KEGG   PATHWAY: fca04142
Entry
fca04142                    Pathway                                
Name
Lysosome - Felis catus (domestic cat)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
fca04142  Lysosome
fca04142

Other DBs
GO: 0005764
Organism
Felis catus (domestic cat) [GN:fca]
Gene
100125859  LAMP1; lysosome-associated membrane glycoprotein 1 precursor [KO:K06528]
100144390  CTSW; cathepsin W precursor [KO:K08569] [EC:3.4.22.-]
100169945  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
100174922  GM2A; ganglioside GM2 activator isoform X1 [KO:K12383]
100216331  ARSB; arylsulfatase B precursor [KO:K01135] [EC:3.1.6.12]
100500935  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
101080406  PSAP; prosaposin isoform X3 [KO:K12382]
101080443  [KO:K01365] [EC:3.4.22.15]
101080759  DMXL1; dmX-like protein 1 isoform X5 [KO:K24155]
101081183  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
101081257  CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646]
101081341  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
101081450  IDS; iduronate 2-sulfatase isoform X3 [KO:K01136] [EC:3.1.6.13]
101082231  ASAH1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
101082314  CD164; sialomucin core protein 24 [KO:K06546]
101082362  MEAK7; MTOR-associated protein MEAK7 isoform X1 [KO:K27947]
101082573  DMXL2; dmX-like protein 2 isoform X1 [KO:K24155]
101082639  [KO:K01365] [EC:3.4.22.15]
101082825  AP3S2; AP-3 complex subunit sigma-2 isoform X1 [KO:K12399]
101083086  AP4E1; AP-4 complex subunit epsilon-1 isoform X1 [KO:K12400]
101083277  NAGA; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
101083283  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
101083562  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
101083690  ARSA; arylsulfatase A isoform X1 [KO:K01134] [EC:3.1.6.8]
101083709  TCIRG1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
101083937  NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
101084116  GALC; galactocerebrosidase isoform X6 [KO:K01202] [EC:3.2.1.46]
101084281  MFSD8; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
101084376  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
101084726  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
101084873  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
101084995  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 isoform X1 [KO:K02154]
101085117  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
101085427  CLN5; ceroid-lipofuscinosis neuronal protein 5 isoform X1 [KO:K12390]
101085538  CTSA; lysosomal protective protein isoform X1 [KO:K13289] [EC:3.4.16.5]
101085628  MANBA; beta-mannosidase isoform X1 [KO:K01192] [EC:3.2.1.25]
101085785  [KO:K12403]
101086138  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
101086359  GAA; lysosomal alpha-glucosidase isoform X1 [KO:K12316] [EC:3.2.1.20]
101086605  [KO:K01365] [EC:3.4.22.15]
101086631  DNASE2; deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
101086729  AP4S1; AP-4 complex subunit sigma-1 isoform X1 [KO:K12403]
101086851  AP1B1; AP-1 complex subunit beta-1 isoform X5 [KO:K12392]
101087880  [KO:K01365] [EC:3.4.22.15]
101087983  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
101088115  ABCB9; ABC-type oligopeptide transporter ABCB9 [KO:K05656]
101088129  NAPSA; napsin-A [KO:K08565] [EC:3.4.23.-]
101088174  GNS; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
101088293  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma isoform X3 [KO:K10087]
101088455  CTSE; cathepsin E isoform X1 [KO:K01382] [EC:3.4.23.34]
101088638  AP4M1; AP-4 complex subunit mu-1 isoform X2 [KO:K12402]
101088646  CLTB; clathrin light chain B isoform X2 [KO:K04645]
101089199  SLC11A2; natural resistance-associated macrophage protein 2 isoform X2 [KO:K21398]
101089593  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
101089646  AP3M1; AP-3 complex subunit mu-1 [KO:K12398]
101089821  CLN3; battenin [KO:K12389]
101089954  SLC11A1; natural resistance-associated macrophage protein 1 [KO:K12347]
101090199  SORT1; sortilin isoform X1 [KO:K12388]
101090226  GGA2; ADP-ribosylation factor-binding protein GGA2 [KO:K12404]
101090686  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
101091083  GBA; lysosomal acid glucosylceramidase isoform X2 [KO:K01201] [EC:3.2.1.45]
101091166  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
101091282  NEU1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
101091428  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
101091582  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X2 [KO:K01125] [EC:3.1.4.45]
101091627  HEXA; beta-hexosaminidase subunit alpha precursor [KO:K12373] [EC:3.2.1.52]
101091770  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
101092140  CTSC; dipeptidyl peptidase 1 isoform X1 [KO:K01275] [EC:3.4.14.1]
101092308  CTNS; cystinosin isoform X1 [KO:K12386]
101092463  ACP2; lysosomal acid phosphatase isoform X1 [KO:K14410] [EC:3.1.3.2]
