KEGG   PATHWAY: hhip04144
Entry
hhip04144                   Pathway                                
Name
Endocytosis - Hippoglossus hippoglossus (Atlantic halibut)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
hhip04144  Endocytosis
hhip04144

Other DBs
GO: 0006897
Organism
Hippoglossus hippoglossus (Atlantic halibut) [GN:hhip]
Gene
117751851  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
117751986  [KO:K12196]
117752036  zmp:0000000660; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
117752047  acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12489]
117752141  [KO:K11247]
117752434  [KO:K18441]
117752481  [KO:K07904]
117752518  arf2b; ADP-ribosylation factor 2b [KO:K07937]
117752550  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
117752606  rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
117752655  chmp6b; charged multivesicular body protein 6 [KO:K12195]
117752695  [KO:K12188]
117752864  snf8; vacuolar-sorting protein SNF8 [KO:K12188]
117753009  chmp2a; charged multivesicular body protein 2a isoform X1 [KO:K12191]
117753175  [KO:K12494]
117753305  [KO:K18441]
117753448  [KO:K07889]
117753547  pld1b; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
117753648  [KO:K04361] [EC:2.7.10.1]
117753744  [KO:K11824]
117753785  nedd4a; E3 ubiquitin-protein ligase NEDD4a isoform X1 [KO:K10591] [EC:2.3.2.26]
117753800  asap1b; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
117753838  arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
117753853  sh3glb1a; endophilin-B1a [KO:K11248]
117753905  actr3b; actin-related protein 3B isoform X1 [KO:K18584]
117753968  chmp5b; charged multivesicular body protein 5 [KO:K12198]
117753981  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
117754004  [KO:K04237]
117754025  chmp4c; charged multivesicular body protein 4c isoform X1 [KO:K24782]
117754056  igf1rb; insulin-like growth factor 1b receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
117754142  [KO:K10396] [EC:5.6.1.3]
117754154  usp8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
117754186  tfr1b; transferrin receptor 1b [KO:K06503]
117754191  sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
117754283  [KO:K05633] [EC:2.3.2.26]
117754467  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
117754491  tgfbr2l; LOW QUALITY PROTEIN: TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
117754569  [KO:K17919]
117754698  [KO:K12562]
117754927  chmp2ba; charged multivesicular body protein 2Ba [KO:K12192]
117754983  [KO:K00909] [EC:2.7.11.14]
117754994  stam2; signal transducing adapter molecule 2 [KO:K04705]
117755046  [KO:K18584]
117755109  [KO:K10396] [EC:5.6.1.3]
117755139  [KO:K04189]
117755305  rab5b; ras-related protein Rab-5B [KO:K07888]
117755331  [KO:K05050]
117755595  rab11fip5a; rab11 family-interacting protein 1 [KO:K12484]
117755741  snx6; sorting nexin-6 isoform X1 [KO:K17920]
117755752  [KO:K17917]
117755868  asap2a; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2a isoform X1 [KO:K12488]
117755927  ehd4; EH domain-containing protein 4 [KO:K12477]
117755965  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
117756011  ldlrap1b; low density lipoprotein receptor adapter protein 1b isoform X1 [KO:K12474]
117756022  pld1a; phospholipase D1a [KO:K01115] [EC:3.1.4.4]
117756089  asap3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
117756101  [KO:K11248]
117756333  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
117756396  chmp3; charged multivesicular body protein 3 [KO:K12193]
117756591  vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
117756696  arf6b; ADP-ribosylation factor 6b [KO:K07941]
117756742  [KO:K23484]
117756753  vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
117756965  iqsec3a; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
117757032  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
117757122  grk1a; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
117757201  washc3; WASH complex subunit 3 isoform X1 [KO:K18463]
117757286  waslb; WASP like actin nucleation promoting factor b isoform X1 [KO:K23612]
117757307  [KO:K07939]
117757439  arfgap3; ADP-ribosylation factor GTPase-activating protein 3 isoform X1 [KO:K12493]
117757666  [KO:K17919]
117757964  rab4a; ras-related protein Rab-4A [KO:K07879]
117758051  igf2r; cation-independent mannose-6-phosphate receptor isoform X1 [KO:K06564]
117758497  si:dkey-71h2.2; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
117758508  arf6a; ADP-ribosylation factor 6a [KO:K07941]
117758585  rab10; ras-related protein Rab-10 [KO:K07903]
117758665  ist1; IST1 homolog isoform X1 [KO:K19476]
