KEGG   PATHWAY: chx04720
Entry
chx04720                    Pathway                                
Name
Long-term potentiation - Capra hircus (goat)
Description
Hippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippocampus induces glutamate release and activation of glutamate receptors in dendritic spines. A large increase in [Ca2+]i resulting from influx through NMDA receptors leads to constitutive activation of CaM kinase II (CaM KII) . Constitutively active CaM kinase II phosphorylates AMPA receptors, resulting in potentiation of the ionic conductance of AMPA receptors. Early-phase LTP (E-LTP) expression is due, in part, to this phosphorylation of the AMPA receptor. It is hypothesized that postsynaptic Ca2+ increases generated through NMDA receptors activate several signal transduction pathways including the Erk/MAP kinase and cAMP regulatory pathways. The convergence of these pathways at the level of the CREB/CRE transcriptional pathway may increase expression of a family of genes required for late-phase LTP (L-LTP).
Class
Organismal Systems; Nervous system
Pathway map
chx04720  Long-term potentiation
chx04720

Other DBs
GO: 0048169
Organism
Capra hircus (goat) [GN:chx]
Gene
100861292  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
102168378  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
102168790  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102169370  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
102169697  CALM3; calmodulin [KO:K02183]
102169966  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
102170858  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
102170985  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
102171059  GRIA1; glutamate receptor 1 isoform X3 [KO:K05197]
102171428  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
102172114  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
102172164  CALM2; calmodulin isoform X1 [KO:K02183]
102172519  KRAS; GTPase KRas isoform X1 [KO:K07827]
102173379  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102174360  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
102174475  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
102174543  RAP1B; ras-related protein Rap-1b [KO:K07836]
102175285  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102175311  [KO:K02183]
102175934  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
102175984  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102176303  PPP1R1A; protein phosphatase 1 regulatory subunit 1A isoform X1 [KO:K08050]
102176762  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
102176770  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102176930  RAP1A; ras-related protein Rap-1A [KO:K04353]
102177097  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
102177187  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
102177339  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
102178145  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
102179767  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102179926  [KO:K04373] [EC:2.7.11.1]
102180505  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
102180724  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
102180890  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102181064  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
102181571  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
102181789  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
102182568  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
102182602  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
102184033  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102184607  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X3 [KO:K04373] [EC:2.7.11.1]
102184768  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102184919  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
102185007  CALM1; calmodulin [KO:K02183]
102185072  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102185084  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
102185715  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
102186040  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102186668  HRAS; GTPase HRas isoform X1 [KO:K02833]
102187180  NRAS; GTPase NRas [KO:K07828]
102187248  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
102187383  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
102187484  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
102187824  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
102188092  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
102188148  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
102188824  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102189537  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
102189653  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
102189950  [KO:K04634]
102190520  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X4 [KO:K04368] [EC:2.7.12.2]
102191283  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
106502751  [KO:K02183]
108634353  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
108636054  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
108638619  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00305  Magnesium cation
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
Reference
PMID:15652868
  Authors
Blitzer RD, Iyengar R, Landau EM.
  Title
Postsynaptic signaling networks: cellular cogwheels underlying long-term plasticity.
  Journal
Biol Psychiatry 57:113-9 (2005)
DOI:10.1016/j.biopsych.2004.02.031
Reference
PMID:10652548
  Authors
Soderling TR, Derkach VA.
  Title
Postsynaptic protein phosphorylation and LTP.
  Journal
Trends Neurosci 23:75-80 (2000)
DOI:10.1016/S0166-2236(99)01490-3
Reference
PMID:11378299
  Authors
Poser S, Storm DR.
  Title
Role of Ca2+-stimulated adenylyl cyclases in LTP and memory formation.
  Journal
Int J Dev Neurosci 19:387-94 (2001)
DOI:10.1016/S0736-5748(00)00094-0
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
  Authors
Purves D, Augustine GJ (ed).
  Title
Neuroscience
  Journal
Sunderland, Mass.:Sinauer Associates (2004)
Reference
PMID:14715912
  Authors
Lynch MA.
  Title
Long-term potentiation and memory.
  Journal
Physiol Rev 84:87-136 (2004)
DOI:10.1152/physrev.00014.2003
Reference
PMID:15857686
  Authors
Kelly PT, Mackinnon RL 2nd, Dietz RV, Maher BJ, Wang J.
  Title
Postsynaptic IP3 receptor-mediated Ca2+ release modulates synaptic transmission in hippocampal neurons.
  Journal
Brain Res Mol Brain Res 135:232-48 (2005)
DOI:10.1016/j.molbrainres.2004.12.018
Reference
PMID:9697848
  Authors
Berridge MJ.
  Title
Neuronal calcium signaling.
  Journal
Neuron 21:13-26 (1998)
DOI:10.1016/S0896-6273(00)80510-3
Related
pathway
chx04010  MAPK signaling pathway
chx04020  Calcium signaling pathway
chx04724  Glutamatergic synapse
KO pathway
ko04720   

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