KEGG   PATHWAY: fca04630
fca04630                    Pathway                                
JAK-STAT signaling pathway - Felis catus (domestic cat)
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Environmental Information Processing; Signal transduction
Pathway map
fca04630  JAK-STAT signaling pathway

Other DBs
GO: 0007259
Felis catus (domestic cat) [GN:fca]
751114  IL2; interleukin-2 precursor [KO:K05429]
111560806  interleukin-3-like [KO:K04736]
751514  IL4; interleukin-4 precursor [KO:K05430]
493803  IL5; interleukin-5 precursor [KO:K05428]
493687  IL6; interleukin-6 precursor [KO:K05405]
101084597  IL7; interleukin-7 isoform X1 [KO:K05431]
101088458  IL9; interleukin-9 [KO:K05432]
493683  IL10; interleukin-10 precursor [KO:K05443]
101085086  IL11; interleukin-11 isoform X2 [KO:K05417]
493741  IL12A; interleukin-12 subunit alpha precursor [KO:K05406]
768273  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
101084678  IL13; interleukin-13 isoform X2 [KO:K05435]
493682  IL15; interleukin-15 precursor [KO:K05433]
101093070  IL17D; interleukin-17D [KO:K05492]
101090582  IL19; interleukin-19 [KO:K05444]
101096130  IL20; interleukin-20 [KO:K22667]
101087399  IL21; interleukin-21 [KO:K05434]
101095184  IL22; interleukin-22 [KO:K05445]
654423  IL23A; interleukin-23 subunit alpha [KO:K05426]
101095874  IL24; interleukin-24 [KO:K22668]
493648  IFNA8; interferon alpha-8 precursor [KO:K05414]
493653  IFNA7; interferon alpha precursor [KO:K05414]
101088440  interferon alpha-2-like [KO:K05414]
101081371  interferon alpha-like [KO:K05414]
493840  IFNA5; LOW QUALITY PROTEIN: interferon alpha-5 [KO:K05414]
111557596  interferon alpha-like [KO:K05414]
493849  IFNB1; interferon beta precursor [KO:K05415]
493965  IFNG; interferon gamma precursor [KO:K04687]
101086758  IFNE; interferon epsilon [KO:K05442]
101092553  IFNK; interferon kappa [KO:K05441]
692347  IL-29; interleukin 29 precursor [KO:K05447]
101091490  IFNL1; interferon lambda-1 isoform X2 [KO:K05447]
101091743  LOW QUALITY PROTEIN: interferon lambda-3-like [KO:K22669]
101091983  interferon lambda-3-like [KO:K22669]
751820  IFNW4; interferon omega 4 precursor [KO:K05440]
751857  IFNW12; interferon omega 12 precursor [KO:K05440]
101088699  LOW QUALITY PROTEIN: interferon omega-1-like [KO:K05440]
751856  IFNW11; LOW QUALITY PROTEIN: interferon omega 11 [KO:K05440]
105259601  LOW QUALITY PROTEIN: interferon omega-1-like [KO:K05440]
101094379  OSM; oncostatin-M isoform X1 [KO:K05418]
101090296  LIF; leukemia inhibitory factor [KO:K05419]
101085857  TSLP; thymic stromal lymphopoietin [KO:K05436]
101083642  cardiotrophin-1 [KO:K05422]
101083389  cardiotrophin-2 [KO:K24382]
101094153  CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427]
101097592  CNTF; ciliary neurotrophic factor [KO:K05420]
493700  CSF3; granulocyte colony-stimulating factor precursor [KO:K05423]
493801  EPO; erythropoietin precursor [KO:K05437]
493931  GH1; somatotropin precursor [KO:K05438]
493838  LEP; leptin precursor [KO:K05424]
100302539  THPO; thrombopoietin precursor [KO:K06854]
751517  PRL; prolactin precursor [KO:K05439]
493978  EGF; pro-epidermal growth factor precursor [KO:K04357]
101087287  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100135774  PDGFB; platelet-derived growth factor subunit B isoform X4 [KO:K17386]
493953  IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068]
101092622  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
101090239  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
105261394  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
101096277  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
101099031  IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067]
101085689  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
101100697  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
101098275  IL9R; interleukin-9 receptor isoform X1 [KO:K05073]
101087601  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
101090038  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
101085930  IL11RA; interleukin-11 receptor subunit alpha isoform X5 [KO:K05056]
101093085  IL12RB1; LOW QUALITY PROTEIN: interleukin-12 receptor subunit beta-1 [KO:K05063]
101088012  IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
101091351  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
101100114  IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X1 [KO:K05077]
101082243  IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
101086565  IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136]
101081159  IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137]
101096026  IL21R; interleukin-21 receptor [KO:K05075]
101100741  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
101083429  IL22RA2; interleukin-22 receptor subunit alpha-2 [KO:K05139]
101087763  IL23R; LOW QUALITY PROTEIN: interleukin-23 receptor [KO:K05065]
101089988  IL27RA; LOW QUALITY PROTEIN: interleukin-27 receptor subunit alpha [KO:K19598]
101089832  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
101092535  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
101090285  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
101086811  IFNGR1; interferon gamma receptor 1 [KO:K05132]
101092286  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
101097499  IFNLR1; interferon lambda receptor 1 [KO:K05140]
101096447  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
101097206  LIFR; leukemia inhibitory factor receptor [KO:K05058]
101100367  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
101083719  CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
101100621  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K05066]
102901718  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
101091636  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
101089787  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
101081364  EPOR; LOW QUALITY PROTEIN: erythropoietin receptor [KO:K05079]
101093244  GHR; growth hormone receptor isoform X1 [KO:K05080]
