KEGG   PATHWAY: efus04020
Entry
efus04020                   Pathway                                
Name
Calcium signaling pathway - Eptesicus fuscus (big brown bat)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
efus04020  Calcium signaling pathway
efus04020

Other DBs
GO: 0019722
Organism
Eptesicus fuscus (big brown bat) [GN:efus]
Gene
103283469  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
103283582  PLN; cardiac phospholamban [KO:K05852]
103283618  SLC8A3; sodium/calcium exchanger 3 [KO:K05849]
103283955  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
103284120  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
103284148  PTGFR; prostaglandin F2-alpha receptor isoform X1 [KO:K04262]
103284158  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103284167  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
103284275  MCOLN2; mucolipin-2 [KO:K04993]
103284403  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
103284606  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
103284694  ITPKC; inositol-trisphosphate 3-kinase C isoform X1 [KO:K00911] [EC:2.7.1.127]
103284712  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
103284886  CCKAR; cholecystokinin receptor type A [KO:K04194]
103284970  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103284973  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
103285018  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
103285158  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
103285376  PDE1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
103285452  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
103285537  FGF1; fibroblast growth factor 1 [KO:K18496]
103285582  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
103285666  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
103285667  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
103285754  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
103285782  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X4 [KO:K04632]
103285844  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
103285922  [KO:K04632]
103286013  ORAI2; protein orai-2 isoform X1 [KO:K16057]
103286068  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
103286119  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
103286155  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
103286378  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
103286379  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
103286498  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
103286515  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
103286741  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
103287027  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
103287033  [KO:K05220]
103287034  P2RX4; P2X purinoceptor 4 [KO:K05218]
103287036  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
103287071  TPCN1; two pore channel protein 1 [KO:K16896]
103287084  NOS1; nitric oxide synthase, brain isoform X2 [KO:K13240] [EC:1.14.13.39]
103287203  P2RX6; P2X purinoceptor 6 [KO:K05221]
103287256  FGFR4; fibroblast growth factor receptor 4 isoform X3 [KO:K05095] [EC:2.7.10.1]
103287276  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
103287336  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
103287362  [KO:K15040]
103287415  FGF7; fibroblast growth factor 7 [KO:K04358]
103287492  RYR3; ryanodine receptor 3 [KO:K04963]
103287505  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
103287675  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
103287676  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
103287703  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
103287770  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
103287907  FGF5; fibroblast growth factor 5 [KO:K04358]
103288035  FGF6; fibroblast growth factor 6 [KO:K04358]
103288060  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X2 [KO:K05850] [EC:7.2.2.10]
103288115  FGF23; fibroblast growth factor 23 [KO:K22428]
103288183  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
103288227  EDNRA; endothelin-1 receptor [KO:K04197]
103288385  EDNRB; endothelin receptor type B [KO:K04198]
103288414  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
103288651  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
103288665  ADRB1; beta-1 adrenergic receptor [KO:K04141]
103288726  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
103288794  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
103288853  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
103289069  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
103289342  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
103289404  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
103289435  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
103289448  VDAC2; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2 [KO:K15040]
103289468  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103289479  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
103289508  TACR2; substance-K receptor [KO:K04223]
103289578  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
103289679  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
103290075  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
103290114  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
103290249  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
103290264  ADRB3; beta-3 adrenergic receptor [KO:K04143]
103290305  FGF20; fibroblast growth factor 20 [KO:K04358]
103290420  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
103290904  TPCN2; two pore channel protein 2 [KO:K14077]
103291051  FGF3; fibroblast growth factor 3 [KO:K04358]
103291052  FGF4; fibroblast growth factor 4 [KO:K04358]
103291053  FGF19; fibroblast growth factor 19 [KO:K22603]
103291218  NGF; beta-nerve growth factor [KO:K02582]
103291221  CASQ2; calsequestrin-2 [KO:K23445]
103291384  TACR1; substance-P receptor [KO:K04222]
103291430  PDE1C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
103291446  TGFA; protransforming growth factor alpha [KO:K08774]
103291470  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
103291537  HRH2; histamine H2 receptor [KO:K04150]
103291538  DRD1; D(1A) dopamine receptor [KO:K04144]
103291596  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
103291622  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
103291698  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
103291879  PTAFR; platelet-activating factor receptor [KO:K04279]
103291991  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
103292236  CALM1; calmodulin-1 isoform X2 [KO:K02183]
103292412  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
103292491  AVPR1A; vasopressin V1a receptor [KO:K04226]
103292852  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
103293119  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
103293186  [KO:K02183]
103293215  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
103293251  HGF; hepatocyte growth factor [KO:K05460]
103293308  [KO:K05863]
103293520  RYR2; ryanodine receptor 2 [KO:K04962]
103293522  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
103293554  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
103293793  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
103293903  TACR3; neuromedin-K receptor [KO:K04224]
103294025  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
103294109  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
103294241  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103294245  TBXA2R; thromboxane A2 receptor [KO:K04264]
103294254  GNA15; guanine nucleotide-binding protein subunit alpha-15 isoform X3 [KO:K04637]
103294255  GNA11; guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
103294320  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
103294332  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
103294432  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
103294487  DRD5; D(1B) dopamine receptor [KO:K05840]
103294529  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
103294577  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
103295046  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
103295071  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
103295085  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
