KEGG   PATHWAY: fca04140
Entry
fca04140                    Pathway                                
Name
Autophagy - animal - Felis catus (domestic cat)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
fca04140  Autophagy - animal
fca04140

Other DBs
GO: 0006914
Organism
Felis catus (domestic cat) [GN:fca]
Gene
493804  INS; insulin precursor [KO:K04526]
100500937  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
101087257  IRS1; insulin receptor substrate 1 [KO:K16172]
101095791  IRS2; insulin receptor substrate 2 [KO:K07187]
101100432  insulin receptor substrate 1-like isoform X2 [KO:K17445]
101093251  IRS4; insulin receptor substrate 4 [KO:K17446]
101094274  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101091892  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101097413  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100271864  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
101093286  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
101093586  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101101686  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X3 [KO:K06276] [EC:2.7.11.1]
101087931  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101092818  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
100499544  AKT2; RAC-beta serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
101091813  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
751103  HRAS; GTPase HRas isoform X1 [KO:K02833]
751104  KRAS; GTPase KRas isoform X2 [KO:K07827]
751105  NRAS; GTPase NRas [KO:K07828]
101092784  MRAS; ras-related protein M-Ras isoform X2 [KO:K07831]
101096187  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
101094623  RRAS2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
101096047  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101081387  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X3 [KO:K04368] [EC:2.7.12.2]
101100281  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101087614  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101087958  MAPK3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
101083686  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
101082094  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
101082969  TSC2; tuberin isoform X1 [KO:K07207]
101101514  TSC1; LOW QUALITY PROTEIN: hamartin [KO:K07206]
768094  BNIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
101083160  RHEB; GTP-binding protein Rheb [KO:K07208]
101086862  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
101098686  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
101098152  MTOR; serine/threonine-protein kinase mTOR isoform X3 [KO:K07203] [EC:2.7.11.1]
101100932  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
101081776  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
101091812  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X3 [KO:K04688] [EC:2.7.11.1]
101092561  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X2 [KO:K04688] [EC:2.7.11.1]
101087383  IGBP1; immunoglobulin-binding protein 1 [KO:K17606]
101086855  immunoglobulin-binding protein 1-like [KO:K17606]
101099271  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
101094667  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101098658  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
101083981  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
101089141  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
101098308  ATG101; autophagy-related protein 101 [KO:K19730]
101091994  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
101080739  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
101090948  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
101088378  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
101095300  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
101092718  WDR45B; WD repeat domain phosphoinositide-interacting protein 3 isoform X1 [KO:K22991]
101100032  WDR45; WD repeat domain phosphoinositide-interacting protein 4 isoform X2 [KO:K22991]
101094780  ATG9A; autophagy-related protein 9A [KO:K17907]
101096716  ATG9B; autophagy-related protein 9B isoform X1 [KO:K17907]
101086619  SUPT20H; transcription factor SPT20 homolog isoform X1 [KO:K21245]
101098691  transcription factor SPT20 homolog [KO:K21245]
111558669  transcription factor SPT20 homolog [KO:K21245]
123383369  transcription factor SPT20 homolog [KO:K21245]
101099338  SMCR8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
101101360  WDR41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
101094546  CD4H9orf72; guanine nucleotide exchange C9orf72 homolog [KO:K23609]
101092668  RAB8A; ras-related protein Rab-8A [KO:K07901]
101097054  RAB39B; ras-related protein Rab-39B [KO:K07925]
101085431  SQSTM1; sequestosome-1 isoform X2 [KO:K14381]
101091955  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
101094867  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
101087312  RAB1A; ras-related protein Rab-1A [KO:K07874]
101097215  RRAGB; ras-related GTP-binding protein B isoform X1 [KO:K16185]
101097430  RRAGA; ras-related GTP-binding protein A [KO:K16185]
101094102  RRAGD; ras-related GTP-binding protein D isoform X2 [KO:K16186]
102901371  RRAGC; ras-related GTP-binding protein C [KO:K16186]
101085024  STK11; serine/threonine-protein kinase STK11 isoform X2 [KO:K07298] [EC:2.7.11.1]
101096000  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
101095885  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X3 [KO:K07198] [EC:2.7.11.31]
101090494  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
101095353  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101087716  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
101091310  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101101463  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
101084765  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
493934  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
493701  BCL2L1; bcl-2-like protein 1 [KO:K04570]
768269  BAD; bcl2-associated agonist of cell death [KO:K02158]
101101015  BECN1; beclin-1 isoform X2 [KO:K08334]
101094563  BECN2; beclin-2 [KO:K08334]
101082779  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
101091893  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
101099249  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
101092860  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
101088613  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
