Homo sapiens (human): 80725
Help
Entry
80725 CDS
T01001
Symbol
SRCIN1, P140, SNIP
Name
(RefSeq) SRC kinase signaling inhibitor 1
KO
K19930
SRC kinase signaling inhibitor 1
Organism
hsa
Homo sapiens (human)
Network
nt06541
Cytoskeleton in neurons
Element
N01838
Regulation of synaptic plasticity, p140Cap
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
80725 (SRCIN1)
Membrane trafficking [BR:
hsa04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
80725 (SRCIN1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
AIP3
Motif
Other DBs
NCBI-GeneID:
80725
NCBI-ProteinID:
NP_079524
OMIM:
610786
HGNC:
29506
Ensembl:
ENSG00000277363
UniProt:
Q9C0H9
LinkDB
All DBs
Position
17:complement(38530031..38607025)
Genome browser
AA seq
1183 aa
AA seq
DB search
MGNAPSQDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRRFSNVGLVHTSERRHTVI
AAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQPNYWSFKTRSSR
HTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSP
GVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVF
YELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPA
PHLASGSPPPGLPSGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQG
VSPSPSAILERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAY
PGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGGPLYGDGYGFRLPPSSPQKLAD
VAAPPGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPP
SELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEK
IEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPAGQPTAVSRLQMQLHLRGLQNS
ASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERL
RYLNDEELITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHF
PGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPNNL
LSQSPKKVTAETDFNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKR
SVDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAP
TPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLT
TTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDED
DEDRIIAELESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSKHGKQRAEYMRIQAQQQA
TKPSKEMSGSNETSSPVSEKPSASRTSIPVLTSFGARNSSISF
NT seq
3552 nt
NT seq
+upstream
nt +downstream
nt
atggggaacgctccgtcccaagatccggagcggagcagcccccccatgctgtctgcggac
gatgcggagtacccgcgggagtaccggaccctggggggcgggggcggcgggggcagcggg
ggccggcgcttctccaacgtggggctggtgcacacgtccgagcggcggcacacggtgatc
gcggcccagagtctggaggcgctcagcgggctccagaaggcggacgccgaccgcaagcgt
gatgccttcatggaccacctgaagagcaagtacccacagcacgccctggccctgcgaggc
cagcaggacaggatgcgagagcagccaaactactggagtttcaagacccgcagctcacgc
cacactcagggagcccagcccgggctggcagaccaggcggcaaagctgtcctacgcctcc
gccgagtcgctggagaccatgtcggaggccgagctgcccctgggcttcagcaggatgaac
cgcttccgacagagcctgcctctctcccgctcggccagccagaccaagctgcgctcccca
ggggtgctgttcctgcagttcggggaggagactcggcgcgtgcacatcacgcacgaggtc
agcagcctggacacgctgcacgcactcatcgcgcacatgttcccgcagaagctcaccatg
ggcatgcttaagtcgcccaataccgccatcctcatcaaagacgaggctcgcaacgtcttc
tacgagctggaggacgtccgggacatccaggaccgcagtattatcaagatctacagaaag
gagcccctctacgctgccttccctggctcacatctcaccaacggggacctccggagagag
atggtgtacgcatcgcgggagtcctcgcccacgcggcgcctcaacaacctgtcaccagcg
ccgcacctggcatccggctcgccgccgcccgggctgccgtcggggctgccgtccgggctg
cagtccggttcgccgtcgcgttcgcgcctatcgtacgccggggggcgcccgccttcgtac
gccggcagcccggtgcaccacgcggccgagaggctgggaggcgccccggccgcccagggc
gtcagccccagccccagcgccatcctggagcggcgcgacgtgaagccggacgaggacctg
gcgagcaaggcgggcggcatggtgctggtgaaaggcgagggcctctatgctgacccctac
gggctgctgcacgagggccgtctgagcctggccgcggccgccggcgacccgttcgcctac
ccgggcgccggcggcctctacaagcgcggctcggtgcgctcgctcagcacctactcggcc
gccgcgctgcagtccgatctggaggactccctgtacaaggcggcgggcggcggcggcccg
ctgtacggcgacggctacggcttccgcctgccgccttcgtcaccgcagaagctggccgac
gtggcagcaccccccggaggtcccccgccaccgcacagcccctactcggggccgcccagc
cgcggctcgccagtgcgccagtccttccgcaaggactcgggctcctcgtccgtctttgcc
gagagtcctggagggaagacccgcagcgcggggagcgcctcgacggccggagctccccct
tcggagctcttccctgggcctggggaacgctcgctggttgggttcgggccgccagtgcca
gccaaggacacggagaccagggagcgcatggaggccatggagaagcagattgccagcctc
acaggcctggtgcagagcgccttactgcgaggctctgagcctgagacccccagcgagaag
attgaaggctccaatggagcagccaccccctcagcaccctgtgggtcaggcggccggagc
agcggggccaccccggtgtccggcccgcccccgccctcggccagcagcacccccgcaggt
cagcctaccgccgttagccggctgcagatgcagcttcacctgcgaggcctgcagaacagc
gccagtgacttgcgcggccagctccagcagttgcgcaagctccagctacagaaccaggag
tcggtgcgcgcgctgctgaagcgcacggaggcagagctgagcatgcgcgtgtcggaggcg
gcgcggcggcaggaggacccgctgcagcggcagcgcaccctggtggaagaggaacggctg
cgctatctcaacgacgaggagcttattacccagcagctcaatgacctggagaaatcggtg
gagaagatccagagagacgtgtcccacaaccaccggctggtgcccggccctgagctggag
gagaaggcactggtgctgaagcagctcggggagacgctgacagagctcaaggctcacttc
ccgggcctgcagagcaagatgcgggtggtgctgcgcgtggaggtggaggcggtgaagttc
ctgaaggaggagccccagcgcctggatgggctcctcaagcgctgccgcggggtcacggac
acgctggcccagatccgaaggcaagtggatgagggtgtgtggccaccccccaacaatctc
ctgagtcagtcccccaagaaggtgacggcagagactgacttcaacaagagcgtggacttc
gaaatgccaccccccagccccccgctgaacctgcatgagctgagcgggccagctgaagga
gcctctcttacccccaaggggggcaaccccaccaaaggcctggacactcctggcaagaga
agcgtggacaaagctgtgtctgttgaggctgcagagcgagactgggaggagaagcgggca
gccctgacccagtacagtgccaaggacatcaaccggctgctggaagagacacaggcagag
ctgctcaaggccatccctgacctggactgtgccagcaaggcccatccaggcccggccccc
actccagatcacaagccccccaaggccccccacggccagaaggcagccccccgaacggag
cccagtgggaggaggggctcagatgagttgaccgtgccccgataccgcacagagaagccc
tccaagtcgcccccaccgccccctccccgccggagcttcccctcctcccatggcctgacc
accacacgtaccggagaggtggtggtcaccagcaagaaggactcggccttcatcaagaag
gctgagtccgaggagctggaggtgcagaagccccaggtgaagctgcgccgggctgtgtct
gaggtggcccgcccagcctccacaccacccatcatggcctcggccatcaaggacgaggat
gacgaggatcgcatcatcgcagagctagagagtggcggaggcagtgtaccacccatgaag
gtggtgactccgggggcctctcggctgaaggcggcccagggccaggcgggcagccccgac
aaaagcaaacatggcaagcagagggccgagtacatgcggatccaggcccagcagcaggcc
actaaaccatctaaagagatgagcgggtcgaatgagacctcgagcccagtctcagaaaag
ccctcggcttccagaacctctatccctgtattgacttcctttggggcaaggaattcttcc
atctccttctag
Homo sapiens (human): 6714
Help
Entry
6714 CDS
T01001
Symbol
SRC, ASV, SRC1, THC6, c-SRC, p60-Src
Name
(RefSeq) SRC proto-oncogene, non-receptor tyrosine kinase
KO
K05704
tyrosine-protein kinase Src [EC:
2.7.10.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa01522
Endocrine resistance
hsa04012
ErbB signaling pathway
hsa04015
Rap1 signaling pathway
hsa04062
Chemokine signaling pathway
hsa04081
Hormone signaling
hsa04137
Mitophagy - animal
hsa04144
Endocytosis
hsa04360
Axon guidance
hsa04370
VEGF signaling pathway
hsa04510
Focal adhesion
hsa04520
Adherens junction
hsa04530
Tight junction
hsa04540
Gap junction
hsa04611
Platelet activation
hsa04613
Neutrophil extracellular trap formation
hsa04625
C-type lectin receptor signaling pathway
hsa04727
GABAergic synapse
hsa04750
Inflammatory mediator regulation of TRP channels
hsa04810
Regulation of actin cytoskeleton
hsa04912
GnRH signaling pathway
hsa04915
Estrogen signaling pathway
hsa04917
Prolactin signaling pathway
hsa04919
Thyroid hormone signaling pathway
hsa04921
Oxytocin signaling pathway
hsa04926
Relaxin signaling pathway
hsa05100
Bacterial invasion of epithelial cells
