KEGG   PATHWAY: dnm04144
Entry
dnm04144                    Pathway                                
Name
Endocytosis - Dasypus novemcinctus (nine-banded armadillo)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
dnm04144  Endocytosis
dnm04144

Other DBs
GO: 0006897
Organism
Dasypus novemcinctus (nine-banded armadillo) [GN:dnm]
Gene
101433245  ARF6; ADP-ribosylation factor 6 [KO:K07941]
101439384  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
101420980  PIP5K1C; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
101425321  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
101426938  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
101445951  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
101441754  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
101432656  DNM1; dynamin-1 [KO:K01528] [EC:3.6.5.5]
101425172  dynamin-3 [KO:K01528] [EC:3.6.5.5]
101416463  DNM2; dynamin-2 [KO:K23484] [EC:3.6.5.5]
101420788  CLTA; clathrin light chain A isoform X1 [KO:K04644]
101433636  clathrin light chain B [KO:K04645]
101443941  CLTC; clathrin heavy chain 1 [KO:K04646]
101416022  CLTCL1; clathrin heavy chain 2 [KO:K04646]
101417548  AP2A1; AP-2 complex subunit alpha-1 [KO:K11824]
101442890  AP2A2; AP-2 complex subunit alpha-2 isoform X2 [KO:K11824]
101434362  AP2B1; AP-2 complex subunit beta [KO:K11825]
101418348  AP2M1; AP-2 complex subunit mu [KO:K11826]
101420387  AP2S1; AP-2 complex subunit sigma [KO:K11827]
101427603  EHD2; EH domain-containing protein 2 [KO:K12469]
101411588  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
101430016  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
101446043  ZFYVE16; LOW QUALITY PROTEIN: zinc finger FYVE domain-containing protein 16 [KO:K04679]
101440572  ZFYVE9; zinc finger FYVE domain-containing protein 9 [KO:K04679]
101415116  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
101429090  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
101447050  SMAD3; mothers against decapentaplegic homolog 3 isoform X2 [KO:K23605]
101429828  TFRC; transferrin receptor protein 1 [KO:K06503]
105746538  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101428297  PDGFRA; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101412269  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
101428113  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
101426561  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
101416767  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101417843  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
101418752  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X2 [KO:K22517] [EC:2.3.2.27]
101412407  CBLC; E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
101435239  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
101417532  SH3GL3; endophilin-A3 isoform X1 [KO:K11247]
101424641  SH3GL1; endophilin-A2 [KO:K11247]
101438626  SH3GL2; endophilin-A1 [KO:K11247]
101425550  SH3GLB1; endophilin-B1 isoform X1 [KO:K11248]
101440005  SH3GLB2; endophilin-B2 isoform X4 [KO:K21269]
101439131  BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
101412354  AMPH; LOW QUALITY PROTEIN: amphiphysin [KO:K12562]
101420200  EPN2; epsin-2 isoform X1 [KO:K12471]
101412086  EPN3; LOW QUALITY PROTEIN: epsin-3 [KO:K12471]
101440704  EPN1; epsin-1 [KO:K12471]
101419342  EPS15; epidermal growth factor receptor substrate 15 isoform X3 [KO:K12472]
101413203  uncharacterized protein LOC101413203 [KO:K12472]
101429722  SPART; spartin isoform X1 [KO:K19366]
101420729  NEDD4; E3 ubiquitin-protein ligase NEDD4 [KO:K10591] [EC:2.3.2.26]
101411641  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X2 [KO:K13305] [EC:2.3.2.26]
101418463  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
101438500  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101422625  RNF41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
101430618  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
101439273  SMURF1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
101439956  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
101429327  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X2 [KO:K05633] [EC:2.3.2.26]
101411649  LDLR; low-density lipoprotein receptor [KO:K12473]
101427041  LDLRAP1; low density lipoprotein receptor adapter protein 1 [KO:K12474]
101414141  disabled homolog 2 isoform X1 [KO:K12475]
101434490  C-C chemokine receptor type 5 [KO:K04180]
101440815  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
101441256  C-X-C chemokine receptor type 2 [KO:K05050]
101440322  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101414151  GRK1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
101433169  GRK3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
101428937  GRK2; LOW QUALITY PROTEIN: beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
101434874  GRK5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
101420405  GRK4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
