KEGG   PATHWAY: dre04142
Entry
dre04142                    Pathway                                
Name
Lysosome biogenesis - Danio rerio (zebrafish)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
dre04142  Lysosome biogenesis
dre04142

Other DBs
GO: 0005764
Organism
Danio rerio (zebrafish) [GN:dre]
Gene
100000085  cd68; lysosome-associated membrane glycoprotein 1 [KO:K06501]
100000165  ap3b2; AP-3 complex subunit beta-2 isoform X1 [KO:K12397]
100000325  rragcb; Ras-related GTP binding Cb [KO:K16186]
100000399  dnase2; deoxyribonuclease-2-alpha precursor [KO:K01158] [EC:3.1.22.1]
100001113  mcoln3b; mucolipin-3 isoform X1 [KO:K04994]
100001785  [KO:K01365] [EC:3.4.22.15]
100002086  tmem175; endosomal/lysosomal proton channel TMEM175 [KO:K24915]
100002366  gaa; lysosomal alpha-glucosidase isoform X1 [KO:K12316] [EC:3.2.1.20]
100003043  lamp3; lysosome-associated membrane glycoprotein 3 [KO:K06562]
100003139  tcirg1a; V-type proton ATPase 116 kDa subunit a 3 [KO:K02154]
100003844  laptm4a; lysosomal-associated transmembrane protein 4A [KO:K12387]
100004342  osbpl6; oxysterol-binding protein-related protein 6 [KO:K20463]
100004557  hyal3; hyaluronidase-3 isoform X1 [KO:K01197] [EC:3.2.1.35]
100004566  atp6ap1a; ATPase H+ transporting accessory protein 1a precursor [KO:K03662]
100005356  [KO:K01369] [EC:3.4.22.34]
100005567  gpr155b; lysosomal cholesterol signaling protein isoform X6 [KO:K28455]
100005887  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
100006090  abca2; ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642]
100006189  osbpl5; oxysterol-binding protein-related protein 5 [KO:K20464]
100006791  zgc:165600; lysosome-associated membrane glycoprotein 5 precursor [KO:K28774]
100007877  ap1g2; AP-1 complex subunit gamma-like 2 [KO:K12391]
100126133  ppt2b; lysosomal thioesterase PPT2 precursor [KO:K01074] [EC:3.1.2.22]
100136870  cln8; protein CLN8 [KO:K12360]
100148085  ap2s1; AP-2 complex subunit sigma [KO:K11827]
100148772  ap5b1; AP-5 complex subunit beta-1 [KO:K19022]
100151075  abca5; cholesterol transporter ABCA5 [KO:K05648]
100151344  si:dkeyp-97e7.9; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
100320445  ostm1; osteopetrosis-associated transmembrane protein 1 precursor [KO:K23863]
100329505  hgsnat; heparan-alpha-glucosaminide N-acetyltransferase isoform X1 [KO:K10532] [EC:2.3.1.78]
100329656  lamtor1; ragulator complex protein LAMTOR1 [KO:K20397]
100329879  cltB; clathrin light chain B isoform X1 [KO:K04645]
100330183  cltcl1; clathrin heavy chain 1 isoform X1 [KO:K04646]
100330411  ap1m1; AP-1 complex subunit mu-1 [KO:K12393]
100331149  [KO:K20174]
100331439  slc29a1b; equilibrative nucleoside transporter 1 [KO:K15014]
100332691  [KO:K02154]
100332784  gaa2; lysosomal alpha-glucosidase isoform X3 [KO:K12316] [EC:3.2.1.20]
100333504  lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
100333521  [KO:K08568] [EC:3.4.18.1]
100333625  dmxl1; dmX-like protein 1 isoform X1 [KO:K24155]
100334018  [KO:K15014]
100334605  fig4a; polyphosphoinositide phosphatase isoform X1 [KO:K22913] [EC:3.1.3.-]
100334661  gga3b; ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404]
100334819  mcoln3a; mucolipin-3 isoform X2 [KO:K04994]
100535239  gpr155a; lysosomal cholesterol signaling protein [KO:K28455]
100537591  zgc:174154; uncharacterized protein LOC100537591 precursor [KO:K01365] [EC:3.4.22.15]
100537934  ap5z1; AP-5 complex subunit zeta-1 [KO:K19025]
100538007  arsB; arylsulfatase B [KO:K01135] [EC:3.1.6.12]
100538220  atp6v1c2; V-type proton ATPase subunit C 1-B [KO:K02148]
101887173  slc29a3; equilibrative nucleoside transporter 3 [KO:K15014]