hsa05120
Epithelial cell signaling in Helicobacter pylori infection
hsa05130
Pathogenic Escherichia coli infection
hsa05131
Shigellosis
hsa05135
Yersinia infection
hsa05152
Tuberculosis
hsa05161
Hepatitis B
hsa05163
Human cytomegalovirus infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05203
Viral carcinogenesis
hsa05205
Proteoglycans in cancer
hsa05207
Chemical carcinogenesis - receptor activation
hsa05208
Chemical carcinogenesis - reactive oxygen species
hsa05219
Bladder cancer
hsa05417
Lipid and atherosclerosis
hsa05418
Fluid shear stress and atherosclerosis
Network
nt06162
Hepatitis B virus (HBV)
nt06167
Human cytomegalovirus (HCMV)
nt06180
Pathogenic Escherichia coli
nt06181
Salmonella
nt06182
Shigella
nt06183
Yersinia
nt06210
ERK signaling (cancer)
nt06214
PI3K signaling (cancer)
nt06223
TNF signaling (cancer)
nt06230
Cell cycle (cancer)
nt06263
Hepatocellular carcinoma
nt06533
Chemokine signaling
nt06541
Cytoskeleton in neurons
Element
N00393
ITGA/B-RhoGAP-RhoA signaling pathway
N00394
HCMV gH to ITGA/B-RhoA signaling pathway
N00538
Ca2+-PYK2-RAS-ERK signaling pathway
N00540
HBV HBx to RAS-ERK signaling pathway
N01068
ITGA/B-FAK-RAC signaling pathway
N01070
ITGA/B-FAK-CDC42 signaling pathway
N01078
EGF-EGFR-Actin signaling pathway
N01079
Shigella IpaC to Actin signaling pathway
N01091
Escherichia EspJ to IGG-FCGR-RAC signaling pathway
N01336
CHRNA7-E2F signaling pathway
N01337
NNK/NNN to CHRNA7-E2F signaling pathway
N01351
E2-ER-RAS-ERK signaling pathway
N01352
BPA to RAS-ERK signaling pathway
N01353
E2 to RAS-ERK signaling pathway
N01358
P4-PR-PI3K signaling pathway
N01359
P4/MPA to PR-PI3K signaling pathway
N01360
P4-PR-RAS-ERK signaling pathway
N01361
P4/MPA to PR-RAS-ERK signaling pathway
N01411
Metals to NFKB signaling pathway
N01767
CXCR4-GNAI-Src signaling pathway
N01838
Regulation of synaptic plasticity, p140Cap
Disease
H00020
Colorectal cancer
H00978
Thrombocytopenia (THC)
Drug target
Bosutinib (
DG00718
):
D03252
D09728
<JP/US>
Dasatinib (
DG00714
):
D03658
<JP>
D06414
<JP/US>
D12609
Ilorasertib:
D10423
Saracatinib (
DG01418
):
D09664
D09665
Tirbanibulin (
DG03082
):
D11691
<US>
D11692
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
6714 (SRC)
04015 Rap1 signaling pathway
6714 (SRC)
04370 VEGF signaling pathway
6714 (SRC)
09133 Signaling molecules and interaction
04081 Hormone signaling
6714 (SRC)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
6714 (SRC)
04137 Mitophagy - animal
6714 (SRC)
09144 Cellular community - eukaryotes
04510 Focal adhesion
6714 (SRC)
04520 Adherens junction
6714 (SRC)
04530 Tight junction
6714 (SRC)
04540 Gap junction
6714 (SRC)
09142 Cell motility
04810 Regulation of actin cytoskeleton
6714 (SRC)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
6714 (SRC)
04613 Neutrophil extracellular trap formation
6714 (SRC)
04625 C-type lectin receptor signaling pathway
6714 (SRC)
04062 Chemokine signaling pathway
6714 (SRC)
09152 Endocrine system
04912 GnRH signaling pathway
6714 (SRC)
04915 Estrogen signaling pathway
6714 (SRC)
04917 Prolactin signaling pathway
6714 (SRC)
04921 Oxytocin signaling pathway
6714 (SRC)
04926 Relaxin signaling pathway
6714 (SRC)
04919 Thyroid hormone signaling pathway
6714 (SRC)
09156 Nervous system
04727 GABAergic synapse
6714 (SRC)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
6714 (SRC)
09158 Development and regeneration
04360 Axon guidance