101092687  CTSH; pro-cathepsin H isoform X1 [KO:K01366] [EC:3.4.22.16]
101092870  LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387]
101092920  HYAL3; hyaluronidase-3 [KO:K01197] [EC:3.2.1.35]
101092977  PLA2G15; phospholipase A2 group XV isoform X3 [KO:K06129] [EC:3.1.1.5]
101093011  [KO:K01197] [EC:3.2.1.35]
101093107  SLC17A5; sialin isoform X1 [KO:K12301]
101093296  TPP1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
101093311  ARSG; arylsulfatase G isoform X1 [KO:K12381] [EC:3.1.6.-]
101093371  GGA1; ADP-ribosylation factor-binding protein GGA1 isoform X2 [KO:K12404]
101093379  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
101093585  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
101094000  HYAL2; hyaluronidase-2 isoform X3 [KO:K01197] [EC:3.2.1.35]
101094134  LIPA; LOW QUALITY PROTEIN: lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
101094270  NPC2; NPC intracellular cholesterol transporter 2 [KO:K13443]
101094625  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
101094715  SGSH; N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
101095225  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
101095227  LAPTM4B; lysosomal-associated transmembrane protein 4B isoform X1 [KO:K12387]
101095232  AP1M2; AP-1 complex subunit mu-2 isoform X3 [KO:K12393]
101095340  FUCA2; plasma alpha-L-fucosidase isoform X1 [KO:K01206] [EC:3.2.1.51]
101095399  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
101095484  HYAL4; hyaluronidase-4 isoform X1 [KO:K01197] [EC:3.2.1.35]
101095578  PPT2; lysosomal thioesterase PPT2 [KO:K01074] [EC:3.1.2.22]
101095731  SPAM1; hyaluronidase PH-20 [KO:K01197] [EC:3.2.1.35]
101095896  IDUA; alpha-L-iduronidase precursor [KO:K01217] [EC:3.2.1.76]
101096367  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X7 [KO:K02154]
101096540  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
101096666  LAMP3; lysosome-associated membrane glycoprotein 3 isoform X4 [KO:K06562]
101097408  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
101097521  CLTA; clathrin light chain A isoform X4 [KO:K04644]
101097650  AP1G2; AP-1 complex subunit gamma-like 2 isoform X3 [KO:K12391]
101097898  AP3B2; AP-3 complex subunit beta-2 isoform X1 [KO:K12397]
101097951  MCOLN1; mucolipin-1 isoform X3 [KO:K04992]
101098389  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
101098470  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
101098591  GGA3; ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404]
101098719  CTSG; cathepsin G [KO:K01319] [EC:3.4.21.20]
101098789  SCARB2; lysosome membrane protein 2 [KO:K12384]
101099002  CD68; macrosialin [KO:K06501]
101099168  GALNS; N-acetylgalactosamine-6-sulfatase [KO:K01132] [EC:3.1.6.4]
101099497  SMPD1; sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]
101099835  CTSF; cathepsin F isoform X1 [KO:K01373] [EC:3.4.22.41]
101099988  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
101100093  WDR7; WD repeat-containing protein 7 isoform X1 [KO:K24738]
101100095  ABCA2; ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642]
101100203  LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387]
101100231  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X1 [KO:K08239] [EC:2.7.8.17]
101100288  SUMF1; formylglycine-generating enzyme isoform X1 [KO:K13444] [EC:1.8.3.7]
101100541  ACP5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
101100558  AP3M2; AP-3 complex subunit mu-2 [KO:K12398]
101100610  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
101100653  AP4B1; AP-4 complex subunit beta-1 isoform X1 [KO:K12401]
101100946  AP3D1; AP-3 complex subunit delta-1 isoform X1 [KO:K12396]
101101049  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase isoform X1 [KO:K10532] [EC:2.3.1.78]
101101185  AP3S1; AP-3 complex subunit sigma-1 isoform X1 [KO:K12399]
101101434  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
101101527  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
102899335  LITAFD; lITAF domain-containing protein isoform X1 [KO:K19363]
105259631  [KO:K01365] [EC:3.4.22.15]
105260768  AP3B1; AP-3 complex subunit beta-1 isoform X2 [KO:K12397]
111559122  [KO:K01365] [EC:3.4.22.15]
111559123  [KO:K01365] [EC:3.4.22.15]
111559124  [KO:K01365] [EC:3.4.22.15]
493693  NPC1; NPC intracellular cholesterol transporter 1 precursor [KO:K12385]
493697  MAN2B1; lysosomal alpha-mannosidase precursor [KO:K12311] [EC:3.2.1.24]
493846  CD63; CD63 antigen [KO:K06497]
493879  GUSB; beta-glucuronidase precursor [KO:K01195] [EC:3.2.1.31]
493927  GLB1; beta-galactosidase precursor [KO:K12309] [EC:3.2.1.23]
493928  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
751112  PDP; procathepsin L isoform X1 [KO:K01365] [EC:3.4.22.15]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
fca00511  Other glycan degradation
fca00531  Glycosaminoglycan degradation
fca04130  SNARE interactions in vesicular transport
fca04140  Autophagy - animal
fca04144  Endocytosis
KO pathway
ko04142   

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