Entry Name JAK-STAT signaling pathway - Felis catus (domestic cat)
Description The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Felis catus (domestic cat) [GN:
fca ]
Gene 100135774 PDGFB; platelet-derived growth factor subunit B isoform X4 [KO:K17386 ]
100271864 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649 ]
101080562 STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705 ]
101080650 STAT4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222 ]
101081159 IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137 ]
101081835 PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063 ] [EC:2.3.2.-]
101082243 IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
101083719 CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059 ]
101084561 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
101085930 IL11RA; interleukin-11 receptor subunit alpha isoform X5 [KO:K05056 ]
101086565 IL20RA; interleukin-20 receptor subunit alpha isoform X3 [KO:K05136 ]
101087287 PDGFA; platelet-derived growth factor subunit A isoform X4 [KO:K04359 ]
101087601 IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
101088012 IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064 ]
101089787 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
101089832 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
101089873 STAT6; signal transducer and activator of transcription 6 [KO:K11225 ]
101089988 IL27RA; LOW QUALITY PROTEIN: interleukin-27 receptor subunit alpha [KO:K19598 ]
101090663 STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224 ]
101090913 STAT5A; signal transducer and activator of transcription 5A isoform X1 [KO:K11223 ]
101091892 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
101092504 STAM; signal transducing adapter molecule 1 isoform X2 [KO:K04705 ]
101092622 IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069 ]
101093085 IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063 ]
101093586 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
101094153 CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427 ]
101094274 PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
101095698 STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692 ]
101095878 IL31RA; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630 ]
101096447 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
101097413 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
101097748 PIAS3; E3 SUMO-protein ligase PIAS3 isoform X2 [KO:K16064 ] [EC:2.3.2.-]
101098207 FHL1; four and a half LIM domains protein 1 isoform X3 [KO:K14365 ]
101099224 STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221 ]
101099916 GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364 ]
101100114 IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X1 [KO:K05077 ]
101100474 PIAS1; E3 SUMO-protein ligase PIAS1 isoform X2 [KO:K04706 ] [EC:2.3.2.-]
101101338 CLCF1; cardiotrophin-like cytokine factor 1 isoform X4 [KO:K05421 ]
105261394 IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737 ]
493700 CSF3; granulocyte colony-stimulating factor precursor [KO:K05423 ]
493741 IL12A; interleukin-12 subunit alpha precursor [KO:K05406 ]
493943 CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625 ]
493953 IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068 ]
493970 MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 homolog [KO:K02539 ]
493978 EGF; pro-epidermal growth factor precursor [KO:K04357 ]
654423 IL23A; interleukin-23 subunit alpha isoform X3 [KO:K05426 ]
768273 IL12B; interleukin-12 subunit beta precursor [KO:K05425 ]
Reference Authors Harrison DA
Title The Jak/STAT pathway.
Journal Reference Authors Kiu H, Nicholson SE
Title Biology and significance of the JAK/STAT signalling pathways.
Journal Reference Authors Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Title Direct effects of type I interferons on cells of the immune system.
Journal Reference Authors Fish EN, Platanias LC
Title Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Journal Reference Authors Ivanenkov YA, Balakin KV, Lavrovsky Y
Title Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Journal Reference Authors O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
Title The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Journal Reference Authors Zoranovic T, Grmai L, Bach EA
Title Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
Journal Reference Authors Ungureanu D, Silvennoinen O
Title SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Journal Reference Authors Richard AJ, Stephens JM
Title The role of JAK-STAT signaling in adipose tissue function.
Journal Reference Authors Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
Title STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Journal Reference Authors Hirano T, Ishihara K, Hibi M
Title Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Journal Reference Authors Rane SG, Reddy EP
Title Janus kinases: components of multiple signaling pathways.
Journal Reference Authors Heim MH
Title The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Journal Reference Authors Morris R, Kershaw NJ, Babon JJ
Title The molecular details of cytokine signaling via the JAK/STAT pathway.
Journal Reference Authors Tzeng HT, Chyuan IT, Lai JH
Title Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
Journal Reference Authors Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
Title JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
Journal Related fca04060 Cytokine-cytokine receptor interaction
KO pathway