108179059  atp6v1e1a; V-type proton ATPase subunit E 1a [KO:K02150]
108181664  hyal4; hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
114367  notS; nothepsin [KO:K01382] [EC:3.4.23.34]
114833  mitfb; melanocyte inducing transcription factor B [KO:K09455]
114834  tfe3a; transcription factor E3a [KO:K09105]
137487590  [KO:K12383]
140811  psaP; prosaposin isoform 2 precursor [KO:K12382]
141380740  [KO:K14379] [EC:3.1.3.2]
192335  atp6v1e1b; V-type proton ATPase subunit E 1 [KO:K02150]
192336  atp6v0ca; ATPase H+ transporting V0 subunit ca [KO:K02155]
192340  scarb2a; lysosome membrane protein 2A [KO:K12384]
195824  atp6ap1b; V-type proton ATPase subunit S1b [KO:K03662]
266798  ap3m1; AP-3 complex subunit mu-1 isoform X1 [KO:K12398]
282673  npc2.1; NPC intracellular cholesterol transporter 2 isoform X1 [KO:K13443]
286779  atp6v1h; V-type proton ATPase subunit H isoform 1 [KO:K02144]
30080  mitfa; melanocyte inducing transcription factor a isoform 2 [KO:K09455]
30443  ctslb; cathepsin Lb precursor [KO:K01365] [EC:3.4.22.15]
321051  ap2m1a; AP-2 complex subunit mu-A isoform 2 [KO:K11826]
321453  ctsla; cathepsin La isoform X1 [KO:K01365] [EC:3.4.22.15]
321461  cd63; CD63 antigen [KO:K06497]
321724  atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661]
321818  ctsA; lysosomal protective protein precursor [KO:K13289] [EC:3.4.16.5]
321853  [KO:K01365] [EC:3.4.22.15]
322811  atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
323579  cltca; clathrin, heavy chain a (Hc) [KO:K04646]
323613  hexB; beta-hexosaminidase subunit beta isoform 1 precursor [KO:K12373] [EC:3.2.1.52]
324254  mtoR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
324307  atp6v0a1a; V-type proton ATPase 116 kDa subunit a isoform 1a [KO:K02154]
324466  ap1g1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
324565  zfyve26; zinc finger FYVE domain-containing protein 26 [KO:K19027]
324781  bloc1s5; biogenesis of lysosome-related organelles complex 1 subunit 5 [KO:K20187]
324818  ctsH; pro-cathepsin H precursor [KO:K01366] [EC:3.4.22.16]
324985  lamp1a; lysosome-associated membrane glycoprotein 1a isoform X1 [KO:K06528]
325358  rraga; ras-related GTP-binding protein A isoform X1 [KO:K16185]
325402  atp6v0cb; ATPase H+ transporting V0 subunit cb [KO:K02155]
327007  vamp8; vesicle-associated membrane protein 8 [KO:K08512]
327237  ap1s2; AP-1 complex subunit sigma-2 [KO:K12394]
327635  gnsB; glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID), b precursor [KO:K01137] [EC:3.1.6.14]
334206  osbpl2b; oxysterol-binding protein-related protein 2b isoform X1 [KO:K20174]
334632  ap2b1; AP-2 complex subunit beta [KO:K11825]
335008  pla2g15; lysosomal phospholipase A and acyltransferase precursor [KO:K06129] [EC:3.1.1.5]
335025  atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
335494  fuca1.1; alpha-L-fucosidase 1, tandem duplicate 1 precursor [KO:K01206] [EC:3.2.1.51]
335642  rogdi; protein rogdi homolog [KO:K24628]
336746  napsa; napsin-A precursor [KO:K01379] [EC:3.4.23.5]
337424  arl8ba; ADP-ribosylation factor-like protein 8B-A [KO:K07955]
337532  scarb2c; lysosome membrane protein 2C [KO:K12384]
337572  ctss2.2; cathepsin S, ortholog 2, tandem duplicate 2 precursor [KO:K01368] [EC:3.4.22.27]
337583  atp6v1ab; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
337690  [KO:K00921] [EC:2.7.1.150]
337771  zgc:162858; uncharacterized protein LOC337771 [KO:K12394]
359839  atp6v1ba; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
359840  atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
