KEGG   PATHWAY: hhip04070
Entry
hhip04070                   Pathway                                
Name
Phosphatidylinositol signaling system - Hippoglossus hippoglossus (Atlantic halibut)
Class
Environmental Information Processing; Signal transduction
Pathway map
hhip04070  Phosphatidylinositol signaling system
hhip04070

Organism
Hippoglossus hippoglossus (Atlantic halibut) [GN:hhip]
Gene
117751764  si:dkey-172j4.3; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
117751911  [KO:K13084] [EC:3.1.3.78]
117752210  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
117752236  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
117752384  plcd3b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A [KO:K05857] [EC:3.1.4.11]
117752436  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
117752448  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117752636  ipmkb; inositol polyphosphate multikinase [KO:K00915] [EC:2.7.1.140 2.7.1.151]
117753608  [KO:K01092] [EC:3.1.3.25]
117753610  impa2; inositol monophosphatase 2 [KO:K01092] [EC:3.1.3.25]
117753740  mtmr6; myotubularin-related protein 6 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
117753775  plcd1a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1a isoform X1 [KO:K05857] [EC:3.1.4.11]
117754098  pip4k2aa; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
117754394  inpp4aa; LOW QUALITY PROTEIN: inositol polyphosphate-4-phosphatase type I A [KO:K01109] [EC:3.1.3.66]
117754595  [KO:K05857] [EC:3.1.4.11]
117754820  pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
117755187  [KO:K00901] [EC:2.7.1.107]
117755294  dgkh; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
117755878  itpk1b; inositol-tetrakisphosphate 1-kinase [KO:K00913] [EC:2.7.1.159 2.7.1.134]
117755890  calm1a; calmodulin-1a [KO:K02183]
117755944  itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
117756187  calml4a; calmodulin-like protein 4a [KO:K02183]
117756460  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
117757530  dgki; diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
117758564  [KO:K05858] [EC:3.1.4.11]
117758565  [KO:K05858] [EC:3.1.4.11]
117758839  calm1b; calmodulin-1b [KO:K02183]
117758857  itpkb; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
117759796  [KO:K01116] [EC:3.1.4.11]
117760018  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
117760130  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
117760186  inpp5d; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084] [EC:3.1.3.86]
117760503  [KO:K00922] [EC:2.7.1.153]
117760625  [KO:K02649]
117760921  mtmr14; myotubularin-related protein 14 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
117760974  ip6k1; inositol hexakisphosphate kinase 1 isoform X1 [KO:K07756] [EC:2.7.4.21]
117761199  dgkab; diacylglycerol kinase, alpha b isoform X1 [KO:K00901] [EC:2.7.1.107]
117761206  inpp1; inositol polyphosphate 1-phosphatase [KO:K01107] [EC:3.1.3.57]
117761371  [KO:K07756] [EC:2.7.4.21]
117761422  [KO:K00920] [EC:2.7.1.149]
117761455  ip6k2b; inositol hexakisphosphate kinase 2b [KO:K07756] [EC:2.7.4.21]
117761634  [KO:K02183]
117761880  [KO:K04958]
117762072  ippk; inositol-pentakisphosphate 2-kinase [KO:K10572] [EC:2.7.1.158]
117762136  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
117762141  pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1 [KO:K00923] [EC:2.7.1.154]
117762692  pi4k2b; phosphatidylinositol 4-kinase type 2-beta [KO:K13711] [EC:2.7.1.67]
117763291  calml4b; calmodulin-like protein 4 [KO:K02183]
117763343  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
117763535  pik3c2g; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923] [EC:2.7.1.154]
117763536  [KO:K05861] [EC:3.1.4.11]
117763645  pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
117763649  ppip5k1b; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1 [KO:K13024] [EC:2.7.4.24]
117763823  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
117764479  dgkaa; diacylglycerol kinase, alpha a [KO:K00901] [EC:2.7.1.107]
117764528  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
117764635  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
117764639  pip4k2ca; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
117764692  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117764914  [KO:K19662] [EC:2.7.11.13]
117765365  inpp4b; type II inositol 3,4-bisphosphate 4-phosphatase isoform X1 [KO:K01109] [EC:3.1.3.66]
117765891  [KO:K19662] [EC:2.7.11.13]
117765921  si:ch73-374l24.1; LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
117765927  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
117766003  cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
117767036  plcd3a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A isoform X1 [KO:K05857] [EC:3.1.4.11]
117767247  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
117767361  inpp5e; phosphatidylinositol polyphosphate 5-phosphatase type IV [KO:K20278] [EC:3.1.3.36]
117767380  pi4kab; phosphatidylinositol 4-kinase, catalytic, alpha b isoform X1 [KO:K00888] [EC:2.7.1.67]
117767497  inpp5l; inositol polyphosphate-5-phosphatase A [KO:K01106] [EC:3.1.3.56]
117767525  cds2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