6714 (SRC)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
6714 (SRC)
05207 Chemical carcinogenesis - receptor activation
6714 (SRC)
05208 Chemical carcinogenesis - reactive oxygen species
6714 (SRC)
05203 Viral carcinogenesis
6714 (SRC)
09162 Cancer: specific types
05219 Bladder cancer
6714 (SRC)
09172 Infectious disease: viral
05161 Hepatitis B
6714 (SRC)
05168 Herpes simplex virus 1 infection
6714 (SRC)
05163 Human cytomegalovirus infection
6714 (SRC)
05167 Kaposi sarcoma-associated herpesvirus infection
6714 (SRC)
09171 Infectious disease: bacterial
05120 Epithelial cell signaling in Helicobacter pylori infection
6714 (SRC)
05130 Pathogenic Escherichia coli infection
6714 (SRC)
05131 Shigellosis
6714 (SRC)
05135 Yersinia infection
6714 (SRC)
05152 Tuberculosis
6714 (SRC)
05100 Bacterial invasion of epithelial cells
6714 (SRC)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
6714 (SRC)
05418 Fluid shear stress and atherosclerosis
6714 (SRC)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
6714 (SRC)
01522 Endocrine resistance
6714 (SRC)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
6714 (SRC)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
6714 (SRC)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
6714 (SRC)
Protein kinases [BR:
hsa01001
]
Non-receptor tyrosine kinases
SRC family
6714 (SRC)
Membrane trafficking [BR:
hsa04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
6714 (SRC)
Endocytosis
Clathrin-mediated endocytosis
Kinases
6714 (SRC)
Lipid raft mediated endocytosis
Caveolin-mediated endocytosis
6714 (SRC)
Macropinocytosis
Kinases
6714 (SRC)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
SH2
SH3_1
SH3_9
SH3_2
SH2_1
DUF7063
SH3_10
ABC1
Haspin_kinase
SH3_3
Motif
Other DBs
NCBI-GeneID:
6714
NCBI-ProteinID:
NP_005408
OMIM:
190090
HGNC:
11283
Ensembl:
ENSG00000197122
UniProt:
P12931
Structure
PDB
PDBj
LinkDB
All DBs
Position
20:37344699..37406050
Genome browser
AA seq
536 aa
AA seq
DB search
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
NT seq
1611 nt
NT seq
+upstream
nt +downstream
nt
atgggtagcaacaagagcaagcccaaggatgccagccagcggcgccgcagcctggagccc
gccgagaacgtgcacggcgctggcgggggcgctttccccgcctcgcagacccccagcaag
ccagcctcggccgacggccaccgcggccccagcgcggccttcgcccccgcggccgccgag
cccaagctgttcggaggcttcaactcctcggacaccgtcacctccccgcagagggcgggc
ccgctggccggtggagtgaccacctttgtggccctctatgactatgagtctaggacggag
acagacctgtccttcaagaaaggcgagcggctccagattgtcaacaacacagagggagac
tggtggctggcccactcgctcagcacaggacagacaggctacatccccagcaactacgtg
gcgccctccgactccatccaggctgaggagtggtattttggcaagatcaccagacgggag
tcagagcggttactgctcaatgcagagaacccgagagggaccttcctcgtgcgagaaagt
gagaccacgaaaggtgcctactgcctctcagtgtctgacttcgacaacgccaagggcctc
aacgtgaagcactacaagatccgcaagctggacagcggcggcttctacatcacctcccgc
acccagttcaacagcctgcagcagctggtggcctactactccaaacacgccgatggcctg
tgccaccgcctcaccaccgtgtgccccacgtccaagccgcagactcagggcctggccaag
gatgcctgggagatccctcgggagtcgctgcggctggaggtcaagctgggccagggctgc
tttggcgaggtgtggatggggacctggaacggtaccaccagggtggccatcaaaaccctg
aagcctggcacgatgtctccagaggccttcctgcaggaggcccaggtcatgaagaagctg
aggcatgagaagctggtgcagttgtatgctgtggtttcagaggagcccatttacatcgtc
acggagtacatgagcaaggggagtttgctggactttctcaagggggagacaggcaagtac
ctgcggctgcctcagctggtggacatggctgctcagatcgcctcaggcatggcgtacgtg
gagcggatgaactacgtccaccgggaccttcgtgcagccaacatcctggtgggagagaac
ctggtgtgcaaagtggcggactttgggctggctcggctcattgaagacaatgagtacacg
gcgcggcaaggtgccaaattccccatcaagtggacggctccagaagctgccctctatggc