368704  ctsC; dipeptidyl peptidase 1 precursor [KO:K01275] [EC:3.4.14.1]
368852  ap4s1; AP-4 complex subunit sigma-1 [KO:K12403]
368907  atp6v1c1a; V-type proton ATPase subunit C 1-A [KO:K02148]
368911  laptm4b; lysosomal-associated transmembrane protein 4B [KO:K12387]
378837  vps13a; intermembrane lipid transfer protein VPS13A [KO:K19525]
378958  dmxl2; dmX-like protein 2 [KO:K24155]
393128  manba; beta-mannosidase precursor [KO:K01192] [EC:3.2.1.25]
393135  ppt2a.2; Lysosomal thioesterase PPT2-A-like precursor [KO:K01074] [EC:3.1.2.22]
393236  sybl1; vesicle-associated membrane protein 7 [KO:K08515]
393279  ap1s1; AP-1 complex subunit sigma-1A isoform 1 [KO:K12394]
393309  ap4b1; AP-4 complex subunit beta-1 [KO:K12401]
393398  ctss1; cathepsin S, ortholog 1 precursor [KO:K01368] [EC:3.4.22.27]
393549  asah1b; acid ceramidase precursor [KO:K12348] [EC:3.5.1.23]
393657  ppt2a.1; lysosomal thioesterase PPT2a.1 precursor [KO:K01074] [EC:3.1.2.22]
393881  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
393902  rab7a; ras-related protein Rab-7a [KO:K07897] [EC:3.6.5.2]
393932  slc15a4; solute carrier family 15 member 4 [KO:K14638]
393935  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
394001  ap2m1b; AP-2 complex subunit mu-B [KO:K11826]
394109  dtnbp1a; dysbindin-A [KO:K20189]
394110  atp6v1aa; ATPase H+ transporting V1 subunit Aa [KO:K02145] [EC:7.1.2.2]
394123  mcoln2; mucolipin-2 [KO:K04993]
403021  ap1m2; AP-1 complex subunit mu-2 [KO:K12393]
403126  tlr3; toll-like receptor 3 precursor [KO:K05401]
403128  tlr9; toll-like receptor 9 precursor [KO:K10161]
403136  tlr8b; toll-like receptor 8b precursor [KO:K10170]
403137  tlr8a; toll-like receptor 8 [KO:K10170]
405845  ppt2a.4; uncharacterized protein LOC405845 precursor [KO:K01074] [EC:3.1.2.22]
406318  cltA; clathrin light chain A [KO:K04644]
406342  tcirg1b; T cell immune regulator 1, ATPase H+ transporting V0 subunit a3b [KO:K02154]
406385  galcb; galactocerebrosidase precursor [KO:K01202] [EC:3.2.1.46]
406486  m6pr; cation-dependent mannose-6-phosphate receptor precursor [KO:K10089]
406511  sort1a; sortilin precursor [KO:K12388]
406625  lgmN; legumain precursor [KO:K01369] [EC:3.4.22.34]
406645  ctsba; cathepsin B precursor [KO:K01363] [EC:3.4.22.1]
406648  ppt1; palmitoyl-protein thioesterase 1 precursor [KO:K01074] [EC:3.1.2.22]
406684  vps26b; vacuolar protein sorting-associated protein 26B [KO:K18466]
406689  mcoln1a; mucolipin-1a [KO:K04992]
406713  lipF; gastric triacylglycerol lipase precursor [KO:K01052] [EC:3.1.1.13]
406801  acp5a; tartrate-resistant acid phosphatase type 5a precursor [KO:K14379] [EC:3.1.3.2]
406830  ppt2a.3; uncharacterized protein LOC406830 precursor [KO:K01074] [EC:3.1.2.22]
415147  gnptg; N-acetylglucosamine-1-phosphotransferase subunit gamma precursor [KO:K10087]
415244  ap3m2; AP-3 complex subunit mu-2 [KO:K12398]
431725  rab7b; ras-related protein Rab-7b [KO:K07897] [EC:3.6.5.2]
431731  litaf; lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
436641  ctsl.1; cathepsin L.1 isoform X1 [KO:K01365] [EC:3.4.22.15]
436688  vps26bl; vacuolar protein sorting-associated protein 26B-like [KO:K18466]
436692  entpd4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
436725  acp5b; tartrate-resistant acid phosphatase type 5b precursor [KO:K14379] [EC:3.1.3.2]
436799  atp6v1f; V-type proton ATPase subunit F [KO:K02151]
436812  ap3s2; AP-3 complex subunit sigma-2 [KO:K12399]
436945  ap4m1; AP-4 complex subunit mu-1 [KO:K12402]
445075  kxd1; kxDL motif-containing protein 1 [KO:K20818]
445081  bloc1s4; biogenesis of lysosome-related organelles complex 1 subunit 4 [KO:K08366]
