Entry Name Fc gamma R-mediated phagocytosis - Dasypus novemcinctus (nine-banded armadillo)
Description Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map dnm04666 Fc gamma R-mediated phagocytosis
Ortholog table Other DBs Organism Dasypus novemcinctus (nine-banded armadillo) [GN:
dnm ]
Gene 101423469 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856 ]
101427594 high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498 ]
101444276 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
101443761 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
101426945 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
101423744 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
101435351 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
101433347 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
101428386 PLCG2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859 ] [EC:3.1.4.11 ]
101411507 PLA2G6; LOW QUALITY PROTEIN: 85/88 kDa calcium-independent phospholipase A2 [KO:K16343 ] [EC:3.1.1.4 ]
101432019 MARCKS; myristoylated alanine-rich C-kinase substrate [KO:K12561 ]
101446965 VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730 ]
101421534 CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
101443257 VASP; LOW QUALITY PROTEIN: vasodilator-stimulated phosphoprotein [KO:K06274 ]
101425573 LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 1A-like [KO:K05757 ]
101434191 ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
101421086 RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
101435156 WASF1; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 1 [KO:K05753 ]
101438258 WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748 ]
101430356 WASF3; wiskott-Aldrich syndrome protein family member 3 [KO:K06083 ]
101435817 LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 3-like [KO:K06083 ]
101420980 PIP5K1C; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889 ] [EC:2.7.1.68 ]
101430699 ASAP3; LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488 ]
101415379 ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [KO:K12488 ]
101428236 ASAP1; LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 [KO:K12488 ]
101417741 FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b [KO:K12560 ]
101417876 LAT; linker for activation of T-cells family member 1 [KO:K07362 ]
101439131 BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C04637 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C06124 Sphingosine 1-phosphate
Reference Authors Garcia-Garcia E, Rosales C
Title Signal transduction during Fc receptor-mediated phagocytosis.
Journal Reference Authors Cox D, Greenberg S
Title Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system.
Journal Reference Authors Swanson JA, Hoppe AD
Title The coordination of signaling during Fc receptor-mediated phagocytosis.
Journal Reference Authors Ravetch JV, Bolland S
Title IgG Fc receptors.
Journal Reference Authors Groves E, Dart AE, Covarelli V, Caron E
Title Molecular mechanisms of phagocytic uptake in mammalian cells.
Journal Reference Authors Kwiatkowska K, Sobota A
Title Signaling pathways in phagocytosis.
Journal Reference Authors Greenberg S
Title Modular components of phagocytosis.
Journal Reference Authors Lennartz MR
Title Phospholipases and phagocytosis: the role of phospholipid-derived second messengers in phagocytosis.
Journal Reference Authors May RC, Machesky LM
Title Phagocytosis and the actin cytoskeleton.
Journal J Cell Sci 114:1061-77 (2001)
Reference Authors Joshi T, Butchar JP, Tridandapani S
Title Fcgamma receptor signaling in phagocytes.
Journal Reference Authors Lee WL, Cosio G, Ireton K, Grinstein S
Title Role of CrkII in Fcgamma receptor-mediated phagocytosis.
Journal Reference Authors Uchida H, Kondo A, Yoshimura Y, Mazaki Y, Sabe H
Title PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages.
Journal Reference Authors Ganesan LP, Wei G, Pengal RA, Moldovan L, Moldovan N, Ostrowski MC, Tridandapani S
Title The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase.
Journal Reference Authors Melendez A, Floto RA, Gillooly DJ, Harnett MM, Allen JM
Title FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking.
Journal Reference Authors Gu H, Botelho RJ, Yu M, Grinstein S, Neel BG
Title Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis.
Journal Reference Authors Dana R, Leto TL, Malech HL, Levy R
Title Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase.
Journal Reference Authors Gold ES, Underhill DM, Morrissette NS, Guo J, McNiven MA, Aderem A
Title Dynamin 2 is required for phagocytosis in macrophages.
Journal Reference Authors Gold ES, Morrissette NS, Underhill DM, Guo J, Bassetti M, Aderem A
Title Amphiphysin IIm, a novel amphiphysin II isoform, is required for macrophage phagocytosis.
Journal Reference Authors Raeder EM, Mansfield PJ, Hinkovska-Galcheva V, Shayman JA, Boxer LA
Title Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis.
Journal J Immunol 163:6785-93 (1999)
Reference Authors Sanchez-Mejorada G, Rosales C
Title Signal transduction by immunoglobulin Fc receptors.
Journal Reference Authors Rosales C (ed).
Title Molecular Mechanisms of Phagocytosis
Journal Springer (2005)
Related dnm04810 Regulation of actin cytoskeleton
KO pathway LinkDB All DBs