cgcttcaccatcaagtcggacgtgtggtccttcgggatcctgctgactgagctcaccaca
aagggacgggtgccctaccctgggatggtgaaccgcgaggtgctggaccaggtggagcgg
ggctaccggatgccctgcccgccggagtgtcccgagtccctgcacgacctcatgtgccag
tgctggcggaaggagcctgaggagcggcccaccttcgagtacctgcaggccttcctggag
gactacttcacgtccaccgagccccagtaccagcccggggagaacctctag
Homo sapiens (human): 11113
Help
Entry
11113 CDS
T01001
Symbol
CIT, CITK, CRIK, MCPH17, STK21
Name
(RefSeq) citron rho-interacting serine/threonine kinase
KO
K16308
citron Rho-interacting kinase [EC:
2.7.11.35
]
Organism
hsa
Homo sapiens (human)
Network
nt06541
Cytoskeleton in neurons
Element
N01838
Regulation of synaptic plasticity, p140Cap
Disease
H00269
Primary microcephaly
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
11113 (CIT)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.35 CRIK-subfamily protein kinase
11113 (CIT)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: AGC group
DMPK family [OT]
11113 (CIT)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
CNH
Pkinase
PK_Tyr_Ser-Thr
PH
C1_1
Pkinase_C
Seadorna_VP7
APH
Motif
Other DBs
NCBI-GeneID:
11113
NCBI-ProteinID:
NP_009105
OMIM:
605629
HGNC:
1985
Ensembl:
ENSG00000122966
UniProt:
O14578
LinkDB
All DBs
Position
12:complement(119685791..119877320)
Genome browser
AA seq
2027 aa
AA seq
DB search
MLKFKYGARNPLDAGAAEPIASRASRLNLFFQGKPPFMTQQQMSPLSREGILDALFVLFE
ECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCGHFAEVQVVREKATG
DIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGG
DLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDF
GSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGR
SPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQKERLKFEGLCCHPFF
SKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSSSPCQLSPSGFSGEELPFVGFS
YSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVS
EVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLH
DIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFK
RKATECQHKLLKAKDQGKPEVGEYAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQ
NIRQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHLKQKEQH
YEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQR
IVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKI
SHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAAL
ESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDN
AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCT
MLEEQVMDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQ
RITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQ
KLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLEN
IQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNE
LKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIV
RSPEHQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVCL
DTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPGLQTKEP
SSSLHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELCLPDG
DVSIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYLLAPSFPDKQRWVTALES
VVAGGRVSREKAEADAKLLGNSLLKLEGDDRLDMNCTLPFSDQVVLVGTEEGLYALNVLK
NSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDISPN
IFEAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHFT
NYSILIGTNKFYEIDMKQYTLEEFLDKNDHSLAPAVFAASSNSFPVSIVQVNSAGQREEY
LLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGT
PARAYLDIPNPRYLGPAISSGAIYLASSYQDKLRVICCKGNLVKESGTEHHRGPSTSRSS
PNKRGPPTYNEHITKRVASSPAPPEGPSHPREPSTPHRYREGRTELRRDKSPGRPLEREK
SPGRMLSTRRERSPGRLFEDSSRGRLPAGAVRTPLSQVNKVWDQSSV
NT seq
6084 nt
NT seq
+upstream
nt +downstream
nt
