Entry
Name
Cytokine-cytokine receptor interaction - Felis catus (domestic cat)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
fca04060 Cytokine-cytokine receptor interaction
Organism
Felis catus (domestic cat) [GN:
fca ]
Gene
100174789 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
100328582 TNFSF13; tumor necrosis factor ligand superfamily member 13 [KO:K05475 ]
101080392 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141 ]
101081146 LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159 ]
101081159 IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137 ]
101082243 IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
101083251 TNFRSF18; tumor necrosis factor receptor superfamily member 18 isoform X1 [KO:K05154 ]
101083719 CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059 ]
101084857 EDA2R; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 27 [KO:K05163 ]
101084868 IL18RAP; interleukin-18 receptor accessory protein isoform X1 [KO:K05174 ]
101085363 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
101085930 IL11RA; interleukin-11 receptor subunit alpha isoform X5 [KO:K05056 ]
101086565 IL20RA; interleukin-20 receptor subunit alpha isoform X3 [KO:K05136 ]
101086618 TNFRSF17; tumor necrosis factor receptor superfamily member 17 isoform X2 [KO:K05153 ]
101087207 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
101087601 IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
101088012 IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064 ]
101088640 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
101089305 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B isoform X1 [KO:K05150 ]
101089787 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
101089832 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
101089877 TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
101089988 IL27RA; LOW QUALITY PROTEIN: interleukin-27 receptor subunit alpha [KO:K19598 ]
101090370 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X2 [KO:K05151 ]
101090616 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
101090651 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147 ]
101090784 TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160 ]
101091467 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
101091748 TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
101092622 IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069 ]
101093085 IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063 ]
101093414 TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376 ]
101094125 IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723 ]
101094153 CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427 ]
101095303 TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X3 [KO:K05155 ]
101095878 IL31RA; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630 ]
101096447 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
101096542 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
101096582 TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
101096644 EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X2 [KO:K05162 ]
101096878 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B isoform X1 [KO:K05148 ]
101098186 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
101098820 RELT; tumor necrosis factor receptor superfamily member 19L isoform X2 [KO:K05156 ]
101099505 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
101099756 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
101100114 IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X1 [KO:K05077 ]
101101338 CLCF1; cardiotrophin-like cytokine factor 1 isoform X4 [KO:K05421 ]
101101519 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
101101575 TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X1 [KO:K05145 ]
102899242 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
105261394 IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737 ]
493665 TNFRSF4; tumor necrosis factor receptor superfamily member 4 precursor [KO:K05142 ]
493700 CSF3; granulocyte colony-stimulating factor precursor [KO:K05423 ]
493741 IL12A; interleukin-12 subunit alpha precursor [KO:K05406 ]
493775 CD4; T-cell surface glycoprotein CD4 precursor [KO:K06454 ]
493806 CXCL12; stromal cell-derived factor 1 precursor [KO:K10031 ]
493881 FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390 ]
493938 IL18R1; interleukin-18 receptor 1 precursor [KO:K05173 ]
493945 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
493953 IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068 ]
493957 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158 ]
654423 IL23A; interleukin-23 subunit alpha isoform X3 [KO:K05426 ]
724036 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
768263 TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375 ]
768273 IL12B; interleukin-12 subunit beta precursor [KO:K05425 ]
790947 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway