KEGG   PATHWAY: gga04512
Entry
gga04512                    Pathway                                
Name
ECM-receptor interaction - Gallus gallus (chicken)
Description
The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
gga04512  ECM-receptor interaction
gga04512

Other DBs
GO: 0005201
Organism
Gallus gallus (chicken) [GN:gga]
Gene
396243  COL1A2; collagen alpha-2(I) chain precursor [KO:K06236]
395532  COL1A1; collagen alpha-1(I) chain [KO:K06236]
395069  COL2A1; collagen alpha-1(II) chain precursor [KO:K19719]
424799  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
422350  COL4A6; collagen alpha-6(IV) chain isoform X2 [KO:K06237]
395530  COL4A1; collagen alpha-1(IV) chain precursor [KO:K06237]
418752  COL4A2; collagen alpha-2(IV) chain precursor [KO:K06237]
422348  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
424797  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
396000  COL6A1; collagen alpha-1(VI) chain precursor [KO:K06238]
428448  COL6A6; collagen alpha-6(VI) chain isoform X2 [KO:K06238]
396292  COL6A2; collagen alpha-2(VI) chain precursor [KO:K06238]
396548  COL6A3; collagen alpha-3(VI) chain precursor [KO:K06238]
396242  COL9A3; collagen alpha-3(IX) chain precursor [KO:K08131]
771873  COL9A1; collagen alpha-1(IX) chain precursor [KO:K08131]
396524  COL9A2; collagen alpha-2(IX) chain precursor [KO:K08131]
374016  LAMA1; laminin subunit alpha-1 precursor [KO:K05637]
421709  LAMA2; LOW QUALITY PROTEIN: laminin subunit alpha-2 [KO:K05637]
428524  LAMA3; laminin subunit alpha-3 isoform X3 [KO:K06240]
428148  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
421749  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
396478  LAMB1; laminin subunit beta-1 [KO:K05636]
373980  LAMB2; laminin subunit beta-1 variant precursor [KO:K06243]
101748153  laminin subunit beta-2 isoform X2 [KO:K06243]
428268  LAMB3; laminin subunit beta-3 [KO:K06244]
396076  LAMB4; laminin subunit beta-4 [KO:K06245]
424442  LAMC1; laminin subunit gamma-1 [KO:K05635]
408043  LAMC2; laminin subunit gamma-2 [KO:K06246]
417180  LAMC3; LOW QUALITY PROTEIN: laminin subunit gamma-3 [KO:K06247]
769665  CHAD; chondroadherin [KO:K06248]
427850  RELN; reelin precursor [KO:K06249] [EC:3.4.21.-]
373987  THBS1; thrombospondin-1 precursor [KO:K16857]
414837  THBS2; thrombospondin-2 precursor [KO:K04659]
420120  COMP; cartilage oligomeric matrix protein [KO:K04659]
396306  THBS4; thrombospondin 4 precursor [KO:K04659]
396133  FN1; fibronectin precursor [KO:K05717]
395210  SPP1; osteopontin precursor [KO:K06250]
395935  VTN; vitronectin precursor [KO:K06251]
396440  TNC; tenascin precursor [KO:K06252]
396213  TNR; tenascin-R precursor [KO:K06252]
424435  TNN; tenascin-N [KO:K06252]
396106  TNX; tenascin-X isoform X4 [KO:K06252]
422535  NPNT; nephronectin isoform X5 [KO:K06824]
422506  FRAS1; extracellular matrix protein FRAS1 isoform X3 [KO:K23379]
418893  FREM2; FRAS1-related extracellular matrix protein 2 [KO:K23380]
427355  FREM1; FRAS1-related extracellular matrix protein 1 isoform X1 [KO:K23380]
419031  VWF; von Willebrand factor precursor [KO:K03900]
396071  IBSP; bone sialoprotein 2 precursor [KO:K06253]
404539  DMP1; dentin matrix acidic phosphoprotein 1 precursor [KO:K23328]
395256  MEPE; ovocleidin-116 precursor [KO:K26442]
396538  AGRN; agrin precursor [KO:K06254]
429806  HSPG2; LOW QUALITY PROTEIN: basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
395951  ITGA1; integrin alpha-1 precursor [KO:K06480]
100857227  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
101749783  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
373946  ITGA3; integrin alpha-3 precursor [KO:K06482]
424121  ITGA4; integrin alpha-4 [KO:K06483]
396226  ITGA6; integrin alpha-6 precursor [KO:K06485]
101749098  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
396225  ITGA8; integrin alpha-8 precursor [KO:K06584]
420757  ITGA9; integrin alpha-9 precursor [KO:K06585]
415560  ITGA11; integrin alpha-11 isoform X2 [KO:K06587]