atgttgaagttcaaatatggagcgcggaatcctttggatgctggtgctgctgaacccatt
gccagccgggcctccaggctgaatctgttcttccaggggaaaccaccctttatgactcaa
cagcagatgtctcctctttcccgagaagggatattagatgccctctttgttctctttgaa
gaatgcagtcagcctgctctgatgaagattaagcacgtgagcaactttgtccggaagtat
tccgacaccatagctgagttacaggagctccagccttcggcaaaggacttcgaagtcaga
agtcttgtaggttgtggtcactttgctgaagtgcaggtggtaagagagaaagcaaccggg
gacatctatgctatgaaagtgatgaagaagaaggctttattggcccaggagcaggtttca
ttttttgaggaagagcggaacatattatctcgaagcacaagcccgtggatcccccaatta
cagtatgcctttcaggacaaaaatcacctttatctggtcatggaatatcagcctggaggg
gacttgctgtcacttttgaatagatatgaggaccagttagatgaaaacctgatacagttt
tacctagctgagctgattttggctgttcacagcgttcatctgatgggatacgtgcatcga
gacatcaagcctgagaacattctcgttgaccgcacaggacacatcaagctggtggatttt
ggatctgccgcgaaaatgaattcaaacaagatggtgaatgccaaactcccgattgggacc
ccagattacatggctcctgaagtgctgactgtgatgaacggggatggaaaaggcacctac
ggcctggactgtgactggtggtcagtgggcgtgattgcctatgagatgatttatgggaga
tcccccttcgcagagggaacctctgccagaaccttcaataacattatgaatttccagcgg
tttttgaaatttccagatgaccccaaagtgagcagtgactttcttgatctgattcaaagc
ttgttgtgcggccagaaagagagactgaagtttgaaggtctttgctgccatcctttcttc
tctaaaattgactggaacaacattcgtaactctcctccccccttcgttcccaccctcaag
tctgacgatgacacctccaattttgatgaaccagagaagaattcgtgggtttcatcctct
ccgtgccagctgagcccctcaggcttctcgggtgaagaactgccgtttgtggggttttcg
tacagcaaggcactggggattcttggtagatctgagtctgttgtgtcgggtctggactcc
cctgccaagactagctccatggaaaagaaacttctcatcaaaagcaaagagctacaagac
tctcaggacaagtgtcacaagatggagcaggaaatgacccggttacatcggagagtgtca
gaggtggaggctgtgcttagtcagaaggaggtggagctgaaggcctctgagactcagaga
tccctcctggagcaggaccttgctacctacatcacagaatgcagtagcttaaagcgaagt
ttggagcaagcacggatggaggtgtcccaggaggatgacaaagcactgcagcttctccat
gatatcagagagcagagccggaagctccaagaaatcaaagagcaggagtaccaggctcaa
gtggaagaaatgaggttgatgatgaatcagttggaagaggatcttgtctcagcaagaaga
cggagtgatctctacgaatctgagctgagagagtctcggcttgctgctgaagaattcaag
cggaaagcgacagaatgtcagcataaactgttgaaggctaaggatcaagggaagcctgaa
gtgggagaatatgcgaaactggagaagatcaatgctgagcagcagctcaaaattcaggag
ctccaagagaaactggagaaggctgtaaaagccagcacggaggccaccgagctgctgcag
aatatccgccaggcaaaggagcgagccgagagggagctggagaagctgcagaaccgagag
gattcttctgaaggcatcagaaagaagctggtggaagctgaggagctcgaagagaaacat
cgggaggcccaagtctcagcccagcacctagaagtgcacctgaaacagaaagagcagcac
tatgaggaaaagattaaagtgttggacaatcagataaagaaagacctggctgacaaggag
acactggagaacatgatgcagagacacgaggaggaggcccatgagaagggcaaaattctc
agcgaacagaaggcgatgatcaatgctatggattccaagatcagatccctggaacagagg
attgtggaactgtctgaagccaataaacttgcagcaaatagcagtctttttacccaaagg
aacatgaaggcccaagaagagatgatttctgaactcaggcaacagaaattttacctggag
acacaggctgggaagttggaggcccagaaccgaaaactggaggagcagctggagaagatc
agccaccaagaccacagtgacaagaatcggctgctggaactggagacaagattgcgggag
gtcagtctagagcacgaggagcagaaactggagctcaagcgccagctcacagagctacag
ctctccctgcaggagcgcgagtcacagttgacagccctgcaggctgcacgggcggccctg
gagagccagcttcgccaggcgaagacagagctggaagagaccacagcagaagctgaagag
gagatccaggcactcacggcacatagagatgaaatccagcgcaaatttgatgctcttcgt
aacagctgtactgtaatcacagacctggaggagcagctaaaccagctgaccgaggacaac
gctgaactcaacaaccaaaacttctacttgtccaaacaactcgatgaggcttctggcgcc
aacgacgagattgtacaactgcgaagtgaagtggaccatctccgccgggagatcacggaa
cgagagatgcagcttaccagccagaagcaaacgatggaggctctgaagaccacgtgcacc
atgctggaggaacaggtcatggatttggaggccctaaacgatgagctgctagaaaaagag
cggcagtgggaggcctggaggagcgtcctgggtgatgagaaatcccagtttgagtgtcgg
gttcgagagctgcagagaatgctggacaccgagaaacagagcagggcgagagccgatcag
cggatcaccgagtctcgccaggtggtggagctggcagtgaaggagcacaaggctgagatt
ctcgctctgcagcaggctctcaaagagcagaagctgaaggccgagagcctctctgacaag