101444381  GRK6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
101446221  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
101428693  ARRB1; beta-arrestin-1 isoform X5 [KO:K04439]
101420825  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
101441119  ACTR2; actin-related protein 2 [KO:K17260]
101420224  actin-related protein 3B isoform X2 [KO:K18584]
101420876  ACTR3; actin-related protein 3 [KO:K18584]
101425573  LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
101410749  actin-related protein 2/3 complex subunit 1B [KO:K05757]
101435756  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
101439790  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
101418884  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
105745582  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
101434191  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
101438370  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
101438979  WIPF3; WAS/WASL-interacting protein family member 3 [KO:K19475]
101411602  WIPF1; WAS/WASL-interacting protein family member 1 [KO:K19475]
101434932  WIPF2; WAS/WASL-interacting protein family member 2 isoform X1 [KO:K19475]
101420025  heat shock 70 kDa protein 1-like [KO:K03283]
101419752  heat shock-related 70 kDa protein 2-like [KO:K03283]
101411149  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101414850  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
101433658  DNAJC6; putative tyrosine-protein phosphatase auxilin [KO:K09526]
101427315  WASHC4; WASH complex subunit 4 [KO:K18465]
101422947  WASHC5; WASH complex subunit 5 [KO:K18464]
101437492  WASHC2C; WASH complex subunit 2C isoform X1 [KO:K18462]
101420089  WASHC1; WASH complex subunit 1 [KO:K18461]
101444285  WASHC3; WASH complex subunit 3 isoform X1 [KO:K18463]
101438046  CAPZA2; LOW QUALITY PROTEIN: F-actin-capping protein subunit alpha-2 [KO:K10364]
101424880  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
101439402  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
101443652  LOW QUALITY PROTEIN: F-actin-capping protein subunit alpha-1-like [KO:K10364]
101436140  CAPZB; F-actin-capping protein subunit beta [KO:K10365]
101434795  VPS29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
101424536  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
101439102  VPS26A; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 26A [KO:K18466]
101432128  VPS35; vacuolar protein sorting-associated protein 35 [KO:K18468]
101422048  SNX3; sorting nexin-3 [KO:K17918]
101415325  SNX12; sorting nexin-12 [KO:K17918]
101432361  USP8; ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
101413119  STAMBP; STAM-binding protein [KO:K11866] [EC:3.4.19.12]
101439272  RAB7A; ras-related protein Rab-7a [KO:K07897]
101431016  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
101434564  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
101442216  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
101432193  TSG101; tumor susceptibility gene 101 protein isoform X1 [KO:K12183]
101431129  MVB12A; multivesicular body subunit 12A [KO:K12186]
101441665  MVB12B; multivesicular body subunit 12B isoform X3 [KO:K12186]
101428848  vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
101446693  VPS37C; vacuolar protein sorting-associated protein 37C isoform X1 [KO:K12185]
101419132  VPS37D; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 37D [KO:K12185]
101442858  VPS37A; vacuolar protein sorting-associated protein 37A [KO:K12185]
101441862  VPS37B; vacuolar protein sorting-associated protein 37B [KO:K12185]
101417673  SNF8; vacuolar-sorting protein SNF8 isoform X2 [KO:K12188]
101423675  VPS36; vacuolar protein-sorting-associated protein 36 isoform X1 [KO:K12190]
101438790  VPS25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
101429295  CHMP6; charged multivesicular body protein 6 [KO:K12195]
101447694  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
101440316  TM9SF1; transmembrane 9 superfamily member 1 isoform X2 [KO:K12194]
101446101  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
101425407  CHMP3; charged multivesicular body protein 3 [KO:K12193]
101436670  CHMP2A; charged multivesicular body protein 2a [KO:K12191]
101440465  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
101438798  CHMP7; charged multivesicular body protein 7 [KO:K15053]
101438946  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
101416497  VPS4A; vacuolar protein sorting-associated protein 4A [KO:K12196]
101424395  VTA1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
101442741  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
101426497  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
101416571  CHMP5; charged multivesicular body protein 5 [KO:K12198]
101433121  IST1; IST1 homolog isoform X1 [KO:K19476]
101418997  PDCD6IP; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
101436409  SPG21; maspardin [KO:K19367]
101431452  IGF2R; cation-independent mannose-6-phosphate receptor isoform X1 [KO:K06564]