445155  lamtor2; ragulator complex protein LAMTOR2 [KO:K20398]
445165  fuca1.2; alpha-L-fucosidase 1, tandem duplicate 2 precursor [KO:K01206] [EC:3.2.1.51]
445244  ap1m3; adaptor related protein complex 1 subunit mu 3 isoform X1 [KO:K12393]
445487  fuca2; plasma alpha-L-fucosidase precursor [KO:K01206] [EC:3.2.1.51]
447897  ap1s3b; AP-1 complex subunit sigma-3b [KO:K12395]
447908  osbpl3a; oxysterol-binding protein-related protein 3A [KO:K20463]
448942  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
449549  zgc:100918; Ras-related protein rab7-like [KO:K07897] [EC:3.6.5.2]
449649  galca; galactocerebrosidase precursor [KO:K01202] [EC:3.2.1.46]
449650  borcs5; BLOC-1-related complex subunit 5 [KO:K20819]
449655  atp6v1c1b; V-type proton ATPase subunit C 1-B [KO:K02148]
449656  osbpl7; oxysterol-binding protein-related protein 7 isoform X1 [KO:K20463]
449791  ap3s1; AP-3 complex subunit sigma-1 [KO:K12399]
449809  cln6a; ceroid-lipofuscinosis neuronal protein 6A [KO:K12359]
449923  [KO:K08512]
450017  atp6v0e1; V-type proton ATPase subunit e 1 [KO:K02153]
450022  ctsZ; cathepsin Z precursor [KO:K08568] [EC:3.4.18.1]
450068  asah1a; N-acylsphingosine amidohydrolase (acid ceramidase) 1a precursor [KO:K12348] [EC:3.5.1.23]
450083  gla; alpha-galactosidase A precursor [KO:K01189] [EC:3.2.1.22]
492340  cln3; battenin [KO:K12389]
492643  gga3a; ADP-ribosylation factor-binding protein GGA3a [KO:K12404]
492808  stx17; syntaxin-17 [KO:K08491]
494576  si:dkey-13a21.4; uncharacterized protein LOC494576 [KO:K07897] [EC:3.6.5.2]
503537  slc29a2; equilibrative nucleoside transporter 2 isoform X1 [KO:K15014]
503600  cltcb; clathrin heavy chain 1 [KO:K04646]
503759  acp2; lysosomal acid phosphatase precursor [KO:K14410] [EC:3.1.3.2]
504109  slc36a4; neutral amino acid uniporter 4 isoform X1 [KO:K14209]
541416  arsA; arylsulfatase A precursor [KO:K01134] [EC:3.1.6.8]
541519  man2b1; lysosomal alpha-mannosidase precursor [KO:K12311] [EC:3.2.1.24]
548343  glb1; beta-galactosidase isoform X1 [KO:K12309] [EC:3.2.1.23]
550415  ap1s3a; AP-1 complex subunit sigma-3a [KO:K12395]
550460  hexA; beta-hexosaminidase subunit alpha precursor [KO:K12373] [EC:3.2.1.52]
550475  ctsK; cathepsin K precursor [KO:K01371] [EC:3.4.22.38]
550529  gm2a; ganglioside GM2 activator precursor [KO:K12383]
553330  npc1; NPC intracellular cholesterol transporter 1 precursor [KO:K12385]
553351  clcn7; H(+)/Cl(-) exchange transporter 7 [KO:K05016]
553365  gnptab; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
553423  sumf1; formylglycine-generating enzyme precursor [KO:K13444] [EC:1.8.3.7]
553460  snap29; synaptosomal-associated protein 29 isoform X1 [KO:K08509]
553529  bloc1s3; biogenesis of lysosome-related organelles complex 1 subunit 3 isoform X1 [KO:K20186]
553594  ctnS; cystinosin precursor [KO:K12386]
553597  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
553681  ap5m1; AP-5 complex subunit mu-1 [KO:K19023]
553691  atp6v0a1b; V-type proton ATPase 116 kDa subunit a isoform 1b [KO:K02154]
553763  ctbS; di-N-acetylchitobiase precursor [KO:K12310] [EC:3.2.1.-]
553767  atpv0e2; ATPase H+ transporting V0 subunit E2 [KO:K02153]
554157  ctss2.1; cathepsin S, ortholog2, tandem duplicate 1 precursor [KO:K01368] [EC:3.4.22.27]
555639  cd164; sialomucin core protein 24 precursor [KO:K06546]
556111  ap5s1; AP-5 complex subunit sigma-1 precursor [KO:K19024]
556597  bloc1s1; biogenesis of lysosome-related organelles complex 1 subunit 1 [KO:K20185]
556700  smpd1; sphingomyelin phosphodiesterase precursor [KO:K12350] [EC:3.1.4.12]
556784  dtnbp1b; dystrobrevin binding protein 1B [KO:K20189]
