KEGG   PATHWAY: efus04260
Entry
efus04260                   Pathway                                
Name
Cardiac muscle contraction - Eptesicus fuscus (big brown bat)
Description
Contraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation of voltage-dependent L-type Ca channels (DHP receptors) upon membrane depolarization triggers the release of Ca2+ via Ca2+ release channels (ryanodine receptors) of sarcoplasmic reticulum (SR) through a Ca2+ -induced Ca release (CICR) mechanism. Ca2+ ions released via the CICR mechanism diffuse through the cytosolic space to contractile proteins to bind to troponinC resulting in the release of inhibition induced by troponinI. The Ca2+ binding to troponinC thereby triggers the sliding of thin and thick filaments, that is, the activation of a crossbridge and subsequent cardiac force development and/or cell shortening. Recovery occurs as Ca2+ is pumped out of the cell by the Na+/Ca2+ exchanger (NCX) or is returned to the sarcoplasmic reticulum (SR) by sarco(endo)plasmic Ca2+ -ATPase (SERCA) pumps on the non-junctional region of the SR.
Class
Organismal Systems; Circulatory system
Pathway map
efus04260  Cardiac muscle contraction
efus04260

Other DBs
GO: 0060048
Organism
Eptesicus fuscus (big brown bat) [GN:efus]
Gene
103283409  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
103283618  SLC8A3; sodium/calcium exchanger 3 [KO:K05849]
103283835  TPM1; tropomyosin alpha-1 chain isoform X5 [KO:K10373]
103284432  [KO:K02263]
103284512  [KO:K02267]
103284530  [KO:K02270]
103284939  [KO:K02271]
103285249  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
103285584  [KO:K02263]
103285725  [KO:K00415]
103286326  [KO:K02270]
103286444  TPM2; tropomyosin beta chain isoform X4 [KO:K10374]
103286820  [KO:K00418]
103286861  [KO:K00419]
103287036  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
103287051  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
103287257  [KO:K02266]
103287284  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
103287703  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
103288904  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
103290416  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
103290420  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
103291221  CASQ2; calsequestrin-2 [KO:K23445]
103291225  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
103291503  [KO:K02271]
103291901  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
103292313  [KO:K02268]
103292328  [KO:K00417]
103292495  [KO:K02268]
103292593  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
103293120  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
103293121  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
103293123  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
103293160  MYL4; myosin light chain 4 [KO:K12750]
103293241  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
103293520  RYR2; ryanodine receptor 2 [KO:K04962]
103293823  FXYD2; sodium/potassium-transporting ATPase subunit gamma isoform X2 [KO:K01538]
103294287  [KO:K00420]
103294778  [KO:K00416]
103295153  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
103295874  [KO:K00411] [EC:7.1.1.8]
103296000  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 isoform X1 [KO:K01540]
103296194  [KO:K00415]
103296211  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
103296315  [KO:K02266]
103296452  SLC9A7; sodium/hydrogen exchanger 7 [KO:K12041]
103296573  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
103296613  [KO:K00420]
103296724  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
103296758  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
103296898  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
103297033  [KO:K02267]
103297130  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X2 [KO:K04862]
103297531  [KO:K01539] [EC:7.2.2.13]
103297573  ATP1A4; sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
103297679  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
103297773  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
103298527  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X2 [KO:K04859]
103298926  TPM3; tropomyosin alpha-3 chain isoform X2 [KO:K09290]
103299167  MYL3; myosin light chain 3 [KO:K12749]
103299284  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
103299655  [KO:K02265]
103299933  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
103300104  [KO:K02271]
103300183  [KO:K02264]
103300797  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
103300900  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
103301304  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
103301506  MYH6; myosin-6 [KO:K17751]
103301550  MYH7; myosin-7 [KO:K17751]
103302033  [KO:K02273]
103302100  SLC9A6; sodium/hydrogen exchanger 6 isoform X1 [KO:K12041]
103302658  [KO:K00413]
103302764  [KO:K02270]
103302935  TNNT2; troponin T, cardiac muscle [KO:K12045]
103303378  TNNI3; troponin I, cardiac muscle [KO:K12044]
103303650  [KO:K02271]
103303687  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
103303689  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
103303711  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
103304194  [KO:K02267]
103305247  [KO:K02272]
103305440  [KO:K02270]
103305443  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
114233099  TRDN; triadin isoform X1 [KO:K23449]
129147386  [KO:K02270]
129147700  CACNG8; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
129149321  [KO:K00419]
129152151  [KO:K00414]
Compound
C00076  Calcium cation
C00080  H+
C00238  Potassium cation
C01330  Sodium cation
Reference
PMID:17988210
  Authors
Bers DM
  Title
Calcium cycling and signaling in cardiac myocytes.