117758705  asap2b; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2b [KO:K12488]
117758755  vta1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
117758845  snx3; sorting nexin-3 [KO:K17918]
117758869  ehd3; EH domain-containing protein 3 [KO:K12476]
117759062  [KO:K18439]
117759165  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
117759352  [KO:K12196]
117759418  cyth4b; cytohesin 4b [KO:K18441]
117759424  [KO:K05069]
117759428  sh3gl3a; endophilin-A3a isoform X1 [KO:K11247]
117759432  spg21; maspardin isoform X1 [KO:K19367]
117759512  [KO:K06751]
117759520  [KO:K06751]
117759620  rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
117759702  [KO:K12196]
117759717  [KO:K04678] [EC:2.3.2.26]
117759887  dnajc6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
117760018  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
117760033  vps37c; vacuolar protein sorting-associated protein 37C [KO:K12185]
117760045  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
117760100  sh3gl1b; SH3-domain GRB2-like 1b isoform X1 [KO:K11247]
117760248  pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
117760340  ldlrb; low-density lipoprotein receptor [KO:K12473]
117760417  [KO:K12489]
117760489  zfyve9b; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
117760668  [KO:K07901]
117760737  eps15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
117760781  [KO:K12472]
117760804  [KO:K07905]
117760805  [KO:K07905]
117760968  [KO:K07939]
117761037  unm_sa1614; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [KO:K12488]
117761057  [KO:K07897]
117761058  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
117761075  [KO:K04393]
117761096  si:dkey-13a21.4; ras-related protein rab7 isoform X1 [KO:K07897]
117761119  [KO:K05704] [EC:2.7.10.2]
117761274  sh3gl2a; SH3 domain containing GRB2 like 2a, endophilin A1 isoform X1 [KO:K11247]
117761291  [KO:K07938]
117761330  iqsec1b; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
117761335  rab22a; ras-related protein Rab-22A [KO:K07891]
117761367  [KO:K07897]
117761379  chmp4ba; charged multivesicular body protein 4b [KO:K12194]
117761424  [KO:K17848]
117761475  [KO:K05632] [EC:2.3.2.26]
117761498  mvb12a; multivesicular body subunit 12A [KO:K12186]
117761558  [KO:K12489]
117761651  capza1a; F-actin-capping protein subunit alpha-1a [KO:K10364]
117761652  rhoca; ras homolog family member Ca [KO:K04513]
117761672  si:dkey-28n18.9; sorting nexin-32 [KO:K17920]
117761821  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
117761850  [KO:K04513]
117761861  cav3; caveolin-3 [KO:K12959]
117761978  zgc:172270; caveolin-2 [KO:K12958]
117762244  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
117762288  kif5ab; kinesin heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
117762302  [KO:K05755]
117762711  iqsec3b; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
117762714  wash1; WASH complex subunit 1 [KO:K18461]
117762754  pard6a; partitioning defective 6 homolog alpha [KO:K06093]
117762885  grk4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
117763009  [KO:K10364]
117763014  cav1; caveolin-1 [KO:K06278]
117763015  cav2; caveolin-2 [KO:K12958]
117763102  rab11fip4b; rab11 family-interacting protein 4B isoform X1 [KO:K12485]
117763110  washc4; WASH complex subunit 4 isoform X1 [KO:K18465]
117763312  wasla; WASP like actin nucleation promoting factor a isoform X1 [KO:K23612]
117763345  eea1; early endosome antigen 1 isoform X1 [KO:K12478]
117763466  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
117763570  tsg101a; tumor susceptibility 101a [KO:K12183]
117763573  [KO:K02833]
117763652  snx1a; sorting nexin-1a [KO:K17917]
117763786  [KO:K07939]
117763797  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
117763847  vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
117763858  chmp1a; charged multivesicular body protein 1a [KO:K12197]
117764033  [KO:K04513]
117764034  [KO:K04513]
117764059  [KO:K12495]
117764122  arf3a; ADP-ribosylation factor 3a [KO:K07938]
117764143  wipf2a; WAS/WASL-interacting protein family member 2 [KO:K19475]
117764283  zgc:158296; caveolin-2 [KO:K12958]
117764349  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
117764378  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
117764431  [KO:K04393]
117764492  iqsec2b; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
117764558  [KO:K12194]
117764649  kif5aa; kinesin family member 5Aa isoform X1 [KO:K10396] [EC:5.6.1.3]
117764671  [KO:K12481]
117764724  capza1b; F-actin-capping protein subunit alpha-1b [KO:K10364]
117764816  rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