101418453  SNX2; sorting nexin-2 [KO:K17917]
101424675  SNX1; sorting nexin-1 [KO:K17917]
101420231  SNX32; sorting nexin-32 [KO:K17920]
101415951  SNX5; sorting nexin-5 [KO:K17920]
101423518  SNX6; sorting nexin-6 [KO:K17920]
101426457  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
101419480  HRAS; GTPase HRas isoform X1 [KO:K02833]
101410814  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
101440447  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
101437298  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
101443396  transforming protein RhoA-like isoform X1 [KO:K04513]
101413434  RHOA; transforming protein RhoA [KO:K04513]
101428513  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
101420800  saoe class I histocompatibility antigen, A alpha chain-like isoform X2 [KO:K06751]
101415823  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
101418741  HLA class I histocompatibility antigen, A-30 alpha chain-like [KO:K06751]
101446223  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
101415391  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
101439136  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101439564  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101435448  HLA class I histocompatibility antigen, B-46 alpha chain-like [KO:K06751]
111758663  HLA class I histocompatibility antigen, A-30 alpha chain-like [KO:K06751]
101430252  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X2 [KO:K06751]
101444704  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
101426756  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101438484  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101411165  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
101427038  HLA class I histocompatibility antigen, B-37 alpha chain-like isoform X1 [KO:K06751]
101412608  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
101447227  HLA class I histocompatibility antigen, Cw-14 alpha chain-like [KO:K06751]
101442840  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
101411454  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
101413764  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101415824  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
105744147  saoe class I histocompatibility antigen, A alpha chain-like isoform X2 [KO:K06751]
101441690  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
101444673  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101428809  HLA class I histocompatibility antigen, B-59 alpha chain-like [KO:K06751]
101412139  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101442557  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
101432742  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101437850  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X3 [KO:K06751]
101422560  saoe class I histocompatibility antigen, A alpha chain-like isoform X2 [KO:K06751]
101427325  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101445227  saoe class I histocompatibility antigen, A alpha chain-like isoform X2 [KO:K06751]
101421532  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
101424781  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101430113  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101435675  HLA class I histocompatibility antigen, B-15 alpha chain-like isoform X2 [KO:K06751]
101419419  HLA class I histocompatibility antigen, B-73 alpha chain-like [KO:K06751]
101442251  HLA class I histocompatibility antigen, Cw-3 alpha chain-like [KO:K06751]
101439095  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
101411831  HLA class I histocompatibility antigen, B-38 alpha chain-like [KO:K06751]
101422917  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
101412902  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
101422259  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101412468  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101414493  HLA class I histocompatibility antigen, B-42 alpha chain-like isoform X1 [KO:K06751]
101442691  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101432034  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
101424334  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101415212  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101442654  BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
101418894  folate receptor alpha-like [KO:K13649]
101420076  folate receptor beta-like [KO:K13649]
101418447  folate receptor alpha-like [KO:K13649]
101436211  CAV1; caveolin-1 [KO:K06278]
101435788  CAV2; caveolin-2 [KO:K12958]
101430628  CAV3; caveolin-3 [KO:K12959]
101430002  EHD3; EH domain-containing protein 3 [KO:K12476]
101411946  EHD4; EH domain-containing protein 4 [KO:K12477]
101443361  EEA1; early endosome antigen 1 isoform X3 [KO:K12478]
101424456  RAB5A; ras-related protein Rab-5A [KO:K07887]
101447878  LOW QUALITY PROTEIN: ras-related protein Rab-5B [KO:K07888]