117768115  cds1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
117768217  [KO:K00920] [EC:2.7.1.149]
117768381  [KO:K02649]
117768394  mtmr3; myotubularin-related protein 3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
117768878  pi4k2a; phosphatidylinositol 4-kinase type 2-alpha [KO:K13711] [EC:2.7.1.67]
117769109  mtmr7a; myotubularin-related protein 7a [KO:K18083] [EC:3.1.3.64 3.1.3.95]
117769146  si:ch73-22a13.3; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
117769310  ocrl; inositol polyphosphate 5-phosphatase OCRL isoform X1 [KO:K01099] [EC:3.1.3.36]
117769550  dgke; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
117769562  inppl1b; inositol polyphosphate phosphatase-like 1b isoform X1 [KO:K15909] [EC:3.1.3.86]
117770135  pip4p2; type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase [KO:K13084] [EC:3.1.3.78]
117770592  [KO:K00889] [EC:2.7.1.68]
117770790  [KO:K19801] [EC:2.7.1.67]
117771113  sacm1la; phosphatidylinositide phosphatase SAC1-A [KO:K21797] [EC:3.1.3.-]
117771229  pi4kaa; phosphatidylinositol 4-kinase alpha isoform X1 [KO:K00888] [EC:2.7.1.67]
117771255  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
117771512  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1 [KO:K00889] [EC:2.7.1.68]
117772317  dgkza; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
117772439  [KO:K00901] [EC:2.7.1.107]
117772523  itpkcb; inositol-trisphosphate 3-kinase Cb [KO:K00911] [EC:2.7.1.127]
117772629  [KO:K00913] [EC:2.7.1.159 2.7.1.134]
117772752  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
117772853  inppl1a; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A [KO:K15909] [EC:3.1.3.86]
117773197  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
117773941  synj1; synaptojanin-1 isoform X1 [KO:K20279] [EC:3.1.3.36]
117773956  itpkca; inositol-trisphosphate 3-kinase C isoform X1 [KO:K00911] [EC:2.7.1.127]
117774077  mtmr4; myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
117774098  inpp4ab; inositol polyphosphate-4-phosphatase type I Ab isoform X1 [KO:K01109] [EC:3.1.3.66]
117774143  mtmr2; myotubularin-related protein 2 isoform X1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
117775143  [KO:K05858] [EC:3.1.4.11]
117775205  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117775240  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
117775372  [KO:K01106] [EC:3.1.3.56]
117775763  inpp5f; phosphatidylinositide phosphatase SAC2 isoform X1 [KO:K21798] [EC:3.1.3.-]
117776672  inpp5b; type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1 [KO:K01099] [EC:3.1.3.36]
117776724  pi4kb; phosphatidylinositol 4-kinase beta isoform X1 [KO:K19801] [EC:2.7.1.67]
117776741  [KO:K00889] [EC:2.7.1.68]
117776924  sacm1lb; phosphatidylinositide phosphatase SAC1-B [KO:K21797] [EC:3.1.3.-]
117776961  dgkb; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
117777363  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
117777858  [KO:K01092] [EC:3.1.3.25]
117777897  pip4p1a; type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase-A [KO:K13084] [EC:3.1.3.78]
117777916  bpnt2; inositol monophosphatase 3 [KO:K15759] [EC:3.1.3.7]
117777997  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
117778034  [KO:K00922] [EC:2.7.1.153]
117778054  [KO:K00889] [EC:2.7.1.68]
117778159  [KO:K02649]
117778391  [KO:K01092] [EC:3.1.3.25]
117778899  ppip5k1a; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X1 [KO:K13024] [EC:2.7.4.24]
117778911  [KO:K05857] [EC:3.1.4.11]
117779227  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117779288  mtmr1a; myotubularin-related protein 1a isoform X1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
117779289  mtm1; myotubularin isoform X1 [KO:K01108] [EC:3.1.3.64 3.1.3.95]
Compound
C00076  Calcium cation
C00137  myo-Inositol
C00269  CDP-diacylglycerol
C00416  Phosphatidate
C00641  1,2-Diacyl-sn-glycerol
C01177  Inositol 1-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01204  Phytic acid
C01220  1D-myo-Inositol 1,4-bisphosphate
C01243  1D-myo-Inositol 1,3,4-trisphosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01272  1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  myo-Inositol 4-phosphate
C04006  1D-myo-Inositol 3-phosphate
C04062  D-myo-Inositol 1,3-bisphosphate
C04063  D-myo-Inositol 3,4-bisphosphate
C04477  1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11174  1-Diphosinositol pentakisphosphate
C11526  5-PP-InsP5
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  1-Phosphatidyl-1D-myo-inositol 5-phosphate
C20690  1D-myo-Inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
Reference
PMID:19580826
  Authors
Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A
  Title
Mammalian phosphoinositide kinases and phosphatases.
  Journal
Prog Lipid Res 48:307-43 (2009)
DOI:10.1016/j.plipres.2009.06.001
Reference
PMID:19439500
  Authors
Shears SB
  Title
Diphosphoinositol polyphosphates: metabolic messengers?
  Journal
Mol Pharmacol 76:236-52 (2009)
DOI:10.1124/mol.109.055897
Related
pathway
hhip04020  Calcium signaling pathway
hhip04144  Endocytosis
hhip04510  Focal adhesion
KO pathway
ko04070   

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