
Organism
Capra hircus (goat) [GN:chx]
Gene
100860883  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100860904  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100860973  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
100861163  MYL11; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
100861185  ITGB2; integrin beta-2 precursor [KO:K06464]
100861373  CYFIP1; LOW QUALITY PROTEIN: cytoplasmic FMR1-interacting protein 1 [KO:K05749]
102168391  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102168455  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
102168474  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
102168557  RDX; radixin isoform X1 [KO:K05762]
102168651  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102168739  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
102168896  FGF23; fibroblast growth factor 23 [KO:K22428]
102168917  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
102168934  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102169193  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
102169370  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
102169384  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102169417  ITGB3; integrin beta-3 [KO:K06493]
102169456  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
102169556  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
102169602  FGF9; fibroblast growth factor 9 [KO:K04358]
102169839  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
102169916  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102169942  FGF19; fibroblast growth factor 19 [KO:K22603]
102170108  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
102170135  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
102170206  FGF4; fibroblast growth factor 4 [KO:K04358]
102170463  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
102170587  CFL1; cofilin-1 [KO:K05765]
102170746  [KO:K05759]
102170749  C8B; complement component C8 beta chain [KO:K03998]
102170818  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
102170938  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
102170985  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
102171022  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
102171024  C8A; complement component C8 alpha chain [KO:K03997]
102171074  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
102171226  FGF5; fibroblast growth factor 5 precursor [KO:K04358]
102171251  PFN4; profilin-4 [KO:K05759]
102171273  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102171274  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
102171364  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
102171403  FGF20; fibroblast growth factor 20 [KO:K04358]
102171599  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
102171711  IQGAP2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
102172115  ITGAL; integrin alpha-L precursor [KO:K05718]
102172116  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
102172198  ITGA2; integrin alpha-2 [KO:K06481]
102172311  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
102172519  KRAS; GTPase KRas isoform X1 [KO:K07827]
102172564  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
102172607  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
102172668  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
102172761  ITGA1; integrin alpha-1 [KO:K06480]
102172767  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102173015  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
102173438  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102173608  ITGB5; integrin beta-5 [KO:K06588]
102174007  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102174051  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102174073  ITGA9; integrin alpha-9 [KO:K06585]
102174079  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
102174218  ACTR2; actin-related protein 2 [KO:K17260]
102174268  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
102174330  CRK; adapter molecule crk isoform X1 [KO:K04438]
102174339  FGF10; fibroblast growth factor 10 [KO:K04358]
102174360  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
102174457  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
102174559  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
102174669  RGCC; regulator of cell cycle RGCC [KO:K26108]
102174891  [KO:K12757]
102174978  KNG1; kininogen-1 isoform X1 [KO:K03898]
102175206  CRKL; crk-like protein [KO:K04438]
102175285  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102175326  PFN1; profilin-1 [KO:K05759]
102175345  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
102175348  [KO:K12757]
102175543  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102175884  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
102176070  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
102176115  [KO:K05759]
102176276  ACTR3; actin-related protein 3 [KO:K18584]
102176451  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
102176587  ITGA5; integrin alpha-5 [KO:K06484]
102176772  MSN; moesin [KO:K05763]
102176802  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
102176919  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102176966  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
102177011  ABI2; abl interactor 2 isoform X1 [KO:K05751]
102177024  MYL10; myosin regulatory light chain 10 [KO:K12756]
102177274  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
102177334  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
102177371  MYH10; myosin-10 isoform X1 [KO:K10352]
102177428  VAV1; proto-oncogene vav [KO:K05730]
102177435  APC2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
102177493  MYH11; myosin-11 isoform X1 [KO:K10352]
102177551  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102177680  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
102177814  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
102178047  MYH9; myosin-9 [KO:K10352]
102178060  ITGB1; integrin beta-1 precursor [KO:K05719]
102178087  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
102178097  PXN; paxillin isoform X1 [KO:K05760]
102178149  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102178396  FGF18; fibroblast growth factor 18 [KO:K04358]
102178454  FGF7; fibroblast growth factor 7 [KO:K04358]
102178569  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
102178723  PFN3; profilin-3 [KO:K05759]
102179249  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
102179261  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
102179273  FGF16; fibroblast growth factor 16 [KO:K04358]
102179293  FAM49A; protein FAM49A [KO:K27976]
102179302  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
102179343  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102179521  C6; complement component C6 isoform X1 [KO:K03995]
102179802  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