ctcaatgacctggagaagaagcatgctatgcttgaaatgaatgcccgaagcttacagcag
aagctggagactgaacgagagctcaaacagaggcttctggaagagcaagccaaattacag
cagcagatggacctgcagaaaaatcacattttccgtctgactcaaggactgcaagaagct
ctagatcgggctgatctactgaagacagaaagaagtgacttggagtatcagctggaaaac
attcaggttctctattctcatgaaaaggtgaaaatggaaggcactatttctcaacaaacc
aaactcattgattttctgcaagccaaaatggaccaacctgctaaaaagaaaaagggttta
tttagtcgacggaaagaggaccctgctttacccacacaggttcctctgcagtacaatgag
ctgaagctggccctggagaaggagaaagctcgctgtgcagagctagaggaagcccttcag
aagacccgcatcgagctccggtccgcccgggaggaagctgcccaccgcaaagcaacggac
cacccacacccatccacgccagccaccgcgaggcagcagatcgccatgtccgccatcgtg
cggtcgccagagcaccagcccagtgccatgagcctgctggccccgccatccagccgcaga
aaggagtcttcaactccagaggaatttagtcggcgtcttaaggaacgcatgcaccacaat
attcctcaccgattcaacgtaggactgaacatgcgagccacaaagtgtgctgtgtgtctg
gataccgtgcactttggacgccaggcatccaaatgtctcgaatgtcaggtgatgtgtcac
cccaagtgctccacgtgcttgccagccacctgcggcttgcctgctgaatatgccacacac
ttcaccgaggccttctgccgtgacaaaatgaactccccaggtctccagaccaaggagccc
agcagcagcttgcacctggaagggtggatgaaggtgcccaggaataacaaacgaggacag
caaggctgggacaggaagtacattgtcctggagggatcaaaagtcctcatttatgacaat
gaagccagagaagctggacagaggccggtggaagaatttgagctgtgccttcccgacggg
gatgtatctattcatggtgccgttggtgcttccgaactcgcaaatacagccaaagcagat
gtcccatacatactgaagatggaatctcacccgcacaccacctgctggcccgggagaacc
ctctacttgctagctcccagcttccctgacaaacagcgctgggtcaccgccttagaatca
gttgtcgcaggtgggagagtttctagggaaaaagcagaagctgatgctaaactgcttgga
aactccctgctgaaactggaaggtgatgaccgtctagacatgaactgcacgctgcccttc
agtgaccaggtggtgttggtgggcaccgaggaagggctctacgccctgaatgtcttgaaa
aactccctaacccatgtcccaggaattggagcagtcttccaaatttatattatcaaggac
ctggagaagctactcatgatagcaggagaagagcgggcactgtgtcttgtggacgtgaag
aaagtgaaacagtccctggcccagtcccacctgcctgcccagcccgacatctcacccaac
atttttgaagctgtcaagggctgccacttgtttggggcaggcaagattgagaacgggctc
tgcatctgtgcagccatgcccagcaaagtcgtcattctccgctacaacgaaaacctcagc
aaatactgcatccggaaagagatagagacctcagagccctgcagctgtatccacttcacc
aattacagtatcctcattggaaccaataaattctacgaaatcgacatgaagcagtacacg
ctcgaggaattcctggataagaatgaccattccttggcacctgctgtgtttgccgcctct
tccaacagcttccctgtctcaatcgtgcaggtgaacagcgcagggcagcgagaggagtac
ttgctgtgtttccacgaatttggagtgttcgtggattcttacggaagacgtagccgcaca
gacgatctcaagtggagtcgcttacctttggcctttgcctacagagaaccctatctgttt
gtgacccacttcaactcactcgaagtaattgagatccaggcacgctcctcagcagggacc
cctgcccgagcgtacctggacatcccgaacccgcgctacctgggccctgccatttcctca
ggagcgatttacttggcgtcctcataccaggataaattaagggtcatttgctgcaaggga
aacctcgtgaaggagtccggcactgaacaccaccggggcccgtccacctcccgcagcagc
cccaacaagcgaggcccacccacgtacaacgagcacatcaccaagcgcgtggcctccagc
ccagcgccgcccgaaggccccagccacccgcgagagccaagcacaccccaccgctaccgc
gaggggcggaccgagctgcgcagggacaagtctcctggccgccccctggagcgagagaag
tcccccggccggatgctcagcacgcggagagagcggtcccccgggaggctgtttgaagac
agcagcaggggccggctgcctgcgggagccgtgaggaccccgctgtcccaggtgaacaag
gtctgggaccagtcttcagtataa
Homo sapiens (human): 2017
Help
Entry
2017 CDS
T01001
Symbol
CTTN, EMS1
Name
(RefSeq) cortactin
KO
K06106
cortactin
Organism
hsa
Homo sapiens (human)
Pathway
hsa04530
Tight junction
hsa05100
Bacterial invasion of epithelial cells
hsa05130
Pathogenic Escherichia coli infection
hsa05131
Shigellosis
hsa05205
Proteoglycans in cancer
Network
nt06180
Pathogenic Escherichia coli
nt06182
Shigella
nt06541
Cytoskeleton in neurons
Element
N01078
EGF-EGFR-Actin signaling pathway
N01079
Shigella IpaC to Actin signaling pathway
N01287
Tight junction-Actin signaling pathway
N01838
Regulation of synaptic plasticity, p140Cap
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09144 Cellular community - eukaryotes