101085646  LEPR; LOW QUALITY PROTEIN: leptin receptor [KO:K05062]
101097002  MPL; thrombopoietin receptor isoform X3 [KO:K05082]
101101444  PRLR; prolactin receptor [KO:K05081]
100510799  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:]
101090765  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:]
101084600  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:]
101084377  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:]
101088959  JAK2; tyrosine-protein kinase JAK2 isoform X2 [KO:K04447] [EC:]
101092339  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:]
101090171  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:]
101084561  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101099224  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
101095698  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
101080650  STAT4; signal transducer and activator of transcription 4 isoform X6 [KO:K11222]
101090913  signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
101090663  STAT5B; LOW QUALITY PROTEIN: signal transducer and activator of transcription 5B [KO:K11224]
101089873  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
101096550  CISH; cytokine-inducible SH2-containing protein [KO:K04701]
111558242  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
101080980  SOCS2; suppressor of cytokine signaling 2 [KO:K04695]
101081846  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
101080974  SOCS4; suppressor of cytokine signaling 4 [KO:K04697]
101080522  SOCS5; suppressor of cytokine signaling 5 [KO:K04698]
109493506  SOCS6; suppressor of cytokine signaling 6 [KO:K04699]
101098835  SOCS7; suppressor of cytokine signaling 7 isoform X1 [KO:K04699]
493934  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
493970  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 homolog [KO:K02539]
493701  BCL2L1; bcl-2-like protein 1 [KO:K04570]
493888  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:]
100379628  MYC; myc proto-oncogene protein [KO:K04377]
100037407  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101090950  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101101311  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
493943  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101085487  AOX1; aldehyde oxidase [KO:K00157] [EC:]
101081938  GFAP; glial fibrillary acidic protein isoform X2 [KO:K05640]
101092504  STAM; signal transducing adapter molecule 1 [KO:K04705]
101080562  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
101095923  PTPN2; tyrosine-protein phosphatase non-receptor type 2 isoform X3 [KO:K18026] [EC:]
101087073  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X2 [KO:K05697] [EC:]
101100970  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
101088344  EP300; histone acetyltransferase p300 [KO:K04498] [EC:]
101094471  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:]
101100474  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
101081835  PIAS2; LOW QUALITY PROTEIN: E3 SUMO-protein ligase PIAS2 [KO:K16063] [EC:2.3.2.-]
101097748  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X2 [KO:K16064] [EC:2.3.2.-]
101100031  PIAS4; E3 SUMO-protein ligase PIAS4 isoform X1 [KO:K16065] [EC:]
101098207  FHL1; four and a half LIM domains protein 1 isoform X3 [KO:K14365]
101085500  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:]
101099916  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101098862  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101088847  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
751103  HRAS; GTPase HRas isoform X1 [KO:K02833]
101096047  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:]
101094274  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:]
101091892  PIK3CB; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:]
101097413  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:]
100271864  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
101093286  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101093586  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101087931  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:]
101092818  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:]
100499544  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:]
101098152  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:]
Harrison DA
The Jak/STAT pathway.
Cold Spring Harb Perspect Biol 4:a011205 (2012)
Kiu H, Nicholson SE
Biology and significance of the JAK/STAT signalling pathways.
Growth Factors 30:88-106 (2012)
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Direct effects of type I interferons on cells of the immune system.
Clin Cancer Res 17:2619-27 (2011)
Fish EN, Platanias LC
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Mol Cancer Res 12:1691-703 (2014)
Ivanenkov YA, Balakin KV, Lavrovsky Y
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Mini Rev Med Chem 11:55-78 (2011)
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Annu Rev Med 66:311-28 (2015)
Zoranovic T, Grmai L, Bach EA
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
JAKSTAT 2:e25408 (2013)
Ungureanu D, Silvennoinen O
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Sci STKE 2005:pe49 (2005)
Richard AJ, Stephens JM
The role of JAK-STAT signaling in adipose tissue function.
Biochim Biophys Acta 1842:431-9 (2014)
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Neuropathol Appl Neurobiol 41:347-70 (2015)
Hirano T, Ishihara K, Hibi M
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Oncogene 19:2548-56 (2000)
Rane SG, Reddy EP
Janus kinases: components of multiple signaling pathways.
Oncogene 19:5662-79 (2000)
Heim MH
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Eur J Clin Invest 26:1-12 (1996)
fca04010  MAPK signaling pathway
fca04060  Cytokine-cytokine receptor interaction
fca04110  Cell cycle
fca04120  Ubiquitin mediated proteolysis
fca04151  PI3K-Akt signaling pathway
fca04210  Apoptosis
KO pathway

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