101099750  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101088919  TP53INP2; tumor protein p53-inducible nuclear protein 2 isoform X1 [KO:K21247]
101080842  VMP1; vacuole membrane protein 1 isoform X1 [KO:K21248]
101084833  STX17; syntaxin-17 [KO:K08491]
101090891  UVRAG; UV radiation resistance-associated gene protein isoform X2 [KO:K21249]
101101490  SH3GLB1; endophilin-B1 isoform X2 [KO:K11248]
101098570  RUBCN; run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X5 [KO:K19330]
101097674  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
101095899  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101084148  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
101100546  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X2 [KO:K04958]
101099780  DAPK3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
101089774  DAPK2; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
101084322  DAPK1; death-associated protein kinase 1 isoform X1 [KO:K08803] [EC:2.7.11.1]
101089823  HMGB1; high mobility group protein B1 [KO:K10802]
101096658  LOW QUALITY PROTEIN: high mobility group protein B1-like [KO:K10802]
109492809  PRAP1; proline-rich acidic protein 1 [KO:K21250]
101095973  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
101087928  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
101091455  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101082607  MTMR4; myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
101089469  MTMR3; myotubularin-related protein 3 isoform X6 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
101083154  MTMR14; myotubularin-related protein 14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
101086572  ZFYVE1; zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603]
101100938  ATG12; ubiquitin-like protein ATG12 isoform X1 [KO:K08336]
101092114  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
101100748  ATG16L1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
101083109  ATG16L2; protein Atg16l2 isoform X1 [KO:K20868]
101093088  ATG7; ubiquitin-like modifier-activating enzyme ATG7 isoform X1 [KO:K08337]
101091921  ATG10; ubiquitin-like-conjugating enzyme ATG10 isoform X1 [KO:K17888]
101088607  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
100142680  CFLAR; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
101098378  RAB33B; ras-related protein Rab-33B isoform X1 [KO:K07920]
101100730  PRKCQ; protein kinase C theta type isoform X2 [KO:K18052] [EC:2.7.11.13]
101083945  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
101094636  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
101097365  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 isoform X2 [KO:K08341]
101085618  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
101094318  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
101081984  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
101095705  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
101094737  ATG4D; cysteine protease ATG4D isoform X1 [KO:K08342] [EC:3.4.22.-]
101088311  ATG4A; cysteine protease ATG4A [KO:K08342] [EC:3.4.22.-]
101081652  ATG4C; cysteine protease ATG4C isoform X1 [KO:K08342] [EC:3.4.22.-]
101097334  ATG4B; cysteine protease ATG4B isoform X1 [KO:K08342] [EC:3.4.22.-]
101082535  NBR1; next to BRCA1 gene 1 protein isoform X2 [KO:K17987]
101087414  OPTN; optineurin isoform X1 [KO:K19946]
101097685  CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 isoform X1 [KO:K21348]
101080772  TAX1BP1; tax1-binding protein 1 isoform X1 [KO:K21347]
101081888  WDFY3; WD repeat and FYVE domain-containing protein 3 isoform X1 [KO:K22262]
100144608  UBA52; ubiquitin-60S ribosomal protein L40 precursor [KO:K02927]
101092929  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
101091319  UBB; polyubiquitin-B [KO:K04551]
101099660  UBC; polyubiquitin-C [KO:K08770]
101085323  SNAP29; synaptosomal-associated protein 29 [KO:K08509]
101085880  VAMP8; vesicle-associated membrane protein 8 [KO:K08512]
101095563  YKT6; synaptobrevin homolog YKT6 isoform X1 [KO:K08516]
101095016  STX7; syntaxin-7 isoform X1 [KO:K08488]
101084910  EPG5; ectopic P granules protein 5 homolog [KO:K23883]
101087796  PLEKHM1; pleckstrin homology domain-containing family M member 1 isoform X1 [KO:K23282]
123378959  pleckstrin homology domain-containing family M member 1-like isoform X1 [KO:K23282]
101094875  VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
101097716  VPS16; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
101087236  VPS18; vacuolar protein sorting-associated protein 18 homolog isoform X1 [KO:K20181]
101091975  VPS33A; vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182]
101082411  VPS39; vam6/Vps39-like protein [KO:K20183]
101099788  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
101087396  BIRC6; baculoviral IAP repeat-containing protein 6 isoform X7 [KO:K10586] [EC:2.3.2.23]
101088506  GORASP2; Golgi reassembly-stacking protein 2 [KO:K26797]
101085067  GORASP1; Golgi reassembly-stacking protein 1 isoform X3 [KO:K26797]
101085959  RAB7A; ras-related protein Rab-7a [KO:K07897]
101088049  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
100125859  LAMP1; lysosome-associated membrane glycoprotein 1 precursor [KO:K06528]
100169945  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
101094625  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
101087880  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
101086605  procathepsin L [KO:K01365] [EC:3.4.22.15]
105259631  procathepsin L-like isoform X2 [KO:K01365] [EC:3.4.22.15]
101080443  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
751112  PDP; procathepsin L isoform X1 [KO:K01365] [EC:3.4.22.15]
101082639  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
111559122  LOW QUALITY PROTEIN: procathepsin L-like [KO:K01365] [EC:3.4.22.15]
111559123  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
111559124  procathepsin L-like isoform X1 [KO:K01365] [EC:3.4.22.15]
101084873  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:20034776
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:24343578
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
fca04010  MAPK signaling pathway
fca04141  Protein processing in endoplasmic reticulum
fca04142  Lysosome
fca04150  mTOR signaling pathway
fca04152  AMPK signaling pathway
fca04910  Insulin signaling pathway
KO pathway
ko04140   
LinkDB

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