117765037  acap3a; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
117765057  arfgef2; LOW QUALITY PROTEIN: brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442]
117765064  pard6b; partitioning defective 6 homolog beta [KO:K06093]
117765132  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
117765171  [KO:K04513]
117765178  [KO:K04513]
117765251  [KO:K12495]
117765289  itchb; itchy E3 ubiquitin protein ligase b isoform X1 [KO:K05632] [EC:2.3.2.26]
117765316  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
117765414  [KO:K03283]
117765415  [KO:K03283]
117765704  [KO:K18441]
117765744  dnm2a; dynamin-3 isoform X1 [KO:K23484]
117765769  cyth1a; cytohesin-1a isoform X1 [KO:K18441]
117765824  zgc:86896; actin-related protein 2/3 complex subunit 1A-A isoform X1 [KO:K05757]
117765836  il2rb; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
117765902  rab5c; ras-related protein Rab-5C [KO:K07889]
117765905  epn3a; epsin-3 isoform X1 [KO:K12471]
117765979  si:dkey-16l2.16; ras-related protein Rab-35 [KO:K07876]
117766044  [KO:K19475]
117766060  [KO:K05757]
117766082  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
117766232  smurf2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
117766234  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
117766345  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
117766403  arf2a; ADP-ribosylation factor 2a [KO:K07937]
117766491  ldlra; low density lipoprotein receptor a isoform X1 [KO:K12473]
117766645  [KO:K18441]
117766682  [KO:K12195]
117766733  epn2; epsin-2 isoform X1 [KO:K12471]
117766880  rab11fip4a; rab11 family-interacting protein 4A [KO:K12485]
117767003  ap2a1; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
117767247  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
117767301  grk5l; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
117767579  cltcl1; clathrin heavy chain 1 isoform X1 [KO:K04646]
117767581  snx2; sorting nexin-2 isoform X1 [KO:K17917]
117767681  git2a; ARF GTPase-activating protein GIT2a isoform X1 [KO:K12487]
117767766  rab11fip1a; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
117767782  [KO:K04500]
117767789  chmp7; charged multivesicular body protein 7 [KO:K15053]
117767857  [KO:K13712] [EC:2.7.1.68]
117767863  [KO:K21269]
117767989  [KO:K11866] [EC:3.4.19.12]
117768027  rab35b; ras-related protein Rab-35b isoform X1 [KO:K07876]
117768139  [KO:K01528] [EC:3.6.5.5]
117768275  [KO:K12186]
117768744  epn3b; epsin-3 isoform X1 [KO:K12471]
117768858  [KO:K12197]
117768910  zfyve27; protrudin isoform X1 [KO:K19368]
117769181  arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
117769196  ehd1a; EH domain-containing protein 1a [KO:K12483]
117769292  psd2; PH and SEC7 domain-containing protein 2 [KO:K12494]
117769298  cltb; clathrin light chain B isoform X1 [KO:K04645]
117769742  [KO:K12484]
117769761  rufy1; LOW QUALITY PROTEIN: RUN and FYVE domain-containing protein 1 [KO:K12482]
117769766  vps37a; vacuolar protein sorting-associated protein 37A [KO:K12185]
117769859  clta; clathrin light chain A isoform X1 [KO:K04644]
117770157  vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
117770277  pdcd6ip; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
117770473  pard6gb; par-6 family cell polarity regulator gamma b [KO:K06093]
117770547  wipf3; WAS/WASL-interacting protein family member 3 [KO:K19475]
117770592  [KO:K00889] [EC:2.7.1.68]
117770628  [KO:K07887]
117770694  [KO:K12486]
117770711  ldlrap1a; low density lipoprotein receptor adapter protein 1a isoform X1 [KO:K12474]
117770797  vps45; vacuolar protein sorting-associated protein 45 [KO:K12479]
117770903  [KO:K04388] [EC:2.7.11.30]
117770957  [KO:K06751]
117770961  [KO:K06751]
117770962  [KO:K06751]
117770969  [KO:K06751]
117770970  [KO:K06751]
117770971  [KO:K06751]
117770972  [KO:K06751]
117770973  [KO:K06751]
117770977  [KO:K06751]
117770979  [KO:K06751]
117770980  [KO:K06751]
117771066  [KO:K04393]
117771096  smap2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
117771343  pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
117771357  [KO:K21269]
117771505  dab2; disabled homolog 2 isoform X1 [KO:K12475]
117771512  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1 [KO:K00889] [EC:2.7.1.68]
117771616  [KO:K12494]
117771647  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
117771673  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
117771676  [KO:K03283]
117771721  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
117771736  git2b; ARF GTPase-activating protein GIT2b isoform X1 [KO:K12487]
117771800  zfyve16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
117771857  [KO:K12484]