557061  igf2r; cation-independent mannose-6-phosphate receptor precursor [KO:K06564]
557483  osbpl2a; oxysterol-binding protein-related protein 2 [KO:K20174]
558153  ap2a1; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
558180  borcs8; BLOC-1-related complex subunit 8 [KO:K20822]
559072  gba1; lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
559228  hyal2b; hyaluronidase-2 isoform X2 [KO:K01197] [EC:3.2.1.35]
559308  slc36a1; proton-coupled amino acid transporter 1 isoform X2 [KO:K14209]
559575  si:ch211-15d5.11; oxidation resistance protein 1 isoform X1 [KO:K25442]
559850  neu1; sialidase-1 precursor [KO:K01186] [EC:3.2.1.18]
559959  ids; iduronate 2-sulfatase precursor [KO:K01136] [EC:3.1.6.13]
560126  naglu; alpha-N-acetylglucosaminidase isoform X2 [KO:K01205] [EC:3.2.1.50]
560455  rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
560593  [KO:K12388]
560602  slc2a6; solute carrier family 2, facilitated glucose transporter member 6 [KO:K08144]
560778  nagA; alpha-N-acetylgalactosaminidase precursor [KO:K01204] [EC:3.2.1.49]
561019  lamtor4; ragulator complex protein LAMTOR4 [KO:K20399]
561117  atp6v0a2b; V-type proton ATPase 116 kDa subunit a isoform 2b [KO:K02154]
561469  atp6v0a2a; V-type proton ATPase 116 kDa subunit a 2 isoform X1 [KO:K02154]
561678  meak7; MTOR-associated protein MEAK7 [KO:K27947]
561697  vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
562137  slc38a9; neutral amino acid transporter 9 [KO:K14995]
562166  ap1b1; AP-1 complex subunit beta-1 [KO:K12392]
562289  tfeB; transcription factor EB isoform X1 [KO:K15590]
562445  arl8bb; ADP-ribosylation factor-like 8Bb [KO:K07955]
562480  si:dkey-72l14.3; Glyco_hydro_56 domain-containing protein [KO:K01197] [EC:3.2.1.35]
562545  borcs6; BLOC-1-related complex subunit 6 [KO:K20820]
562996  dnase2b; deoxyribonuclease-2-beta isoform X2 [KO:K01158] [EC:3.1.22.1]
563215  vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
563316  ap3b1a; AP-3 complex subunit beta-1 isoform X3 [KO:K12397]
563328  lamp1b; lysosome-associated membrane glycoprotein 1b precursor [KO:K06528]
563359  ap3d1; AP-3 complex subunit delta-1 [KO:K12396]
563390  si:dkey-26g8.5; uncharacterized protein LOC563390 precursor [KO:K01365] [EC:3.4.22.15]
563580  slc29a1a; equilibrative nucleoside transporter 1a isoform X1 [KO:K15014]
563849  sgsH; N-sulphoglucosamine sulphohydrolase precursor [KO:K01565] [EC:3.10.1.1]
564048  plekhm1; pleckstrin homology domain-containing family M member 1 isoform 1 [KO:K23282]
564077  scarb2b; lysosome membrane protein 2 [KO:K12384]
564342  mfsd8; major facilitator superfamily domain-containing protein 8 [KO:K12307]
564372  osbP; oxysterol-binding protein 1 [KO:K20456]
564731  mfsd8l1; major facilitator superfamily domain-containing protein 8 [KO:K12307]
564790  arsG; arylsulfatase G precursor [KO:K12381] [EC:3.1.6.-]
564996  tfe3b; transcription factor E3b [KO:K09105]
565099  npc2.2; Epididymal secretory protein E1-like precursor [KO:K13443]
565246  [KO:K10532] [EC:2.3.1.78]
565503  osbpl1a; oxysterol-binding protein-related protein 1 isoform X1 [KO:K20174]
565588  ctsF; cathepsin F precursor [KO:K01373] [EC:3.4.22.41]
565645  mfsd8l2; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
565852  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
566506  gnsA; N-acetylglucosamine-6-sulfatase precursor [KO:K01137] [EC:3.1.6.14]
566517  aga; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase precursor [KO:K01444] [EC:3.5.1.26]
566559  akt1s1; proline-rich AKT1 substrate 1 [KO:K16184]
567046  cts12; procathepsin L isoform X2 [KO:K01365] [EC:3.4.22.15]