396420  ITGAV; integrin alpha-V precursor [KO:K06487]
374058  ITGB1; integrin beta-1 precursor [KO:K05719]
374209  ITGB3; integrin beta-3 precursor [KO:K06493]
417374  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
395142  ITGB5; integrin beta-5 precursor [KO:K06588]
424191  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
107049666  integrin beta-7 [KO:K06590]
395470  ITGB8; integrin beta-8 isoform X3 [KO:K06591]
395666  CD44; CD44 antigen precursor [KO:K06256]
421960  SDC1; syndecan-1 [KO:K06257]
419184  SDC4; syndecan-4 precursor [KO:K16338]
427508  SV2B; synaptic vesicle glycoprotein 2B [KO:K06258]
431597  SV2C; synaptic vesicle glycoprotein 2C [KO:K06258]
101748017  synaptic vesicle glycoprotein 2A [KO:K06258]
417730  CD36; platelet glycoprotein 4 [KO:K06259]
100857508  GP5; platelet glycoprotein V [KO:K06260]
101750889  platelet glycoprotein Ib alpha chain-like [KO:K06261]
100857333  GP1BA; platelet glycoprotein Ib alpha chain [KO:K06261]
107051576  GP1BB; platelet glycoprotein Ib beta chain [KO:K06262]
100049058  DAG1; dystroglycan precursor [KO:K06265]
418408  CD47; leukocyte surface antigen CD47 precursor [KO:K06266]
416163  HMMR; hyaluronan mediated motility receptor [KO:K06267]
Compound
G10505  Hyaluronic acid
Reference
PMID:11572082
  Authors
van der Flier A, Sonnenberg A.
  Title
Function and interactions of integrins.
  Journal
Cell Tissue Res 305:285-98 (2001)
DOI:10.1007/s004410100417
Reference
PMID:12921709
  Authors
Reddy KV, Mangale SS.
  Title
Integrin receptors: the dynamic modulators of endometrial function.
  Journal
Tissue Cell 35:260-73 (2003)
DOI:10.1016/S0040-8166(03)00039-9
Reference
PMID:12125070
  Authors
Milner R, Campbell IL.
  Title
The integrin family of cell adhesion molecules has multiple functions within the CNS.
  Journal
J Neurosci Res 69:286-91 (2002)
DOI:10.1002/jnr.10321
Reference
PMID:12796473
  Authors
Cichy J, Pure E.
  Title
The liberation of CD44.
  Journal
J Cell Biol 161:839-43 (2003)
DOI:10.1083/jcb.200302098
Reference
PMID:7698997
  Authors
Elenius K, Jalkanen M.
  Title
Function of the syndecans--a family of cell surface proteoglycans.
  Journal
J Cell Sci 107 ( Pt 11):2975-82 (1994)
Reference
PMID:10617638
  Authors
Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS.
  Title
The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
  Journal
J Biol Chem 275:451-60 (2000)
DOI:10.1074/jbc.275.1.451
Reference
PMID:15036264
  Authors
Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L.
  Title
Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
  Journal
Crit Rev Oncol Hematol 49:245-58 (2004)
DOI:10.1016/j.critrevonc.2003.09.009
Reference
PMID:15381249
  Authors
Canobbio I, Balduini C, Torti M.
  Title
Signalling through the platelet glycoprotein Ib-V-IX complex.
  Journal
Cell Signal 16:1329-44 (2004)
DOI:10.1016/j.cellsig.2004.05.008
Reference
PMID:11331578
  Authors
Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R.
  Title
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
  Journal
EMBO J 20:2120-30 (2001)
DOI:10.1093/emboj/20.9.2120
Reference
PMID:12736199
  Authors
Martin PT.
  Title
Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
  Journal
Glycobiology 13:55R-66R (2003)
DOI:10.1093/glycob/cwg076
Reference
PMID:15229478
  Authors
Toole BP.
  Title
Hyaluronan: from extracellular glue to pericellular cue.
  Journal
Nat Rev Cancer 4:528-39 (2004)
DOI:10.1038/nrc1391
Reference
PMID:12845610
  Authors
Bosman FT, Stamenkovic I.
  Title
Functional structure and composition of the extracellular matrix.
  Journal
J Pathol 200:423-8 (2003)
DOI:10.1002/path.1437
Reference
PMID:29079659
  Authors
van der Ven AT, Vivante A, Hildebrandt F
  Title
Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.
  Journal
J Am Soc Nephrol 29:36-50 (2018)
DOI:10.1681/ASN.2017050561
Related
pathway
gga04510  Focal adhesion
KO pathway
ko04512   
LinkDB

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