103295094  MCOLN1; mucolipin-1 [KO:K04992]
103295153  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
103295224  FGF10; fibroblast growth factor 10 isoform X1 [KO:K04358]
103295274  OXTR; oxytocin receptor [KO:K04229]
103295391  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X3 [KO:K08794] [EC:2.7.11.17]
103295438  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
103295457  VEGFC; vascular endothelial growth factor C [KO:K05449]
103295581  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X3 [KO:K05850] [EC:7.2.2.10]
103295594  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
103295625  HRH1; histamine H1 receptor [KO:K04149]
103295727  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
103295729  ADRB2; beta-2 adrenergic receptor [KO:K04142]
103295746  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103295749  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
103295862  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
103295904  PHKB; phosphorylase b kinase regulatory subunit beta isoform X2 [KO:K07190]
103295907  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
103295948  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
103295972  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
103296121  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
103296210  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103296244  ORAI3; protein orai-3 [KO:K16058]
103296250  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
103296626  VEGFA; vascular endothelial growth factor A [KO:K05448]
103296724  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
103296993  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
103297165  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
103297187  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
103297484  AVPR1B; vasopressin V1b receptor [KO:K04227]
103297514  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X3 [KO:K05850] [EC:7.2.2.10]
103297530  CASQ1; calsequestrin-1 [KO:K23468]
103297653  FGF21; fibroblast growth factor 21 [KO:K22429]
103297659  SPHK2; sphingosine kinase 2 isoform X3 [KO:K04718] [EC:2.7.1.91]
103297679  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
103297693  CALM3; calmodulin-3 isoform X1 [KO:K02183]
103297773  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
103297786  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
103297809  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform [KO:K07190]
103298055  BDKRB2; B2 bradykinin receptor isoform X2 [KO:K03916]
103298154  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
103298163  C6H4orf3; uncharacterized protein C4orf3 homolog isoform X2 [KO:K26467]
103298181  VEGFD; vascular endothelial growth factor D [KO:K05449]
103298189  GRPR; gastrin-releasing peptide receptor [KO:K04169]
103298309  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
103298318  SMIM6; small integral membrane protein 6 [KO:K26468]
103298394  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
103298572  CALML5; calmodulin-like protein 5 [KO:K02183]
103298573  [KO:K02183]
103298735  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
103298794  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
103298815  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
103298850  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
103299170  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
103299229  SLN; sarcolipin [KO:K22642]
103299264  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
103299369  ADORA2B; adenosine receptor A2b [KO:K04267]
103299600  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
103299789  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
103299890  P2RX1; P2X purinoceptor 1 [KO:K05215]
103299894  P2RX5; P2X purinoceptor 5 [KO:K05219]
103299933  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
103299975  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
103300060  HTR7; 5-hydroxytryptamine receptor 7 isoform X2 [KO:K04163]
103300240  NTSR1; neurotensin receptor type 1 [KO:K04211]
103300348  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 [KO:K05857] [EC:3.1.4.11]
103300381  ADORA2A; adenosine receptor A2a [KO:K04266]
103300415  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
103300420  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103300605  MST1R; macrophage-stimulating protein receptor isoform X2 [KO:K05100] [EC:2.7.10.1]
103300723  PHKA1; LOW QUALITY PROTEIN: phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform [KO:K07190]
103300744  CACNA1H; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
103300797  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
103300989  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
103301061  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
103301082  ITPKB; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
103301270  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
103301304  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
103301468  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
103301470  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
103301472  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
103301676  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
103301781  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
103301812  TNNC2; troponin C, skeletal muscle [KO:K12042]
103301893  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
103301926  TFEB; transcription factor EB [KO:K15590]
103301940  NTRK3; NT-3 growth factor receptor [KO:K05101] [EC:2.7.10.1]
103302014  AGTR1; type-1 angiotensin II receptor [KO:K04166]
103302042  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
103302044  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
103302140  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
103302242  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
103302277  P2RX3; P2X purinoceptor 3 [KO:K05217]
103302409  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
103302464  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
103302698  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
103302797  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
103303043  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103303121  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
103303193  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
103303616  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
103303624  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
103303646  FGF16; fibroblast growth factor 16 [KO:K04358]
103303678  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103303711  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
103303724  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
103303954  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
103303960  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
103304154  FGF9; fibroblast growth factor 9 isoform X1 [KO:K04358]
103304832  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
103304916  [KO:K02183]
103305103  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
103305203  F2R; proteinase-activated receptor 1 [KO:K03914]
103305406  LHCGR; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
103305414  CALM2; calmodulin-2 [KO:K02183]
103305443  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
103305553  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
114229025  [KO:K05096] [EC:2.7.10.1]
114232924  MRLN; myoregulin [KO:K22643]
114233099  TRDN; triadin isoform X1 [KO:K23449]
114234667  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
129147012  BDKRB1; B1 bradykinin receptor [KO:K03915]
129147180  [KO:K04634]
129148056  [KO:K05220]
129148148  [KO:K05220]
129148251  [KO:K06856]
129148572  [KO:K02183]
129149245  FGF2; fibroblast growth factor 2 [KO:K18497]
129149821  [KO:K05210]
129150056  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
129150189  CALML6; calmodulin-like protein 6 [KO:K02183]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
efus04010  MAPK signaling pathway
efus04070  Phosphatidylinositol signaling system
efus04210  Apoptosis
efus04720  Long-term potentiation
efus04730  Long-term depression
KO pathway
ko04020   

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