04530 Tight junction
2017 (CTTN)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
2017 (CTTN)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
2017 (CTTN)
05131 Shigellosis
2017 (CTTN)
05100 Bacterial invasion of epithelial cells
2017 (CTTN)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
2017 (CTTN)
09183 Protein families: signaling and cellular processes
04812 Cytoskeleton proteins [BR:
hsa04812
]
2017 (CTTN)
Membrane trafficking [BR:
hsa04131
]
Endocytosis
Clathrin-mediated endocytosis
Others
2017 (CTTN)
Others
Actin-binding proteins
Nucleation-promoting factors (NPFs)
2017 (CTTN)
Cytoskeleton proteins [BR:
hsa04812
]
Eukaryotic cytoskeleton proteins
Actin filaments / Microfilaments
Actin-binding proteins
Others
2017 (CTTN)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
HS1_rep
SH3_9
SH3_1
SH3_2
TAF4
Motif
Other DBs
NCBI-GeneID:
2017
NCBI-ProteinID:
NP_005222
OMIM:
164765
HGNC:
3338
Ensembl:
ENSG00000085733
UniProt:
Q14247
Q53HG7
Structure
PDB
PDBj
LinkDB
All DBs
Position
11:70398529..70436575
Genome browser
AA seq
550 aa
AA seq
DB search
MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE
NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG
FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG
KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQT
DRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQSERQDSAAVGFDYKEKLAKHESQQ
DYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKE
KEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSPV
YEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYP
AEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGL
FPANYVELRQ
NT seq
1653 nt
NT seq
+upstream
nt +downstream
nt
atgtggaaagcttcagcaggccacgctgtgtccatcgcccaggatgacgcgggggccgat
gactgggagaccgaccctgattttgtgaatgatgtgagtgagaaggagcaaagatggggt
gccaagacggtgcagggctccgggcaccaggagcatatcaacatacacaagctgagggag
aatgtctttcaagagcatcagacccttaaggagaaggaacttgaaacaggaccaaaagct
tcccatggctatggagggaaatttggtgtggaacaagaccgaatggataagtcagctgtc
ggccacgaatatcagtcgaaactttccaagcactgctcgcaggtggactcggtccgtggc
ttcggaggcaagtttggtgtccagatggacagagttgatcagtctgctgtaggctttgaa
taccaggggaagactgagaagcatgcctcccagaaagactactccagtggttttggcggc
aagtatggcgtgcaggccgaccgagtagacaagagcgcggtgggcttcgactaccagggc
aagacggagaagcacgagtcacagagagattactccaaaggtttcggcggcaaatacggt
atcgacaaggacaaagtggataagagcgccgttggctttgagtatcaaggcaaaacggag
aagcacgagtcccagaaagactatgtgaaagggtttggaggaaaatttggtgtgcagaca
gacagacaagacaaatgtgcccttggctgggatcaccaggagaaattgcagctgcatgaa
tcccaaaaagattataagactggttttggaggcaaattcggtgttcagtcggagaggcag
gactccgctgctgtggggtttgattacaaggagaagctggccaagcacgagtcccagcaa
gactactccaaaggattcggcgggaagtatggggtgcagaaggatcggatggataagaat
gcgtcaacctttgaggatgtcacccaggtgtcctctgcctaccagaagacagtacctgtc
gaagctgtgaccagcaaaacaagtaacatcagagctaactttgaaaacctcgctaaggag
aaagagcaggaggacaggcggaaggcggaggcggagagagcccagcggatggccaaggag
cggcaggagcaggaagaggccaggaggaagctggaggagcaagccagagccaaaacgcaa
acgccccctgtgtcgcccgcacctcagccaaccgaggagaggctgccctcgagccccgtc
tatgaggatgcggcttccttcaaggcagagctgagctacagaggccctgtgagtgggacg
gagccggagcccgtgtacagcatggaggccgctgactaccgagaggccagcagccagcag
ggcctggcctatgccacagaggctgtctatgaaagcgcagaggccccgggccactatccc
gcagaggacagcacctacgatgagtacgagaacgatctggggatcacagccgtcgccctg
tacgactaccaggctgcgggcgatgatgagatctcatttgaccctgatgacatcatcacc
aacatcgagatgattgacgacggctggtggcgcggggtgtgcaagggccggtacgggctc
ttcccagccaactatgtggagctgcggcagtag
DBGET
integrated database retrieval system