117771896  grk3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
117771903  [KO:K08291] [EC:2.7.11.16]
117771935  [KO:K12186]
117772264  dnm1a; dynamin-1a isoform X1 [KO:K01528] [EC:3.6.5.5]
117772467  arrb1; beta-arrestin-1 [KO:K04439]
117772622  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
117772737  [KO:K18466]
117772958  spartb; spartin b isoform X1 [KO:K19366]
117772967  cbl; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
117773018  ap2s1; AP-2 complex subunit sigma [KO:K11827]
117773126  grk7b; rhodopsin kinase grk7-b [KO:K00909] [EC:2.7.11.14]
117773166  [KO:K12469]
117773245  ehd2b; EH domain-containing protein 2b isoform X1 [KO:K12469]
117773253  folr; folate receptor [KO:K13649]
117773414  si:ch211-167j9.5; tyrosine kinase receptor Cad96Ca [KO:K05093] [EC:2.7.10.1]
117773450  [KO:K18439]
117773465  [KO:K04646]
117773840  rabep1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
117773898  [KO:K05070]
117773906  snx12; sorting nexin-12 isoform X1 [KO:K17918]
117773908  [KO:K05070]
117773966  vps37d; vacuolar protein sorting-associated protein 37D [KO:K12185]
117773983  [KO:K04707] [EC:2.3.2.27]
117774084  cltca; clathrin, heavy chain a (Hc) isoform X1 [KO:K04646]
117774132  [KO:K03283]
117774134  [KO:K03283]
117774335  [KO:K11825]
117774371  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
117774383  grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
117774421  chmp1b; charged multivesicular body protein 1b [KO:K12197]
117774430  sparta; spartin a isoform X1 [KO:K19366]
117774511  cblb; E3 ubiquitin-protein ligase CBL-B-B [KO:K22517] [EC:2.3.2.27]
117774538  vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
117774692  [KO:K04439]
117774737  [KO:K18584]
117774776  vps26bl; vacuolar protein sorting-associated protein 26B-like [KO:K18466]
117774876  grk1b; rhodopsin kinase GRK1b [KO:K00909] [EC:2.7.11.14]
117774919  pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
117774925  [KO:K06751]
117775094  gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
117775137  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
117775140  [KO:K12486]
117775174  snx5; sorting nexin-5 [KO:K17920]
117775300  wipf1b; WAS/WASL-interacting protein family member 1 [KO:K19475]
117775303  washc2c; WASH complex subunit 2 isoform X1 [KO:K18462]
117775342  [KO:K17260]
117775479  [KO:K12484]
117775510  [KO:K06751]
117775693  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
117775752  [KO:K12494]
117775793  [KO:K12494]
117775971  [KO:K05050]
117776092  [KO:K10396] [EC:5.6.1.3]
117776285  rab11al; RAB11a, member RAS oncogene family, like [KO:K07904]
117776325  cblc; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
117776408  si:dkey-283b15.4; cytohesin-2 [KO:K18441]
117776557  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
117776677  washc5; WASH complex subunit 5 [KO:K18464]
117776711  epn1; epsin-1 isoform X1 [KO:K12471]
117776735  [KO:K04180]
117776741  [KO:K00889] [EC:2.7.1.68]
117776839  cdc42l; cell division cycle 42, like [KO:K04393]
117777113  rab5ab; RAB5A, member RAS oncogene family, b [KO:K07887]
117777178  [KO:K04388] [EC:2.7.11.30]
117777208  bin1b; myc box-dependent-interacting protein 1b isoform X1 [KO:K12562]
117777501  [KO:K12491]
117777649  zfyve9a; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
117777712  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
117777738  [KO:K07901]
117777757  [KO:K12472]
117777888  [KO:K10396] [EC:5.6.1.3]
117777977  [KO:K05754]
117777981  [KO:K07905]
117778018  agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
117778054  [KO:K00889] [EC:2.7.1.68]
117778070  [KO:K12472]
117778092  tfr1a; transferrin receptor 1a isoform X1 [KO:K06503]
117778292  [KO:K11247]
117778310  amph; amphiphysin [KO:K12562]
117778404  [KO:K11826]
117778455  rab31; ras-related protein Rab-31 [KO:K07891]
117778457  [KO:K12196]
117778715  [KO:K12198]
117778717  [KO:K04237]
117778739  [KO:K04189]
117778749  grk7a; rhodopsin kinase grk7a [KO:K00909] [EC:2.7.11.14]
117778855  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
117778866  arf1; ADP-ribosylation factor 1 isoform X1 [KO:K07937]
117779115  zgc:101810; actin-related protein 2 isoform X1 [KO:K17260]
117779396  si:dkey-19b23.8; low density lipoprotein receptor adapter protein 1 [KO:K12474]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
hhip04060  Cytokine-cytokine receptor interaction
hhip04070  Phosphatidylinositol signaling system
hhip04130  SNARE interactions in vesicular transport
hhip04142  Lysosome
hhip04350  TGF-beta signaling pathway
KO pathway
ko04144   

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