567078  vps39; vam6/Vps39-like protein isoform X2 [KO:K20183]
567222  arl8a; ADP-ribosylation factor-like protein 8A [KO:K07955]
567333  ctsO; cathepsin O isoform X2 [KO:K01374] [EC:3.4.22.42]
567534  tpcn1; two pore channel protein 1 isoform X2 [KO:K16896]
567623  zgc:174153; uncharacterized protein LOC567623 precursor [KO:K01365] [EC:3.4.22.15]
567720  iduA; alpha-L-iduronidase isoform X1 [KO:K01217] [EC:3.2.1.76]
567869  hyal2a; hyaluronidase-2 isoform X2 [KO:K01197] [EC:3.2.1.35]
567921  osbpl3b; oxysterol-binding protein-related protein 3 isoform X2 [KO:K20463]
567959  snapin; SNARE-associated protein Snapin [KO:K20002]
569262  ncoa7b; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
569298  ctsbb; cathepsin Bb precursor [KO:K01363] [EC:3.4.22.1]
569326  zgc:174855; uncharacterized protein LOC569326 precursor [KO:K01365] [EC:3.4.22.15]
569407  cln5; bis(monoacylglycero)phosphate synthase CLN5 [KO:K12390]
569719  nagpa; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor [KO:K01125] [EC:3.1.4.45]
570077  tti1; TELO2-interacting protein 1 homolog [KO:K20403]
570148  abcb9; ABC-type oligopeptide transporter ABCB9 [KO:K05656]
570467  ap4e1; AP-4 complex subunit epsilon-1 [KO:K12400]
570568  rragd; ras-related GTP-binding protein D [KO:K16186]
570764  cln6b; ceroid-lipofuscinosis neuronal protein 6 homolog isoform X1 [KO:K12359]
571066  [KO:K12301]
571441  gusB; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
572502  wdr7; WD repeat-containing protein 7 isoform X1 [KO:K24738]
573437  vps29; vacuolar protein sorting-associated protein 29 [KO:K18467]
573492  rragca; Ras-related GTP binding Ca [KO:K16186]
606665  bloc1s2; biogenesis of lysosome-related organelles complex 1 subunit 2 isoform 1 [KO:K16750]
619265  tmem251; lysosomal enzyme trafficking factor [KO:K26747]
65225  ctsD; cathepsin D precursor [KO:K01379] [EC:3.4.23.5]
664759  borcs7; BLOC-1-related complex subunit 7 [KO:K20821]
664772  hyal1; hyaluronidase-1 isoform X1 [KO:K01197] [EC:3.2.1.35]
678623  slc11a2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
767760  slc17a5; sialin [KO:K12301]
767799  zgc:153169; uncharacterized protein LOC767799 [KO:K01444] [EC:3.5.1.26]
768177  deptor; DEP domain-containing mTOR-interacting protein [KO:K20402]
777614  tpcn2; two pore channel protein 2 [KO:K14077]
777634  telo2; telomere length regulation protein TEL2 homolog isoform 1 [KO:K11137]
791159  galns; N-acetylgalactosamine-6-sulfatase precursor [KO:K01132] [EC:3.1.6.4]
791189  hyal6; hyaluronoglucosaminidase 6 [KO:K01197] [EC:3.2.1.35]
791203  spam1; hyaluronidase PH-20 precursor [KO:K01197] [EC:3.2.1.35]
791215  bloc1s6; biogenesis of lysosome-related organelles complex 1 subunit 6 [KO:K20188]
792689  mlst8; target of rapamycin complex subunit lst8 [KO:K08266]
792966  [KO:K13289] [EC:3.4.16.5]
793551  spg11; spatacsin isoform 2 [KO:K19026]
795916  mcoln1b; mucolipin-1b [KO:K04992]
796031  si:dkeyp-75b4.8; lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1 [KO:K19363]
798347  tpp1; tripeptidyl-peptidase 1 precursor [KO:K01279] [EC:3.4.14.9]
798361  gga1; ADP-ribosylation factor-binding protein GGA1 [KO:K12404]
798746  vps13c; intermembrane lipid transfer protein VPS13C isoform X1 [KO:K19525]
798985  vps16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
799153  sort1b; sortilin 1b precursor [KO:K12388]
799859  [KO:K20189]
Compound
C00002  ATP
C00008  ADP
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 22:339-352 (2022)
DOI:10.1038/s41577-021-00626-8
Reference
PMID:19672277
  Authors
Saftig P, Klumperman J
  Title
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function.