  Journal
Annu Rev Physiol 70:23-49 (2008)
DOI:10.1146/annurev.physiol.70.113006.100455
Reference
PMID:11805843
  Authors
Bers DM
  Title
Cardiac excitation-contraction coupling.
  Journal
Nature 415:198-205 (2002)
DOI:10.1038/415198a
Reference
PMID:16799263
  Authors
Endoh M
  Title
Signal transduction and Ca2+ signaling in intact myocardium.
  Journal
J Pharmacol Sci 100:525-37 (2006)
DOI:10.1254/jphs.CPJ06009X
Reference
PMID:18981594
  Authors
Endoh M
  Title
Cardiac Ca2+ signaling and Ca2+ sensitizers.
  Journal
Circ J 72:1915-25 (2008)
DOI:10.1253/circj.CJ-08-0838
Reference
PMID:16552170
  Authors
Bers DM, Despa S
  Title
Cardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts.
  Journal
J Pharmacol Sci 100:315-22 (2006)
DOI:10.1254/jphs.CPJ06001X
Reference
PMID:10747208
  Authors
Gordon AM, Homsher E, Regnier M
  Title
Regulation of contraction in striated muscle.
  Journal
Physiol Rev 80:853-924 (2000)
DOI:10.1152/physrev.2000.80.2.853
Reference
PMID:16701909
  Authors
Phrommintikul A, Chattipakorn N
  Title
Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death.
  Journal
Int J Cardiol 112:142-52 (2006)
DOI:10.1016/j.ijcard.2005.11.106
Reference
PMID:16096350
  Authors
Lacinova L
  Title
Voltage-dependent calcium channels.
  Journal
Gen Physiol Biophys 24 Suppl 1:1-78 (2005)
Reference
PMID:12763850
  Authors
Lingrel J, Moseley A, Dostanic I, Cougnon M, He S, James P, Woo A, O'Connor K, Neumann J
  Title
Functional roles of the alpha isoforms of the Na,K-ATPase.
  Journal
Ann N Y Acad Sci 986:354-9 (2003)
DOI:10.1111/j.1749-6632.2003.tb07214.x
Reference
PMID:11294886
  Authors
Berg JS, Powell BC, Cheney RE
  Title
A millennial myosin census.
  Journal
Mol Biol Cell 12:780-94 (2001)
DOI:10.1091/mbc.12.4.780
Reference
PMID:15736582
  Authors
Parmacek MS, Solaro RJ
  Title
Biology of the troponin complex in cardiac myocytes.
  Journal
Prog Cardiovasc Dis 47:159-76 (2004)
DOI:10.1016/j.pcad.2004.07.003
Reference
PMID:14659803
  Authors
Yamashita H, Sugiura S, Fujita H, Yasuda S, Nagai R, Saeki Y, Sunagawa K, Sugi H
  Title
Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction.
  Journal
Cardiovasc Res 60:580-8 (2003)
DOI:10.1016/j.cardiores.2003.09.011
Reference
PMID:19403607
  Authors
Pritchard TJ, Kranias EG
  Title
Junctin and the histidine-rich Ca2+ binding protein: potential roles in heart failure and arrhythmogenesis.
  Journal
J Physiol 587:3125-33 (2009)
DOI:10.1113/jphysiol.2009.172171
Reference
PMID:28596175
  Authors
Landstrom AP, Dobrev D, Wehrens XHT
  Title
Calcium Signaling and Cardiac Arrhythmias.
  Journal
Circ Res 120:1969-1993 (2017)
DOI:10.1161/CIRCRESAHA.117.310083
Related
pathway
efus04020  Calcium signaling pathway
KO pathway
ko04260   

DBGET integrated database retrieval system