102179809  ITGAE; integrin alpha-E isoform X1 [KO:K06524]
102179831  ACTB; actin, cytoplasmic 1 [KO:K05692]
102179873  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
102180100  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
102180150  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
102180190  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
102180225  GSN; gelsolin isoform X1 [KO:K05768]
102180259  C7; complement component C7 [KO:K03996]
102180282  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
102180368  [KO:K06594]
102180381  FGF6; fibroblast growth factor 6 [KO:K04358]
102180632  CFL2; cofilin-2 [KO:K05765]
102180827  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102180910  ITGAX; integrin alpha-X [KO:K06462]
102180975  BRK1; protein BRICK1 [KO:K05752]
102181007  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102181064  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
102181169  RHOA; transforming protein RhoA [KO:K04513]
102181217  PAK5; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
102181454  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
102181571  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
102181692  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
102181695  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
102181773  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
102181781  EZR; ezrin [KO:K08007]
102181980  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
102182076  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
102182147  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
102182530  PAK4; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
102182562  [KO:K05764]
102182581  [KO:K04347]
102182617  ENAH; protein enabled homolog isoform X1 [KO:K05746]
102182645  FN1; fibronectin isoform X1 [KO:K05717]
102182759  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
102182890  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102183109  PFN2; profilin-2 isoform X1 [KO:K05759]
102183190  ITGA4; integrin alpha-4 [KO:K06483]
102183294  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
102183402  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
102183419  C5; complement C5 [KO:K03994]
102183451  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
102183685  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102183793  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
102183869  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
102183974  [KO:K03999]
102184154  SOS2; son of sevenless homolog 2 [KO:K03099]
102184232  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
102184366  RRAS; ras-related protein R-Ras [KO:K07829]
102184374  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
102184426  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
102184511  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
102184724  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
102185018  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
102185042  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102185175  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
102185194  FAM49B; protein FAM49B isoform X1 [KO:K27976]
102185415  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
102185499  ITGA3; integrin alpha-3 [KO:K06482]
102185660  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102185710  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
102185860  FGF21; fibroblast growth factor 21 [KO:K22429]
102185873  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
102186040  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102186374  NCKAP1L; nck-associated protein 1-like [KO:K05750]
102186530  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
102186592  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X2 [KO:K00889] [EC:2.7.1.68]
102186668  HRAS; GTPase HRas isoform X1 [KO:K02833]
102186774  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
102186892  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
102187022  SCIN; adseverin [KO:K05768]
102187061  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
102187119  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
102187180  NRAS; GTPase NRas [KO:K07828]
102187491  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
102187521  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102187654  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
102187707  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
102187813  ITGAV; integrin alpha-V precursor [KO:K06487]
102187843  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
102187899  BDKRB2; B2 bradykinin receptor [KO:K03916]
102187978  MYH14; myosin-14 isoform X1 [KO:K10352]
102188297  [KO:K05720]
102188466  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
102188539  ITGB6; integrin beta-6 precursor [KO:K06589]
102188638  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102188710  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102188740  VCL; vinculin isoform X1 [KO:K05700]
102188824  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102188850  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
102189196  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
102189399  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
102189645  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
102190079  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
102190179  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
102190275  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
102190345  [KO:K05748]
102190516  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
102190520  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X4 [KO:K04368] [EC:2.7.12.2]
102190641  MYLK; LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
102190712  RRAS2; ras-related protein R-Ras2 [KO:K07830]
102191175  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
102191275  C9; LOW QUALITY PROTEIN: complement component C9 [KO:K04000]
102191301  ITGB8; integrin beta-8 isoform X2 [KO:K06591]
102191777  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
102467078  TMSB4X; thymosin beta-4 [KO:K05764]
106502173  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
106503050  SSH1; protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
106503410  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
106503491  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
108633196  BDKRB1; B1 bradykinin receptor [KO:K03915]
108633307  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
108634211  FGF3; fibroblast growth factor 3 [KO:K04358]
108634241  INS; insulin [KO:K04526]
108634517  [KO:K18584]
108635132  [KO:K05741]
108638619  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
chx04010  MAPK signaling pathway
chx04510  Focal adhesion
chx04520  Adherens junction
KO pathway
ko04810   

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