KEGG   PATHWAY: fca05310
Entry
fca05310                    Pathway                                
Name
Asthma - Felis catus (domestic cat)
Description
Asthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and airway inflammation. Inhaled allergens encounter antigen presenting cells (APC) that line the airway. Upon recognition of the antigen and activation by APC, naive T cells differentiate into TH2 cells. Activated TH2 stimulate the formation of IgE by B cells. IgE molecules bind to IgE receptors located on mast cells. The crosslinking of mast-cell-bound IgE by allergens leads to the release of biologically active mediators (histamine, leukotrienes) by means of degranulation and, so, to the immediate symptoms of allergy. Mast cells also release chemotactic factors that contribute to the recruitment of inflammatory cells, particularly eosinophils, whose proliferation and differentiation from bone marrow progenitors is promoted by IL-5. The activation of eosinophils leads to release of toxic granules and oxygen free radicals that lead to tissue damage and promote the development of chronic inflammation.
Class
Human Diseases; Immune disease
Pathway map
fca05310  Asthma
fca05310

Organism
Felis catus (domestic cat) [GN:fca]
Gene
101088996  DRA; HLA class II histocompatibility antigen, DR alpha chain-like precursor [KO:K06752]
100169654  SLC26A3; chloride anion exchanger precursor [KO:K06752]
101098301  DLA class II histocompatibility antigen, DR-1 beta chain precursor [KO:K06752]
111556169  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
101082906  HLA class II histocompatibility antigen, DO beta chain isoform X2 [KO:K06752]
101084108  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
101088734  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
111556173  HLA class II histocompatibility antigen, DM beta chain-like isoform X1 [KO:K06752]
101090518  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
111560441  HLA class II histocompatibility antigen, DO beta chain-like isoform X1 [KO:K06752]
101090771  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
111560440  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
101082653  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
101090265  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
101084962  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
111560443  HLA class II histocompatibility antigen, DM alpha chain-like [KO:K06752]
111560444  HLA class II histocompatibility antigen, DO alpha chain-like [KO:K06752]
111560445  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
111556176  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
111558969  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
111558970  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
102899262  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
111559549  uncharacterized protein LOC111559549 [KO:K10785]
751514  IL4; interleukin-4 precursor [KO:K05430]
493850  CD40LG; CD40 ligand [KO:K03161]
101085363  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
101094323  FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha [KO:K08089]
101101505  high affinity immunoglobulin epsilon receptor subunit beta [KO:K08090]
102902259  high affinity immunoglobulin epsilon receptor subunit beta isoform X2 [KO:K08090]
102902189  membrane-spanning 4-domains subfamily A member 3-like [KO:K08090]
102902042  membrane-spanning 4-domains subfamily A member 3-like [KO:K08090]
101089236  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
101088458  IL9; interleukin-9 [KO:K05432]
493683  IL10; interleukin-10 precursor [KO:K05443]
101084678  IL13; interleukin-13 isoform X2 [KO:K05435]
493803  IL5; interleukin-5 precursor [KO:K05428]
493755  TNF; tumor necrosis factor precursor [KO:K03156]
111560806  interleukin-3-like [KO:K04736]
Compound
C00388  Histamine
C00696  Prostaglandin D2
C02166  Leukotriene C4
C04598  2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine
C05951  Leukotriene D4
Reference
  Authors
Busse WW, Lemanske RF Jr.
  Title
Asthma.
  Journal
N Engl J Med 344:350-62 (2001)
DOI:10.1056/NEJM200102013440507
Reference
  Authors
Renauld JC.
  Title
New insights into the role of cytokines in asthma.
  Journal
J Clin Pathol 54:577-89 (2001)
DOI:10.1136/jcp.54.8.577
Reference
  Authors
Romagnani S.
  Title
The role of lymphocytes in allergic disease.
  Journal
J Allergy Clin Immunol 105:399-408 (2000)
DOI:10.1067/mai.2000.104575
Reference
  Authors
Averbeck M, Gebhardt C, Emmrich F, Treudler R, Simon JC.
  Title
Immunologic principles of allergic disease.
  Journal
J Dtsch Dermatol Ges 5:1015-28 (2007)
DOI:10.1111/j.1610-0387.2007.06538.x
Reference
  Authors
Conroy DM, Williams TJ.
  Title
Eotaxin and the attraction of eosinophils to the asthmatic lung.
  Journal
Respir Res 2:150-6 (2001)
DOI:10.1186/rr52
Reference
  Authors
Effros RM, Nagaraj H.
  Title
Asthma: new developments concerning immune mechanisms, diagnosis and treatment.
  Journal
Curr Opin Pulm Med 13:37-43 (2007)
DOI:10.1097/MCP.0b013e3280108757
Reference
  Authors
Barnes PJ.
  Title
Immunology of asthma and chronic obstructive pulmonary disease.
  Journal
Nat Rev Immunol 8:183-92 (2008)
DOI:10.1038/nri2254
Reference
  Authors
Holgate ST, Polosa R.
  Title
Treatment strategies for allergy and asthma.
  Journal
Nat Rev Immunol 8:218-30 (2008)
DOI:10.1038/nri2262
Reference
  Authors
Valenta R.
  Title
The future of antigen-specific immunotherapy of allergy.
  Journal
Nat Rev Immunol 2:446-53 (2002)
DOI:10.1038/nri824
Reference
  Authors
Trivedi SG, Lloyd CM.
  Title
Eosinophils in the pathogenesis of allergic airways disease.
  Journal
Cell Mol Life Sci 64:1269-89 (2007)
DOI:10.1007/s00018-007-6527-y
Reference
  Authors
Heinecke JW.
  Title
Eosinophil-dependent bromination in the pathogenesis of asthma.
  Journal
J Clin Invest 105:1331-2 (2000)
DOI:10.1172/JCI10072
Related
pathway
fca04060  Cytokine-cytokine receptor interaction
fca04514  Cell adhesion molecules
fca04612  Antigen processing and presentation
fca04630  JAK-STAT signaling pathway
fca04660  T cell receptor signaling pathway
fca04662  B cell receptor signaling pathway
fca04664  Fc epsilon RI signaling pathway
KO pathway
ko05310   
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