101415602  RAB5B; ras-related protein Rab-5B [KO:K07888]
101440834  RAB5C; ras-related protein Rab-5C [KO:K07889]
101434231  RABEP1; rab GTPase-binding effector protein 1 [KO:K12480]
101443266  RBSN; rabenosyn-5 [KO:K12481]
101446930  RAB4A; ras-related protein Rab-4A isoform X1 [KO:K07879]
101425039  RUFY1; RUN and FYVE domain-containing protein 1 isoform X1 [KO:K12482]
101428840  RUFY2; RUN and FYVE domain-containing protein 2 isoform X2 [KO:K12482]
101430952  EHD1; EH domain-containing protein 1 [KO:K12483]
101420226  VPS45; vacuolar protein sorting-associated protein 45 isoform X1 [KO:K12479]
101417486  SNX4; sorting nexin-4 [KO:K17919]
101443663  RAB31; ras-related protein Rab-31 [KO:K07891]
101435786  RAB22A; ras-related protein Rab-22A isoform X2 [KO:K07891]
101446708  RAB10; ras-related protein Rab-10 [KO:K07903]
101432365  GTP-binding protein YPTC1-like [KO:K07901]
101437080  RAB11A; ras-related protein Rab-11A [KO:K07904]
101432817  RAB11B; ras-related protein Rab-11B [KO:K07905]
101426512  RAB11FIP2; rab11 family-interacting protein 2 isoform X1 [KO:K12484]
101414114  RAB11FIP5; rab11 family-interacting protein 5 isoform X2 [KO:K12484]
101423679  RAB11FIP1; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
101421364  ZFYVE27; protrudin isoform X4 [KO:K19368]
101434771  KIF5A; kinesin heavy chain [KO:K10396]
101426868  KIF5C; kinesin heavy chain [KO:K10396]
101435822  KIF5B; kinesin-1 heavy chain [KO:K10396]
101421398  RAB11FIP3; LOW QUALITY PROTEIN: rab11 family-interacting protein 3 [KO:K12485]
101429995  RAB11FIP4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
101422709  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
101445775  PARD6A; partitioning defective 6 homolog alpha isoform X2 [KO:K06093]
101441656  partitioning defective 6 homolog gamma [KO:K06093]
101441030  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
101428270  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
101447889  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
101421534  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101421319  SMAP2; stromal membrane-associated protein 2 [KO:K12486]
101438342  SMAP1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
101443022  GIT1; ARF GTPase-activating protein GIT1 [KO:K05737]
101412217  GIT2; LOW QUALITY PROTEIN: ARF GTPase-activating protein GIT2 [KO:K12487]
101430699  ASAP3; LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
101415379  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [KO:K12488]
101428236  ASAP1; LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 [KO:K12488]
101420296  ACAP1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
101415748  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X2 [KO:K12489]
101412124  ACAP3; LOW QUALITY PROTEIN: arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 [KO:K12489]
101412946  ARAP1; LOW QUALITY PROTEIN: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 [KO:K18439]
101410888  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X3 [KO:K18440]
101415638  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X2 [KO:K12490]
111764096  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2-like [KO:K12491]
101417033  AGAP2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
101446429  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
101421225  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
101413900  ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
101415718  PSD; PH and SEC7 domain-containing protein 1 [KO:K12494]
101435172  PSD2; PH and SEC7 domain-containing protein 2 [KO:K12494]
101437889  PH and SEC7 domain-containing protein 4 isoform X2 [KO:K12494]
101411922  PH and SEC7 domain-containing protein 3 [KO:K12494]
101415531  IQSEC3; IQ motif and SEC7 domain-containing protein 3 [KO:K12495]
101445880  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X2 [KO:K12495]
101441518  IQSEC2; LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 2 [KO:K12495]
101415773  CYTH2; cytohesin-2 [KO:K18441]
101421521  CYTH3; cytohesin-3 isoform X1 [KO:K18441]
101443219  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
101445050  CYTH4; cytohesin-4 [KO:K18441]
101429761  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442]
101440022  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
101413220  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
101417169  LOW QUALITY PROTEIN: ADP-ribosylation factor 2-like [KO:K07937]
101446137  ARF1; ADP-ribosylation factor 1 [KO:K07937]
101429811  ARF3; ADP-ribosylation factor 3 [KO:K07938]
101422460  ARF4; ADP-ribosylation factor 4 [KO:K07939]
101426211  ARF5; ADP-ribosylation factor 5 [KO:K07940]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
dnm04060  Cytokine-cytokine receptor interaction
dnm04070  Phosphatidylinositol signaling system
dnm04130  SNARE interactions in vesicular transport
dnm04142  Lysosome
dnm04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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