  Journal
Nat Rev Mol Cell Biol 10:623-35 (2009)
DOI:10.1038/nrm2745
Reference
PMID:31611045
  Authors
Savini M, Zhao Q, Wang MC
  Title
Lysosomes: Signaling Hubs for Metabolic Sensing and Longevity.
  Journal
Trends Cell Biol 29:876-887 (2019)
DOI:10.1016/j.tcb.2019.08.008
Reference
PMID:33433692
  Authors
Meyer-Schwesinger C
  Title
Lysosome function in glomerular health and disease.
  Journal
Cell Tissue Res 385:371-392 (2021)
DOI:10.1007/s00441-020-03375-7
Reference
PMID:34345172
  Authors
Allemailem KS, Almatroudi A, Alrumaihi F, Almatroodi SA, Alkurbi MO, Basfar GT, Rahmani AH, Khan AA
  Title
Novel Approaches of Dysregulating Lysosome Functions in Cancer Cells by Specific Drugs and Its Nanoformulations: A Smart Approach of Modern Therapeutics.
  Journal
Int J Nanomedicine 16:5065-5098 (2021)
DOI:10.2147/IJN.S321343
Reference
PMID:36096887
  Authors
Zhang W, Yang X, Li Y, Yu L, Zhang B, Zhang J, Cho WJ, Venkatarangan V, Chen L, Burugula BB, Bui S, Wang Y, Duan C, Kitzman JO, Li M
  Title
GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway.
  Journal
Nat Commun 13:5351 (2022)
DOI:10.1038/s41467-022-33025-1
Reference
PMID:38357444
  Authors
Liu Q, Wang W, Xu L, Zhang Q, Wang H
  Title
The host mannose-6-phosphate pathway and viral infection.
  Journal
Front Cell Infect Microbiol 14:1349221 (2024)
DOI:10.3389/fcimb.2024.1349221
Reference
PMID:38711187
  Authors
He Y, Fan Y, Ahmadpoor X, Wang Y, Li ZA, Zhu W, Lin H
  Title
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases.
  Journal
Med Res Rev 44:2472-2509 (2024)
DOI:10.1002/med.22047
Reference
PMID:40759742
  Authors
Radulovic M, Yang C, Stenmark H
  Title
Lysosomal membrane homeostasis and its importance in physiology and disease.
  Journal
Nat Rev Mol Cell Biol 27:71-87 (2026)
DOI:10.1038/s41580-025-00873-w
Reference
PMID:41214333
  Authors
Watson ET, Wegeng WR, Aravani S, Ernst AM, von Blume J
  Title
Mechanistic insights into cargo sorting and export from the Golgi apparatus.
  Journal
Nat Rev Mol Cell Biol 26:940-956 (2025)
DOI:10.1038/s41580-025-00907-3
Related
pathway
dre00511  Other glycan degradation
dre00531  Glycosaminoglycan degradation
dre04130  SNARE interactions in vesicular transport
dre04140  Autophagy - animal
dre04144  Endocytosis
dre04145  Phagocytosis
dre04150  mTOR signaling pathway
dre04620  Toll-like receptor signaling pathway
KO pathway
ko04142   

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